Abstract：
:The immune response of 56 colorectal cancer patients to a single infusion of 1 mg of radiolabeled (111In) mouse B72.3-GYK-DTPA immunoconjugate was examined using a double-antigen radiometric assay system. The incidence of antibody response was 48% to polyclonal mouse IgG, 71% to mouse B72.3, and 62% to chimeric B72.3. Twelve patients (23%) had an antibody response to B72.3 V region in the absence of binding to polyclonal mouse IgG. An antiidiotype response was demonstrated in sera from 36% of 25 patients examined and correlated well with chimeric B72.3-GYK-DTPA immunoconjugate binding (r = 0.72, moderately well with mouse B72.3 binding (r = 0.56), and not at all with polyclonal mouse IgG binding (r = 0.28). The peak antibody response occurred most frequently 2 weeks postinfusion, although a "delayed" peak response to chimeric B72.2 occurred in 29% of patients. This study suggests that mouse B72.3 causes an immune response in the majority of patients and that antibody response to the V region is common. Understanding the physiological significance of these antibody responses will require correlation with the kinetics and tumor localization of repeat infusions of such immunoconjugates.
journal_name
J Clin Immunoljournal_title
Journal of clinical immunologyauthors
Khazaeli MB,Saleh MN,Liu T,Kaladas PM,Gilman SC,LoBuglio AFdoi
10.1007/BF00918141subject
Has Abstractpub_date
1992-03-01 00:00:00pages
116-21issue
2eissn
0271-9142issn
1573-2592journal_volume
12pub_type
杂志文章abstract：:Increased levels of serum IgD can be found in single patients with a variety of clinical syndromes and in the disease entity designated hyper-IgD syndrome which is associated with periodic fever and lymphadenopathy. We investigated 17 patients, both children and adults, with high serum IgD levels ranging from 220 to 5...
journal_title：Journal of clinical immunology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/BF00917104
更新日期：1989-09-01 00:00:00
abstract：:Sixty patients (16 children, 44 adults) participated in the study aiming at evaluating: (i) IgG levels when switching patients from intravenous IgG (IVIG) infusions in hospital to subcutaneous (SCIG) self-infusions at home using the same cumulative monthly dose, (ii) protections against infections, and (iii) safety of...
journal_title：Journal of clinical immunology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s10875-006-9002-x
更新日期：2006-03-01 00:00:00
abstract：:There has been a growing body of evidence suggesting that CD4+ Th1/Th2 cell responses participate in pathologic and immunologic processes in infectious disease. Bacterial meningitis is a fatal disease of children and is associated with a spectrum of clinical syndromes. This study provides evidence of CD4+ enhanced int...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/BF01541324
更新日期：1995-11-01 00:00:00
abstract：:This special article deals with the role of processing enzymes in the generation of bioactive cytokines, particularly IL-1 beta and the novel cytokine IL-18, which was formerly called IFN gamma-inducing factor (IGIF). The "classical" pathways of cytokine processing are described, as well as the importance of alternati...
journal_title：Journal of clinical immunology
pub_type： 杂志文章,评审
doi：10.1023/a:1020506300324
更新日期：1999-01-01 00:00:00
abstract：:Bias in cytokine responses has been proposed as a contributing mechanism to pathogenesis in persistent HIV or hepatitis C virus (HCV) infections. We investigated whether coinfection with HCV modifies the profile of antigen-specific cytokine secretion in women persistently infected with HIV compared to women with singl...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-005-2819-x
更新日期：2005-03-01 00:00:00
abstract：:Treatment of primary immunodeficiency (PI) is typically initiated with intravenous immunoglobulin (IVIG) loading and then continued with IVIG or subcutaneous IgG (SCIG). This prospective, open-label, multicenter, 6-month study evaluated a new regimen of initiating IgG therapy with SCIG in 18 previously untreated patie...
journal_title：Journal of clinical immunology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s10875-011-9588-5
更新日期：2011-12-01 00:00:00
abstract：:Aging represents a complex remodeling in which both innate and adaptive immunities deteriorate. Age-related changes in humoral immunity are responsible for the reduced vaccine responses observed in elderly individuals. Although T cell alterations play a significant role in age-related humoral immune changes, alteratio...
journal_title：Journal of clinical immunology
pub_type： 杂志文章,评审
doi：10.1007/s10875-010-9501-7
更新日期：2011-06-01 00:00:00
abstract：:This study aimed to verify whether rs4986790 A > G single nucleotide polymorphism of toll like receptor 4 (TLR-4) associates with a more severe course of hepatitis B virus (HBV) chronic infection. A cross-sectional study enrolled 191 Caucasian HBV-positive patients: 28 HBsAg + inactive carriers, 121 chronic hepatitis ...
journal_title：Journal of clinical immunology
pub_type： 信件
doi：10.1007/s10875-012-9822-9
更新日期：2013-02-01 00:00:00
abstract：:Initially used as a replacement therapy for immunodeficiency diseases, intravenous immunoglobulin (IVIg) is now widely used for a number of autoimmune and inflammatory diseases. Considerable progress has been made in understanding the mechanisms by which IVIg exerts immunomodulatory effects in autoimmune and inflammat...
journal_title：Journal of clinical immunology
pub_type： 杂志文章,评审
doi：10.1007/s10875-007-9088-9
更新日期：2007-05-01 00:00:00
abstract：PURPOSE:The aim of the present study was to evaluate whether the anti-Rheumatoid arthritis (RA) effect of curcumin is associated with the regulation of B cell-activating factor belonging to the TNF family (BAFF) production. METHODS:Collagen-induced arthritis (CIA) was induced in DBA/1 J mice by immunization with bovin...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-012-9839-0
更新日期：2013-04-01 00:00:00
abstract：:Natural killer (NK) cell deficiency (NKD) is a subset of primary immunodeficiency disorders (PID) in which an abnormality of NK cells represents a major immunological defect resulting in the patient's clinical immunodeficiency. This is distinct from a much larger group of PIDs that include an NK cell abnormality as a ...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-019-00711-7
更新日期：2020-01-01 00:00:00
abstract：:We read with interest the recent paper in the JoCI, entitled 'Study of the expression of Toll-Like Receptors in Different Histological Types of Colorectal Polyps and Their Relationship with Colorectal Cancer' by Eiró et al. TLR7 and 9 expression is altered in CRC vs. normal control; which is proposed to be correlated ...
journal_title：Journal of clinical immunology
pub_type： 评论,信件
doi：10.1007/s10875-012-9719-7
更新日期：2012-12-01 00:00:00
abstract：:Immunosuppression-associated lymphoproliferative disorders can be related to primary as well as acquired immune disorders. Interferon gamma receptor (IFN-γR) deficiency is a rare primary immune disorder, characterized by increased susceptibility to mycobacterial infections. Here we report the first case of an Epstein ...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-013-9907-0
更新日期：2013-08-01 00:00:00
abstract：PURPOSE:Severe Combined Immune Deficiency (SCID) is universally fatal unless treated with hematopoietic stem cell transplantation (HSCT). Following the identification of disseminated Bacille Calmette-Guérin (BCG) infections in Canadian First Nations, Métis and Inuit (FNMI) children with unrecognized primary immune defi...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-013-9952-8
更新日期：2013-11-01 00:00:00
abstract：:We have evaluated the functional properties of the OK-T8+/OKT4+ T-cell subpopulations in nine patients with a new syndrome of acquired immune deficiency (AIDS). Despite polyclonal hypergammaglobulinemia in the sera of these patients, their peripheral blood lymphocytes (PBL) produced negligible quantities of immunoglob...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/BF00915797
更新日期：1983-10-01 00:00:00
abstract：:Total levels of IgM and secretory IgM as well as specific antibodies to poliovirus type I antigen, Escherichia coli O antigens, and beta-lactoglobulin were measured in unstimulated and stimulated saliva as well as nasal secretion using an enzyme-linked immunosorbent assay (ELISA). The levels of these antibodies in IgA...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/BF00917328
更新日期：1986-07-01 00:00:00
abstract：OBJECTIVES:The study clarified whether the T-helper (Th)1/Th2 imbalance existed only in coronary arterial inflammation or in both coronary arterial inflammation and myocardial inflammation and explored the significance of the imbalance of Th1/Th2 function after acute myocardial infarction (AMI). BACKGROUND:There are t...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-005-4088-0
更新日期：2005-05-01 00:00:00
abstract：:Hypogammaglobulinemia is a common symptom in different immunodeficiencies. It is, however, not usually associated with Epstein-Barr virus (EBV) infections. The X-linked lymphoproliferative disease (XLP) on the other hand shows immunological changes in response to the EBV. Here we report three previously healthy boys, ...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1023/B:JOCI.0000040922.26286.36
更新日期：2004-09-01 00:00:00
abstract：:Apart from cellular immunity and immunopathology, various cytokines have been implicated in malaria-associated immunosuppression. In this study, serum levels of transforming growth factor-beta (TGF-beta) were determined with an enzyme-linked immunosorbent assay in 37 patients with acute Plasmodium falciparum malaria p...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/BF01541734
更新日期：1995-03-01 00:00:00
abstract：BACKGROUND:The peroxisome proliferator-activated receptors (PPARs) have been implicated in immune regulation. We determined the transcriptional expression of the three isoforms, PPARalpha, PPARgamma1, and PPARgamma2 in the peritoneal macrophages, CD4- and CD8-positive lymphocytes in non-obese diabetic (NOD) mice at 5 a...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-009-9300-1
更新日期：2009-09-01 00:00:00
abstract：:Catecholamines have been suggested to be responsible for altered cellular immunity after stress. This study was performed to determine the effects of adrenaline and noradrenaline on lymphocyte subpopulations and NK cell functions. Subjects were given a subcutaneous injection of either NaCl, adrenaline (5 micrograms/kg...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/BF00920243
更新日期：1993-09-01 00:00:00
abstract：INTRODUCTION:The molecular and cellular interactions between the immune system and bone tissue have been established. Sex hormone deficiency after menopause has multifunctional role by influencing growth, differentiation, and metabolism of the skeletal and the immune system. DISCUSSION:We have used nonparametric and m...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-009-9321-9
更新日期：2009-11-01 00:00:00
abstract：:Chronic Granulomatous Disease (CGD), caused by genetic defects in components of the phagocyte NADPH oxidase pathway, leads to recurrent life-threatening bacterial and invasive fungal infections. While a number of unique pathogens have been associated with this disease, the causative organisms may be difficult to ident...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-013-9967-1
更新日期：2014-02-01 00:00:00
abstract：:This study shows that specific humoral immunity could be transferred from marrow donors to marrow recipients. Peripheral blood lymphocytes from long-term human marrow recipients produced IgG anti-tetanus toxoid antibody after in vitro tetanus toxoid stimulation. Antitetanus toxoid antibody biosynthesis was induced usi...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/BF00915378
更新日期：1986-09-01 00:00:00
abstract：INTRODUCTION:Experimental allergic encephalomyelitis (EAE) is a T cell-mediated autoimmune disease model for multiple sclerosis (MS). We have shown earlier that 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) and curcumin ameliorate EAE by modulating inflammatory signaling pathways in T lymphocytes. Toll-like rec...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-008-9202-7
更新日期：2008-09-01 00:00:00
abstract：:A monoclonal antibody produced by hybridomas obtained from a mouse immunized with drug-resistant cells recognizes certain hamster and human drug-resistant cell lines but not their drug-sensitive parental lines. Preliminary characterization of the antigen indicates that it is a molecule of approximately 180,000 daltons...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/BF00917144
更新日期：1984-09-01 00:00:00
abstract：:Intravenous immunoglobin (i.v.IG) is generated from the plasma of more than 10,000 healthy subjects. Originally i.v.IG was employed to supplement the missing Igs in subjects with immune-deficiencies. Later on it was given successfully to patients with autoimmune conditions, in some of which the benefits were confirmed...
journal_title：Journal of clinical immunology
pub_type： 杂志文章,评审
doi：10.1023/b:joci.0000019809.55787.ec
更新日期：2004-03-01 00:00:00
abstract：:Subjects with primary immune deficiency diseases treated with intravenous immunoglobulin (n=42) received intravenous infusions of Carimune NF Liquid every 3-4 weeks for 6 months without routine premedication. The mean dose/patient/infusion was 278.5-800.7 mg/kg. Also, 80.4% of infusions achieved maximum rates of >or=3...
journal_title：Journal of clinical immunology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s10875-007-9096-9
更新日期：2007-09-01 00:00:00
abstract：:Matrix metalloproteinases (also named matrixin or MMPs) are a major group of enzymes that regulate cell-matrix composition by using zinc for their proteolytic activities. They are essential for various normal biological processes such as embryonic development, morphogenesis, reproduction tissue resorption, and remodel...
journal_title：Journal of clinical immunology
pub_type： 杂志文章,评审
doi：10.1007/s10875-006-9022-6
更新日期：2006-07-01 00:00:00
abstract：:Various factors seem to be etiologic in the susceptibility to sinopulmonary infections in ataxia-telangiectasia (A-T) patients, i.e., low serum and salivary IgA, low serum IgG2, and even aspiration of saliva. S. pneumoniae is a common pathogen responsible from pulmonary infections and impaired antibody response to pol...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1023/a:1020599810261
更新日期：1999-09-01 00:00:00
