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Curcumin protects against collagen-induced arthritis via suppression of BAFF production.

Abstract：

PURPOSE:The aim of the present study was to evaluate whether the anti-Rheumatoid arthritis (RA) effect of curcumin is associated with the regulation of B cell-activating factor belonging to the TNF family (BAFF) production. METHODS:Collagen-induced arthritis (CIA) was induced in DBA/1 J mice by immunization with bovine type II collagen. To investigate the anti-arthritic effect of curcumin in the CIA model, mice were injected intraperitoneally with curcumin (50 mg/kg) on every other day either from day 1 or from day 28 after the first immunization. The clinical severity of arthritis was monitored. BAFF, interleukin-6 (IL-6) and interferon-γ (IFNγ) production in serum were measured. Furthermore, the effect of curcumin on IFNγ-induced BAFF expression and transcriptional activation in B lymphocytes was determined by qPCR, Western Blot, and luciferase assay. Finally, IFNγ related signal transducers and activators of transcription 1 (STAT1) signaling in B lymphocytes were studied using Western Blot. RESULTS:Curcumin dramatically attenuated the progression and severity of CIA in DBA/1 J mice, accompanied with decrease of BAFF production in serum and spleen cells as well as decrease of serum IFNγ and IL-6. Treatment of B lymphocytes with curcumin suppressed IFNγ-induced BAFF expression, STAT1 phosphorylation and nuclear translocation, suggesting that curcumin may repress IFNγ-induced BAFF expression via negatively interfering with STAT1 signaling. CONCLUSION:The results of the present study suggest that suppression of BAFF production may be a novel mechanism by which curcumin improves RA.

journal_name

J Clin Immunol

journal_title

Journal of clinical immunology

authors

Huang G,Xu Z,Huang Y,Duan X,Gong W,Zhang Y,Fan J,He F

doi

10.1007/s10875-012-9839-0

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

550-7

issue

3

eissn

0271-9142

issn

1573-2592

journal_volume

33

pub_type

杂志文章

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