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Disparity in FcεRI-induced degranulation of primary human lung and skin mast cells exposed to adenosine.

Abstract：

:Inhaled and intravenously administered adenosine induces mast cell-mediated (histamine-dependent) bronchospasm in asthmatics without causing urticaria. A differential response to adenosine by human lung and skin mast cells is shown: low concentrations potentiate FcεRI-induced degranulation of human lung mast cells but not that of skin mast cells. Human lung mast cells were found to express ∼ 3-fold more A3AR messenger RNA (mRNA) than skin mast cells, suggesting the involvement of the G(i)-linked A3AR. Indeed, the adenosine-induced potentiation was sensitive to inhibition by pertussis toxin and, furthermore, could be induced with an A3AR-specific agonist. This study reveals a previously unrecognized disparity in the response to adenosine by primary human mast cells from lung and skin that might explain why adenosine induces a pulmonary but not dermatologic allergy-like response in vivo. In addition, we identify the A3AR as a potentiating receptor of FcεRI-induced degranulation, thereby implicating it in the in vivo bronchoconstrictive response to adenosine in asthmatics.

journal_name

J Clin Immunol

journal_title

Journal of clinical immunology

authors

Gomez G,Zhao W,Schwartz LB

doi

10.1007/s10875-011-9517-7

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

479-87

issue

3

eissn

0271-9142

issn

1573-2592

journal_volume

31

pub_type

杂志文章

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