Current state of the hybridoma technology.

abstract：OBJECTIVE:This study was to investigate the evidence for complement activation in renal biopsy specimens of patients with myeloperoxidase (MPO)-antineutrophil cytoplasmic autoantibody (ANCA)-associated pauci-immune vasculitis. METHODS:Renal biopsy specimens from seven patients with MPO-ANCA positive pauci-immune necro...

journal_title：Journal of clinical immunology

authors： Xing GQ,Chen M,Liu G,Heeringa P,Zhang JJ,Zheng X,E J,Kallenberg CG,Zhao MH

更新日期：2009-05-01 00:00:00

abstract：:Regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a requisite role in the maintenance of immunological homeostasis and prevention of peripheral self-tolerance breakdown. Although Foxp3 by itself is neither necessary nor sufficient to specify many aspects of the Treg cell phenot...

journal_title：Journal of clinical immunology

authors： Georgiev P,Charbonnier LM,Chatila TA

更新日期：2019-10-01 00:00:00

abstract：:A patient affected with multiple myeloma displayed in the serum, urine, and cerebrospinal fluid a paraprotein with identical electrophoretic mobility. The paraprotein, which was polymeric, appeared in the serum and cerebrospinal fluid mainly as the dimer and tetramer, whereas in the urine the tetramer was predominant....

journal_title：Journal of clinical immunology

authors： Bollengier F,Mahler A,Gillard A,Wijffels E

更新日期：1986-07-01 00:00:00

abstract：PURPOSE:To investigate whether there is an increased incidence of chronic autoimmune thyroiditis (CAT) in individuals living in the vicinity of industrial plants that manufacture petroleum byproducts in the state of São Paulo, Brazil. METHODS:Between 1989 and 2004, 6,306 patients of both sexes, from 5 to 78 years old ...

journal_title：Journal of clinical immunology

authors： Zaccarelli-Marino MA

更新日期：2012-10-01 00:00:00

abstract：:This special article deals with the role of processing enzymes in the generation of bioactive cytokines, particularly IL-1 beta and the novel cytokine IL-18, which was formerly called IFN gamma-inducing factor (IGIF). The "classical" pathways of cytokine processing are described, as well as the importance of alternati...

journal_title：Journal of clinical immunology

authors： Fantuzzi G,Dinarello CA

更新日期：1999-01-01 00:00:00

abstract：:The concentrations of the neuropeptides substance P, somatostatin, and calcitonin gene-related peptide in human nasal secretions were quantified by radioimmunoassays, concurrently with that of histamine, in the course of nasal challenge of allergic and control subjects with ryegrass antigen to examine contributions of...

journal_title：Journal of clinical immunology

authors： Walker KB,Serwonska MH,Valone FH,Harkonen WS,Frick OL,Scriven KH,Ratnoff WD,Browning JG,Payan DG,Goetzl EJ

更新日期：1988-03-01 00:00:00

abstract：:The role of tumor necrosis factor-alpha in the shedding of soluble tumor necrosis factor receptors in endotoxemia was investigated. The appearance of the soluble tumor necrosis factor receptors was assessed in four healthy volunteers following an intravenous injection of tumor necrosis factor-alpha and in eight chimpa...

journal_title：Journal of clinical immunology

authors： Jansen J,van der Poll T,Levi M,ten Cate H,Gallati H,ten Cate JW,van Deventer SJ

更新日期：1995-01-01 00:00:00

abstract：:We have undertaken an immunofluorescent analysis of the immunoglobulin heavy and light chains expressed by pre-B cells from normal human fetal and adult bone marrow using purified mouse monoclonal and goat antibodies to human immunoglobulin isotypes. Our results indicate that (i) the great majority of normal pre-B cel...

journal_title：Journal of clinical immunology

authors： Kubagawa H,Gathings WE,Levitt D,Kearney JF,Cooper MD

更新日期：1982-10-01 00:00:00

abstract：:Immune complexes and 1-O-alkyl-2-acetyl-SN-glycero-3-phosphorylcholine (AGEPC) are potent platelet-activating factors which interact with distinct receptors on human platelets. The mechanisms of platelet activation by these two stimuli were investigated by examining the effects of AGEPC on human platelets which had be...

journal_title：Journal of clinical immunology

authors： Valone FH

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVE:Dynamic cytokine profiles from endogenously activated T cells in transit from lymph node to the infected sites via the blood compartment after recent exposure to Mycobacterium tuberculosis may differentiate disease progressors from non-disease progressors in a BCG-vaccinated population. METHODS:Household con...

journal_title：Journal of clinical immunology

authors： Hussain R,Talat N,Ansari A,Shahid F,Hasan Z,Dawood G

更新日期：2011-10-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is associated with T- and B-cell dysfunction. Immunoglobulin (Ig) production is under the control of T cells and their derived cytokines such as interleukin 2 (IL-2) and IL-4. Herein we studied the regulation of the production of immunoglobulins and cytokines by peripheral blood mononuclear c...

journal_title：Journal of clinical immunology

authors： Briolay J,Dechanet J,Blanchard D,Banchereau J,Miossec P

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:Tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) is a negative regulator of the nuclear factor-κB (NF-κB) pathway. It has recently been recognized that TNFAIP3 deficiency leads to early onset of autoinflammatory and autoimmune syndrome resembling Behçet's disease. Here, we report a novel mutation in...

journal_title：Journal of clinical immunology

authors： Dong X,Liu L,Wang Y,Yang X,Wang W,Lin L,Sun B,Hou J,Ying W,Hui X,Zhou Q,Liu D,Yao H,Sun J,Wang X

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:Multiple sclerosis (MS) is an autoimmune disease of the central nervous system mediated by T cells. B7-H3 plays a diverse role in regulating T cell responses. However, its expression and clinical significance in MS are not well known. This study analyzed the expression of membrane B7-H3 (mB7-H3) and levels of s...

journal_title：Journal of clinical immunology

authors： Jiang J,Jiang J,Liu C,Zhang G,Gao L,Chen Y,Zhu R,Wang T,Wang F,Zhang X,Xue Q

更新日期：2013-01-01 00:00:00

abstract：:Matrix metalloproteinases (also named matrixin or MMPs) are a major group of enzymes that regulate cell-matrix composition by using zinc for their proteolytic activities. They are essential for various normal biological processes such as embryonic development, morphogenesis, reproduction tissue resorption, and remodel...

journal_title：Journal of clinical immunology

authors： Ram M,Sherer Y,Shoenfeld Y

更新日期：2006-07-01 00:00:00

abstract：:Increased levels of serum IgD can be found in single patients with a variety of clinical syndromes and in the disease entity designated hyper-IgD syndrome which is associated with periodic fever and lymphadenopathy. We investigated 17 patients, both children and adults, with high serum IgD levels ranging from 220 to 5...

journal_title：Journal of clinical immunology

authors： Hiemstra I,Vossen JM,van der Meer JW,Weemaes CM,Out TA,Zegers BJ

更新日期：1989-09-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to assess the diagnostic delay in pediatric patients with primary immunodeficiencies (PID) at a tertiary care hospital in Peru. METHODS:A descriptive study was carried out in which patients from a third-level referral center in Peru were included. Those without a specific diagnosis o...

journal_title：Journal of clinical immunology

authors： Veramendi-Espinoza LE,Zafra-Tanaka JH,Pérez-Casquino GA,Córdova-Calderón WO

更新日期：2017-05-01 00:00:00

abstract：:The complement system plays a central role in defense to encapsulated bacteria through opsonization and membrane attack complex (MAC) dependent lysis. The three activation pathways (classical, lectin, and alternative) converge in the cleavage of C5, which initiates MAC formation and target lysis. C5 deficiency is asso...

journal_title：Journal of clinical immunology

authors： Colobran R,Franco-Jarava C,Martín-Nalda A,Baena N,Gabau E,Padilla N,de la Cruz X,Pujol-Borrell R,Comas D,Soler-Palacín P,Hernández-González M

更新日期：2016-05-01 00:00:00

abstract：:Rat T lymphoblasts arrested in the G1 phase of the cell cycle by interleukin-2 (IL-2) deprivation can be forced to proceed to the S phase when they are stimulated with IL-2 or the phorbol ester phorbol 12,13-dibutyrate (PDBu). When PDBu is used as a stimulus, extracellular regulated kinase 2 (ERK2) is activated by thr...

journal_title：Journal of clinical immunology

authors： Lisbona C,Alemany S,Fernández-Renart M

更新日期：1997-11-01 00:00:00

abstract：:Aging represents a complex remodeling in which both innate and adaptive immunities deteriorate. Age-related changes in humoral immunity are responsible for the reduced vaccine responses observed in elderly individuals. Although T cell alterations play a significant role in age-related humoral immune changes, alteratio...

journal_title：Journal of clinical immunology

authors： Frasca D,Blomberg BB

更新日期：2011-06-01 00:00:00

abstract：:The acquired immunodeficiency syndrome (AIDS) is defined in clinical terms by the development of Kaposi's sarcoma and/or severe opportunistic infections in persons without predisposing conditions. A hallmark of the syndrome has been a decrease in the number of CD4+ T helper cells. The reduction in the frequency of the...

journal_title：Journal of clinical immunology

authors： Katz JD,Nishanian P,Mitsuyasu R,Bonavida B

更新日期：1988-11-01 00:00:00

abstract：PURPOSE:Combined immunodeficiency (CID) presents a unique challenge to clinicians. Two patients presented with the prior clinical diagnosis of common variable immunodeficiency (CVID) disorder marked by an early age of presentation, opportunistic infections, and persistent lymphopenia. Due to the presence of atypical cl...

journal_title：Journal of clinical immunology

authors： Buchbinder D,Baker R,Lee YN,Ravell J,Zhang Y,McElwee J,Nugent D,Coonrod EM,Durtschi JD,Augustine NH,Voelkerding KV,Csomos K,Rosen L,Browne S,Walter JE,Notarangelo LD,Hill HR,Kumánovics A

更新日期：2015-02-01 00:00:00

abstract：PURPOSE:To review the clinical and laboratory spectrum of RAG gene defects in humans, and discuss the mechanisms underlying phenotypic heterogeneity, the basis of immune dysregulation, and the current and perspective treatment modalities. METHODS:Literature review and analysis of medical records RESULTS: RAG gene defe...

journal_title：Journal of clinical immunology

authors： Delmonte OM,Schuetz C,Notarangelo LD

更新日期：2018-08-01 00:00:00

abstract：:An absolute requirement for monocytes was demonstrated in the T-cell proliferative response to tetanus toxoid (TT) antigen. Antigen-pulsed monocytes were shown to be effective in triggering T-cell proliferation. Using 125I-radiolabeled TT antigen, uptake by monocytes increased progressively over an 18-hr period, at wh...

journal_title：Journal of clinical immunology

authors： Alpert SD,Jonsen ME,Broff MD,Schneeberger E,Geha RS

更新日期：1981-01-01 00:00:00

abstract：:Fas-associated death domain (FADD) is an adapter protein that is recruited to the death-inducing signaling complex (DISC) during signaling via death receptors. FADD is a common conduit in both CD95-mediated and TNF-R-mediated apoptosis. In aging, T cells show increased susceptibility to death receptor-induced apoptosi...

journal_title：Journal of clinical immunology

authors： Gupta S,Kim C,Yel L,Gollapudi S

更新日期：2004-01-01 00:00:00

abstract：:Interferon-γ receptor 1 (IFN-γR1) deficiency is one of the primary immunodeficiencies conferring Mendelian Susceptibility to Mycobacterial Disease (MSMD). Some cases of neoplasms have been recently reported in patients with MSMD, underlying the already known link between immunodeficiency and carcinogenesis. We report ...

journal_title：Journal of clinical immunology

authors： Taramasso L,Boisson-Dupuis S,Garrè ML,Bondi E,Cama A,Nozza P,Morana G,Casanova JL,Marazzi MG

更新日期：2014-11-01 00:00:00

abstract：:MECP2 (methyl CpG binding protein 2) duplication causes syndromic intellectual disability. Patients often suffer from life-threatening infections, suggesting an additional immunodeficiency. We describe for the first time the detailed infectious and immunological phenotype of MECP2 duplication syndrome. 17/27 analyzed ...

journal_title：Journal of clinical immunology

authors： Bauer M,Kölsch U,Krüger R,Unterwalder N,Hameister K,Kaiser FM,Vignoli A,Rossi R,Botella MP,Budisteanu M,Rosello M,Orellana C,Tejada MI,Papuc SM,Patat O,Julia S,Touraine R,Gomes T,Wenner K,Xu X,Afenjar A,Toutain

更新日期：2015-02-01 00:00:00

abstract：PURPOSE:Autosomal Dominant Hyper IgE Recurrent Infection Syndrome (AD-HIES) is caused by mutations in STAT3 and characterized by eczema, recurrent bacterial infections, and skeletal and connective tissue abnormalities. To further understand the minimal trauma fractures of AD-HIES, we examined bone mineral density (BMD)...

journal_title：Journal of clinical immunology

authors： Sowerwine KJ,Shaw PA,Gu W,Ling JC,Collins MT,Darnell DN,Anderson VL,Davis J,Hsu A,Welch P,Puck JM,Holland SM,Freeman AF

更新日期：2014-02-01 00:00:00

abstract：:It has been postulated that patients with ulcerative colitis (UC) have altered reactivity of gut-associated lymphoid tissue. In such cases there is intense infiltration of the mucosa with immune competent cells and associated tissue damage. We have shown previously that the dietary supplementation with the n-3 polyuns...

journal_title：Journal of clinical immunology

authors： Almallah YZ,Ewen SW,El-Tahir A,Mowat NA,Brunt PW,Sinclair TS,Heys SD,Eremin O

更新日期：2000-01-01 00:00:00

abstract：:The sensitivity of tumor cells to lysis by natural killer (NK) and interleukin-2 (IL-2)-activated killer (LAK) cells was studied in three ovarian carcinoma cell lines (2780.9S, SKOV-3, and CHOAUXB1), four multidrug-resistant (MDR) variants, and a melphalan-resistant line. The antitumor activity of LAK cells was evalua...

journal_title：Journal of clinical immunology

authors： Savas B,Cole SP,Tsuruo T,Pross HF

更新日期：1996-11-01 00:00:00

abstract：:Allogeneic bone marrow-engrafted adults immunized with meningococcal types A and C and pneumococcal type 14 polysaccharide antigens showed only low antibody titers of the IgM class, no antibody titers of the IgG or IgA classes, and no bactericidal activity in vitro. The analytical isoelectrofocusing showed the appeara...

journal_title：Journal of clinical immunology

authors： Quinti I,Velardi A,Le Moli S,Guerra E,D'Amelio R,Mastrantonio P,Martelli MF,Aiuti F

更新日期：1990-05-01 00:00:00