Toll like receptor 4 D299G associates with disease progression in Caucasian patients with chronic HBV infection: relationship with gender.

abstract：:Interferon-γ receptor 1 (IFN-γR1) deficiency is one of the primary immunodeficiencies conferring Mendelian Susceptibility to Mycobacterial Disease (MSMD). Some cases of neoplasms have been recently reported in patients with MSMD, underlying the already known link between immunodeficiency and carcinogenesis. We report ...

journal_title：Journal of clinical immunology

authors： Taramasso L,Boisson-Dupuis S,Garrè ML,Bondi E,Cama A,Nozza P,Morana G,Casanova JL,Marazzi MG

更新日期：2014-11-01 00:00:00

abstract：PURPOSE:The dysregulated expression of miRNAs in the immune system may be critical for immune responses to pathogens and evolve into the inflammation seen in sepsis. The aim of this study is to explore the important role of miRNAs in the regulation of the immune response during neonatal sepsis. METHODS:Using a microar...

journal_title：Journal of clinical immunology

authors： Chen J,Jiang S,Cao Y,Yang Y

更新日期：2014-04-01 00:00:00

abstract：:The immune system is affected by the aging process and undergoes significant age-related changes, termed immunosenescence. Different T cell subsets are affected by this process. Alterations within the bone marrow and thymus lead to a shift in the composition of the T cell repertoire from naïve to antigen-experienced T...

journal_title：Journal of clinical immunology

authors： Arnold CR,Wolf J,Brunner S,Herndler-Brandstetter D,Grubeck-Loebenstein B

更新日期：2011-04-01 00:00:00

abstract：:Testing of cytotoxic function using a panel of natural killer (NK)-sensitive target cells, including a unique herpes simplex virus-infected Raji-cell target, was performed in conjunction with phenotypic cell analysis by dual-color flow cytometry to characterize the NK system. Subjects included in the study were at ris...

journal_title：Journal of clinical immunology

authors： Plaeger-Marshall S,Spina CA,Giorgi JV,Mitsuyasu R,Wolfe P,Gottlieb M,Beall G

更新日期：1987-01-01 00:00:00

abstract：:It has been postulated that patients with ulcerative colitis (UC) have altered reactivity of gut-associated lymphoid tissue. In such cases there is intense infiltration of the mucosa with immune competent cells and associated tissue damage. We have shown previously that the dietary supplementation with the n-3 polyuns...

journal_title：Journal of clinical immunology

authors： Almallah YZ,Ewen SW,El-Tahir A,Mowat NA,Brunt PW,Sinclair TS,Heys SD,Eremin O

更新日期：2000-01-01 00:00:00

abstract：PURPOSE:Mendelian susceptibility to mycobacterial disease (MSMD) is a rare primary immunodeficiency, triggered by non-tuberculous mycobacteria or Bacillus Calmette-Guérin (BCG) vaccines and characterized by severe diseases. All known genetic etiologies are inborn errors of IFN-γ-mediated immunity. Here, we report the m...

journal_title：Journal of clinical immunology

authors： Sarrafzadeh SA,Nourizadeh M,Mahloojirad M,Fazlollahi MR,Shokouhi Shoormasti R,Badalzadeh M,Deswarte C,Casanova JL,Pourpak Z,Bustamante J,Moin M

更新日期：2019-04-01 00:00:00

abstract：:This phase III, open-label, multi-centre study investigated the efficacy, safety, pharmacokinetics and quality of life impact of Evogam(®), a new chromatographically fractionated 16% subcutaneous immunoglobulin, utilising a 1:1 dose transition ratio from previous immunoglobulin therapy. Thirty-five previously treated ...

journal_title：Journal of clinical immunology

authors： Empson MB,Tang ML,Pearce LK,Rozen L,Gold MS,Katelaris CH,Langton D,Smart J,Smith WB,Steele RH,Ziegler JB,Maher D

更新日期：2012-10-01 00:00:00

abstract：INTRODUCTION:The molecular and cellular interactions between the immune system and bone tissue have been established. Sex hormone deficiency after menopause has multifunctional role by influencing growth, differentiation, and metabolism of the skeletal and the immune system. DISCUSSION:We have used nonparametric and m...

journal_title：Journal of clinical immunology

authors： Kósa JP,Balla B,Kiss J,Podani J,Takács I,Lazáry A,Nagy Z,Bácsi K,Karsai A,Speer G,Lakatos P

更新日期：2009-11-01 00:00:00

abstract：:We have evaluated the functional properties of the OK-T8+/OKT4+ T-cell subpopulations in nine patients with a new syndrome of acquired immune deficiency (AIDS). Despite polyclonal hypergammaglobulinemia in the sera of these patients, their peripheral blood lymphocytes (PBL) produced negligible quantities of immunoglob...

journal_title：Journal of clinical immunology

authors： Benveniste E,Schroff R,Stevens RH,Gottlieb MS

更新日期：1983-10-01 00:00:00

abstract：:Alloimmune diseases can occur in pregnancy and after blood transfusions, where antibodies are formed, targeting foreign cells and tissues for destruction by myeloid cells through IgG Fc-receptors (FcγR). In pregnancy, antibodies against human blood group or platelet antigens (e.g. HPA1-a) cause life-threatening anemia...

journal_title：Journal of clinical immunology

authors： Sonneveld ME,van der Schoot CE,Vidarsson G

更新日期：2016-05-01 00:00:00

abstract：:Using an enzyme-linked immunoassay we tested the sera of 71 patients with digestive system cancer, 35 patients with various nonmalignant disorders, and 28 normal individuals for anti-CEA activity. Antibodies were found in the sera of 51% of the patients. Most of the patients positive for the antibodies (70%) had no ev...

journal_title：Journal of clinical immunology

authors： Konstadoulakis MM,Syrigos KN,Albanopoulos C,Mayers G,Golematis B

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Although some previous studies have reported that genetic and immunological factors play important roles in the pathogenesis of Kawasaki disease (KD), the etiological factors of this enigmatical pediatric disease are still poorly understood. PURPOSE:This study aims to investigate whether polymorphisms of th...

journal_title：Journal of clinical immunology

authors： Huang FY,Chang TY,Chen MR,Chiu NC,Chi H,Lee HC,Lin SP,Chen CK,Chan HW,Chen WF,Liu HF,Chu CC,Lin M,Lee YJ

更新日期：2008-09-01 00:00:00

abstract：:There has been a growing body of evidence suggesting that CD4+ Th1/Th2 cell responses participate in pathologic and immunologic processes in infectious disease. Bacterial meningitis is a fatal disease of children and is associated with a spectrum of clinical syndromes. This study provides evidence of CD4+ enhanced int...

journal_title：Journal of clinical immunology

authors： Raziuddin S,el-Awad ME,Telmesani AW,Bilal NE,al-Janadi M

更新日期：1995-11-01 00:00:00

abstract：PURPOSE:Health-related quality of life (HRQOL) has not been examined in patients with predominant antibody deficiency both pre- and post-immunoglobulin G (IgG) treatment initiation. HRQOL and health resource utilization (HRU) were assessed in newly diagnosed patients with primary immunodeficiency disease (PIDD) pre- an...

journal_title：Journal of clinical immunology

authors： Routes J,Costa-Carvalho BT,Grimbacher B,Paris K,Ochs HD,Filipovich A,Hintermeyer M,de Melo KM,Workman S,Ito D,Ye X,Bonnet P,Li-McLeod J

更新日期：2016-07-01 00:00:00

abstract：:Live-attenuated vaccines (LAVs) can protect humans against 12 viral and three bacterial diseases. By definition, any clinical infection caused by a LAV that is sufficiently severe to require medical intervention attests to an inherited or acquired immunodeficiency that must be diagnosed or identified. Self-healing inf...

journal_title：Journal of clinical immunology

authors： Pöyhönen L,Bustamante J,Casanova JL,Jouanguy E,Zhang Q

更新日期：2019-05-01 00:00:00

abstract：:The addition of indomethacin to concanavalin A (Con A)-induced cultures of human peripheral blood leukocytes (PBL) caused an increase in interferon response, regardless of whether the PBLs were derived from multiple sclerosis (MS) patients or from control donors. Specifically the response rates increased from 71 to 10...

journal_title：Journal of clinical immunology

authors： Vervliet G,Deckmyn H,Carton H,Billiau A

更新日期：1985-03-01 00:00:00

abstract：PURPOSE:Immune thrombocytopenic purpura (ITP) and autoimmune hemolytic anemia (AIHA) are associated in the definition of Evans syndrome (ES). The occurrence of neurological involvement in this population is poorly described and suggests an underlying primary immunodeficiency (PID). We aimed to describe the clinical man...

journal_title：Journal of clinical immunology

authors： Pincez T,Neven B,Le Pointe HD,Varlet P,Fernandes H,Gareton A,Leverger G,Leblanc T,Chambost H,Michel G,Pasquet M,Millot F,Hermine O,Mathian A,Hully M,Zephir H,Hamidou M,Durand JM,Perel Y,Landman-Parker J,Rieux-Lauc

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:To assess the serum profile of factors involved in endothelial, T-cell, and fibroblast interplay in patients with Raynaud's phenomenon (RP) associated with nailfold vodeocapillaroscopy (NVC) scleroderma findings and/or systemic sclerosis (SSc) marker autoantibodies, recently labeled as early SSc patients. METH...

journal_title：Journal of clinical immunology

authors： Vettori S,Cuomo G,Iudici M,D'Abrosca V,Giacco V,Barra G,De Palma R,Valentini G

更新日期：2014-08-01 00:00:00

abstract：:The origin of natural antibodies has long been a subject of controversy. Polyreactive natural antibodies recognize multiple ligands and are thought to arise from B1 B cells. Natural antibodies against carbohydrate antigens such as Gal alpha 1-3Gal or against blood groups A and B are thought to be "elicited" by gut bac...

journal_title：Journal of clinical immunology

authors： Parker W,Yu PB,Holzknecht ZE,Lundberg K,Buckley RH,Platt JL

更新日期：1997-07-01 00:00:00

abstract：PURPOSE:Patients affected by primary immunodeficiency usually undergo a wide range of infections, including reactivation of latent ones. Here we report two cases suffering from late-onset combined immunodeficiency in which ulcerative enteritis due to human Cytomegalovirus caused a life-threatening malabsorption syndrom...

journal_title：Journal of clinical immunology

authors： Ciccocioppo R,Comoli P,Gallia A,Basso S,Baldanti F,Corazza GR

更新日期：2014-08-01 00:00:00

abstract：PURPOSE:To review the clinical and laboratory spectrum of RAG gene defects in humans, and discuss the mechanisms underlying phenotypic heterogeneity, the basis of immune dysregulation, and the current and perspective treatment modalities. METHODS:Literature review and analysis of medical records RESULTS: RAG gene defe...

journal_title：Journal of clinical immunology

authors： Delmonte OM,Schuetz C,Notarangelo LD

更新日期：2018-08-01 00:00:00

abstract：:We have examined the primary immune responses, the numbers of total T (T11+) cells, T-helper (T4+) cells, T-suppressor (T8+) cells, and natural killer (NK) (Leu7+) cells, in 118 healthy control subjects and compared the data to those obtained from 20 patients with clinically diagnosed malignant mesothelioma and 375 lo...

journal_title：Journal of clinical immunology

authors： Lew F,Tsang P,Holland JF,Warner N,Selikoff IJ,Bekesi JG

更新日期：1986-05-01 00:00:00

abstract：:Human papillomavirus (HPV) infects the transformation zone of the cervix and is the primary cause of cervical cancer. The infection is localized to the cervix and mucosal immunity is likely to be an important determinant for viral clearance. Previous studies of immunity to HPV have measured immune markers in the blood...

journal_title：Journal of clinical immunology

authors： Castle PE,Hildesheim A,Bowman FP,Strickler HD,Walker JL,Pustilnik T,Edwards RP,Crowley-Nowick PA

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study is to determine when during hematopoiesis Siglec-8 gets expressed, whether it is expressed on hematologic malignancies, and if there are other non-human species that express Siglec-8. METHODS:Siglec-8 mRNA and cell surface expression was monitored during in vitro maturation of human eos...

journal_title：Journal of clinical immunology

authors： Hudson SA,Herrmann H,Du J,Cox P,Haddad el-B,Butler B,Crocker PR,Ackerman SJ,Valent P,Bochner BS

更新日期：2011-12-01 00:00:00

abstract：PURPOSE:Nijmegen Breakage Syndrome (NBS) is a rare inherited condition, characterized by microcephaly, chromosomal instability, immunodeficiency, and predisposition to malignancy. This retrospective study, characterizing the clinical and immunological status of patients with NBS at time of diagnosis, was designed to as...

journal_title：Journal of clinical immunology

authors： Wolska-Kuśnierz B,Gregorek H,Chrzanowska K,Piątosa B,Pietrucha B,Heropolitańska-Pliszka E,Pac M,Klaudel-Dreszler M,Kostyuchenko L,Pasic S,Marodi L,Belohradsky BH,Čižnár P,Shcherbina A,Kilic SS,Baumann U,Seidel MG,Genner

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Chronic granulomatous disease (CGD) is characterized by mutation in any one of the five genes coding NADPH oxidase components that leads to functional abnormality preventing the killing of phagocytosed microbes by affecting the progression of a respiratory burst. CGD patients have an increased susceptibility...

journal_title：Journal of clinical immunology

authors： Kulkarni M,Hule G,de Boer M,van Leeuwen K,Kambli P,Aluri J,Gupta M,Dalvi A,Mhatre S,Taur P,Desai M,Madkaikar M

更新日期：2018-11-01 00:00:00

abstract：:Data collection for the national registry for patients with primary immunodeficiency disorders in the Republic of Ireland commenced in 1996. One hundred and fifteen cases of primary immunodeficiency diseases were registered between December 1996 and February 2003. The most frequent primary immunodeficiency disorders w...

journal_title：Journal of clinical immunology

authors： Abuzakouk M,Feighery C

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Major histocompatibility complex class II (MHC-II) expression deficiency is a combined primary immunodeficiency leading to the impairment of the cellular and humoral immune responses. A majority of affected patients belong to consanguineous families particularly from the Maghreb, where a founder effect for...

journal_title：Journal of clinical immunology

authors： Ben-Mustapha I,Ben-Farhat K,Guirat-Dhouib N,Dhemaied E,Larguèche B,Ben-Ali M,Chemli J,Bouguila J,Ben-Mansour L,Mellouli F,Khemiri M,Béjaoui M,Barbouche MR

更新日期：2013-05-01 00:00:00

abstract：:This is the second report on the continuing efforts of LAGID to increase the recognition and registration of patients with primary immunodeficiency diseases in 12 Latin American countries: Argentina, Brazil, Chile, Colombia, Costa Rica, Honduras, Mexico, Panama, Paraguay, Peru, Uruguay, and Venezuela. This report reve...

journal_title：Journal of clinical immunology

authors： Leiva LE,Zelazco M,Oleastro M,Carneiro-Sampaio M,Condino-Neto A,Costa-Carvalho BT,Grumach AS,Quezada A,Patiño P,Franco JL,Porras O,Rodríguez FJ,Espinosa-Rosales FJ,Espinosa-Padilla SE,Almillategui D,Martínez C,Tafur JR,

更新日期：2007-01-01 00:00:00

abstract：:Glucocorticoids (GC) represent the main treatment for pemphigus; however, some patients show GC resistance. GC sensitivity was evaluated in 19 pemphigus patients and 41 controls by the number of binding sites [B(max) (fmol/mg protein)] and the affinity of GC receptor [Kd (nM)] to dexamethasone (DEX) as well as by the ...

journal_title：Journal of clinical immunology

authors： Chriguer RS,Roselino AM,de Castro M

更新日期：2012-08-01 00:00:00