Abstract:
BACKGROUND:An outbreak of multisystem inflammatory syndrome in children, including Kawasaki disease (KD), emerged during COVID-19 pandemic. We explored whether Kawasaki-like disease (KD), when associated with confirmed SARS-CoV-2 infection, has specific characteristics. METHODS:We included children and adolescents with KD criteria admitted in the department of general pediatrics of a university hospital in Paris, France, between January 1, 2018, and May 26, 2020. The incidence of KD was compared between the outbreak and a pre-outbreak control period (January 1, 2018, to April 25). Characteristics of patients with positive SARS-CoV-2 testing (KD-SARS-CoV-2) were compared to those of the pre-outbreak period (classic KD). RESULTS:A total of 30 and 59 children with KD were admitted during the outbreak and pre-outbreak periods, respectively (incidence ratio 13.2 [8.3-21.0]). During the outbreak, 23/30 (77%) children were diagnosed as KD-SARS-CoV-2. When compared with patients with classic KD, those with KD-SARS-CoV-2 were more frequently of sub-Saharan African ancestry (OR 4.4 [1.6-12.6]) and older (median 8.2 vs. 4.0 years, p < 0.001), had more often initial gastrointestinal (OR 84 [4.9-1456]) and neurological (OR 7.3 [1.9-27.7] manifestations, and shock syndrome (OR 13.7 [4.2-45.1]). They had significantly higher CRP and ferritin levels. Noticeably, they had more frequently myocarditis (OR 387 [38-3933]). CONCLUSIONS:Children and adolescents with KD-SARS-CoV-2 have specific features when compared with those with classic KD. These findings should raise awareness and facilitate the study of their pathogenesis.
journal_name
J Clin Immunoljournal_title
Journal of clinical immunologyauthors
Toubiana J,Cohen JF,Brice J,Poirault C,Bajolle F,Curtis W,Moulin F,Matczak S,Leruez M,Casanova JL,Chalumeau M,Taylor M,Allali Sdoi
10.1007/s10875-020-00941-0subject
Has Abstractpub_date
2021-01-04 00:00:00eissn
0271-9142issn
1573-2592pii
10.1007/s10875-020-00941-0pub_type
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journal_title:Journal of clinical immunology
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pub_type: 已发布勘误
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journal_title:Journal of clinical immunology
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of clinical immunology
pub_type: 杂志文章
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更新日期:1985-09-01 00:00:00
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pub_type: 杂志文章
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