Adaptive and Innate Immune Responses in Autism: Rationale for Therapeutic Use of Intravenous Immunoglobulin.

abstract：:This special article deals with the role of processing enzymes in the generation of bioactive cytokines, particularly IL-1 beta and the novel cytokine IL-18, which was formerly called IFN gamma-inducing factor (IGIF). The "classical" pathways of cytokine processing are described, as well as the importance of alternati...

journal_title：Journal of clinical immunology

authors： Fantuzzi G,Dinarello CA

更新日期：1999-01-01 00:00:00

abstract：:In this retrospective study 103 serum samples from 16 females with systemic lupus erythematosus (SLE), obtained during a mean follow-up time of 2 years, were investigated for the presence of anti-denatured [single-stranded (ss)] DNA antibodies of the IgG, IgM, and IgA classes. The anti-ssDNA antibodies were determined...

journal_title：Journal of clinical immunology

authors： Gripenberg M,Leirisalo M,Johansson E,Gripenberg G

更新日期：1985-09-01 00:00:00

abstract：PURPOSE:Combined immunodeficiency (CID) presents a unique challenge to clinicians. Two patients presented with the prior clinical diagnosis of common variable immunodeficiency (CVID) disorder marked by an early age of presentation, opportunistic infections, and persistent lymphopenia. Due to the presence of atypical cl...

journal_title：Journal of clinical immunology

authors： Buchbinder D,Baker R,Lee YN,Ravell J,Zhang Y,McElwee J,Nugent D,Coonrod EM,Durtschi JD,Augustine NH,Voelkerding KV,Csomos K,Rosen L,Browne S,Walter JE,Notarangelo LD,Hill HR,Kumánovics A

更新日期：2015-02-01 00:00:00

abstract：:Since 2013, the International Union of Immunological Societies (IUIS) expert committee (EC) on Inborn Errors of Immunity (IEI) has published an updated phenotypic classification of IEI, which accompanies and complements their genotypic classification into ten tables. This phenotypic classification is user-friendly and...

journal_title：Journal of clinical immunology

authors： Bousfiha A,Jeddane L,Picard C,Al-Herz W,Ailal F,Chatila T,Cunningham-Rundles C,Etzioni A,Franco JL,Holland SM,Klein C,Morio T,Ochs HD,Oksenhendler E,Puck J,Torgerson TR,Casanova JL,Sullivan KE,Tangye SG

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:The purpose of the study was to determine associations between pre-antiretroviral therapy (ART) senescent CD8+ T lymphocytes and naïve versus non-naive CD8+ and CD4+ T lymphocyte subpopulations and CD4+ responses after initiation of ART in younger versus older individuals. METHODS:Retrospective analysis of 1...

journal_title：Journal of clinical immunology

authors： Hoffman RM,Jamieson BD,Bosch RJ,Currier J,Kitchen CM,Schmid I,Zhu Y,Bennett K,Mitsuyasu R

更新日期：2011-10-01 00:00:00

abstract：:Anti-CD3 monoclonal antibody (MoAb) induces proliferation of freshly isolated peripheral blood T cells only in the presence of monocytes/macrophages and requires binding of the Fc portion of antibody to monocytes/macrophages. In this investigation, we examined whether monocytes process anti-CD3 similar to any soluble ...

journal_title：Journal of clinical immunology

authors： Vayuvegula B,Ohira K,Gollapudi S,Gupta S

更新日期：1990-09-01 00:00:00

abstract：:Hematopoietic stem cell transplantation (HSCT) is curative for severe combined immunodeficiency (SCID), but data on long-term impact of pre-HSCT chemotherapy, immune reconstitution and quality of life (QoL) of specific SCID genotypes are limited. We evaluated the long-term immune-reconstitution, health outcome and QoL...

journal_title：Journal of clinical immunology

authors： Abd Hamid IJ,Slatter MA,McKendrick F,Pearce MS,Gennery AR

更新日期：2018-08-01 00:00:00

abstract：:This study evaluates metaphase chromosome protein 1 (MCP1), a nuclear antigen, as a diagnostic marker for systemic lupus erythematosus (SLE). Reactivity of sera from 114 Portuguese patients with autoimmune rheumatic disease or from healthy blood donors (HBD), against MCP1, produced in bacteria (bact-MCP1) or in its na...

journal_title：Journal of clinical immunology

authors： Bronze-da-Rocha E,Nóvoa A,Teixeira N,Vasconcelos CS,Cerveira C,Castro e Melo J,Carvalho MC

更新日期：2012-08-01 00:00:00

abstract：INTRODUCTION:Several differences have been described between neonatal and adult immune responses. The predisposition in early life to Th2-type response or tolerance makes it a susceptible period for infections and allergic sensitization. OBJECTIVE:The aim of this work was to evaluate the effects of CpG-containing olig...

journal_title：Journal of clinical immunology

authors： de Brito CA,Fusaro AE,Victor JR,Rigato PO,Goldoni AL,Muniz BP,Duarte AJ,Sato MN

更新日期：2010-03-01 00:00:00

abstract：:The autoantigen of celiac disease, transglutaminase 2 (TG2), adopts an open conformation during enzymatic activation. We studied diagnostic accuracy of serodiagnostic assays using TG2 in its open and closed conformation as antigens in patients with diagnostic difficulties. The open TG2 antibody (TG2ab) test identified...

journal_title：Journal of clinical immunology

authors： Lindfors K,Koskinen O,Kurppa K,Laurila K,Collin P,Haimila K,Partanen J,Saavalainen P,Mäki M,Kaukinen K

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVES:The study clarified whether the T-helper (Th)1/Th2 imbalance existed only in coronary arterial inflammation or in both coronary arterial inflammation and myocardial inflammation and explored the significance of the imbalance of Th1/Th2 function after acute myocardial infarction (AMI). BACKGROUND:There are t...

journal_title：Journal of clinical immunology

authors： Cheng X,Liao YH,Ge H,Li B,Zhang J,Yuan J,Wang M,Liu Y,Guo Z,Chen J,Zhang J,Zhang L

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Recently, two functional IL18 promoter variants, -607C>A (rs1946518) and -137G>C (rs187238), were associated with viral clearance in patients with hepatitis C. The present study focused on their relevance for treatment response. METHODS:Seven hundred fifty-seven chronically infected European patients and 79...

journal_title：Journal of clinical immunology

authors： Haas SL,Weiss C,Bugert P,Gundt J,Witt H,Singer MV,Berg T,Böcker U

更新日期：2009-09-01 00:00:00

abstract：:We have examined the primary immune responses, the numbers of total T (T11+) cells, T-helper (T4+) cells, T-suppressor (T8+) cells, and natural killer (NK) (Leu7+) cells, in 118 healthy control subjects and compared the data to those obtained from 20 patients with clinically diagnosed malignant mesothelioma and 375 lo...

journal_title：Journal of clinical immunology

authors： Lew F,Tsang P,Holland JF,Warner N,Selikoff IJ,Bekesi JG

更新日期：1986-05-01 00:00:00

abstract：:COX2 (prostaglandin G/H synthase, PTGS2) is a well-validated target in the fields of both oncology and inflammation. Despite their significant toxicity profile, non-steroidal anti-inflammatory drugs (NSAIDs) have become standard of care in the treatment of many COX2-mediated inflammatory conditions. In this report, we...

journal_title：Journal of clinical immunology

authors： Ferguson GD,Jensen-Pergakes K,Wilkey C,Jhaveri U,Richard N,Verhelle D,De Parseval LM,Corral LG,Xie W,Morris CL,Brady H,Chan K

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:Autosomal recessive hyper-IgE syndrome is a rare combined immunodeficiency characterized by susceptibility to viral infections, atopic eczema, high serum IgE and defective T cell activation. The genetic etiologies are diverse. Null mutations in DOCK8 and TYK2 are responsible for many cases. This study aims to p...

journal_title：Journal of clinical immunology

authors： Alsum Z,Hawwari A,Alsmadi O,Al-Hissi S,Borrero E,Abu-Staiteh A,Khalak HG,Wakil S,Eldali AM,Arnaout R,Al-Ghonaium A,Al-Muhsen S,Al-Dhekri H,Al-Saud B,Al-Mousa H

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:In severe sepsis, functional impairment and decreased numbers of dendritic cells (DCs) are essential reasons for immune function paralysis, secondary organ infection, and organ failure. We investigated the effects of N-acetylcysteine (NAC) administration on protecting lung DCs function in a zymosan-induced gene...

journal_title：Journal of clinical immunology

authors： Wang HW,Yang W,Lu JY,Li F,Sun JZ,Zhang W,Guo NN,Gao L,Kang JR

更新日期：2013-04-01 00:00:00

abstract：:Chronic Granulomatous Disease (CGD), caused by genetic defects in components of the phagocyte NADPH oxidase pathway, leads to recurrent life-threatening bacterial and invasive fungal infections. While a number of unique pathogens have been associated with this disease, the causative organisms may be difficult to ident...

journal_title：Journal of clinical immunology

authors： Ramesh M,Resnick E,Hui Y,Maglione PJ,Mehta H,Kattan J,Bouvier NM,LaBombardi V,Victor TR,Chaturvedi S,Cunningham-Rundles C

更新日期：2014-02-01 00:00:00

abstract：:Apart from cellular immunity and immunopathology, various cytokines have been implicated in malaria-associated immunosuppression. In this study, serum levels of transforming growth factor-beta (TGF-beta) were determined with an enzyme-linked immunosorbent assay in 37 patients with acute Plasmodium falciparum malaria p...

journal_title：Journal of clinical immunology

authors： Wenisch C,Parschalk B,Burgmann H,Looareesuwan S,Graninger W

更新日期：1995-03-01 00:00:00

abstract：:A monoclonal antibody produced by hybridomas obtained from a mouse immunized with drug-resistant cells recognizes certain hamster and human drug-resistant cell lines but not their drug-sensitive parental lines. Preliminary characterization of the antigen indicates that it is a molecule of approximately 180,000 daltons...

journal_title：Journal of clinical immunology

authors： O'Hara CJ,Grover J,Price GB

更新日期：1984-09-01 00:00:00

abstract：:A number of primary immunodeficiency diseases represent a paradox of immunodeficiency and autoimmunity. In this minireview, we present basic concepts of apoptosis and disorder of apoptosis as one of the mechanisms to explain such a paradox between immunodeficiency and autoimmunity, which is exemplified by autoimmune l...

journal_title：Journal of clinical immunology

authors： Oliveira JB,Gupta S

更新日期：2008-05-01 00:00:00

abstract：:Treatment of primary immunodeficiency (PI) is typically initiated with intravenous immunoglobulin (IVIG) loading and then continued with IVIG or subcutaneous IgG (SCIG). This prospective, open-label, multicenter, 6-month study evaluated a new regimen of initiating IgG therapy with SCIG in 18 previously untreated patie...

journal_title：Journal of clinical immunology

authors： Borte M,Quinti I,Soresina A,Fernández-Cruz E,Ritchie B,Schmidt DS,McCusker C

更新日期：2011-12-01 00:00:00

abstract：:Thirty two HIV-infected children, on highly active antiretroviral therapy (HAART) and > 500 CD4+ T cells/mm3, were rated according to the time-course of viral load (VL) during the whole follow-up period (> 18 months) in a longitudinal retrospective study. (a) uVL group: 15 children with VL below 400 copies/mL; (b) dVL...

journal_title：Journal of clinical immunology

authors： Resino S,Galán I,Bellón JM,Navarro ML,León JA,Muñoz-Fernandez MA

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:The aim of this study is to determine when during hematopoiesis Siglec-8 gets expressed, whether it is expressed on hematologic malignancies, and if there are other non-human species that express Siglec-8. METHODS:Siglec-8 mRNA and cell surface expression was monitored during in vitro maturation of human eos...

journal_title：Journal of clinical immunology

authors： Hudson SA,Herrmann H,Du J,Cox P,Haddad el-B,Butler B,Crocker PR,Ackerman SJ,Valent P,Bochner BS

更新日期：2011-12-01 00:00:00

abstract：:Increased levels of serum IgD can be found in single patients with a variety of clinical syndromes and in the disease entity designated hyper-IgD syndrome which is associated with periodic fever and lymphadenopathy. We investigated 17 patients, both children and adults, with high serum IgD levels ranging from 220 to 5...

journal_title：Journal of clinical immunology

authors： Hiemstra I,Vossen JM,van der Meer JW,Weemaes CM,Out TA,Zegers BJ

更新日期：1989-09-01 00:00:00

abstract：:The complement system plays a central role in defense to encapsulated bacteria through opsonization and membrane attack complex (MAC) dependent lysis. The three activation pathways (classical, lectin, and alternative) converge in the cleavage of C5, which initiates MAC formation and target lysis. C5 deficiency is asso...

journal_title：Journal of clinical immunology

authors： Colobran R,Franco-Jarava C,Martín-Nalda A,Baena N,Gabau E,Padilla N,de la Cruz X,Pujol-Borrell R,Comas D,Soler-Palacín P,Hernández-González M

更新日期：2016-05-01 00:00:00

abstract：:The 22q11.2 deletion syndrome (22q11.2 del), also known as DiGeorge syndrome, is a genetic disorder with an estimated incidence of 1:3000 to 1:6000 births. These patients may suffer from affection of many organ systems with cardiac malformations, immunodeficiency, hypoparathyroidism, autoimmunity, palate anomalies, an...

journal_title：Journal of clinical immunology

authors： Grinde D,Øverland T,Lima K,Schjalm C,Mollnes TE,Abrahamsen TG

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:This study was to investigate the evidence for complement activation in renal biopsy specimens of patients with myeloperoxidase (MPO)-antineutrophil cytoplasmic autoantibody (ANCA)-associated pauci-immune vasculitis. METHODS:Renal biopsy specimens from seven patients with MPO-ANCA positive pauci-immune necro...

journal_title：Journal of clinical immunology

authors： Xing GQ,Chen M,Liu G,Heeringa P,Zhang JJ,Zheng X,E J,Kallenberg CG,Zhao MH

更新日期：2009-05-01 00:00:00

abstract：:Prior to the advent of cardiac bypass, most children with congenital cardiac anomalies and chromosome 22q11.2 deletion syndrome died. With improved technology, there is now a wave of young adults with chromosome 22q11.2 deletion syndrome requiring clinical care. Fifteen young children and 20 adults with chromosome 22q...

journal_title：Journal of clinical immunology

authors： Jawad AF,Prak EL,Boyer J,McDonald-McGinn DM,Zackai E,McDonald K,Sullivan KE

更新日期：2011-12-01 00:00:00

abstract：:To compare the efficacy of immunoglobulin replacement therapy given intravenously versus subcutaneously to prevent infections in patients with primary antibody deficiency syndromes, an international, multicenter, open label, crossover study was designed. Forty patients were randomized to receive either subcutaneous or...

journal_title：Journal of clinical immunology

authors： Chapel HM,Spickett GP,Ericson D,Engl W,Eibl MM,Bjorkander J

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Although some previous studies have reported that genetic and immunological factors play important roles in the pathogenesis of Kawasaki disease (KD), the etiological factors of this enigmatical pediatric disease are still poorly understood. PURPOSE:This study aims to investigate whether polymorphisms of th...

journal_title：Journal of clinical immunology

authors： Huang FY,Chang TY,Chen MR,Chiu NC,Chi H,Lee HC,Lin SP,Chen CK,Chan HW,Chen WF,Liu HF,Chu CC,Lin M,Lee YJ

更新日期：2008-09-01 00:00:00