The Elements Steering Pathogenesis in IgG-Mediated Alloimmune Diseases.

abstract：:A monoclonal antibody produced by hybridomas obtained from a mouse immunized with drug-resistant cells recognizes certain hamster and human drug-resistant cell lines but not their drug-sensitive parental lines. Preliminary characterization of the antigen indicates that it is a molecule of approximately 180,000 daltons...

journal_title：Journal of clinical immunology

authors： O'Hara CJ,Grover J,Price GB

更新日期：1984-09-01 00:00:00

abstract：:Increasing evidence is accumulating which indicates that immunological abnormalities contribute to the development of liver disease and its signs and symptoms. Platelet-associated IgG (PAIgG) levels were quantified in 42 patients with biopsy-proven liver disease of various etiologies to determine the relationship of t...

journal_title：Journal of clinical immunology

authors： Graber D,Giuliani D,Leevy CM,Morse BS

更新日期：1984-03-01 00:00:00

abstract：:Because binding of antiphospholipid antibody (aPL) to phosphatidylethanolamine (PE) is central to the definition of the antigenic epitope targeted by aPLs, we examined the binding of aPL-positive SLE sera to PE under various conditions. No serum bound to PE uncontaminated with lysophosphatidylethanolamine (1PE), but m...

journal_title：Journal of clinical immunology

authors： Qamar T,Gharavi AE,Levy RA,Lockshin MD

更新日期：1990-07-01 00:00:00

abstract：:Treatment of primary immunodeficiency (PI) is typically initiated with intravenous immunoglobulin (IVIG) loading and then continued with IVIG or subcutaneous IgG (SCIG). This prospective, open-label, multicenter, 6-month study evaluated a new regimen of initiating IgG therapy with SCIG in 18 previously untreated patie...

journal_title：Journal of clinical immunology

authors： Borte M,Quinti I,Soresina A,Fernández-Cruz E,Ritchie B,Schmidt DS,McCusker C

更新日期：2011-12-01 00:00:00

abstract：:Data collection for the national registry for patients with primary immunodeficiency disorders in the Republic of Ireland commenced in 1996. One hundred and fifteen cases of primary immunodeficiency diseases were registered between December 1996 and February 2003. The most frequent primary immunodeficiency disorders w...

journal_title：Journal of clinical immunology

authors： Abuzakouk M,Feighery C

更新日期：2005-01-01 00:00:00

abstract：:Atopic dermatitis in humans and dogs is a chronic relapsing allergic skin disease. Dogs show a spontaneous disease similar to the human counterpart and represent a model to improve our understanding of the immunological mechanisms, the pathogenesis of the disease, and new therapy development. The aim of the study was ...

journal_title：Journal of clinical immunology

authors： Ricklin ME,Roosje P,Summerfield A

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:An outbreak of multisystem inflammatory syndrome in children, including Kawasaki disease (KD), emerged during COVID-19 pandemic. We explored whether Kawasaki-like disease (KD), when associated with confirmed SARS-CoV-2 infection, has specific characteristics. METHODS:We included children and adolescents wit...

journal_title：Journal of clinical immunology

authors： Toubiana J,Cohen JF,Brice J,Poirault C,Bajolle F,Curtis W,Moulin F,Matczak S,Leruez M,Casanova JL,Chalumeau M,Taylor M,Allali S

更新日期：2021-01-04 00:00:00

abstract：:Anesthetic drugs can influence the immune system, particularly granulocyte function. The goal of the present study was to evaluate if lidocaine used for epidural anesthesia during cesarean section can influence neonatal neutrophil chemotaxis. We measured chemotaxis and plasma cord lidocaine and cortisol levels in (A) ...

journal_title：Journal of clinical immunology

authors： Gasparoni A,De Amici D,Ciardelli L,Autelli M,Regazzi-Bonora M,Bartoli A,Chirico G,Rondini G

更新日期：1998-05-01 00:00:00

abstract：:Skin window techniques to investigate neutrophil inflammatory reactions in human skin have been limited by cellular distortion and difficulties in quantitation. We have developed a quantitative approach based on the assessment of the myeloperoxidase (MPO) released from sonicated membrane filters to which exuding infla...

journal_title：Journal of clinical immunology

authors： Bedard PM,Zweiman B,Atkins PC

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:DNA Ligase 4 (LIG4) is a key factor in the non-homologous end-joining (NHEJ) DNA double-strand break repair pathway needed for V(D)J recombination and the generation of the T cell receptor and immunoglobulin molecules. Defects in LIG4 result in a variable syndrome of growth retardation, pancytopenia, combined i...

journal_title：Journal of clinical immunology

authors： Felgentreff K,Baxi SN,Lee YN,Dobbs K,Henderson LA,Csomos K,Tsitsikov EN,Armanios M,Walter JE,Notarangelo LD

更新日期：2016-05-01 00:00:00

abstract：:Palifermin (recombinant human keratinocyte growth factor) prevents the development of acute, lethal graft-versus-host disease (GVHD). It does so, at least in part, by protecting cells from injury. Another property of Palifermin is immune regulation. How the latter influences the evolution of GVHD remains uncertain. We...

journal_title：Journal of clinical immunology

authors： Ellison CA,Gibson IW,Hayglass KT,Gartner JG

更新日期：2006-09-01 00:00:00

abstract：:Subjects with primary immune deficiency diseases treated with intravenous immunoglobulin (n=42) received intravenous infusions of Carimune NF Liquid every 3-4 weeks for 6 months without routine premedication. The mean dose/patient/infusion was 278.5-800.7 mg/kg. Also, 80.4% of infusions achieved maximum rates of >or=3...

journal_title：Journal of clinical immunology

authors： Berger M,Cunningham-Rundles C,Bonilla FA,Melamed I,Bichler J,Zenker O,Ballow M

更新日期：2007-09-01 00:00:00

abstract：:These studies report findings that demonstrate that human alpha lymphotoxin (LT) induces local, visible, and microscopic inflammatory reactions in normal skin. Skin sites in rabbits, when inoculated with a single injection of native or recombinant human alpha lymphotoxin, demonstrated erythema, swelling, and warmth wi...

journal_title：Journal of clinical immunology

authors： Averbook BJ,Yamamoto RS,Ulich TR,Jeffes EW,Masunaka I,Granger GA

更新日期：1987-07-01 00:00:00

abstract：:Liver infiltrating lymphocytes (LIL) were isolated from HCV-positive (+) and HCV-negative (-) end-stage livers. Phenotypic analysis and functional studies using proliferative and lymphocytotoxic assays were performed with the isolated LIL. Two CD3+ lymphocyte populations were found in LIL using FITC anti-CD3 monoclona...

journal_title：Journal of clinical immunology

authors： Jin Y,Fuller L,Carreno M,Zucker K,Roth D,Esquenazi V,Karatzas T,Swanson SJ 3rd,Tzakis AG,Miller J

更新日期：1997-03-01 00:00:00

abstract：PURPOSE:Patients affected by primary immunodeficiency usually undergo a wide range of infections, including reactivation of latent ones. Here we report two cases suffering from late-onset combined immunodeficiency in which ulcerative enteritis due to human Cytomegalovirus caused a life-threatening malabsorption syndrom...

journal_title：Journal of clinical immunology

authors： Ciccocioppo R,Comoli P,Gallia A,Basso S,Baldanti F,Corazza GR

更新日期：2014-08-01 00:00:00

abstract：:This special article deals with the role of processing enzymes in the generation of bioactive cytokines, particularly IL-1 beta and the novel cytokine IL-18, which was formerly called IFN gamma-inducing factor (IGIF). The "classical" pathways of cytokine processing are described, as well as the importance of alternati...

journal_title：Journal of clinical immunology

authors： Fantuzzi G,Dinarello CA

更新日期：1999-01-01 00:00:00

abstract：INTRODUCTION:Complement deficiencies are rare primary immunodeficiency disorders, the diagnosis of which is often underestimated. Only a small number of molecular studies have been carried out for the characterization of the underlying genetic defects in these cases. PURPOSE:Reporting the first family from the Arabian...

journal_title：Journal of clinical immunology

authors： Arnaout R,Al Shorbaghi S,Al Dhekri H,Al-Mousa H,Al Ghonaium A,Al Saud B,Al Muhsen S,Al Baik L,Hawwari A

更新日期：2013-05-01 00:00:00

abstract：:We studied immunological functions of peripheral blood lymphocytes (PBL) from human T-cell leukemia virus type I (HTLV-I)-seropositive healthy carriers in vitro. Proliferative responses of PBL to T-cell and B-cell mitogens such as concanavalin A (Con A), pokeweed mitogen (PWM), and Staphylococcus aureus Cowan I (SAC) ...

journal_title：Journal of clinical immunology

authors： Tanaka Y,Oda S,Nagata K,Mori N,Sakamoto H,Eto S,Yamashita U

更新日期：1989-11-01 00:00:00

abstract：PURPOSE:The dysregulated expression of miRNAs in the immune system may be critical for immune responses to pathogens and evolve into the inflammation seen in sepsis. The aim of this study is to explore the important role of miRNAs in the regulation of the immune response during neonatal sepsis. METHODS:Using a microar...

journal_title：Journal of clinical immunology

authors： Chen J,Jiang S,Cao Y,Yang Y

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Purified allergens with reduced IgE reactivity are required to improve the safety and efficacy of allergen-specific immunotherapy (IT). OBJECTIVE:The present study investigates the efficacy of purified cockroach allergen immunotherapy with proteolytically active and inactive Per a 10 in allergic mouse model...

journal_title：Journal of clinical immunology

authors： Srivastava D,Mehta AK,Arora N,Gaur SN,Singh BP

更新日期：2010-05-01 00:00:00

abstract：:This review describes a series of studies performed in our laboratory which have focused on the activation and subsequent proliferation and differentiation of human B lymphocytes. Utilizing polyclonal signals which activate B cells by interacting with their surface membrane Ig, we have examined the events in the trans...

journal_title：Journal of clinical immunology

authors： Muraguchi A,Kehrl JH,Butler JL,Fauci AS

更新日期：1984-09-01 00:00:00

abstract：:Augmentation of the cytolytic activity of human natural killer cells and of antibody-dependent cell-mediated cytotoxicity has been attributed to human interferons. With the purification to homogeneity of human leukocyte interferon, it became possible to test directly whether pure interferon could increase the activity...

journal_title：Journal of clinical immunology

authors： Herberman RB,Ortaldo JR,Rubinstein M,Pestka S

更新日期：1981-07-01 00:00:00

abstract：:Although CpG methylation is thought to be a negative regulator of gene transcription, its relationship with cytokine expression remains unclear. Interleukin (IL)-4 and interferon (IFN)-gamma are major cytokines that affect the differentiation of naïve CD4+ T lymphocytes into the Th1 and Th2 lineage. We used bisulfite ...

journal_title：Journal of clinical immunology

authors： Kwon NH,Kim JS,Lee JY,Oh MJ,Choi DC

更新日期：2008-03-01 00:00:00

abstract：:Severe combined immunodeficiency is a life-threatening primary immune deficiency characterized by low numbers of naïve T cells. Early diagnosis and treatment of this disease decreases mortality. In 2008, Wisconsin began newborn screening of infants for severe combined immunodeficiency and other forms of T-cell lymphop...

journal_title：Journal of clinical immunology

authors： Verbsky JW,Baker MW,Grossman WJ,Hintermeyer M,Dasu T,Bonacci B,Reddy S,Margolis D,Casper J,Gries M,Desantes K,Hoffman GL,Brokopp CD,Seroogy CM,Routes JM

更新日期：2012-02-01 00:00:00

abstract：:COX2 (prostaglandin G/H synthase, PTGS2) is a well-validated target in the fields of both oncology and inflammation. Despite their significant toxicity profile, non-steroidal anti-inflammatory drugs (NSAIDs) have become standard of care in the treatment of many COX2-mediated inflammatory conditions. In this report, we...

journal_title：Journal of clinical immunology

authors： Ferguson GD,Jensen-Pergakes K,Wilkey C,Jhaveri U,Richard N,Verhelle D,De Parseval LM,Corral LG,Xie W,Morris CL,Brady H,Chan K

更新日期：2007-03-01 00:00:00

abstract：:This study was undertaken to investigate whether maternal periodontal disease and variant genotypes of IL-6 gene are associated with adverse pregnancy outcomes. A total of 145 pregnant women were recruited from St Mary's Hospital, Manchester, UK. Bleeding on probing (BOP) and pocket depth indices were recorded on all ...

journal_title：Journal of clinical immunology

authors： Dashash M,Nugent J,Baker P,Tansinda D,Blinkhorn F

更新日期：2008-05-01 00:00:00

abstract：:To explore the role of phospholipid fatty acids in binding of antiphospholipid antibody (aPL) in ELISA, we tested aPL binding to phospholipids containing fatty acids of varying chain length and degree of saturation using direct ELISA and inhibition methods. Polyclonal IgG and IgM human aPL's bind to C18:1 phosphatidyl...

journal_title：Journal of clinical immunology

authors： Levy RA,Gharavi AE,Sammaritano LR,Habina L,Lockshin MD

更新日期：1990-05-01 00:00:00

abstract：OBJECTIVE:The aim of this study is to determine when during hematopoiesis Siglec-8 gets expressed, whether it is expressed on hematologic malignancies, and if there are other non-human species that express Siglec-8. METHODS:Siglec-8 mRNA and cell surface expression was monitored during in vitro maturation of human eos...

journal_title：Journal of clinical immunology

authors： Hudson SA,Herrmann H,Du J,Cox P,Haddad el-B,Butler B,Crocker PR,Ackerman SJ,Valent P,Bochner BS

更新日期：2011-12-01 00:00:00

abstract：:Chemotherapeutic agent is characterized by its concentration in tumor cells with minimum side effects. Oleandrin, a polyphenolic cardiac glycoside is known to induce apoptosis in tumor cells. However, no report is available on its efficacy in primary cells. In this report we are providing the evidence that oleandrin i...

journal_title：Journal of clinical immunology

authors： Sreenivasan Y,Raghavendra PB,Manna SK

更新日期：2006-07-01 00:00:00

abstract：:Five common variable immunodeficiency (CVI) patients were analyzed for expression of immunoglobulin (Ig) genes. In the pokeweed mitogen (PWM)-induced Ig-production assay, the combination of T and B cells showed that all patients' T cells had normal helper functions and all patients' B cells had profound defects. The d...

journal_title：Journal of clinical immunology

authors： Kaneko H,Kondo N,Motoyoshi F,Mori S,Kobayashi Y,Inoue Y,Orii T

更新日期：1991-09-01 00:00:00