Thymus-dependent lymphocytes in leprosy. II. Effect of chemotherapy on T-lymphocyte subpopulations.

abstract：BACKGROUND:Although interleukin-17 (IL-17) has been reported to participate in the pathogenesis of infectious, autoimmune and allergic disorders, the precise role in allograft rejection remains uncertain. This study illustrates that IL-17 contributes to the pathogenesis of chronic allograft rejection. RESULT:Utilizing...

journal_title：Journal of clinical immunology

authors： Itoh S,Nakae S,Axtell RC,Velotta JB,Kimura N,Kajiwara N,Iwakura Y,Saito H,Adachi H,Steinman L,Robbins RC,Fischbein MP

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:Complete DiGeorge syndrome (cDGS) describes a subset of patients with DiGeorge syndrome that have thymic aplasia, and thus are at risk for severe opportunistic infections. Patients with cDGS and mycobacterial infection have not previously been described. We present this case to illustrate that patients with cDG...

journal_title：Journal of clinical immunology

authors： Yin SM,Ferdman RM,Wang L,Markert ML,Tam JS

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:A substantial part of rheumatoid arthritis (RA) patients is chronically treated with adalimumab. Some of these patients produce antibodies against adalimumab, which correlate with lower serum drug levels and reduced clinical response. Long term exposure to antigens may result in antigen specific IgG4 production...

journal_title：Journal of clinical immunology

authors： van Schouwenburg PA,Krieckaert CL,Nurmohamed M,Hart M,Rispens T,Aarden L,Wouters D,Wolbink GJ

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:The specific antibody response to the unconjugated 23-valent pneumococcal polysaccharide vaccine is one of the most common tests used to assess for possible humoral immunodeficiency. The results can be difficult to interpret because most people have been immunized with one or more of the pneumococcal vaccines a...

journal_title：Journal of clinical immunology

authors： Bausch-Jurken MT,Verbsky JW,Gonzaga KA,Elms NP,Hintermeyer MK,Gauld SB,Routes JM

更新日期：2017-07-01 00:00:00

abstract：:It has been postulated that patients with ulcerative colitis (UC) have altered reactivity of gut-associated lymphoid tissue. In such cases there is intense infiltration of the mucosa with immune competent cells and associated tissue damage. We have shown previously that the dietary supplementation with the n-3 polyuns...

journal_title：Journal of clinical immunology

authors： Almallah YZ,Ewen SW,El-Tahir A,Mowat NA,Brunt PW,Sinclair TS,Heys SD,Eremin O

更新日期：2000-01-01 00:00:00

abstract：:A patient affected with multiple myeloma displayed in the serum, urine, and cerebrospinal fluid a paraprotein with identical electrophoretic mobility. The paraprotein, which was polymeric, appeared in the serum and cerebrospinal fluid mainly as the dimer and tetramer, whereas in the urine the tetramer was predominant....

journal_title：Journal of clinical immunology

authors： Bollengier F,Mahler A,Gillard A,Wijffels E

更新日期：1986-07-01 00:00:00

abstract：:To better understand the role of Ia antigen expression, accessory cell function, and antigen ingestion in antigen presentation and the initiation of T cell proliferation, we studied these events in two acute monoblastic leukemia (AMoL) lines. The cell lines were positive for surface Ia antigen; one stimulated prolifer...

journal_title：Journal of clinical immunology

authors： Giller RH,Mori M,Hayward AR

更新日期：1984-11-01 00:00:00

abstract：:The immune system is affected by the aging process and undergoes significant age-related changes, termed immunosenescence. Different T cell subsets are affected by this process. Alterations within the bone marrow and thymus lead to a shift in the composition of the T cell repertoire from naïve to antigen-experienced T...

journal_title：Journal of clinical immunology

authors： Arnold CR,Wolf J,Brunner S,Herndler-Brandstetter D,Grubeck-Loebenstein B

更新日期：2011-04-01 00:00:00

abstract：:Rapidly progressive glomerulonephritis (RPGN) is characterized by rapid and progressive loss of renal function and the presence of crescentic glomerulonephritis (CGN). Early diagnosis and appropriate treatment is mandatory to prevent death and/or renal failure. We have evaluated an ANCA-GBM dot-blot diagnostic test in...

journal_title：Journal of clinical immunology

authors： Rutgers A,Damoiseaux J,Roozendaal C,Limburg PC,Stegeman CA,Tervaert JW

更新日期：2004-07-01 00:00:00

abstract：:MECP2 (methyl CpG binding protein 2) duplication causes syndromic intellectual disability. Patients often suffer from life-threatening infections, suggesting an additional immunodeficiency. We describe for the first time the detailed infectious and immunological phenotype of MECP2 duplication syndrome. 17/27 analyzed ...

journal_title：Journal of clinical immunology

authors： Bauer M,Kölsch U,Krüger R,Unterwalder N,Hameister K,Kaiser FM,Vignoli A,Rossi R,Botella MP,Budisteanu M,Rosello M,Orellana C,Tejada MI,Papuc SM,Patat O,Julia S,Touraine R,Gomes T,Wenner K,Xu X,Afenjar A,Toutain

更新日期：2015-02-01 00:00:00

abstract：:Oligoclonal free light chains (FLC) banding has been described in multiple sclerosis (MS) and should be correlated with disease activity. However, discrepancies between studies have been reported because of differences in methods. A new quantitative, rapid, and automated method using nephelometry is now available. Our...

journal_title：Journal of clinical immunology

authors： Desplat-Jégo S,Feuillet L,Pelletier J,Bernard D,Chérif AA,Boucraut J

更新日期：2005-07-01 00:00:00

abstract：:Chemotherapeutic agent is characterized by its concentration in tumor cells with minimum side effects. Oleandrin, a polyphenolic cardiac glycoside is known to induce apoptosis in tumor cells. However, no report is available on its efficacy in primary cells. In this report we are providing the evidence that oleandrin i...

journal_title：Journal of clinical immunology

authors： Sreenivasan Y,Raghavendra PB,Manna SK

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Purified allergens with reduced IgE reactivity are required to improve the safety and efficacy of allergen-specific immunotherapy (IT). OBJECTIVE:The present study investigates the efficacy of purified cockroach allergen immunotherapy with proteolytically active and inactive Per a 10 in allergic mouse model...

journal_title：Journal of clinical immunology

authors： Srivastava D,Mehta AK,Arora N,Gaur SN,Singh BP

更新日期：2010-05-01 00:00:00

abstract：:Review of the limited data currently available on the ratios of helper (OKT4+) to suppressor (OKT8+) T cells in autoimmune liver disease (primary biliary cirrhosis and chronic active lupoid hepatitis) and virally induced liver disease indicates that this OKT4+:OKT8+ ratio is elevated in autoimmune liver disease manife...

journal_title：Journal of clinical immunology

authors： Thomas HC,Brown D,Labrooy J,Epstein O

更新日期：1982-07-01 00:00:00

abstract：OBJECTIVE:Different sets of warning signs can be used if primary immunodeficiency (PID) is suspected: those of the Jeffrey Modell Foundation (JMF), the German Patients' Organisation for Primary Immunodeficiencies (DSAI) and the Association of the Scientific Medical Societies in Germany (AWMF). A few studies have tested...

journal_title：Journal of clinical immunology

authors： Lankisch P,Schiffner J,Ghosh S,Babor F,Borkhardt A,Laws HJ

更新日期：2015-04-01 00:00:00

abstract：:The staphylococcal enterotoxins have been termed superantigens based on their ability to stimulate polyclonal proliferative responses of murine and human T lymphocytes expressing particular T-cell receptor V beta gene products. Certain of these toxins have been shown both to activate and to induce anergy in reactive T...

journal_title：Journal of clinical immunology

authors： Gelfand EW,Saloga J,Lack G

更新日期：1995-11-01 00:00:00

abstract：:Using fresh whole blood or isolated lymphocytes, the activity of in vivo generated cytotoxic T-lymphocytes (CTL) was measured as the OKT3-specific lysis of HL-60 targets, in a cross-sectional study of 53 HIV (+) patients. CTL activity in the entire HIV(+) group was two to three times higher than in HIV(-) controls, wi...

journal_title：Journal of clinical immunology

authors： Vanham G,Kestens L,Penne G,Goilav C,Gigase P,Colebunders R,Vandenbruaene M,Goeman J,van der Groen G,Ceuppens JL

更新日期：1991-11-01 00:00:00

abstract：:Fas-associated death domain (FADD) is an adapter protein that is recruited to the death-inducing signaling complex (DISC) during signaling via death receptors. FADD is a common conduit in both CD95-mediated and TNF-R-mediated apoptosis. In aging, T cells show increased susceptibility to death receptor-induced apoptosi...

journal_title：Journal of clinical immunology

authors： Gupta S,Kim C,Yel L,Gollapudi S

更新日期：2004-01-01 00:00:00

abstract：:A number of primary immunodeficiency diseases represent a paradox of immunodeficiency and autoimmunity. In this minireview, we present basic concepts of apoptosis and disorder of apoptosis as one of the mechanisms to explain such a paradox between immunodeficiency and autoimmunity, which is exemplified by autoimmune l...

journal_title：Journal of clinical immunology

authors： Oliveira JB,Gupta S

更新日期：2008-05-01 00:00:00

abstract：:We report the updated classification of Inborn Errors of Immunity/Primary Immunodeficiencies, compiled by the International Union of Immunological Societies Expert Committee. This report documents the key clinical and laboratory features of 430 inborn errors of immunity, including 64 gene defects that have either been...

journal_title：Journal of clinical immunology

authors： Tangye SG,Al-Herz W,Bousfiha A,Chatila T,Cunningham-Rundles C,Etzioni A,Franco JL,Holland SM,Klein C,Morio T,Ochs HD,Oksenhendler E,Picard C,Puck J,Torgerson TR,Casanova JL,Sullivan KE

更新日期：2020-01-01 00:00:00

abstract：:Cross-sectional and limited sequential studies of neutrophil and monocyte chemotaxis were done using cells isolated from cord blood and peripheral blood of 2- to 6-day-old neonates and infants at 4 and 6 months of age. These studies show that cord blood phagocyte chemotaxis is comparable to adult values, whereas phago...

journal_title：Journal of clinical immunology

authors： Raghunathan R,Miller ME,Everett S,Leake RD

更新日期：1982-07-01 00:00:00

abstract：:Autism is a complex polygenic neurodevelopmental disorder characterized by deficits in communication and social interactions as well as specific stereotypical behaviors. Both genetic and environmental factors appear to contribute to the pathogenesis of autism. Accumulating data including changes in immune responses, l...

journal_title：Journal of clinical immunology

authors： Gupta S,Samra D,Agrawal S

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:Oxygen therapy (hyperoxia) is essential for the treatment of some neonatal critical care conditions. The lung is the primary target for the changes induced by hyperoxia. Secretory immunoglobulin A (SIgA), IgA and secretory component (SC) reflect the local immunity in the respiratory tract induced by hyperoxia. ...

journal_title：Journal of clinical immunology

authors： Liu DY,Jiang T,Wang S,Cao X

更新日期：2013-07-01 00:00:00

abstract：PURPOSE:To elucidate the relative role of the immune system and intestinal epithelium in the ethiopatogenesis of Celiac disease (CD). METHODS:A patient with childhood CD who underwent allogeneic bone marrow transplantation (BMT) for chronic myelogenous leukemia was followed for 5 years after resumption of gluten conta...

journal_title：Journal of clinical immunology

authors： Ben-Horin S,Polak-Charcon S,Barshack I,Picard O,Fudim E,Yavzori M,Avivi C,Mardoukh C,Shimoni A,Chowers Y,Maor Y

更新日期：2013-11-01 00:00:00

abstract：:The Wiskott-Aldrich syndrome (WAS) is a rare X-linked disorder originally described by Dr. Alfred Wiskott in 1937 and Dr. Robert Aldrich in 1954 as a familial disease characterized by infections, bleeding tendency, and eczema. Today, it is well recognized that the syndrome has a wide clinical spectrum ranging from mil...

journal_title：Journal of clinical immunology

authors： Candotti F

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVES:The study clarified whether the T-helper (Th)1/Th2 imbalance existed only in coronary arterial inflammation or in both coronary arterial inflammation and myocardial inflammation and explored the significance of the imbalance of Th1/Th2 function after acute myocardial infarction (AMI). BACKGROUND:There are t...

journal_title：Journal of clinical immunology

authors： Cheng X,Liao YH,Ge H,Li B,Zhang J,Yuan J,Wang M,Liu Y,Guo Z,Chen J,Zhang J,Zhang L

更新日期：2005-05-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is associated with T- and B-cell dysfunction. Immunoglobulin (Ig) production is under the control of T cells and their derived cytokines such as interleukin 2 (IL-2) and IL-4. Herein we studied the regulation of the production of immunoglobulins and cytokines by peripheral blood mononuclear c...

journal_title：Journal of clinical immunology

authors： Briolay J,Dechanet J,Blanchard D,Banchereau J,Miossec P

更新日期：1992-01-01 00:00:00

abstract：:To compare the efficacy of immunoglobulin replacement therapy given intravenously versus subcutaneously to prevent infections in patients with primary antibody deficiency syndromes, an international, multicenter, open label, crossover study was designed. Forty patients were randomized to receive either subcutaneous or...

journal_title：Journal of clinical immunology

authors： Chapel HM,Spickett GP,Ericson D,Engl W,Eibl MM,Bjorkander J

更新日期：2000-03-01 00:00:00

abstract：:The experiments described have shown that, whereas the injection of tetanus toxoid (tet) into 8 of 12 control individuals resulted in the appearance of specific anti-tet-IgG antibodies in their plasma, immunization of 14 anergic patients did not elicit an antibody response. This observation was extended to an in vitro...

journal_title：Journal of clinical immunology

authors： Mazaheri R,Rode HN,Abikar K,Ing A,Nohr C,Gordon J

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:Tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) is a negative regulator of the nuclear factor-κB (NF-κB) pathway. It has recently been recognized that TNFAIP3 deficiency leads to early onset of autoinflammatory and autoimmune syndrome resembling Behçet's disease. Here, we report a novel mutation in...

journal_title：Journal of clinical immunology

authors： Dong X,Liu L,Wang Y,Yang X,Wang W,Lin L,Sun B,Hou J,Ying W,Hui X,Zhou Q,Liu D,Yao H,Sun J,Wang X

更新日期：2019-02-01 00:00:00