当前位置： SCI文献检索 > JOURNAL OF CLINICAL IMMUNOLOGY期刊下所有文献 > Effect of IL-2 therapy on CD8+ cell noncytotoxic anti-HIV response during primary HIV-1 infection.

Effect of IL-2 therapy on CD8+ cell noncytotoxic anti-HIV response during primary HIV-1 infection.

Abstract：

:Early treatment intervention during human immunodeficiency virus (HIV) infection is a strategy aimed to preserve and/or enhance the developing anti-HIV immune responses. We report the effect of highly active antiretroviral therapy (HAART) combined with intermittent subcutaneous doses of Interleukin 2 (IL-2) on CD8(+) cell noncytotoxic anti-HIV responses (CNAR), as well as on viral loads and CD4(+) cell/CD8(+) cell numbers in subjects with primary HIV-1 infection. Twenty-four patients received HAART, 24 received a combination of HAART plus IL-2, and 12 elected no-therapy. In comparison to HAART alone, IL-2 treatment led to significant increases in CD4(+) cell numbers through week 48 of the study. No effect was observed on viral loads or the CD8(+) cell population. The first cycle of IL-2 enhanced CNAR; later cycles showed no substantial effect. This study suggests that HAART combined with IL-2 could provide an immunologic benefit in the treatment of early HIV infection.

journal_name

J Clin Immunol

journal_title

Journal of clinical immunology

authors

Martinez-Mariño B,Ashlock BM,Shiboski S,Hecht FM,Levy JA

doi

10.1023/B:JOCI.0000019778.96564.26

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

135-44

issue

2

eissn

0271-9142

issn

1573-2592

pii

484435

journal_volume

24

pub_type

临床试验,杂志文章

相关文献

JOURNAL OF CLINICAL IMMUNOLOGY文献大全
  • Regulation of human B-cell activation, proliferation, and differentiation by soluble factors.

    abstract：:This review describes a series of studies performed in our laboratory which have focused on the activation and subsequent proliferation and differentiation of human B lymphocytes. Utilizing polyclonal signals which activate B cells by interacting with their surface membrane Ig, we have examined the events in the trans...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00917136

    authors： Muraguchi A,Kehrl JH,Butler JL,Fauci AS

    更新日期：1984-09-01 00:00:00

  • Lymphocyte phenotype and function in the chronic fatigue syndrome.

    abstract：:Lymphocytes of 18 patients meeting the Centers for Disease Control (CDC) case definition for the chronic fatigue syndrome (CFS), 10 similar, chronically fatigued patients not fully conforming to the CDC case definition, and 17 matched, healthy individuals were studied to determine the presence of abnormalities of peri...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00920633

    authors： Straus SE,Fritz S,Dale JK,Gould B,Strober W

    更新日期：1993-01-01 00:00:00

  • Aging affects human B cell responses.

    abstract：:Aging represents a complex remodeling in which both innate and adaptive immunities deteriorate. Age-related changes in humoral immunity are responsible for the reduced vaccine responses observed in elderly individuals. Although T cell alterations play a significant role in age-related humoral immune changes, alteratio...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章,评审

    doi：10.1007/s10875-010-9501-7

    authors： Frasca D,Blomberg BB

    更新日期：2011-06-01 00:00:00

  • Rheumatic fever and rheumatic heart disease: cellular mechanisms leading autoimmune reactivity and disease.

    abstract：INTRODUCTION:Rheumatic fever (RF) is an autoimmune disease caused by the gram-positive bacteria Streptococcus pyogenes that follows a nontreated throat infection in susceptible children. The disease manifests as polyarthritis, carditis, chorea, erythema marginatum, and/or subcutaneous nodules. Carditis, the most seriou...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章,评审

    doi：10.1007/s10875-009-9332-6

    authors： Guilherme L,Kalil J

    更新日期：2010-01-01 00:00:00

  • Phagocyte chemotaxis in the perinatal period.

    abstract：:Cross-sectional and limited sequential studies of neutrophil and monocyte chemotaxis were done using cells isolated from cord blood and peripheral blood of 2- to 6-day-old neonates and infants at 4 and 6 months of age. These studies show that cord blood phagocyte chemotaxis is comparable to adult values, whereas phago...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00915228

    authors： Raghunathan R,Miller ME,Everett S,Leake RD

    更新日期：1982-07-01 00:00:00

  • The comparison of the efficacy and safety of intravenous versus subcutaneous immunoglobulin replacement therapy.

    abstract：:To compare the efficacy of immunoglobulin replacement therapy given intravenously versus subcutaneously to prevent infections in patients with primary antibody deficiency syndromes, an international, multicenter, open label, crossover study was designed. Forty patients were randomized to receive either subcutaneous or...

    journal_title：Journal of clinical immunology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1023/a:1006678312925

    authors： Chapel HM,Spickett GP,Ericson D,Engl W,Eibl MM,Bjorkander J

    更新日期：2000-03-01 00:00:00

  • Long-Term Outcome of Adenosine Deaminase-Deficient Patients-a Single-Center Experience.

    abstract：PURPOSE:Inherited defects in the adenosine deaminase (ADA) enzyme can cause severe combined immune deficiency (SCID) and systemic abnormalities. Management options for ADA-deficient patients include enzyme replacement therapy (ERT), hematopoietic stem cell transplantation (HSCT), and gene therapy (GT). Here, we describ...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-017-0421-7

    authors： Scott O,Kim VH,Reid B,Pham-Huy A,Atkinson AR,Aiuti A,Grunebaum E

    更新日期：2017-08-01 00:00:00

  • Activation profile of intracellular mitogen-activated protein kinases in peripheral lymphocytes of patients with systemic lupus erythematosus.

    abstract：INTRODUCTION:Systemic lupus erythematosus (SLE) is a systemic autoimmune disease associated with aberrant activation of T and B lymphocytes. Abnormal activation of intracellular signaling molecules in lymphocytes by inflammatory cytokines can instigate the inflammation in SLE. MATERIALS AND METHODS:The activation of e...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-009-9318-4

    authors： Wong CK,Wong PT,Tam LS,Li EK,Chen DP,Lam CW

    更新日期：2009-11-01 00:00:00

  • Transduction of primary lymphocytes with Epstein-Barr virus (EBV) latent membrane protein-specific T-cell receptor induces lysis of virus-infected cells: A novel strategy for the treatment of Hodgkin's disease and nasopharyngeal carcinoma.

    abstract：:Adoptive immunotherapy with in vitro expanded cytotoxic T lymphocytes specific for Epstein-Barr virus (EBV) can successfully treat post-transplant lymphoproliferative disease (PTLD). However, extension of a similar strategy to Hodgkin's disease (HD) and nasopharyngeal carcinoma (NPC) is limited by the poor immunogenic...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-006-6532-1

    authors： Jurgens LA,Khanna R,Weber J,Orentas RJ

    更新日期：2006-01-01 00:00:00

  • Cell death modulation by intravenous immunoglobulin.

    abstract：:The induction of cell death in immune cells by naturally occurring antibodies specific for death receptors may present an important antiinflammatory mechanism of intravenous immunoglobulin (IVIG). Conversely, the protection of tissue cells from death receptor-mediated apoptosis by blocking antibodies is thought to con...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章,评审

    doi：10.1007/s10875-010-9411-8

    authors： von Gunten S,Simon HU

    更新日期：2010-05-01 00:00:00

  • A Unique Presentation of Infantile-Onset Colitis and Eosinophilic Disease without Recurrent Infections Resulting from a Novel Homozygous CARMIL2 Variant.

    abstract：PURPOSE:This study aimed to characterize the clinical phenotype, genetic basis, and consequent immunological phenotype of a boy with severe infantile-onset colitis and eosinophilic gastrointestinal disease, and no evidence of recurrent or severe infections. METHODS:Trio whole-exome sequencing (WES) was utilized for pa...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-019-00631-6

    authors： Kurolap A,Eshach Adiv O,Konnikova L,Werner L,Gonzaga-Jauregui C,Steinberg M,Mitsialis V,Mory A,Nunberg MY,Wall S,Shaoul R,Overton JD,Regeneron Genetics Center.,Shuldiner AR,Zohar Y,Paperna T,Snapper SB,Shouval DS,Bari

    更新日期：2019-05-01 00:00:00

  • Cytokine measurements and interpretation of cytokine assays in human disease.

    abstract：:Cytokines are powerful mediator and communication molecules capable of regulating a wide spectrum of biologic functions, including immune responses. Although the role of cytokines in the pathogenesis of human disease is not yet understood, assays for cytokines have become a common feature in research and clinical labo...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章,评审

    doi：10.1007/BF01546317

    authors： Whiteside TL

    更新日期：1994-11-01 00:00:00

  • Molecular steps of cell suicide: an insight into immune senescence.

    abstract：:The cellular and molecular basis of immune senescence is unclear. A number of mechanisms have been proposed. In this issue of the Journal of Clinical Immunology, some of the mechanisms for various immunologic abnormalities in aging are presented. In this article, various molecular steps of both death receptor and mito...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章,评审

    doi：10.1023/a:1006653917314

    authors： Gupta S

    更新日期：2000-07-01 00:00:00

  • Chronic arsenic exposure impairs macrophage functions in the exposed individuals.

    abstract：INTRODUCTION:Owing to the established roles of human macrophages in immune defense, we investigated the effect of chronic arsenic exposure upon these major hematopoietic cells in 70 arsenic-exposed individuals with skin lesions and 64 unexposed individuals. METHODS:Human monocyte-derived macrophages were prepared from...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-009-9304-x

    authors： Banerjee N,Banerjee S,Sen R,Bandyopadhyay A,Sarma N,Majumder P,Das JK,Chatterjee M,Kabir SN,Giri AK

    更新日期：2009-09-01 00:00:00

  • TLR-mediated B cell defects and IFN-α in common variable immunodeficiency.

    abstract：:Common variable immune deficiency (CVID) B cells have impaired responses to TLR7 and TLR9 agonists including poor cell proliferation, loss of cytokine production, and failure to produce IgG or IgA. We show that TLR7- or 9-activated B cells from CVID subjects with >0.5% peripheral isotype-switched CD27(+) B cells (grou...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-011-9602-y

    authors： Yu JE,Zhang L,Radigan L,Sanchez-Ramon S,Cunningham-Rundles C

    更新日期：2012-02-01 00:00:00

  • Subset markers of CD8(+) cells and their relation to enhanced cytotoxic T-cell activity during human immunodeficiency virus infection.

    abstract：:Using fresh whole blood or isolated lymphocytes, the activity of in vivo generated cytotoxic T-lymphocytes (CTL) was measured as the OKT3-specific lysis of HL-60 targets, in a cross-sectional study of 53 HIV (+) patients. CTL activity in the entire HIV(+) group was two to three times higher than in HIV(-) controls, wi...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00918800

    authors： Vanham G,Kestens L,Penne G,Goilav C,Gigase P,Colebunders R,Vandenbruaene M,Goeman J,van der Groen G,Ceuppens JL

    更新日期：1991-11-01 00:00:00

  • Endogenously activated interleukin-4 differentiates disease progressors and non-progressors in tuberculosis susceptible families: a 2-year biomarkers follow-up study.

    abstract：OBJECTIVE:Dynamic cytokine profiles from endogenously activated T cells in transit from lymph node to the infected sites via the blood compartment after recent exposure to Mycobacterium tuberculosis may differentiate disease progressors from non-disease progressors in a BCG-vaccinated population. METHODS:Household con...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-011-9566-y

    authors： Hussain R,Talat N,Ansari A,Shahid F,Hasan Z,Dawood G

    更新日期：2011-10-01 00:00:00

  • Vaccination with rabies to study the humoral and cellular immune response to a T-cell dependent neoantigen in man.

    abstract：:We investigated the humoral (antigen-specific immunoglobulin isotypes, IgG subclasses, and avidity maturation) and cellular (antigen-specific in vitro proliferation) immune response in 18 healthy adult volunteers, following a primary and a single booster vaccination with the T-cell dependent neoantigen rabies administ...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1023/b:joci.0000010429.36461.6b

    authors： Brinkman DM,Jol-van der Zijde CM,ten Dam MM,Vossen JM,Osterhaus AD,Kroon FP,van Tol MJ

    更新日期：2003-11-01 00:00:00

  • Characterizing the pregnancy immune phenotype: results of the viral immunity and pregnancy (VIP) study.

    abstract：PURPOSE:The increased risk of morbidity and mortality from certain microbial infections and the demonstrated improvements in the clinical course of some autoimmune diseases support the existence of pregnancy-related alterations in immune status. Elucidating the changes in innate and adaptive immunity during gestation m...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-011-9627-2

    authors： Kraus TA,Engel SM,Sperling RS,Kellerman L,Lo Y,Wallenstein S,Escribese MM,Garrido JL,Singh T,Loubeau M,Moran TM

    更新日期：2012-04-01 00:00:00

  • The presence of anti-carcinoembryonic antigen (CEA) antibodies in the sera of patients with gastrointestinal malignancies.

    abstract：:Using an enzyme-linked immunoassay we tested the sera of 71 patients with digestive system cancer, 35 patients with various nonmalignant disorders, and 28 normal individuals for anti-CEA activity. Antibodies were found in the sera of 51% of the patients. Most of the patients positive for the antibodies (70%) had no ev...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF01540984

    authors： Konstadoulakis MM,Syrigos KN,Albanopoulos C,Mayers G,Golematis B

    更新日期：1994-09-01 00:00:00

  • Altered miRNAs expression profiles and modulation of immune response genes and proteins during neonatal sepsis.

    abstract：PURPOSE:The dysregulated expression of miRNAs in the immune system may be critical for immune responses to pathogens and evolve into the inflammation seen in sepsis. The aim of this study is to explore the important role of miRNAs in the regulation of the immune response during neonatal sepsis. METHODS:Using a microar...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-014-0004-9

    authors： Chen J,Jiang S,Cao Y,Yang Y

    更新日期：2014-04-01 00:00:00

  • Adenosine deaminase deficient severe combined immunodeficiency presenting as atypical haemolytic uraemic syndrome.

    abstract：PURPOSE:Adenosine deaminase (ADA) deficiency is a systemic disorder of purine metabolism. Deficiency of the purine salvage enzyme ADA leads to the build-up of the toxic metabolites, deoxyadenosine triphosphate and deoxyadenosine. ADA is ubiquitously expressed in all tissues of the body but most profoundly affects lymph...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-015-0158-0

    authors： Nikolajeva O,Worth A,Hague R,Martinez-Alier N,Smart J,Adams S,Davies EG,Gaspar HB

    更新日期：2015-05-01 00:00:00

  • Susceptibility to leprosy is associated with M-ficolin polymorphisms.

    abstract：PURPOSE:Mycobacterium leprae exploits complement activation and opsonophagocytosis to infect phagocytes. M-ficolin is encoded by the FCN1 gene and initiates the lectin pathway on monocyte surfaces. We investigated FCN1 promoter polymorphisms that could be responsible for the high interindividual variability of M-ficoli...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-012-9770-4

    authors： Boldt AB,Sanchez MI,Stahlke ER,Steffensen R,Thiel S,Jensenius JC,Prevedello FC,Mira MT,Kun JF,Messias-Reason IJ

    更新日期：2013-01-01 00:00:00

  • Bone density and fractures in autosomal dominant hyper IgE syndrome.

    abstract：PURPOSE:Autosomal Dominant Hyper IgE Recurrent Infection Syndrome (AD-HIES) is caused by mutations in STAT3 and characterized by eczema, recurrent bacterial infections, and skeletal and connective tissue abnormalities. To further understand the minimal trauma fractures of AD-HIES, we examined bone mineral density (BMD)...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-013-9982-2

    authors： Sowerwine KJ,Shaw PA,Gu W,Ling JC,Collins MT,Darnell DN,Anderson VL,Davis J,Hsu A,Welch P,Puck JM,Holland SM,Freeman AF

    更新日期：2014-02-01 00:00:00

  • Antibacterial polysaccharide antibody deficiency after allogeneic bone marrow transplantation.

    abstract：:Allogeneic bone marrow-engrafted adults immunized with meningococcal types A and C and pneumococcal type 14 polysaccharide antigens showed only low antibody titers of the IgM class, no antibody titers of the IgG or IgA classes, and no bactericidal activity in vitro. The analytical isoelectrofocusing showed the appeara...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00917916

    authors： Quinti I,Velardi A,Le Moli S,Guerra E,D'Amelio R,Mastrantonio P,Martelli MF,Aiuti F

    更新日期：1990-05-01 00:00:00

  • Nijmegen Breakage Syndrome: Clinical and Immunological Features, Long-Term Outcome and Treatment Options - a Retrospective Analysis.

    abstract：PURPOSE:Nijmegen Breakage Syndrome (NBS) is a rare inherited condition, characterized by microcephaly, chromosomal instability, immunodeficiency, and predisposition to malignancy. This retrospective study, characterizing the clinical and immunological status of patients with NBS at time of diagnosis, was designed to as...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-015-0186-9

    authors： Wolska-Kuśnierz B,Gregorek H,Chrzanowska K,Piątosa B,Pietrucha B,Heropolitańska-Pliszka E,Pac M,Klaudel-Dreszler M,Kostyuchenko L,Pasic S,Marodi L,Belohradsky BH,Čižnár P,Shcherbina A,Kilic SS,Baumann U,Seidel MG,Genner

    更新日期：2015-08-01 00:00:00

  • Anti-ribosomal ribonucleoprotein autoantibodies in systemic lupus erythematosus.

    abstract：:Sera from systemic lupus erythematosus (SLE) patients giving a fluorescent ribosomal pattern on tissue and cell preparations also showed precipitating autoantibodies against purified rat liver ribosomes. Ribosomal antigen is also present in rabbit thymus cellular extract (RTE), since the same sera gave precipitin line...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00915287

    authors： Meroni PL,de Bartolo G,Barcellini W,Riboldi PS,Basile R,Betterle C,Zanussi C

    更新日期：1984-01-01 00:00:00

  • Thymus-dependent lymphocytes in leprosy. II. Effect of chemotherapy on T-lymphocyte subpopulations.

    abstract：:The basis of the immunological unresponsiveness seen in leprosy patients is unknown. Untreated lepromatous leprosy patients display an unspecific cellular anergy which disappears with treatment, leaving an anergy specific for Mycobacterium leprae. These patients suffer from a complication, erythema nodosum leprosum, c...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00916889

    authors： Mshana RN,Haregewoin A,Belehu A

    更新日期：1982-04-01 00:00:00

  • Newborn screening for severe combined immunodeficiency; the Wisconsin experience (2008-2011).

    abstract：:Severe combined immunodeficiency is a life-threatening primary immune deficiency characterized by low numbers of naïve T cells. Early diagnosis and treatment of this disease decreases mortality. In 2008, Wisconsin began newborn screening of infants for severe combined immunodeficiency and other forms of T-cell lymphop...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-011-9609-4

    authors： Verbsky JW,Baker MW,Grossman WJ,Hintermeyer M,Dasu T,Bonacci B,Reddy S,Margolis D,Casper J,Gries M,Desantes K,Hoffman GL,Brokopp CD,Seroogy CM,Routes JM

    更新日期：2012-02-01 00:00:00

  • A portrait of the Bcl-2 protein family: life, death, and the whole picture.

    abstract：:The Bcl-2 family of proteins are important regulators of cell death. They are comprised of two opposing factions, the proapoptotic versus the antiapoptotic members. Both are required for normal development and cellular homeostasis of the immune system and other tissues. However, in certain circumstances they may parti...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章,评审

    doi：10.1023/a:1020598632068

    authors： Pellegrini M,Strasser A

    更新日期：1999-11-01 00:00:00