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Macrophage T-cell interaction in man: handling of tetanus toxoid antigen by human monocytes.

Abstract：

:An absolute requirement for monocytes was demonstrated in the T-cell proliferative response to tetanus toxoid (TT) antigen. Antigen-pulsed monocytes were shown to be effective in triggering T-cell proliferation. Using 125I-radiolabeled TT antigen, uptake by monocytes increased progressively over an 18-hr period, at which time 80-85% of the monocytes contained radiolabeled material. The ability of antigen-pulsed monocytes to trigger T-cell proliferation paralleled antigen uptake over an 18-hr period. Monocytes pulsed with antigen, then washed, lost their ability to trigger T-cell proliferation following a 24- to 48-hr culture period. Metabolic inhibitors blocked antigen uptake by monocytes and monocyte triggering of T-cell proliferation. Trypsin treatment of TT-pulsed monocytes did not affect the amount of antigen associated with monocytes or T-cell triggering by monocytes. Anti HLA-DR alloantibodies, which when added during antigen pulsing of monocytes inhibit the capacity of these monocytes to trigger T-cell proliferation, did not interfere with antigen uptake. These results indicate that human monocytes present antigen to T cells via an active process and in association with Dr determinants, and that the immunogenic moiety of antigen does not remain indefinitely available to the T cell.

journal_name

J Clin Immunol

journal_title

Journal of clinical immunology

authors

Alpert SD,Jonsen ME,Broff MD,Schneeberger E,Geha RS

doi

10.1007/BF00915473

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

21-9

issue

1

eissn

0271-9142

issn

1573-2592

journal_volume

1

pub_type

杂志文章

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