当前位置： SCI文献检索 > JOURNAL OF CLINICAL IMMUNOLOGY期刊下所有文献 > Antiidiotypic response against murine monoclonal antibodies reactive with tumor-associated antigen TAG-72.

Antiidiotypic response against murine monoclonal antibodies reactive with tumor-associated antigen TAG-72.

Abstract：

:The immune response of 42 gastrointestinal and ovarian cancer patients at 1 month after exposure to murine monoclonal antibodies (B72.3 and CC49) reactive with the tumor-associated antigen TAG-72 was studied. The incidence of human anti-mouse antibody response was 89% to B72.3 and 70% to CC49. To evaluate the antiidiotypic immune response, we developed a serological assay based on affinity chromatography to remove the interference due to the presence of TAG-72, antiisotypic, and antiallotypic immunoglobulins in the serum. Seventy-eight percent of patients who received B72.3 developed an antiidiotypic response; in 33% of the patients, this was the only immune response detected. The antiidiotypic immune response after treatment with CC49 was present in 54% of the patients. Twelve percent of the patients who received CC49 developed an antiidiotypic response in the absence of antiisotypic or antiallotypic immune response. The lower immunogenicity of the variable region of CC49 is encouraging when considering the use of chimeric or humanized antibodies derived from the murine monoclonal antibody CC49 in clinical studies.

journal_name

J Clin Immunol

journal_title

Journal of clinical immunology

authors

Blanco I,Kawatsu R,Harrison K,Leichner P,Augustine S,Baranowska-Kortylewicz J,Tempero M,Colcher D

doi

10.1023/a:1027396714623

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

96-106

issue

1

eissn

0271-9142

issn

1573-2592

journal_volume

17

pub_type

杂志文章

相关文献

JOURNAL OF CLINICAL IMMUNOLOGY文献大全
  • Slow subcutaneous immunoglobulin therapy in a patient with reactions to intramuscular immunoglobulin.

    abstract：:A 35-year-old man with common variable hypogammaglobulinemia had repeated anaphylactic reactions to intramuscular human immune serum globulin (HISG), preventing him from receiving the injections. He was able to tolerate slow subcutaneous HISG infusions without local or systemic side effects at a dose of 12 ml/week giv...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00915353

    authors： Welch MJ,Stiehm ER

    更新日期：1983-07-01 00:00:00

  • Frequent anti-V-region immune response to mouse B72.3 monoclonal antibody.

    abstract：:The immune response of 56 colorectal cancer patients to a single infusion of 1 mg of radiolabeled (111In) mouse B72.3-GYK-DTPA immunoconjugate was examined using a double-antigen radiometric assay system. The incidence of antibody response was 48% to polyclonal mouse IgG, 71% to mouse B72.3, and 62% to chimeric B72.3....

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00918141

    authors： Khazaeli MB,Saleh MN,Liu T,Kaladas PM,Gilman SC,LoBuglio AF

    更新日期：1992-03-01 00:00:00

  • The DC-SIGNR 7/5 genotype is associated with high dendritic cell counts and their subsets in patients infected with HIV-1.

    abstract：PURPOSE:The aim of this study was to assess peripheral blood dendritic cell (DC) frequencies and Dendritic Cell-specific intracellular adhesion molecule 3 grabbing non-integrin related (DC-SIGNR) genotyping in healthy individuals, injecting drug users and HIV-1 infected individuals and correlate with different clinical...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-013-9868-3

    authors： Chaudhary O,Bala M,Singh J,Hazarika A,Kumar R,Luthra K

    更新日期：2013-05-01 00:00:00

  • Monitoring of CD4+ and CD8+ T-cell responses after dendritic cell-based immunotherapy using CFSE dye dilution analysis.

    abstract：:CFSE dye dilution analysis and [3H] thymidine incorporation were used side by side to assess proliferative responses of peripheral blood mononuclear cells (PBMCs) after vaccination of renal cell carcinoma patients (n=6) with antigen-loaded dendritic cells. Immune responses against the control antigen keyhole limpet he...

    journal_title：Journal of clinical immunology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s10875-004-6237-2

    authors： Putz T,Ramoner R,Gander H,Rahm A,Bartsch G,Höltl L,Thurnher M

    更新日期：2004-11-01 00:00:00

  • In vitro differentiation of human monocytes into dendritic cells by peptic-tryptic digest of gliadin is independent of genetic predisposition and the presence of celiac disease.

    abstract：INTRODUCTION:This study was done to further reveal the role of the innate immune system in celiac disease. METHODS:Dendritic cells were matured from venous blood of patients with active or treated celiac disease and DQ2-DQ8-positive or negative controls. Dendritic cells were treated with a peptic-tryptic digest of gli...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-008-9228-x

    authors： Rakhimova M,Esslinger B,Schulze-Krebs A,Hahn EG,Schuppan D,Dieterich W

    更新日期：2009-01-01 00:00:00

  • Decreased serum levels of TGF-beta in patients with acute Plasmodium falciparum malaria.

    abstract：:Apart from cellular immunity and immunopathology, various cytokines have been implicated in malaria-associated immunosuppression. In this study, serum levels of transforming growth factor-beta (TGF-beta) were determined with an enzyme-linked immunosorbent assay in 37 patients with acute Plasmodium falciparum malaria p...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF01541734

    authors： Wenisch C,Parschalk B,Burgmann H,Looareesuwan S,Graninger W

    更新日期：1995-03-01 00:00:00

  • Health-Related Quality of Life and Health Resource Utilization in Patients with Primary Immunodeficiency Disease Prior to and Following 12 Months of Immunoglobulin G Treatment.

    abstract：PURPOSE:Health-related quality of life (HRQOL) has not been examined in patients with predominant antibody deficiency both pre- and post-immunoglobulin G (IgG) treatment initiation. HRQOL and health resource utilization (HRU) were assessed in newly diagnosed patients with primary immunodeficiency disease (PIDD) pre- an...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-016-0279-0

    authors： Routes J,Costa-Carvalho BT,Grimbacher B,Paris K,Ochs HD,Filipovich A,Hintermeyer M,de Melo KM,Workman S,Ito D,Ye X,Bonnet P,Li-McLeod J

    更新日期：2016-07-01 00:00:00

  • Primary immunodeficiency diseases in Latin America: the second report of the LAGID registry.

    abstract：:This is the second report on the continuing efforts of LAGID to increase the recognition and registration of patients with primary immunodeficiency diseases in 12 Latin American countries: Argentina, Brazil, Chile, Colombia, Costa Rica, Honduras, Mexico, Panama, Paraguay, Peru, Uruguay, and Venezuela. This report reve...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-006-9052-0

    authors： Leiva LE,Zelazco M,Oleastro M,Carneiro-Sampaio M,Condino-Neto A,Costa-Carvalho BT,Grumach AS,Quezada A,Patiño P,Franco JL,Porras O,Rodríguez FJ,Espinosa-Rosales FJ,Espinosa-Padilla SE,Almillategui D,Martínez C,Tafur JR,

    更新日期：2007-01-01 00:00:00

  • Defective monocyte function in acquired immune deficiency syndrome (AIDS): evidence from a monocyte-dependent T-cell proliferative system.

    abstract：:T-cell proliferative responses to the mitogenic monoclonal antibody anti-Leu 4 were assessed in healthy controls, lymphadenopathy syndrome (LAS) patients, and acquired immune deficiency syndrome (AIDS) patients. While 19% of the control group showed low anti-Leu 4 responses (less than 12,000 cpm), 60% of the LAS patie...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00915164

    authors： Prince HE,Moody DJ,Shubin BI,Fahey JL

    更新日期：1985-01-01 00:00:00

  • Matrix metalloproteinase-9 and autoimmune diseases.

    abstract：:Matrix metalloproteinases (also named matrixin or MMPs) are a major group of enzymes that regulate cell-matrix composition by using zinc for their proteolytic activities. They are essential for various normal biological processes such as embryonic development, morphogenesis, reproduction tissue resorption, and remodel...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章,评审

    doi：10.1007/s10875-006-9022-6

    authors： Ram M,Sherer Y,Shoenfeld Y

    更新日期：2006-07-01 00:00:00

  • Myasthenia gravis induces the activation and maturation of lymphocytes in thymoma.

    abstract：:The biological differences between lymphocytes separated from thymoma patients with myasthenia gravis (MG) and those separated from thymoma patients without MG was examined. We investigated whether lymphocytes in thymoma (Th-L) of patients with and without MG could react to interleukin-2 (IL-2) to develop cytolytic ac...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF01541224

    authors： Takahashi K,Monden Y,Saito S,Kamamura Y,Uyama T

    更新日期：1996-07-01 00:00:00

  • Efficacy, safety and pharmacokinetics of a novel subcutaneous immunoglobulin, Evogam®, in primary immunodeficiency.

    abstract：:This phase III, open-label, multi-centre study investigated the efficacy, safety, pharmacokinetics and quality of life impact of Evogam(®), a new chromatographically fractionated 16% subcutaneous immunoglobulin, utilising a 1:1 dose transition ratio from previous immunoglobulin therapy. Thirty-five previously treated ...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s10875-011-9641-4

    authors： Empson MB,Tang ML,Pearce LK,Rozen L,Gold MS,Katelaris CH,Langton D,Smart J,Smith WB,Steele RH,Ziegler JB,Maher D

    更新日期：2012-10-01 00:00:00

  • Resistance to exogenous TGF-β effects in patients with systemic lupus erythematosus.

    abstract：BACKGROUND:The mechanisms underlying the loss of self-tolerance in systemic lupus erythematosus (SLE) are incompletely deciphered. TGF-β plays a key role in self-tolerance demonstrated by the onset of a fatal autoimmune syndrome associated with lupus autoantibodies in mice lacking a functional TGF-β receptor. The prese...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-011-9531-9

    authors： Elbeldi-Ferchiou A,Ben Ahmed M,Smiti-Khanfir M,Houman MH,Abdeladhim M,Belhadj Hmida N,Cerf-Bensussan N,Louzir H

    更新日期：2011-08-01 00:00:00

  • Vaccination with rabies to study the humoral and cellular immune response to a T-cell dependent neoantigen in man.

    abstract：:We investigated the humoral (antigen-specific immunoglobulin isotypes, IgG subclasses, and avidity maturation) and cellular (antigen-specific in vitro proliferation) immune response in 18 healthy adult volunteers, following a primary and a single booster vaccination with the T-cell dependent neoantigen rabies administ...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1023/b:joci.0000010429.36461.6b

    authors： Brinkman DM,Jol-van der Zijde CM,ten Dam MM,Vossen JM,Osterhaus AD,Kroon FP,van Tol MJ

    更新日期：2003-11-01 00:00:00

  • The transfer of antigen-specific humoral immunity from marrow donors to marrow recipients.

    abstract：:This study shows that specific humoral immunity could be transferred from marrow donors to marrow recipients. Peripheral blood lymphocytes from long-term human marrow recipients produced IgG anti-tetanus toxoid antibody after in vitro tetanus toxoid stimulation. Antitetanus toxoid antibody biosynthesis was induced usi...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00915378

    authors： Lum LG,Seigneuret MC,Storb R

    更新日期：1986-09-01 00:00:00

  • Evidence of a plasma-mediated "window" of immunodeficiency in rats following trauma.

    abstract：:The etiology of immunodeficiency following trauma was investigated. Plasma collected from Fischer rats 1-8 hr following a 40% surface area thermal injury (TI) displays immunosuppressive activity (ISA). Peak ISA (4 hr) exceeded 90% inhibition of Con A3-induced proliferation of normal spleen cells. Splenic macrophage IL...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00916942

    authors： Mills CD,Caldwell MD,Gann DS

    更新日期：1989-03-01 00:00:00

  • Interleukin-6 -174 genotype, periodontal disease and adverse pregnancy outcomes: a pilot study.

    abstract：:This study was undertaken to investigate whether maternal periodontal disease and variant genotypes of IL-6 gene are associated with adverse pregnancy outcomes. A total of 145 pregnant women were recruited from St Mary's Hospital, Manchester, UK. Bleeding on probing (BOP) and pocket depth indices were recorded on all ...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-007-9162-3

    authors： Dashash M,Nugent J,Baker P,Tansinda D,Blinkhorn F

    更新日期：2008-05-01 00:00:00

  • Severe combined immunodeficiency (SCID) in Canadian children: a national surveillance study.

    abstract：PURPOSE:Severe Combined Immune Deficiency (SCID) is universally fatal unless treated with hematopoietic stem cell transplantation (HSCT). Following the identification of disseminated Bacille Calmette-Guérin (BCG) infections in Canadian First Nations, Métis and Inuit (FNMI) children with unrecognized primary immune defi...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-013-9952-8

    authors： Rozmus J,Junker A,Thibodeau ML,Grenier D,Turvey SE,Yacoub W,Embree J,Haddad E,Langley JM,Ramsingh RM,Singh VA,Long R,Schultz KR

    更新日期：2013-11-01 00:00:00

  • Cell death modulation by intravenous immunoglobulin.

    abstract：:The induction of cell death in immune cells by naturally occurring antibodies specific for death receptors may present an important antiinflammatory mechanism of intravenous immunoglobulin (IVIG). Conversely, the protection of tissue cells from death receptor-mediated apoptosis by blocking antibodies is thought to con...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章,评审

    doi：10.1007/s10875-010-9411-8

    authors： von Gunten S,Simon HU

    更新日期：2010-05-01 00:00:00

  • Cytokine production is altered in monocytes from children with hemolytic uremic syndrome.

    abstract：PURPOSE:The interaction of Shiga toxin (Stx) and/or lipopolysaccharide (LPS) with monocytes (Mo) may be central to the pathogenesis of hemolytic uremic syndrome (HUS), providing the cytokines necessary to sensitize endothelial cells to Stx action. We have previously demonstrated phenotypical alterations in Mo from HUS ...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-011-9646-z

    authors： Fernández GC,Ramos MV,Landoni VI,Bentancor LV,Fernández-Brando RJ,Exeni R,Laso Mdel C,Exeni A,Grimoldi I,Isturiz MA,Palermo MS

    更新日期：2012-06-01 00:00:00

  • Expression of immunoglobulin genes in common variable immunodeficiency.

    abstract：:Five common variable immunodeficiency (CVI) patients were analyzed for expression of immunoglobulin (Ig) genes. In the pokeweed mitogen (PWM)-induced Ig-production assay, the combination of T and B cells showed that all patients' T cells had normal helper functions and all patients' B cells had profound defects. The d...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00918184

    authors： Kaneko H,Kondo N,Motoyoshi F,Mori S,Kobayashi Y,Inoue Y,Orii T

    更新日期：1991-09-01 00:00:00

  • Genetic polymorphisms in the CD40 ligand gene and Kawasaki disease.

    abstract：BACKGROUND:Although some previous studies have reported that genetic and immunological factors play important roles in the pathogenesis of Kawasaki disease (KD), the etiological factors of this enigmatical pediatric disease are still poorly understood. PURPOSE:This study aims to investigate whether polymorphisms of th...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-008-9203-6

    authors： Huang FY,Chang TY,Chen MR,Chiu NC,Chi H,Lee HC,Lin SP,Chen CK,Chan HW,Chen WF,Liu HF,Chu CC,Lin M,Lee YJ

    更新日期：2008-09-01 00:00:00

  • Human fetal liver cells induce colonies in spleen of lethally irradiated mice.

    abstract：:Murine hematopoietic tissues contain cells which, upon injection into lethally irradiated mice, produce nodules on the surface of their spleen (colony-forming unit--spleen; CFU-S). The exact hierarchical level of the hematopoietic progenitors which give rise to CFU-S is not fully established; however, cell populations...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1023/a:1027302310505

    authors： Rezzoug F,Tocci A,Safsafi K,Vivier G,Touraine JL

    更新日期：1997-05-01 00:00:00

  • Intravenous immunoglobulin: an update on the clinical use and mechanisms of action.

    abstract：:Initially used as a replacement therapy for immunodeficiency diseases, intravenous immunoglobulin (IVIg) is now widely used for a number of autoimmune and inflammatory diseases. Considerable progress has been made in understanding the mechanisms by which IVIg exerts immunomodulatory effects in autoimmune and inflammat...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章,评审

    doi：10.1007/s10875-007-9088-9

    authors： Negi VS,Elluru S,Sibéril S,Graff-Dubois S,Mouthon L,Kazatchkine MD,Lacroix-Desmazes S,Bayry J,Kaveri SV

    更新日期：2007-05-01 00:00:00

  • N-acetylcysteine administration is associated with reduced activation of NF-kB and preserves lung dendritic cells function in a zymosan-induced generalized inflammation model.

    abstract：PURPOSE:In severe sepsis, functional impairment and decreased numbers of dendritic cells (DCs) are essential reasons for immune function paralysis, secondary organ infection, and organ failure. We investigated the effects of N-acetylcysteine (NAC) administration on protecting lung DCs function in a zymosan-induced gene...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-012-9852-3

    authors： Wang HW,Yang W,Lu JY,Li F,Sun JZ,Zhang W,Guo NN,Gao L,Kang JR

    更新日期：2013-04-01 00:00:00

  • Bone density and fractures in autosomal dominant hyper IgE syndrome.

    abstract：PURPOSE:Autosomal Dominant Hyper IgE Recurrent Infection Syndrome (AD-HIES) is caused by mutations in STAT3 and characterized by eczema, recurrent bacterial infections, and skeletal and connective tissue abnormalities. To further understand the minimal trauma fractures of AD-HIES, we examined bone mineral density (BMD)...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-013-9982-2

    authors： Sowerwine KJ,Shaw PA,Gu W,Ling JC,Collins MT,Darnell DN,Anderson VL,Davis J,Hsu A,Welch P,Puck JM,Holland SM,Freeman AF

    更新日期：2014-02-01 00:00:00

  • Effect of IL-2 therapy on CD8+ cell noncytotoxic anti-HIV response during primary HIV-1 infection.

    abstract：:Early treatment intervention during human immunodeficiency virus (HIV) infection is a strategy aimed to preserve and/or enhance the developing anti-HIV immune responses. We report the effect of highly active antiretroviral therapy (HAART) combined with intermittent subcutaneous doses of Interleukin 2 (IL-2) on CD8(+) ...

    journal_title：Journal of clinical immunology

    pub_type： 临床试验,杂志文章

    doi：10.1023/B:JOCI.0000019778.96564.26

    authors： Martinez-Mariño B,Ashlock BM,Shiboski S,Hecht FM,Levy JA

    更新日期：2004-03-01 00:00:00

  • Current Status of the Management of Mendelian Susceptibility to Mycobacterial Disease in Mainland China.

    abstract：PURPOSE:Although many studies have investigated Mendelian susceptibility to mycobacterial disease (MSMD) worldwide, there is no report of the long-term clinical management and prognosis for MSMD in China. METHODS:This is a cohort study from January 2000 to June 2018. Three hundred and twenty-four patients with bacillu...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-019-00672-x

    authors： Ying W,Liu D,Dong X,Wang W,Hui X,Hou J,Yao H,Zhou Q,Sun B,Sun J,Wang X

    更新日期：2019-08-01 00:00:00

  • Differential expression of perforin in cytotoxic lymphocyte in HIV/AIDS patients of China.

    abstract：:Cytotoxic lymphocytes are critical in the control of HIV replication, it has been shown that perforin is the key effector of killing machinery for CTLs and NK cells, so we investigated the circulating levels of perforin in CD8+ T cells and NK cells by flow cytometry intracellular stain in Chinese HIV infected individu...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-006-9027-1

    authors： Qi W,Yongjun J,Yanan W,Zining Z,Xiaoxu H,Jing L,Hong S

    更新日期：2006-07-01 00:00:00

  • Life-Threatening Infections Due to Live-Attenuated Vaccines: Early Manifestations of Inborn Errors of Immunity.

    abstract：:Live-attenuated vaccines (LAVs) can protect humans against 12 viral and three bacterial diseases. By definition, any clinical infection caused by a LAV that is sufficiently severe to require medical intervention attests to an inherited or acquired immunodeficiency that must be diagnosed or identified. Self-healing inf...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章,评审

    doi：10.1007/s10875-019-00642-3

    authors： Pöyhönen L,Bustamante J,Casanova JL,Jouanguy E,Zhang Q

    更新日期：2019-05-01 00:00:00