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Interleukin-6 -174 genotype, periodontal disease and adverse pregnancy outcomes: a pilot study.

Abstract：

:This study was undertaken to investigate whether maternal periodontal disease and variant genotypes of IL-6 gene are associated with adverse pregnancy outcomes. A total of 145 pregnant women were recruited from St Mary's Hospital, Manchester, UK. Bleeding on probing (BOP) and pocket depth indices were recorded on all teeth. Amplification refractory mutation system-polymerase chain reaction was used for -174 IL-6 genotyping. Birth weight was assessed using the individualized birth ratio (IBR) with intrauterine growth restriction (IUGR) defined as an IBR below the fifth percentile. The G/G genotype results in more BOP % sites in Caucasian (P < 0.001) and Afro-Caribbean pregnant women (P = 0.035). In addition, a marginal significant association between the -174 C/C genotype and IUGR was observed (P = 0.06). The -174* C allele was more frequent in women with IUGR than in normal women (63 vs 37%, P = 0.05). Moreover, the combination between the carriage of -174C allele and increased bleeding sites have increased the risk of IUGR (P = 0.006). Future studies, with a larger sample size, are required to better clarify the relationship between the IL-6 gene polymorphism, periodontal disease, and IUGR.

journal_name

J Clin Immunol

journal_title

Journal of clinical immunology

authors

Dashash M,Nugent J,Baker P,Tansinda D,Blinkhorn F

doi

10.1007/s10875-007-9162-3

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

237-43

issue

3

eissn

0271-9142

issn

1573-2592

journal_volume

28

pub_type

杂志文章

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