Decreased serum levels of TGF-beta in patients with acute Plasmodium falciparum malaria.

abstract：PURPOSE:Severe combined immunodeficiency (SCID) is a syndrome of diverse genetic cause characterized by profound deficiencies of T, B and sometimes NK cell function. Non-ablative HLA-identical or rigorously T cell-depleted haploidentical parental bone marrow transplantation (BMT) results in thymus-dependent genetically...

journal_title：Journal of clinical immunology

authors： Buckley RH,Win CM,Moser BK,Parrott RE,Sajaroff E,Sarzotti-Kelsoe M

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:To elucidate the relative role of the immune system and intestinal epithelium in the ethiopatogenesis of Celiac disease (CD). METHODS:A patient with childhood CD who underwent allogeneic bone marrow transplantation (BMT) for chronic myelogenous leukemia was followed for 5 years after resumption of gluten conta...

journal_title：Journal of clinical immunology

authors： Ben-Horin S,Polak-Charcon S,Barshack I,Picard O,Fudim E,Yavzori M,Avivi C,Mardoukh C,Shimoni A,Chowers Y,Maor Y

更新日期：2013-11-01 00:00:00

abstract：:Utilizing a rat model of semiallogeneic intestinal transplantation, recipients were evaluated for accumulation of donor-specific cytotoxic T cells in spleen, mesenteric lymph nodes, Peyer's patches, lamina propria, and intraepithelial lymphocytes using limiting dilution analysis. Naive animals exhibited a low frequenc...

journal_title：Journal of clinical immunology

authors： Sirinek LP,O'Dorisio MS,Dunaway DJ

更新日期：1995-09-01 00:00:00

abstract：:The first description of the hybridoma technology in 1975 seemed to hold enormous promise for the treatment of a variety of human disease. The ability to produce monoclonal antibodies led to the availability of large amounts of homogeneous and predictable preparations of antibody. The potential to renew indefinitely a...

journal_title：Journal of clinical immunology

authors： Pirofski L,Casadevall A,Rodriguez L,Zuckier LS,Scharff MD

更新日期：1990-11-01 00:00:00

abstract：OBJECTIVES:The study clarified whether the T-helper (Th)1/Th2 imbalance existed only in coronary arterial inflammation or in both coronary arterial inflammation and myocardial inflammation and explored the significance of the imbalance of Th1/Th2 function after acute myocardial infarction (AMI). BACKGROUND:There are t...

journal_title：Journal of clinical immunology

authors： Cheng X,Liao YH,Ge H,Li B,Zhang J,Yuan J,Wang M,Liu Y,Guo Z,Chen J,Zhang J,Zhang L

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:The crucial role of T helper (Th) cells and chronic inflammation in atherosclerosis and coronary artery disease is no longer controversial. Evidence has revealed that Th cell type 1 (Th1) is closely associated with the pathogenesis of acute coronary syndrome (ACS). But the mechanisms involved in the generati...

journal_title：Journal of clinical immunology

authors： Guo M,Mao X,Ji Q,Lang M,Li S,Peng Y,Zhou W,Xiong B,Zeng Q

更新日期：2010-03-01 00:00:00

abstract：:MECP2 (methyl CpG binding protein 2) duplication causes syndromic intellectual disability. Patients often suffer from life-threatening infections, suggesting an additional immunodeficiency. We describe for the first time the detailed infectious and immunological phenotype of MECP2 duplication syndrome. 17/27 analyzed ...

journal_title：Journal of clinical immunology

authors： Bauer M,Kölsch U,Krüger R,Unterwalder N,Hameister K,Kaiser FM,Vignoli A,Rossi R,Botella MP,Budisteanu M,Rosello M,Orellana C,Tejada MI,Papuc SM,Patat O,Julia S,Touraine R,Gomes T,Wenner K,Xu X,Afenjar A,Toutain

更新日期：2015-02-01 00:00:00

abstract：:Cytokines are powerful mediator and communication molecules capable of regulating a wide spectrum of biologic functions, including immune responses. Although the role of cytokines in the pathogenesis of human disease is not yet understood, assays for cytokines have become a common feature in research and clinical labo...

journal_title：Journal of clinical immunology

authors： Whiteside TL

更新日期：1994-11-01 00:00:00

abstract：:Glucocorticoids (GC) represent the main treatment for pemphigus; however, some patients show GC resistance. GC sensitivity was evaluated in 19 pemphigus patients and 41 controls by the number of binding sites [B(max) (fmol/mg protein)] and the affinity of GC receptor [Kd (nM)] to dexamethasone (DEX) as well as by the ...

journal_title：Journal of clinical immunology

authors： Chriguer RS,Roselino AM,de Castro M

更新日期：2012-08-01 00:00:00

abstract：:Biallelic mutations in SLC29A3 cause histiocytosis-lymphadenopathy plus syndrome, also known as H syndrome (HS). HS is a complex disorder, with ~ 25% of patients developing autoinflammatory complications consisting of unexplained fevers, persistently elevated inflammatory markers, and unusual lymphadenopathies, with i...

journal_title：Journal of clinical immunology

authors： Lara-Reyna S,Poulter JA,Vasconcelos EJR,Kacar M,McDermott MF,Tooze R,Doffinger R,Savic S

更新日期：2020-12-07 00:00:00

abstract：:T-cell proliferative responses to the mitogenic monoclonal antibody anti-Leu 4 were assessed in healthy controls, lymphadenopathy syndrome (LAS) patients, and acquired immune deficiency syndrome (AIDS) patients. While 19% of the control group showed low anti-Leu 4 responses (less than 12,000 cpm), 60% of the LAS patie...

journal_title：Journal of clinical immunology

authors： Prince HE,Moody DJ,Shubin BI,Fahey JL

更新日期：1985-01-01 00:00:00

abstract：:We investigated the humoral (antigen-specific immunoglobulin isotypes, IgG subclasses, and avidity maturation) and cellular (antigen-specific in vitro proliferation) immune response in 18 healthy adult volunteers, following a primary and a single booster vaccination with the T-cell dependent neoantigen rabies administ...

journal_title：Journal of clinical immunology

authors： Brinkman DM,Jol-van der Zijde CM,ten Dam MM,Vossen JM,Osterhaus AD,Kroon FP,van Tol MJ

更新日期：2003-11-01 00:00:00

abstract：:During the last five decades, elegant mouse models of hematopoiesis have yielded most of the seminal insights into this complex biological system of self-renewal and lineage commitment. More recent advances in assays to measure human stem and progenitor cells as well as high resolution RNA profiling have revealed that...

journal_title：Journal of clinical immunology

authors： Parekh C,Crooks GM

更新日期：2013-05-01 00:00:00

abstract：:Hematopoietic stem cell transplantation (HSCT) is curative for severe combined immunodeficiency (SCID), but data on long-term impact of pre-HSCT chemotherapy, immune reconstitution and quality of life (QoL) of specific SCID genotypes are limited. We evaluated the long-term immune-reconstitution, health outcome and QoL...

journal_title：Journal of clinical immunology

authors： Abd Hamid IJ,Slatter MA,McKendrick F,Pearce MS,Gennery AR

更新日期：2018-08-01 00:00:00

abstract：:To investigate the associations of IkappaBalpha gene polymorphisms with the development and clinical manifestations of systemic lupus erythematosus (SLE), 110 patients with SLE and 120 unrelated healthy controls were enrolled in this study. The IkappaBalpha -881 A/G, -826 C/T, -550 A/T, -519 C/T, and -297 C/T polymorp...

journal_title：Journal of clinical immunology

authors： Lin CH,Wang SC,Ou TT,Li RN,Tsai WC,Liu HW,Yen JH

更新日期：2008-05-01 00:00:00

abstract：PURPOSE:The increased risk of morbidity and mortality from certain microbial infections and the demonstrated improvements in the clinical course of some autoimmune diseases support the existence of pregnancy-related alterations in immune status. Elucidating the changes in innate and adaptive immunity during gestation m...

journal_title：Journal of clinical immunology

authors： Kraus TA,Engel SM,Sperling RS,Kellerman L,Lo Y,Wallenstein S,Escribese MM,Garrido JL,Singh T,Loubeau M,Moran TM

更新日期：2012-04-01 00:00:00

abstract：:Using fresh whole blood or isolated lymphocytes, the activity of in vivo generated cytotoxic T-lymphocytes (CTL) was measured as the OKT3-specific lysis of HL-60 targets, in a cross-sectional study of 53 HIV (+) patients. CTL activity in the entire HIV(+) group was two to three times higher than in HIV(-) controls, wi...

journal_title：Journal of clinical immunology

authors： Vanham G,Kestens L,Penne G,Goilav C,Gigase P,Colebunders R,Vandenbruaene M,Goeman J,van der Groen G,Ceuppens JL

更新日期：1991-11-01 00:00:00

abstract：:Increased levels of serum IgD can be found in single patients with a variety of clinical syndromes and in the disease entity designated hyper-IgD syndrome which is associated with periodic fever and lymphadenopathy. We investigated 17 patients, both children and adults, with high serum IgD levels ranging from 220 to 5...

journal_title：Journal of clinical immunology

authors： Hiemstra I,Vossen JM,van der Meer JW,Weemaes CM,Out TA,Zegers BJ

更新日期：1989-09-01 00:00:00

abstract：INTRODUCTION:We used proteomic analyses to assess how drug abuse modulates immunologic responses to infections with the human immunodeficiency virus type 1 (HIV-1). METHODS:Two-dimensional difference gel electrophoresis was utilized to determine changes in the proteome of peripheral blood mononuclear cells (PBMC) isol...

journal_title：Journal of clinical immunology

authors： Reynolds JL,Mahajan SD,Aalinkeel R,Nair B,Sykes DE,Agosto-Mujica A,Hsiao CB,Schwartz SA

更新日期：2009-09-01 00:00:00

abstract：:The use of exogenous serum to provide protection against infections began more than a century ago. Over time, this concept matured and led to the preparation of concentrated immunoglobulin (IgG) products that were safe and effective when delivered subcutaneously (SC) or intramuscularly (IM) but were not ideal for intr...

journal_title：Journal of clinical immunology

authors： Torgerson TR

更新日期：2013-01-01 00:00:00

abstract：:Activated PI3K δ syndrome (APDS) is a primary immunodeficiency caused by heterogeneous germline gain-of-function mutations which ultimately lead to the hyperactivation of the phosphoinositide-3-kinase δ (PI3K δ). PI3K δ exists as a heterodimer composed of a catalytic and a regulatory subunit. APDS type 2 is caused by ...

journal_title：Journal of clinical immunology

authors： Ramirez L,Tamayo W,Ale H

更新日期：2020-10-01 00:00:00

abstract：:The concentrations of serum IgG and IgM antibodies to polyclonal IgA (IgAp), IgA1, and IgA2 were determined by enzyme immunoassay in 31 patients with IgA nephropathy and 30 healthy controls. Patients with IgA nephropathy had significantly raised concentrations of serum IgA compared to controls (Mann-Whitney U test, P ...

journal_title：Journal of clinical immunology

authors： Jones CL,Hosking CS,Kincaid-Smith P,Powell HR,Richardson SC,Sennhauser FH,Roberton DM

更新日期：1989-07-01 00:00:00

abstract：PURPOSE:To review the clinical and laboratory spectrum of RAG gene defects in humans, and discuss the mechanisms underlying phenotypic heterogeneity, the basis of immune dysregulation, and the current and perspective treatment modalities. METHODS:Literature review and analysis of medical records RESULTS: RAG gene defe...

journal_title：Journal of clinical immunology

authors： Delmonte OM,Schuetz C,Notarangelo LD

更新日期：2018-08-01 00:00:00

abstract：:Sixty patients (16 children, 44 adults) participated in the study aiming at evaluating: (i) IgG levels when switching patients from intravenous IgG (IVIG) infusions in hospital to subcutaneous (SCIG) self-infusions at home using the same cumulative monthly dose, (ii) protections against infections, and (iii) safety of...

journal_title：Journal of clinical immunology

authors： Gardulf A,Nicolay U,Asensio O,Bernatowska E,Böck A,Carvalho BC,Granert C,Haag S,Hernández D,Kiessling P,Kus J,Pons J,Niehues T,Schmidt S,Schulze I,Borte M

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Several autoimmune disorders have been linked to adverse pregnancy outcome. IgA deficiency shares many autoimmune traits, but its association with pregnancy outcome is unknown. METHODS:Prospective population-based cohort study in Sweden of 613 mothers with IgA deficiency (IgA levels < .07 g/L) diagnosed in ...

journal_title：Journal of clinical immunology

authors： Ludvigsson JF,Neovius M,Stephansson O,Hammarström L

更新日期：2014-10-01 00:00:00

abstract：:Since 2013, the International Union of Immunological Societies (IUIS) expert committee (EC) on Inborn Errors of Immunity (IEI) has published an updated phenotypic classification of IEI, which accompanies and complements their genotypic classification into ten tables. This phenotypic classification is user-friendly and...

journal_title：Journal of clinical immunology

authors： Bousfiha A,Jeddane L,Picard C,Al-Herz W,Ailal F,Chatila T,Cunningham-Rundles C,Etzioni A,Franco JL,Holland SM,Klein C,Morio T,Ochs HD,Oksenhendler E,Puck J,Torgerson TR,Casanova JL,Sullivan KE,Tangye SG

更新日期：2020-01-01 00:00:00

abstract：:The concentrations of seven immunoglobulin isotypes (IgA, IgE, IgM, IgG1, IgG2, IgG3, and IgG4) were measured in the sera of 207 Finnish blood donors, and they were allotyped with anti-Gm antibodies: anti-f, anti-a, anti-x, and anti-n. The above population could be divided into 12 phenotypes, and significant differenc...

journal_title：Journal of clinical immunology

authors： Sarvas H,Rautonen N,Mäkelä O

更新日期：1991-01-01 00:00:00

abstract：:Interferon-γ receptor 1 (IFN-γR1) deficiency is one of the primary immunodeficiencies conferring Mendelian Susceptibility to Mycobacterial Disease (MSMD). Some cases of neoplasms have been recently reported in patients with MSMD, underlying the already known link between immunodeficiency and carcinogenesis. We report ...

journal_title：Journal of clinical immunology

authors： Taramasso L,Boisson-Dupuis S,Garrè ML,Bondi E,Cama A,Nozza P,Morana G,Casanova JL,Marazzi MG

更新日期：2014-11-01 00:00:00

abstract：:Severe congenital neutropenia (SCN), originally described by the Swedish pediatrician Rolf Kostmann, constitutes a heterogeneous disorder associated with a dramatic decrease of peripheral neutrophil granulocytes. Patients suffer from life-threatening bacterial infections unless treated by recombinant human granulocyte...

journal_title：Journal of clinical immunology

authors： Klein C

更新日期：2017-02-01 00:00:00

abstract：:Total levels of IgM and secretory IgM as well as specific antibodies to poliovirus type I antigen, Escherichia coli O antigens, and beta-lactoglobulin were measured in unstimulated and stimulated saliva as well as nasal secretion using an enzyme-linked immunosorbent assay (ELISA). The levels of these antibodies in IgA...

journal_title：Journal of clinical immunology

authors： Mellander L,Björkander J,Carlsson B,Hanson LA

更新日期：1986-07-01 00:00:00