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Chronic arsenic exposure impairs macrophage functions in the exposed individuals.

Abstract：

INTRODUCTION:Owing to the established roles of human macrophages in immune defense, we investigated the effect of chronic arsenic exposure upon these major hematopoietic cells in 70 arsenic-exposed individuals with skin lesions and 64 unexposed individuals. METHODS:Human monocyte-derived macrophages were prepared from peripheral blood mononuclear cells, by culture of the adherent cells for 6 days in medium supplemented with granulocyte-monocyte colony stimulating factor. Parameters studied included cell adhesion capacity, expression of CD54 and F-actin, nitric oxide production, phagocytic capacity, and effect of arsenic on Rho A-ROCK pathway. RESULTS:In macrophages of exposed individuals when compared to unexposed group, there was cell rounding accompanied with a significant (p < 0.001) loss of cell adhesion capacity, decrease in nitric oxide production, impaired phagocytic capacity, and decreased CD 54 and F-actin expression. Additionally, chronic arsenic exposure affected Rho A-ROCK pathway which in turn impaired macrophage functions. DISCUSSION AND CONCLUSION:These altogether could contribute significantly to arsenic-induced immunosuppression observed in the arsenic-exposed individuals.

journal_name

J Clin Immunol

journal_title

Journal of clinical immunology

authors

Banerjee N,Banerjee S,Sen R,Bandyopadhyay A,Sarma N,Majumder P,Das JK,Chatterjee M,Kabir SN,Giri AK

doi

10.1007/s10875-009-9304-x

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

582-94

issue

5

eissn

0271-9142

issn

1573-2592

journal_volume

29

pub_type

杂志文章

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