Aging affects human B cell responses.

Abstract:

:Aging represents a complex remodeling in which both innate and adaptive immunities deteriorate. Age-related changes in humoral immunity are responsible for the reduced vaccine responses observed in elderly individuals. Although T cell alterations play a significant role in age-related humoral immune changes, alterations in B cells also occur. We here provide an overview of age-related changes in B cell markers and functions. Our studies have shown that intrinsic changes in B cells with age contribute to reduced antibody responses such as those to the influenza vaccine.

journal_name

J Clin Immunol

authors

Frasca D,Blomberg BB

doi

10.1007/s10875-010-9501-7

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

430-5

issue

3

eissn

0271-9142

issn

1573-2592

journal_volume

31

pub_type

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