Overview of routes of IgG administration.

abstract：:Cytotoxic lymphocytes are critical in the control of HIV replication, it has been shown that perforin is the key effector of killing machinery for CTLs and NK cells, so we investigated the circulating levels of perforin in CD8+ T cells and NK cells by flow cytometry intracellular stain in Chinese HIV infected individu...

journal_title：Journal of clinical immunology

authors： Qi W,Yongjun J,Yanan W,Zining Z,Xiaoxu H,Jing L,Hong S

更新日期：2006-07-01 00:00:00

abstract：:Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by defects of nicotinamide adenine dinucleotide phosphate oxidase. Catalase-positive bacteria and fungi are phagocytosed, but persist within phagocytes, resulting in granulomatous inflammation. Although allogeneic hematopoietic stem cell transpla...

journal_title：Journal of clinical immunology

authors： Shigemura T,Nakazawa Y,Hirabayashi K,Kobayashi N,Sakashita K,Agematsu K,Koike K

更新日期：2015-01-01 00:00:00

abstract：:The immune response of 42 gastrointestinal and ovarian cancer patients at 1 month after exposure to murine monoclonal antibodies (B72.3 and CC49) reactive with the tumor-associated antigen TAG-72 was studied. The incidence of human anti-mouse antibody response was 89% to B72.3 and 70% to CC49. To evaluate the antiidio...

journal_title：Journal of clinical immunology

authors： Blanco I,Kawatsu R,Harrison K,Leichner P,Augustine S,Baranowska-Kortylewicz J,Tempero M,Colcher D

更新日期：1997-01-01 00:00:00

abstract：:Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency among adults and is characterized by a B cell dysfunction and increased risk of respiratory tract infections with encapsulated bacteria. However, a large proportion of patients also has inflammatory and autoimmune complicat...

journal_title：Journal of clinical immunology

authors： Jørgensen SF,Fevang B,Aukrust P

更新日期：2019-01-01 00:00:00

abstract：:The origin of natural antibodies has long been a subject of controversy. Polyreactive natural antibodies recognize multiple ligands and are thought to arise from B1 B cells. Natural antibodies against carbohydrate antigens such as Gal alpha 1-3Gal or against blood groups A and B are thought to be "elicited" by gut bac...

journal_title：Journal of clinical immunology

authors： Parker W,Yu PB,Holzknecht ZE,Lundberg K,Buckley RH,Platt JL

更新日期：1997-07-01 00:00:00

abstract：OBJECTIVE:The aim of this study is to determine when during hematopoiesis Siglec-8 gets expressed, whether it is expressed on hematologic malignancies, and if there are other non-human species that express Siglec-8. METHODS:Siglec-8 mRNA and cell surface expression was monitored during in vitro maturation of human eos...

journal_title：Journal of clinical immunology

authors： Hudson SA,Herrmann H,Du J,Cox P,Haddad el-B,Butler B,Crocker PR,Ackerman SJ,Valent P,Bochner BS

更新日期：2011-12-01 00:00:00

abstract：:Glucocorticoids (GC) represent the main treatment for pemphigus; however, some patients show GC resistance. GC sensitivity was evaluated in 19 pemphigus patients and 41 controls by the number of binding sites [B(max) (fmol/mg protein)] and the affinity of GC receptor [Kd (nM)] to dexamethasone (DEX) as well as by the ...

journal_title：Journal of clinical immunology

authors： Chriguer RS,Roselino AM,de Castro M

更新日期：2012-08-01 00:00:00

abstract：:Light chain amyloidosis (AL) is a protein folding disorder with an underlying B cell neoplasia where the monoclonal immunoglobulin light chains (LCs) produced from insoluble amyloid fibrils. The deposition of these fibrillar aggregates in vital organs causes severe organ dysfunction over time and is associated with hi...

journal_title：Journal of clinical immunology

authors： Abraham RS,Geyer SM,Ramírez-Alvarado M,Price-Troska TL,Gertz MA,Fonseca R

更新日期：2004-07-01 00:00:00

abstract：:Apart from cellular immunity and immunopathology, various cytokines have been implicated in malaria-associated immunosuppression. In this study, serum levels of transforming growth factor-beta (TGF-beta) were determined with an enzyme-linked immunosorbent assay in 37 patients with acute Plasmodium falciparum malaria p...

journal_title：Journal of clinical immunology

authors： Wenisch C,Parschalk B,Burgmann H,Looareesuwan S,Graninger W

更新日期：1995-03-01 00:00:00

abstract：:Despite multiple sexual exposures to HIV-1 virus, some individuals remain HIV-1 seronegative. Although several genetic factors have been related to HIV-1 resistance, the homozygosity for a mutation in CCR5 gene (the 32-bp deletion, i.e., CCR5-Delta32 allele) is presently considered the most relevant one. The C-type le...

journal_title：Journal of clinical immunology

authors： Rathore A,Chatterjee A,Sivarama P,Yamamoto N,Dhole TN

更新日期：2008-01-01 00:00:00

abstract：:We showed previously that the conserved extended MHC haplotype [HLA-B8, SCO1, DR3] carries recessive susceptibility genes for IgA and IgG4 deficiency and dominant genes for IgD and IgG3 deficiency. [HLA-B18, F1C30, DR3] has similar class II and III regions to [HLA-B8, SC01, DR3] and is common in the Basques. We theref...

journal_title：Journal of clinical immunology

authors： Calvo B,Castaño L,Marcus-Bagley D,Fici DA,Awdeh Z,Alper CA

更新日期：2000-05-01 00:00:00

abstract：:The etiology of immunodeficiency following trauma was investigated. Plasma collected from Fischer rats 1-8 hr following a 40% surface area thermal injury (TI) displays immunosuppressive activity (ISA). Peak ISA (4 hr) exceeded 90% inhibition of Con A3-induced proliferation of normal spleen cells. Splenic macrophage IL...

journal_title：Journal of clinical immunology

authors： Mills CD,Caldwell MD,Gann DS

更新日期：1989-03-01 00:00:00

abstract：PURPOSE:To evaluate mortality risk factors in pediatric-onset common variable immunodeficiency disorders (CVID), we evaluated the largest single-institution cohort of pediatric-onset CVID patients. Previous publications on CVID have provided valuable descriptive data, but lack risk stratification to guide physicians in...

journal_title：Journal of clinical immunology

authors： Baloh C,Reddy A,Henson M,Prince K,Buckley R,Lugar P

更新日期：2019-10-01 00:00:00

abstract：:An emerging paradigm for the treatment of primary immunodeficiency disease (PIDD) with immunoglobulin (IgG) replacement therapy emphasizes the tailoring of treatments to each patient with the goal of preventing infections and minimizing side effects. Increasing evidence shows that the IgG dose needed to prevent infect...

journal_title：Journal of clinical immunology

authors： Shapiro RS,Wasserman RL,Bonagura V,Gupta S

更新日期：2017-02-01 00:00:00

abstract：:Stimulator of interferon genes (STING)-associated vasculopathy with onset in infancy (SAVI) is a rare disorder that is associated with extensive inflammation throughout the body due to a high interferon state. Common clinical manifestations of this disorder include chronic lung disease, digital necrosis, recurrent low...

journal_title：Journal of clinical immunology

authors： Ma M,Mazumder S,Kwak H,Adams M,Gregory M

更新日期：2020-11-01 00:00:00

abstract：PURPOSE:Complete DiGeorge syndrome (cDGS) describes a subset of patients with DiGeorge syndrome that have thymic aplasia, and thus are at risk for severe opportunistic infections. Patients with cDGS and mycobacterial infection have not previously been described. We present this case to illustrate that patients with cDG...

journal_title：Journal of clinical immunology

authors： Yin SM,Ferdman RM,Wang L,Markert ML,Tam JS

更新日期：2015-07-01 00:00:00

abstract：:Autism is a complex polygenic neurodevelopmental disorder characterized by deficits in communication and social interactions as well as specific stereotypical behaviors. Both genetic and environmental factors appear to contribute to the pathogenesis of autism. Accumulating data including changes in immune responses, l...

journal_title：Journal of clinical immunology

authors： Gupta S,Samra D,Agrawal S

更新日期：2010-05-01 00:00:00

abstract：:The biological differences between lymphocytes separated from thymoma patients with myasthenia gravis (MG) and those separated from thymoma patients without MG was examined. We investigated whether lymphocytes in thymoma (Th-L) of patients with and without MG could react to interleukin-2 (IL-2) to develop cytolytic ac...

journal_title：Journal of clinical immunology

authors： Takahashi K,Monden Y,Saito S,Kamamura Y,Uyama T

更新日期：1996-07-01 00:00:00

abstract：PURPOSE:Sarcoidosis is a non-caseating granulomatous disease for which a role for infectious antigens continues to strengthen. Recent studies have reported molecular evidence of mycobacteria or propionibacteria. We assessed for immune responses against mycobacterial and propionibacterial antigens in sarcoidosis broncho...

journal_title：Journal of clinical immunology

authors： Oswald-Richter KA,Beachboard DC,Seeley EH,Abraham S,Shepherd BE,Jenkins CA,Culver DA,Caprioli RM,Drake WP

更新日期：2012-10-01 00:00:00

abstract：:Palifermin (recombinant human keratinocyte growth factor) prevents the development of acute, lethal graft-versus-host disease (GVHD). It does so, at least in part, by protecting cells from injury. Another property of Palifermin is immune regulation. How the latter influences the evolution of GVHD remains uncertain. We...

journal_title：Journal of clinical immunology

authors： Ellison CA,Gibson IW,Hayglass KT,Gartner JG

更新日期：2006-09-01 00:00:00

abstract：:Interferon-γ receptor 1 (IFN-γR1) deficiency is one of the primary immunodeficiencies conferring Mendelian Susceptibility to Mycobacterial Disease (MSMD). Some cases of neoplasms have been recently reported in patients with MSMD, underlying the already known link between immunodeficiency and carcinogenesis. We report ...

journal_title：Journal of clinical immunology

authors： Taramasso L,Boisson-Dupuis S,Garrè ML,Bondi E,Cama A,Nozza P,Morana G,Casanova JL,Marazzi MG

更新日期：2014-11-01 00:00:00

abstract：:Treatment of primary immunodeficiency (PI) is typically initiated with intravenous immunoglobulin (IVIG) loading and then continued with IVIG or subcutaneous IgG (SCIG). This prospective, open-label, multicenter, 6-month study evaluated a new regimen of initiating IgG therapy with SCIG in 18 previously untreated patie...

journal_title：Journal of clinical immunology

authors： Borte M,Quinti I,Soresina A,Fernández-Cruz E,Ritchie B,Schmidt DS,McCusker C

更新日期：2011-12-01 00:00:00

abstract：PURPOSE:Inherited defects in the adenosine deaminase (ADA) enzyme can cause severe combined immune deficiency (SCID) and systemic abnormalities. Management options for ADA-deficient patients include enzyme replacement therapy (ERT), hematopoietic stem cell transplantation (HSCT), and gene therapy (GT). Here, we describ...

journal_title：Journal of clinical immunology

authors： Scott O,Kim VH,Reid B,Pham-Huy A,Atkinson AR,Aiuti A,Grunebaum E

更新日期：2017-08-01 00:00:00

abstract：:We studied immunological functions of peripheral blood lymphocytes (PBL) from human T-cell leukemia virus type I (HTLV-I)-seropositive healthy carriers in vitro. Proliferative responses of PBL to T-cell and B-cell mitogens such as concanavalin A (Con A), pokeweed mitogen (PWM), and Staphylococcus aureus Cowan I (SAC) ...

journal_title：Journal of clinical immunology

authors： Tanaka Y,Oda S,Nagata K,Mori N,Sakamoto H,Eto S,Yamashita U

更新日期：1989-11-01 00:00:00

abstract：:IL-15 is essential for the development and differentiation of NK cells. It selectively induces proliferation of CD8+ memory T lymphocytes. Despite its importance in both innate and adaptive immune responses, little is known about its production in HIV-infected persons. We report here that IL-15 levels are significantl...

journal_title：Journal of clinical immunology

authors： Ahmad R,Sindhu ST,Toma E,Morisset R,Ahmad A

更新日期：2003-03-01 00:00:00

abstract：:We have undertaken an immunofluorescent analysis of the immunoglobulin heavy and light chains expressed by pre-B cells from normal human fetal and adult bone marrow using purified mouse monoclonal and goat antibodies to human immunoglobulin isotypes. Our results indicate that (i) the great majority of normal pre-B cel...

journal_title：Journal of clinical immunology

authors： Kubagawa H,Gathings WE,Levitt D,Kearney JF,Cooper MD

更新日期：1982-10-01 00:00:00

abstract：:To better understand the role of Ia antigen expression, accessory cell function, and antigen ingestion in antigen presentation and the initiation of T cell proliferation, we studied these events in two acute monoblastic leukemia (AMoL) lines. The cell lines were positive for surface Ia antigen; one stimulated prolifer...

journal_title：Journal of clinical immunology

authors： Giller RH,Mori M,Hayward AR

更新日期：1984-11-01 00:00:00

abstract：OBJECTIVES:The study clarified whether the T-helper (Th)1/Th2 imbalance existed only in coronary arterial inflammation or in both coronary arterial inflammation and myocardial inflammation and explored the significance of the imbalance of Th1/Th2 function after acute myocardial infarction (AMI). BACKGROUND:There are t...

journal_title：Journal of clinical immunology

authors： Cheng X,Liao YH,Ge H,Li B,Zhang J,Yuan J,Wang M,Liu Y,Guo Z,Chen J,Zhang J,Zhang L

更新日期：2005-05-01 00:00:00

abstract：:Biallelic mutations in SLC29A3 cause histiocytosis-lymphadenopathy plus syndrome, also known as H syndrome (HS). HS is a complex disorder, with ~ 25% of patients developing autoinflammatory complications consisting of unexplained fevers, persistently elevated inflammatory markers, and unusual lymphadenopathies, with i...

journal_title：Journal of clinical immunology

authors： Lara-Reyna S,Poulter JA,Vasconcelos EJR,Kacar M,McDermott MF,Tooze R,Doffinger R,Savic S

更新日期：2020-12-07 00:00:00

abstract：:The immune system is affected by the aging process and undergoes significant age-related changes, termed immunosenescence. Different T cell subsets are affected by this process. Alterations within the bone marrow and thymus lead to a shift in the composition of the T cell repertoire from naïve to antigen-experienced T...

journal_title：Journal of clinical immunology

authors： Arnold CR,Wolf J,Brunner S,Herndler-Brandstetter D,Grubeck-Loebenstein B

更新日期：2011-04-01 00:00:00