Abstract:
:Rheumatoid arthritis (RA) is associated with T- and B-cell dysfunction. Immunoglobulin (Ig) production is under the control of T cells and their derived cytokines such as interleukin 2 (IL-2) and IL-4. Herein we studied the regulation of the production of immunoglobulins and cytokines by peripheral blood mononuclear cells from RA patients and controls. In the controls, IL-4 inhibited Ig production in response to Staphylococcus aureus and pokeweed mitogen stimulation. IL-2 induced maximal Ig production in association with Staphylococcus aureus, whereas it inhibited pokeweed mitogen-induced production. In patients, levels of Ig production in response to mitogens and cytokines were reduced, particularly for the response to IL 2. The inhibitory effect of IL-4 on mitogen-induced Ig production was observed in RA patients as in the controls. Spontaneous production of IL-6 was increased in RA patients. These levels were correlated with indicators of active disease such as sedimentation rate and Ritchie index. IL-4 inhibited the production of IL-6, IL-1 beta, and tumor necrosis factor alpha (TNF alpha) by both controls and rheumatoid patients. Thus as first described for the T-cell response, mononuclear cells from RA patients display a reduced response to mitogens and cytokines which induce their B-cell differentiation into Ig-screening cells. However, IL-4 was able to inhibit Ig and cytokine production, properties suggesting a potential antiinflammatory role for this cytokine.
journal_name
J Clin Immunoljournal_title
Journal of clinical immunologyauthors
Briolay J,Dechanet J,Blanchard D,Banchereau J,Miossec Pdoi
10.1007/BF00918271subject
Has Abstractpub_date
1992-01-01 00:00:00pages
36-44issue
1eissn
0271-9142issn
1573-2592journal_volume
12pub_type
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更新日期:1981-01-01 00:00:00
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更新日期:1992-07-01 00:00:00
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更新日期:1991-01-01 00:00:00
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pub_type: 杂志文章,收录出版
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