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Probabilistic regulation of IL-4 production.

Abstract：

:Among a population of uniformly differentiated TH(2) cells, only a portion express IL-4 upon stimulation and those that do often express the product of only a single allele. We review the evidence for the basis of IL-4 monoallelism and argue that it depends upon probabilistic expression of the Il4 gene. Further, we argue that probabilistic expression may provide a powerful mechanism through which certain key functions of IL-4, such as immunoglobulin class switching and determination of macrophage phenotype, may be efficiently regulated.

journal_name

J Clin Immunol

journal_title

Journal of clinical immunology

authors

Guo L,Hu-Li J,Paul WE

doi

10.1007/s10875-005-8218-5

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

573-81

issue

6

eissn

0271-9142

issn

1573-2592

journal_volume

25

pub_type

杂志文章,评审

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