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Molecular characterization of complement components (C3, C4, and factor B) in human saliva.

Abstract：

:A molecular analysis of complement components (C3, C4, and factor B) in human saliva was performed by SDS-PAGE and immunoblotting. Complement C3 was detected as a molecule composed of a 115-kDa alpha-chain linked to a 70-kDa beta chain by disulfide bonds, and C3 levels ranged from 0.52 to 15.0 micrograms/ml (n = 15). C4 was detected as a triple-chain molecule (98-kDa alpha chain, 73-kDa beta chain, and 33-kDa gamma chain) linked by disulfide bonds, and C4 levels ranged from 0.086 to 4.8 micrograms/ml. Factor B was detected as a 100-kDa single chain, and factor B levels ranged from 0.042 to 0.62/microgram/ml. The sizes and subunit structures of the complement components in human saliva were compatible with those reported in human serum. The results of a hemolytic assay indicated that the complement molecules in human saliva were functionally active. These complement components may participate in the local immune and inflammatory responses in the oral cavity.

journal_name

J Clin Immunol

journal_title

Journal of clinical immunology

authors

Andoh A,Fujiyama Y,Kimura T,Uchihara H,Sakumoto H,Okabe H,Bamba T

doi

10.1023/a:1027320425291

subject

Has Abstract

pub_date

1997-09-01 00:00:00

pages

404-7

issue

5

eissn

0271-9142

issn

1573-2592

journal_volume

17

pub_type

杂志文章

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