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Clinical and immunological studies in patients with an increased serum IgD level.

Abstract：

:Increased levels of serum IgD can be found in single patients with a variety of clinical syndromes and in the disease entity designated hyper-IgD syndrome which is associated with periodic fever and lymphadenopathy. We investigated 17 patients, both children and adults, with high serum IgD levels ranging from 220 to 5300 IU/ml. Eight patients had periodic fever and lymphadenopathy, four showed a humoral immunodeficiency, and the remainder had a variety of clinical abnormalities. Serum IgA levels were consistently high in all patients except in those with an immunodeficiency. Serum IgD complexes were detectable in each serum, which indicates that the occurrence is not pathognomic for the syndrome of periodic fever. Antibody formation against the primary antigen Helix pomatia hemocyanine and the secondary antigen tetanus toxoid showed no abnormalities in the patients without an immunodeficiency. Bone marrow origin of serum IgD was strongly suggested by enumeration of IgD-containing plasma cells. We conclude that no apparent relationship exists between the several clinical syndromes and increased serum IgD.

journal_name

J Clin Immunol

journal_title

Journal of clinical immunology

authors

Hiemstra I,Vossen JM,van der Meer JW,Weemaes CM,Out TA,Zegers BJ

doi

10.1007/BF00917104

subject

Has Abstract

pub_date

1989-09-01 00:00:00

pages

393-400

issue

5

eissn

0271-9142

issn

1573-2592

journal_volume

9

pub_type

临床试验,杂志文章,多中心研究

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