Aging affects human B cell responses.

abstract：:Utilizing a rat model of semiallogeneic intestinal transplantation, recipients were evaluated for accumulation of donor-specific cytotoxic T cells in spleen, mesenteric lymph nodes, Peyer's patches, lamina propria, and intraepithelial lymphocytes using limiting dilution analysis. Naive animals exhibited a low frequenc...

journal_title：Journal of clinical immunology

authors： Sirinek LP,O'Dorisio MS,Dunaway DJ

更新日期：1995-09-01 00:00:00

abstract：:A patient affected with multiple myeloma displayed in the serum, urine, and cerebrospinal fluid a paraprotein with identical electrophoretic mobility. The paraprotein, which was polymeric, appeared in the serum and cerebrospinal fluid mainly as the dimer and tetramer, whereas in the urine the tetramer was predominant....

journal_title：Journal of clinical immunology

authors： Bollengier F,Mahler A,Gillard A,Wijffels E

更新日期：1986-07-01 00:00:00

abstract：:Treatment of primary immunodeficiency (PI) is typically initiated with intravenous immunoglobulin (IVIG) loading and then continued with IVIG or subcutaneous IgG (SCIG). This prospective, open-label, multicenter, 6-month study evaluated a new regimen of initiating IgG therapy with SCIG in 18 previously untreated patie...

journal_title：Journal of clinical immunology

authors： Borte M,Quinti I,Soresina A,Fernández-Cruz E,Ritchie B,Schmidt DS,McCusker C

更新日期：2011-12-01 00:00:00

abstract：:The experiments described have shown that, whereas the injection of tetanus toxoid (tet) into 8 of 12 control individuals resulted in the appearance of specific anti-tet-IgG antibodies in their plasma, immunization of 14 anergic patients did not elicit an antibody response. This observation was extended to an in vitro...

journal_title：Journal of clinical immunology

authors： Mazaheri R,Rode HN,Abikar K,Ing A,Nohr C,Gordon J

更新日期：1984-01-01 00:00:00

abstract：:Leishmaniasis is caused by parasitic protozoa transmitted by the bite of a female sand fly and is currently endemic in 88 countries. BALB/c mice are highly susceptible to the infection with the parasite Leishmania major, and this susceptibility has been attributed, in part, to the expansion of Th2 cells, production of...

journal_title：Journal of clinical immunology

authors： Hosseini N,Abolhassani M

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:To investigate whether there is an increased incidence of chronic autoimmune thyroiditis (CAT) in individuals living in the vicinity of industrial plants that manufacture petroleum byproducts in the state of São Paulo, Brazil. METHODS:Between 1989 and 2004, 6,306 patients of both sexes, from 5 to 78 years old ...

journal_title：Journal of clinical immunology

authors： Zaccarelli-Marino MA

更新日期：2012-10-01 00:00:00

abstract：:Murine B16 melanoma cell line is poorly immunogenic and highly aggressive. We recently reported that the transmembrane staphylococcal enterotoxin A (TM-SEA) anchors onto B16 cells and stimulates lymphocyte proliferation. The purpose of the study was to investigate whether vaccination with B16 cells bearing membrane-an...

journal_title：Journal of clinical immunology

authors： Ma W,Yu H,Wang Q,Jin H,Solheim J,Labhasetwar V

更新日期：2004-05-01 00:00:00

abstract：:This is the second report on the continuing efforts of LAGID to increase the recognition and registration of patients with primary immunodeficiency diseases in 12 Latin American countries: Argentina, Brazil, Chile, Colombia, Costa Rica, Honduras, Mexico, Panama, Paraguay, Peru, Uruguay, and Venezuela. This report reve...

journal_title：Journal of clinical immunology

authors： Leiva LE,Zelazco M,Oleastro M,Carneiro-Sampaio M,Condino-Neto A,Costa-Carvalho BT,Grumach AS,Quezada A,Patiño P,Franco JL,Porras O,Rodríguez FJ,Espinosa-Rosales FJ,Espinosa-Padilla SE,Almillategui D,Martínez C,Tafur JR,

更新日期：2007-01-01 00:00:00

abstract：:We studied immunological functions of peripheral blood lymphocytes (PBL) from human T-cell leukemia virus type I (HTLV-I)-seropositive healthy carriers in vitro. Proliferative responses of PBL to T-cell and B-cell mitogens such as concanavalin A (Con A), pokeweed mitogen (PWM), and Staphylococcus aureus Cowan I (SAC) ...

journal_title：Journal of clinical immunology

authors： Tanaka Y,Oda S,Nagata K,Mori N,Sakamoto H,Eto S,Yamashita U

更新日期：1989-11-01 00:00:00

abstract：:Anti-CD3 monoclonal antibody (MoAb) induces proliferation of freshly isolated peripheral blood T cells only in the presence of monocytes/macrophages and requires binding of the Fc portion of antibody to monocytes/macrophages. In this investigation, we examined whether monocytes process anti-CD3 similar to any soluble ...

journal_title：Journal of clinical immunology

authors： Vayuvegula B,Ohira K,Gollapudi S,Gupta S

更新日期：1990-09-01 00:00:00

abstract：:Regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a requisite role in the maintenance of immunological homeostasis and prevention of peripheral self-tolerance breakdown. Although Foxp3 by itself is neither necessary nor sufficient to specify many aspects of the Treg cell phenot...

journal_title：Journal of clinical immunology

authors： Georgiev P,Charbonnier LM,Chatila TA

更新日期：2019-10-01 00:00:00

abstract：INTRODUCTION:This study was done to further reveal the role of the innate immune system in celiac disease. METHODS:Dendritic cells were matured from venous blood of patients with active or treated celiac disease and DQ2-DQ8-positive or negative controls. Dendritic cells were treated with a peptic-tryptic digest of gli...

journal_title：Journal of clinical immunology

authors： Rakhimova M,Esslinger B,Schulze-Krebs A,Hahn EG,Schuppan D,Dieterich W

更新日期：2009-01-01 00:00:00

abstract：:The sensitivity of tumor cells to lysis by natural killer (NK) and interleukin-2 (IL-2)-activated killer (LAK) cells was studied in three ovarian carcinoma cell lines (2780.9S, SKOV-3, and CHOAUXB1), four multidrug-resistant (MDR) variants, and a melphalan-resistant line. The antitumor activity of LAK cells was evalua...

journal_title：Journal of clinical immunology

authors： Savas B,Cole SP,Tsuruo T,Pross HF

更新日期：1996-11-01 00:00:00

abstract：PURPOSE:Mycobacterium leprae exploits complement activation and opsonophagocytosis to infect phagocytes. M-ficolin is encoded by the FCN1 gene and initiates the lectin pathway on monocyte surfaces. We investigated FCN1 promoter polymorphisms that could be responsible for the high interindividual variability of M-ficoli...

journal_title：Journal of clinical immunology

authors： Boldt AB,Sanchez MI,Stahlke ER,Steffensen R,Thiel S,Jensenius JC,Prevedello FC,Mira MT,Kun JF,Messias-Reason IJ

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Owing to the established roles of human macrophages in immune defense, we investigated the effect of chronic arsenic exposure upon these major hematopoietic cells in 70 arsenic-exposed individuals with skin lesions and 64 unexposed individuals. METHODS:Human monocyte-derived macrophages were prepared from...

journal_title：Journal of clinical immunology

authors： Banerjee N,Banerjee S,Sen R,Bandyopadhyay A,Sarma N,Majumder P,Das JK,Chatterjee M,Kabir SN,Giri AK

更新日期：2009-09-01 00:00:00

abstract：:The immune response of 56 colorectal cancer patients to a single infusion of 1 mg of radiolabeled (111In) mouse B72.3-GYK-DTPA immunoconjugate was examined using a double-antigen radiometric assay system. The incidence of antibody response was 48% to polyclonal mouse IgG, 71% to mouse B72.3, and 62% to chimeric B72.3....

journal_title：Journal of clinical immunology

authors： Khazaeli MB,Saleh MN,Liu T,Kaladas PM,Gilman SC,LoBuglio AF

更新日期：1992-03-01 00:00:00

abstract：INTRODUCTION:Non-homologous end joining gene 1 (NHEJ1) defect is a rare form of primary immune deficiency. Very few cases have been described from around the world. PURPOSE:We are reporting the first family from the Arabian Gulf with three siblings presenting with combined immunodeficiency (CID), microcephaly, and gro...

journal_title：Journal of clinical immunology

authors： Sheikh F,Hawwari A,Alhissi S,Al Gazlan S,Al Dhekri H,Rehan Khaliq AM,Borrero E,El-Baik L,Arnaout R,Al-Mousa H,Alazami AM

更新日期：2017-08-01 00:00:00

abstract：:To study the mechanisms of hepatocyte injury, we examined serum interleukin-6 (IL-6) level in acute hepatitis patients. Based on their clinical features, these patients were divided into three groups, acute hepatitis (AH), severe acute hepatitis, and fulminant hepatic failure (FHF). The present study demonstrated that...

journal_title：Journal of clinical immunology

authors： Sun Y,Tokushige K,Isono E,Yamauchi K,Obata H

更新日期：1992-05-01 00:00:00

abstract：:The in vitro maturation of monocytes from patients with lymphadenopathy syndrome (LAS) was studied by means of enzymatic activity performed during a 7-day incubation period. Monocytes from LAS patients, healthy homosexuals, and healthy heterosexuals were assayed for beta-galactosidase and beta-N-acetylglucosaminidase ...

journal_title：Journal of clinical immunology

authors： Offenberger J,Lieu T,Frick O,Ammann AJ

更新日期：1986-11-01 00:00:00

abstract：:Live-attenuated vaccines (LAVs) can protect humans against 12 viral and three bacterial diseases. By definition, any clinical infection caused by a LAV that is sufficiently severe to require medical intervention attests to an inherited or acquired immunodeficiency that must be diagnosed or identified. Self-healing inf...

journal_title：Journal of clinical immunology

authors： Pöyhönen L,Bustamante J,Casanova JL,Jouanguy E,Zhang Q

更新日期：2019-05-01 00:00:00

abstract：:The concentrations of serum IgG and IgM antibodies to polyclonal IgA (IgAp), IgA1, and IgA2 were determined by enzyme immunoassay in 31 patients with IgA nephropathy and 30 healthy controls. Patients with IgA nephropathy had significantly raised concentrations of serum IgA compared to controls (Mann-Whitney U test, P ...

journal_title：Journal of clinical immunology

authors： Jones CL,Hosking CS,Kincaid-Smith P,Powell HR,Richardson SC,Sennhauser FH,Roberton DM

更新日期：1989-07-01 00:00:00

abstract：:We previously reported that several DNA fragments from human prostate-specific membrane antigen (hPSM), mouse prostatic acid phosphatase (mPAP), and human prostate-specific antigen (hPSA) genes were selected and fused to create a novel hPSM-mPAP-hPSA fusion gene (named 3P gene), and human secondary lymphoid tissue che...

journal_title：Journal of clinical immunology

authors： Li N,Qin H,Li X,Zhou C,Wang D,Ma W,Lin C,Zhang Y,Wang S,Zhang S

更新日期：2007-01-01 00:00:00

abstract：:Immunosuppression-associated lymphoproliferative disorders can be related to primary as well as acquired immune disorders. Interferon gamma receptor (IFN-γR) deficiency is a rare primary immune disorder, characterized by increased susceptibility to mycobacterial infections. Here we report the first case of an Epstein ...

journal_title：Journal of clinical immunology

authors： Bax HI,Freeman AF,Anderson VL,Vesterhus P,Laerum D,Pittaluga S,Wilson WH,Holland SM

更新日期：2013-08-01 00:00:00

abstract：:The concentrations of the neuropeptides substance P, somatostatin, and calcitonin gene-related peptide in human nasal secretions were quantified by radioimmunoassays, concurrently with that of histamine, in the course of nasal challenge of allergic and control subjects with ryegrass antigen to examine contributions of...

journal_title：Journal of clinical immunology

authors： Walker KB,Serwonska MH,Valone FH,Harkonen WS,Frick OL,Scriven KH,Ratnoff WD,Browning JG,Payan DG,Goetzl EJ

更新日期：1988-03-01 00:00:00

abstract：PURPOSE:DNA Ligase 4 (LIG4) is a key factor in the non-homologous end-joining (NHEJ) DNA double-strand break repair pathway needed for V(D)J recombination and the generation of the T cell receptor and immunoglobulin molecules. Defects in LIG4 result in a variable syndrome of growth retardation, pancytopenia, combined i...

journal_title：Journal of clinical immunology

authors： Felgentreff K,Baxi SN,Lee YN,Dobbs K,Henderson LA,Csomos K,Tsitsikov EN,Armanios M,Walter JE,Notarangelo LD

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:Home-based subcutaneous immunoglobulin (SCIg) therapy is an alternative to hospital-based intravenous infusions (IVIg). However, SCIg requires patient training and long-term support to ensure proper adherence, optimal efficacy and safety. We evaluated if switching patients to home-based SCIg including an interp...

journal_title：Journal of clinical immunology

authors： Perraudin C,Bourdin A,Spertini F,Berger J,Bugnon O

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Chronic granulomatous disease (CGD) is characterized by mutation in any one of the five genes coding NADPH oxidase components that leads to functional abnormality preventing the killing of phagocytosed microbes by affecting the progression of a respiratory burst. CGD patients have an increased susceptibility...

journal_title：Journal of clinical immunology

authors： Kulkarni M,Hule G,de Boer M,van Leeuwen K,Kambli P,Aluri J,Gupta M,Dalvi A,Mhatre S,Taur P,Desai M,Madkaikar M

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:The study clarified whether the T-helper (Th)1/Th2 imbalance existed only in coronary arterial inflammation or in both coronary arterial inflammation and myocardial inflammation and explored the significance of the imbalance of Th1/Th2 function after acute myocardial infarction (AMI). BACKGROUND:There are t...

journal_title：Journal of clinical immunology

authors： Cheng X,Liao YH,Ge H,Li B,Zhang J,Yuan J,Wang M,Liu Y,Guo Z,Chen J,Zhang J,Zhang L

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:The purpose of the study was to determine associations between pre-antiretroviral therapy (ART) senescent CD8+ T lymphocytes and naïve versus non-naive CD8+ and CD4+ T lymphocyte subpopulations and CD4+ responses after initiation of ART in younger versus older individuals. METHODS:Retrospective analysis of 1...

journal_title：Journal of clinical immunology

authors： Hoffman RM,Jamieson BD,Bosch RJ,Currier J,Kitchen CM,Schmid I,Zhu Y,Bennett K,Mitsuyasu R

更新日期：2011-10-01 00:00:00

abstract：:Sixty patients (16 children, 44 adults) participated in the study aiming at evaluating: (i) IgG levels when switching patients from intravenous IgG (IVIG) infusions in hospital to subcutaneous (SCIG) self-infusions at home using the same cumulative monthly dose, (ii) protections against infections, and (iii) safety of...

journal_title：Journal of clinical immunology

authors： Gardulf A,Nicolay U,Asensio O,Bernatowska E,Böck A,Carvalho BC,Granert C,Haag S,Hernández D,Kiessling P,Kus J,Pons J,Niehues T,Schmidt S,Schulze I,Borte M

更新日期：2006-03-01 00:00:00