当前位置： SCI文献检索 > JOURNAL OF CLINICAL IMMUNOLOGY期刊下所有文献 > Autologous human cytomegalovirus-specific cytotoxic T cells as rescue therapy for ulcerative enteritis in primary immunodeficiency.

Autologous human cytomegalovirus-specific cytotoxic T cells as rescue therapy for ulcerative enteritis in primary immunodeficiency.

Abstract：

PURPOSE:Patients affected by primary immunodeficiency usually undergo a wide range of infections, including reactivation of latent ones. Here we report two cases suffering from late-onset combined immunodeficiency in which ulcerative enteritis due to human Cytomegalovirus caused a life-threatening malabsorption syndrome. METHODS:The assessment of the viral load was carried out on both blood and mucosal samples by quantitative real-time polymerase chain reaction assay. The generation of autologous virus-specific cytotoxic T cell lines was performed according to Good Manufacturing Practice protocol after peripheral blood mononuclear cells were collected through a single leukapheresis. RESULTS:In both patients, the viral load resulted negligible in peripheral blood, but very high in mucosal specimens (range 1.064 - 1.031.692 copies/10(5) cells). After two rounds of antiviral therapy proved unsuccessful, the generation of virus-specific cytotoxic T cell lines was carried out despite severe lymphopenia, and their infusion resulted safe and durably effective in healing intestinal ulcerations and resetting the viral load. CONCLUSIONS:Virus-specific cellular therapy was useful in reconstituting specific immunity and treating severe human Cytomegalovirus-related enteritis in patients with primary immunodeficiency.

journal_name

J Clin Immunol

journal_title

Journal of clinical immunology

authors

Ciccocioppo R,Comoli P,Gallia A,Basso S,Baldanti F,Corazza GR

doi

10.1007/s10875-014-0060-1

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

681-5

issue

6

eissn

0271-9142

issn

1573-2592

journal_volume

34

pub_type

杂志文章

相关文献

JOURNAL OF CLINICAL IMMUNOLOGY文献大全
  • The role of HLA DQ2 and DQ8 in dissecting celiac-like disease in common variable immunodeficiency.

    abstract：OBJECTIVES:Gastrointestinal manifestations are frequent in patients with common variable immunodeficiency (CVID), and some of the patients present with celiac-like features. Diagnosing celiac disease (CD) in CVID however is challenging, as autoantibody detection and histopathology of the small intestine cannot reliably...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-013-9892-3

    authors： Venhoff N,Emmerich F,Neagu M,Salzer U,Koehn C,Driever S,Kreisel W,Rizzi M,Effelsberg NM,Kollert F,Goldacker S,Voll RE,Warnatz K,Thiel J

    更新日期：2013-07-01 00:00:00

  • Significance of unconventional peripheral CD4+CD8dim T cell subsets.

    abstract：:Routine T cells phenotyping occasionally reveals a CD4+CD8dim T cell subset with an apparently homogeneous dot plot. The aim of this study was to elucidate their immunological significance from analysis of 31 healthy donors, 21 elderly and 220 immune deficient patients. CD4+CD8dim T cells expressed reduced levels of C...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-005-5257-x

    authors： Lambert C,Ibrahim M,Iobagiu C,Genin C

    更新日期：2005-09-01 00:00:00

  • Immune function in chronic active Epstein-Barr virus infection.

    abstract：:The spectrum of illness attributed to Epstein-Barr virus (EBV) includes patients with symptoms persisting for more than 1 year without any other obvious underlying disease. High titers of antibodies to EBV, either IgG antiviral capsid antigen or anti-early antigen, can be demonstrated. In this study, 13 patients diagn...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00915168

    authors： Kibler R,Lucas DO,Hicks MJ,Poulos BT,Jones JF

    更新日期：1985-01-01 00:00:00

  • Glucocorticoid sensitivity and proinflammatory cytokines pattern in pemphigus.

    abstract：:Glucocorticoids (GC) represent the main treatment for pemphigus; however, some patients show GC resistance. GC sensitivity was evaluated in 19 pemphigus patients and 41 controls by the number of binding sites [B(max) (fmol/mg protein)] and the affinity of GC receptor [Kd (nM)] to dexamethasone (DEX) as well as by the ...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-012-9679-y

    authors： Chriguer RS,Roselino AM,de Castro M

    更新日期：2012-08-01 00:00:00

  • Flebogamma(®) 5 % DIF Intravenous Immunoglobulin for Replacement Therapy in Children with Primary Immunodeficiency Diseases.

    abstract：PURPOSE:The previous studies with Flebogamma(®) 5 % DIF intravenous immunoglobulin (IVIG) contained insufficient numbers of pediatric subjects to fully warrant a pediatric indication by the FDA. The objective of this study was to evaluate the efficacy, safety, and pharmacokinetics of Flebogamma® 5 % DIF for replacement...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s10875-016-0303-4

    authors： Ballow M,Pinciaro PJ,Craig T,Kleiner G,Moy J,Ochs HD,Sleasman J,Smits W

    更新日期：2016-08-01 00:00:00

  • Two patients with complete defects in interferon gamma receptor-dependent signaling.

    abstract：:Unusual susceptibility to mycobacterial infections can be caused by deleterious mutations in genes that encode the interferon-gamma receptor 1 chain. Such mutations hamper the activation of macrophages by a type 1 immune response and result in enhanced survival of intracellular pathogens. We here report two patients w...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-007-9097-8

    authors： Noordzij JG,Hartwig NG,Verreck FA,De Bruin-Versteeg S,De Boer T,Van Dissel JT,De Groot R,Ottenhoff TH,Van Dongen JJ

    更新日期：2007-09-01 00:00:00

  • Chronic arsenic exposure impairs macrophage functions in the exposed individuals.

    abstract：INTRODUCTION:Owing to the established roles of human macrophages in immune defense, we investigated the effect of chronic arsenic exposure upon these major hematopoietic cells in 70 arsenic-exposed individuals with skin lesions and 64 unexposed individuals. METHODS:Human monocyte-derived macrophages were prepared from...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-009-9304-x

    authors： Banerjee N,Banerjee S,Sen R,Bandyopadhyay A,Sarma N,Majumder P,Das JK,Chatterjee M,Kabir SN,Giri AK

    更新日期：2009-09-01 00:00:00

  • Analysis of the costimulatory requirements for generating human virus-specific in vitro T helper and effector responses.

    abstract：:The present study analyzes the role of CD28-B7-mediated costimulation during in vitro human peripheral blood memory T cell activation by influenza A virus. Inhibition studies using the B7-binding fusion protein CTLA4Ig and antibodies against CD80 and CD86 demonstrate that CTLA4Ig and anti-CD86 inhibited influenza-spec...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1023/a:1010987426835

    authors： Blazevic V,Trubey CM,Shearer GM

    更新日期：2001-07-01 00:00:00

  • Characterizing the pregnancy immune phenotype: results of the viral immunity and pregnancy (VIP) study.

    abstract：PURPOSE:The increased risk of morbidity and mortality from certain microbial infections and the demonstrated improvements in the clinical course of some autoimmune diseases support the existence of pregnancy-related alterations in immune status. Elucidating the changes in innate and adaptive immunity during gestation m...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-011-9627-2

    authors： Kraus TA,Engel SM,Sperling RS,Kellerman L,Lo Y,Wallenstein S,Escribese MM,Garrido JL,Singh T,Loubeau M,Moran TM

    更新日期：2012-04-01 00:00:00

  • Correction to: Unusual Severe Seborrheic Dermatitis in Two Siblings with Autosomal Recessive Chronic Granulomatous Disease.

    abstract：:The original version of this article contained an error in Fig. 1. The incomplete heredogram mistakenly appeared in panel d. ...

    journal_title：Journal of clinical immunology

    pub_type： 已发布勘误

    doi：10.1007/s10875-019-00701-9

    authors： Zurro NB,de Oliveira Junior EB,França TT,Dantas VM,Tavares de Albuquerque JA,Condino-Neto A

    更新日期：2019-11-01 00:00:00

  • Developmental, malignancy-related, and cross-species analysis of eosinophil, mast cell, and basophil siglec-8 expression.

    abstract：OBJECTIVE:The aim of this study is to determine when during hematopoiesis Siglec-8 gets expressed, whether it is expressed on hematologic malignancies, and if there are other non-human species that express Siglec-8. METHODS:Siglec-8 mRNA and cell surface expression was monitored during in vitro maturation of human eos...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-011-9589-4

    authors： Hudson SA,Herrmann H,Du J,Cox P,Haddad el-B,Butler B,Crocker PR,Ackerman SJ,Valent P,Bochner BS

    更新日期：2011-12-01 00:00:00

  • Acidomonas methanolica-associated necrotizing lymphadenitis in a patient with chronic granulomatous disease.

    abstract：PURPOSE:Adenitis for which no causative organism can be isolated is a common occurrence in patients with chronic granulomatous disease (CGD). Here we identify Acidomonas methanolica as a pathogen associated with adenitis in a patient with CGD. METHODS:The causative pathogen was obtained after prolonged incubation of a...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-012-9728-6

    authors： Chase JM,Holland SM,Greenberg DE,Marshall-Batty K,Zelazny AM,Church JA

    更新日期：2012-12-01 00:00:00

  • Efficacy, safety and pharmacokinetics of a novel subcutaneous immunoglobulin, Evogam®, in primary immunodeficiency.

    abstract：:This phase III, open-label, multi-centre study investigated the efficacy, safety, pharmacokinetics and quality of life impact of Evogam(®), a new chromatographically fractionated 16% subcutaneous immunoglobulin, utilising a 1:1 dose transition ratio from previous immunoglobulin therapy. Thirty-five previously treated ...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s10875-011-9641-4

    authors： Empson MB,Tang ML,Pearce LK,Rozen L,Gold MS,Katelaris CH,Langton D,Smart J,Smith WB,Steele RH,Ziegler JB,Maher D

    更新日期：2012-10-01 00:00:00

  • ANCA-GBM dot-blot: evaluation of an assay in the differential diagnosis of patients presenting with rapidly progressive glomerulonephritis.

    abstract：:Rapidly progressive glomerulonephritis (RPGN) is characterized by rapid and progressive loss of renal function and the presence of crescentic glomerulonephritis (CGN). Early diagnosis and appropriate treatment is mandatory to prevent death and/or renal failure. We have evaluated an ANCA-GBM dot-blot diagnostic test in...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1023/B:JOCI.0000029115.79266.ae

    authors： Rutgers A,Damoiseaux J,Roozendaal C,Limburg PC,Stegeman CA,Tervaert JW

    更新日期：2004-07-01 00:00:00

  • Disseminated Cryptococcosis Due to Anti-Granulocyte-Macrophage Colony-Stimulating Factor Autoantibodies in the Absence of Pulmonary Alveolar Proteinosis.

    abstract：INTRODUCTION:Autoantibodies to granulocyte-macrophage colony-stimulating factor (GM-CSF) can cause acquired pulmonary alveolar proteinosis (PAP). Cases of acquired PAP susceptible to typical respiratory pathogens and opportunistic infections have been reported. Anti-GM-CSF autoantibodies have been reported in a few pat...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-016-0364-4

    authors： Kuo CY,Wang SY,Shih HP,Tu KH,Huang WC,Ding JY,Lin CH,Yeh CF,Ho MW,Chang SC,He CY,Chen HK,Ho CH,Lee CH,Chi CY,Ku CL

    更新日期：2017-02-01 00:00:00

  • Role of homozygous DC-SIGNR 5/5 tandem repeat polymorphism in HIV-1 exposed seronegative North Indian individuals.

    abstract：:Despite multiple sexual exposures to HIV-1 virus, some individuals remain HIV-1 seronegative. Although several genetic factors have been related to HIV-1 resistance, the homozygosity for a mutation in CCR5 gene (the 32-bp deletion, i.e., CCR5-Delta32 allele) is presently considered the most relevant one. The C-type le...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-007-9131-x

    authors： Rathore A,Chatterjee A,Sivarama P,Yamamoto N,Dhole TN

    更新日期：2008-01-01 00:00:00

  • Prognostic Value of Blood-Based Inflammatory Biomarkers in Secondary Hemophagocytic Lymphohistiocytosis.

    abstract：PURPOSE:Hemophagocytic lymphohistiocytosis (HLH) is a rare systematic immune disease manifested with excessive activation of lymphocytes and macrophages. This study was designed to explore the feasible prognostic factors of secondary HLH (sHLH). METHOD:We retrospectively analyzed 179 patients with newly diagnosed sHLH...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-020-00801-x

    authors： Huang J,Yin G,Duan L,Tian T,Xu J,Wang J,Gao X,Cheng W,Liu L,Qiu H

    更新日期：2020-07-01 00:00:00

  • Complement activation is involved in renal damage in human antineutrophil cytoplasmic autoantibody associated pauci-immune vasculitis.

    abstract：OBJECTIVE:This study was to investigate the evidence for complement activation in renal biopsy specimens of patients with myeloperoxidase (MPO)-antineutrophil cytoplasmic autoantibody (ANCA)-associated pauci-immune vasculitis. METHODS:Renal biopsy specimens from seven patients with MPO-ANCA positive pauci-immune necro...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-008-9268-2

    authors： Xing GQ,Chen M,Liu G,Heeringa P,Zhang JJ,Zheng X,E J,Kallenberg CG,Zhao MH

    更新日期：2009-05-01 00:00:00

  • Immunological functions and phenotypes of peripheral blood lymphocytes from human T-cell leukemia virus-I carriers.

    abstract：:We studied immunological functions of peripheral blood lymphocytes (PBL) from human T-cell leukemia virus type I (HTLV-I)-seropositive healthy carriers in vitro. Proliferative responses of PBL to T-cell and B-cell mitogens such as concanavalin A (Con A), pokeweed mitogen (PWM), and Staphylococcus aureus Cowan I (SAC) ...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00918017

    authors： Tanaka Y,Oda S,Nagata K,Mori N,Sakamoto H,Eto S,Yamashita U

    更新日期：1989-11-01 00:00:00

  • Expression of immunoglobulin genes in common variable immunodeficiency.

    abstract：:Five common variable immunodeficiency (CVI) patients were analyzed for expression of immunoglobulin (Ig) genes. In the pokeweed mitogen (PWM)-induced Ig-production assay, the combination of T and B cells showed that all patients' T cells had normal helper functions and all patients' B cells had profound defects. The d...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00918184

    authors： Kaneko H,Kondo N,Motoyoshi F,Mori S,Kobayashi Y,Inoue Y,Orii T

    更新日期：1991-09-01 00:00:00

  • Severe combined immunodeficiency (SCID) in Canadian children: a national surveillance study.

    abstract：PURPOSE:Severe Combined Immune Deficiency (SCID) is universally fatal unless treated with hematopoietic stem cell transplantation (HSCT). Following the identification of disseminated Bacille Calmette-Guérin (BCG) infections in Canadian First Nations, Métis and Inuit (FNMI) children with unrecognized primary immune defi...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-013-9952-8

    authors： Rozmus J,Junker A,Thibodeau ML,Grenier D,Turvey SE,Yacoub W,Embree J,Haddad E,Langley JM,Ramsingh RM,Singh VA,Long R,Schultz KR

    更新日期：2013-11-01 00:00:00

  • Oleandrin-mediated expression of Fas potentiates apoptosis in tumor cells.

    abstract：:Chemotherapeutic agent is characterized by its concentration in tumor cells with minimum side effects. Oleandrin, a polyphenolic cardiac glycoside is known to induce apoptosis in tumor cells. However, no report is available on its efficacy in primary cells. In this report we are providing the evidence that oleandrin i...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章,收录出版

    doi：10.1007/s10875-006-9028-0

    authors： Sreenivasan Y,Raghavendra PB,Manna SK

    更新日期：2006-07-01 00:00:00

  • A prospective study of influenza vaccination and a comparison of immunologic parameters in children and adults with chromosome 22q11.2 deletion syndrome (digeorge syndrome/velocardiofacial syndrome).

    abstract：:Prior to the advent of cardiac bypass, most children with congenital cardiac anomalies and chromosome 22q11.2 deletion syndrome died. With improved technology, there is now a wave of young adults with chromosome 22q11.2 deletion syndrome requiring clinical care. Fifteen young children and 20 adults with chromosome 22q...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-011-9569-8

    authors： Jawad AF,Prak EL,Boyer J,McDonald-McGinn DM,Zackai E,McDonald K,Sullivan KE

    更新日期：2011-12-01 00:00:00

  • High frequency of immune dysfunctions in asbestos workers and in patients with malignant mesothelioma.

    abstract：:We have examined the primary immune responses, the numbers of total T (T11+) cells, T-helper (T4+) cells, T-suppressor (T8+) cells, and natural killer (NK) (Leu7+) cells, in 118 healthy control subjects and compared the data to those obtained from 20 patients with clinically diagnosed malignant mesothelioma and 375 lo...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00918702

    authors： Lew F,Tsang P,Holland JF,Warner N,Selikoff IJ,Bekesi JG

    更新日期：1986-05-01 00:00:00

  • CpG-induced Th1-type response in the downmodulation of early development of allergy and inhibition of B7 expression on T cells of newborn mice.

    abstract：INTRODUCTION:Several differences have been described between neonatal and adult immune responses. The predisposition in early life to Th2-type response or tolerance makes it a susceptible period for infections and allergic sensitization. OBJECTIVE:The aim of this work was to evaluate the effects of CpG-containing olig...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-009-9358-9

    authors： de Brito CA,Fusaro AE,Victor JR,Rigato PO,Goldoni AL,Muniz BP,Duarte AJ,Sato MN

    更新日期：2010-03-01 00:00:00

  • NK 1.1+ T cell: a two-faced lymphocyte in immune modulation of the IL-4/IFN-gamma paradigm.

    abstract：:T lymphocytes expressing NK1.1 marker (NK1.1+) have been suggested as being important in peripheral immune modulation. Alteration of the balance between Th1 proinflammatory and Th2 anti-inflammatory cytokine-producing cells can ameliorate immune-mediated disorders. The aim of the study was to determine the role of NK1...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1023/a:1019974005134

    authors： Trop S,Ilan Y

    更新日期：2002-09-01 00:00:00

  • Anti-ribosomal ribonucleoprotein autoantibodies in systemic lupus erythematosus.

    abstract：:Sera from systemic lupus erythematosus (SLE) patients giving a fluorescent ribosomal pattern on tissue and cell preparations also showed precipitating autoantibodies against purified rat liver ribosomes. Ribosomal antigen is also present in rabbit thymus cellular extract (RTE), since the same sera gave precipitin line...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00915287

    authors： Meroni PL,de Bartolo G,Barcellini W,Riboldi PS,Basile R,Betterle C,Zanussi C

    更新日期：1984-01-01 00:00:00

  • Catecholamines induce alterations of distribution and activity of human natural killer (NK) cells.

    abstract：:Catecholamines have been suggested to be responsible for altered cellular immunity after stress. This study was performed to determine the effects of adrenaline and noradrenaline on lymphocyte subpopulations and NK cell functions. Subjects were given a subcutaneous injection of either NaCl, adrenaline (5 micrograms/kg...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00920243

    authors： Schedlowski M,Falk A,Rohne A,Wagner TO,Jacobs R,Tewes U,Schmidt RE

    更新日期：1993-09-01 00:00:00

  • Disparity in FcεRI-induced degranulation of primary human lung and skin mast cells exposed to adenosine.

    abstract：:Inhaled and intravenously administered adenosine induces mast cell-mediated (histamine-dependent) bronchospasm in asthmatics without causing urticaria. A differential response to adenosine by human lung and skin mast cells is shown: low concentrations potentiate FcεRI-induced degranulation of human lung mast cells but...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-011-9517-7

    authors： Gomez G,Zhao W,Schwartz LB

    更新日期：2011-06-01 00:00:00

  • Infectious and immunologic phenotype of MECP2 duplication syndrome.

    abstract：:MECP2 (methyl CpG binding protein 2) duplication causes syndromic intellectual disability. Patients often suffer from life-threatening infections, suggesting an additional immunodeficiency. We describe for the first time the detailed infectious and immunological phenotype of MECP2 duplication syndrome. 17/27 analyzed ...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-015-0129-5

    authors： Bauer M,Kölsch U,Krüger R,Unterwalder N,Hameister K,Kaiser FM,Vignoli A,Rossi R,Botella MP,Budisteanu M,Rosello M,Orellana C,Tejada MI,Papuc SM,Patat O,Julia S,Touraine R,Gomes T,Wenner K,Xu X,Afenjar A,Toutain

    更新日期：2015-02-01 00:00:00