Dramatic Improvement in the Multifocal Positron Emission Tomography Findings of a Young Adult with Chronic Granulomatous Disease Following Allogeneic Hematopoietic Stem Cell Transplantation.

abstract：PURPOSE:We carried out a retrospective analysis of 27 patients with Adenosine Deaminase (ADA) deficiency diagnosed in a single center from 1997 to the 2013, for evaluating whether data regarding types of disease-inducing mutations, biochemical and immunological features as well as clinical outcomes of patients treated ...

journal_title：Journal of clinical immunology

authors： Baffelli R,Notarangelo LD,Imberti L,Hershfield MS,Serana F,Santisteban I,Bolda F,Porta F,Lanfranchi A

更新日期：2015-10-01 00:00:00

abstract：:CFSE dye dilution analysis and [3H] thymidine incorporation were used side by side to assess proliferative responses of peripheral blood mononuclear cells (PBMCs) after vaccination of renal cell carcinoma patients (n=6) with antigen-loaded dendritic cells. Immune responses against the control antigen keyhole limpet he...

journal_title：Journal of clinical immunology

authors： Putz T,Ramoner R,Gander H,Rahm A,Bartsch G,Höltl L,Thurnher M

更新日期：2004-11-01 00:00:00

abstract：:Using our gp120/41-expressing, NK cell activity-resistant CEM.NKR cell clones as targets in HIV-1-specific antibody-dependent cellular cytotoxicity (ADCC) assays, we demonstrate here that the serum titers of anti-HIV-1 ADCC antibodies bear a significant (P < 0.05) positive correlation with the peripheral blood CD4+ T ...

journal_title：Journal of clinical immunology

authors： Ahmad R,Sindhu ST,Toma E,Morisset R,Vincelette J,Menezes J,Ahmad A

更新日期：2001-05-01 00:00:00

abstract：:Apart from cellular immunity and immunopathology, various cytokines have been implicated in malaria-associated immunosuppression. In this study, serum levels of transforming growth factor-beta (TGF-beta) were determined with an enzyme-linked immunosorbent assay in 37 patients with acute Plasmodium falciparum malaria p...

journal_title：Journal of clinical immunology

authors： Wenisch C,Parschalk B,Burgmann H,Looareesuwan S,Graninger W

更新日期：1995-03-01 00:00:00

abstract：:We have undertaken an immunofluorescent analysis of the immunoglobulin heavy and light chains expressed by pre-B cells from normal human fetal and adult bone marrow using purified mouse monoclonal and goat antibodies to human immunoglobulin isotypes. Our results indicate that (i) the great majority of normal pre-B cel...

journal_title：Journal of clinical immunology

authors： Kubagawa H,Gathings WE,Levitt D,Kearney JF,Cooper MD

更新日期：1982-10-01 00:00:00

abstract：:During the last five decades, elegant mouse models of hematopoiesis have yielded most of the seminal insights into this complex biological system of self-renewal and lineage commitment. More recent advances in assays to measure human stem and progenitor cells as well as high resolution RNA profiling have revealed that...

journal_title：Journal of clinical immunology

authors： Parekh C,Crooks GM

更新日期：2013-05-01 00:00:00

abstract：:The addition of indomethacin to concanavalin A (Con A)-induced cultures of human peripheral blood leukocytes (PBL) caused an increase in interferon response, regardless of whether the PBLs were derived from multiple sclerosis (MS) patients or from control donors. Specifically the response rates increased from 71 to 10...

journal_title：Journal of clinical immunology

authors： Vervliet G,Deckmyn H,Carton H,Billiau A

更新日期：1985-03-01 00:00:00

abstract：:The etiology of immunodeficiency following trauma was investigated. Plasma collected from Fischer rats 1-8 hr following a 40% surface area thermal injury (TI) displays immunosuppressive activity (ISA). Peak ISA (4 hr) exceeded 90% inhibition of Con A3-induced proliferation of normal spleen cells. Splenic macrophage IL...

journal_title：Journal of clinical immunology

authors： Mills CD,Caldwell MD,Gann DS

更新日期：1989-03-01 00:00:00

abstract：PURPOSE:The aim of the present study was to evaluate whether the anti-Rheumatoid arthritis (RA) effect of curcumin is associated with the regulation of B cell-activating factor belonging to the TNF family (BAFF) production. METHODS:Collagen-induced arthritis (CIA) was induced in DBA/1 J mice by immunization with bovin...

journal_title：Journal of clinical immunology

authors： Huang G,Xu Z,Huang Y,Duan X,Gong W,Zhang Y,Fan J,He F

更新日期：2013-04-01 00:00:00

abstract：:Review of the limited data currently available on the ratios of helper (OKT4+) to suppressor (OKT8+) T cells in autoimmune liver disease (primary biliary cirrhosis and chronic active lupoid hepatitis) and virally induced liver disease indicates that this OKT4+:OKT8+ ratio is elevated in autoimmune liver disease manife...

journal_title：Journal of clinical immunology

authors： Thomas HC,Brown D,Labrooy J,Epstein O

更新日期：1982-07-01 00:00:00

abstract：:WHIM syndrome is an autosomal dominant immunodeficiency disease caused by mutations affecting the carboxy-terminus of CXCR4. To characterize novel genetic causes of the syndrome, we recruited a pediatric patient with possible WHIM syndrome, performed CXCR4 gene sequencing and compared his clinical phenotype and CXCR4 ...

journal_title：Journal of clinical immunology

authors： Liu Q,Pan C,Lopez L,Gao J,Velez D,Anaya-O'Brien S,Ulrick J,Littel P,Corns JS,Ellenburg DT,Malech HL,Murphy PM,McDermott DH

更新日期：2016-05-01 00:00:00

abstract：:Bias in cytokine responses has been proposed as a contributing mechanism to pathogenesis in persistent HIV or hepatitis C virus (HCV) infections. We investigated whether coinfection with HCV modifies the profile of antigen-specific cytokine secretion in women persistently infected with HIV compared to women with singl...

journal_title：Journal of clinical immunology

authors： Villacres MC,Literat O,Degiacomo M,Du W,La Rosa C,Diamond DJ,Kovacs A

更新日期：2005-03-01 00:00:00

abstract：:Increasing evidence is accumulating which indicates that immunological abnormalities contribute to the development of liver disease and its signs and symptoms. Platelet-associated IgG (PAIgG) levels were quantified in 42 patients with biopsy-proven liver disease of various etiologies to determine the relationship of t...

journal_title：Journal of clinical immunology

authors： Graber D,Giuliani D,Leevy CM,Morse BS

更新日期：1984-03-01 00:00:00

abstract：:This is the second report on the continuing efforts of LAGID to increase the recognition and registration of patients with primary immunodeficiency diseases in 12 Latin American countries: Argentina, Brazil, Chile, Colombia, Costa Rica, Honduras, Mexico, Panama, Paraguay, Peru, Uruguay, and Venezuela. This report reve...

journal_title：Journal of clinical immunology

authors： Leiva LE,Zelazco M,Oleastro M,Carneiro-Sampaio M,Condino-Neto A,Costa-Carvalho BT,Grumach AS,Quezada A,Patiño P,Franco JL,Porras O,Rodríguez FJ,Espinosa-Rosales FJ,Espinosa-Padilla SE,Almillategui D,Martínez C,Tafur JR,

更新日期：2007-01-01 00:00:00

abstract：:Persistent, generalized lymphadenopathy (PGL) is a recognized component of human immunodeficiency virus (HIV) infection. We conducted longitudinal studies of B and T cell function in seven homosexual men with HIV infection and PGL. All seven had abnormal antibody-mediated immunity as studied by sequential assessment o...

journal_title：Journal of clinical immunology

authors： Ochs HD,Junker AK,Collier AC,Virant FS,Handsfield HH,Wedgwood RJ

更新日期：1988-01-01 00:00:00

abstract：:Using fresh whole blood or isolated lymphocytes, the activity of in vivo generated cytotoxic T-lymphocytes (CTL) was measured as the OKT3-specific lysis of HL-60 targets, in a cross-sectional study of 53 HIV (+) patients. CTL activity in the entire HIV(+) group was two to three times higher than in HIV(-) controls, wi...

journal_title：Journal of clinical immunology

authors： Vanham G,Kestens L,Penne G,Goilav C,Gigase P,Colebunders R,Vandenbruaene M,Goeman J,van der Groen G,Ceuppens JL

更新日期：1991-11-01 00:00:00

abstract：:The first description of the hybridoma technology in 1975 seemed to hold enormous promise for the treatment of a variety of human disease. The ability to produce monoclonal antibodies led to the availability of large amounts of homogeneous and predictable preparations of antibody. The potential to renew indefinitely a...

journal_title：Journal of clinical immunology

authors： Pirofski L,Casadevall A,Rodriguez L,Zuckier LS,Scharff MD

更新日期：1990-11-01 00:00:00

abstract：:The human monoclonal autoantibody 16/6 is a common anti-DNA idiotype found to have clinical relevance in patients with systemic lupus erythematosus (SLE). Therefore the ability of peripheral blood T cells of SLE patients and healthy controls to proliferate and to produce helper T-cell factors following stimulation wit...

journal_title：Journal of clinical immunology

authors： Mendlovic S,Shoenfeld Y,Bakimer R,Segal R,Dayan M,Mozes E

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND:Nonalcoholic steatohepatitis (NASH) is a chronic inflammatory liver disease influenced by risk factors for the metabolic syndrome. In adult patients, NASH is associated with an altered phenotype and functionality of peripheral immune cells, the recruitment of leukocytes and intrahepatic activation, and an ex...

journal_title：Journal of clinical immunology

authors： Ferreyra Solari NE,Inzaugarat ME,Baz P,De Matteo E,Lezama C,Galoppo M,Galoppo C,Cherñavsky AC

更新日期：2012-06-01 00:00:00

abstract：:The expression of chemokine receptors on leukocytes is related to their activation state. However, the exact mechanism underlying the induction of each chemokine receptor is poorly understood. Here, we investigated how CCR5, a chemokine receptor implicated in T cell trafficking and HIV infection, is induced in human T...

journal_title：Journal of clinical immunology

authors： Yang YF,Tomura M,Iwasaki M,Mukai T,Gao P,Ono S,Zou JP,Shearer GM,Fujiwara H,Hamaoka T

更新日期：2001-03-01 00:00:00

abstract：:To compare the efficacy of immunoglobulin replacement therapy given intravenously versus subcutaneously to prevent infections in patients with primary antibody deficiency syndromes, an international, multicenter, open label, crossover study was designed. Forty patients were randomized to receive either subcutaneous or...

journal_title：Journal of clinical immunology

authors： Chapel HM,Spickett GP,Ericson D,Engl W,Eibl MM,Bjorkander J

更新日期：2000-03-01 00:00:00

abstract：:Thirty two HIV-infected children, on highly active antiretroviral therapy (HAART) and > 500 CD4+ T cells/mm3, were rated according to the time-course of viral load (VL) during the whole follow-up period (> 18 months) in a longitudinal retrospective study. (a) uVL group: 15 children with VL below 400 copies/mL; (b) dVL...

journal_title：Journal of clinical immunology

authors： Resino S,Galán I,Bellón JM,Navarro ML,León JA,Muñoz-Fernandez MA

更新日期：2003-07-01 00:00:00

abstract：:Chronic Granulomatous Disease (CGD) is a rare primary immunodeficiency due to a defect in one of the NADPH oxidase complex subunits; 70 % of cases are X-linked, due to a CYBB mutation, resulting in defective production of gp91PHOX. Female carriers of X-linked CGD have previously been considered to be unaffected. It is...

journal_title：Journal of clinical immunology

authors： Battersby AC,Cale AM,Goldblatt D,Gennery AR

更新日期：2013-11-01 00:00:00

abstract：:Human papillomavirus (HPV) infects the transformation zone of the cervix and is the primary cause of cervical cancer. The infection is localized to the cervix and mucosal immunity is likely to be an important determinant for viral clearance. Previous studies of immunity to HPV have measured immune markers in the blood...

journal_title：Journal of clinical immunology

authors： Castle PE,Hildesheim A,Bowman FP,Strickler HD,Walker JL,Pustilnik T,Edwards RP,Crowley-Nowick PA

更新日期：2002-01-01 00:00:00

abstract：:In this retrospective study 103 serum samples from 16 females with systemic lupus erythematosus (SLE), obtained during a mean follow-up time of 2 years, were investigated for the presence of anti-denatured [single-stranded (ss)] DNA antibodies of the IgG, IgM, and IgA classes. The anti-ssDNA antibodies were determined...

journal_title：Journal of clinical immunology

authors： Gripenberg M,Leirisalo M,Johansson E,Gripenberg G

更新日期：1985-09-01 00:00:00

abstract：:Treatment of primary immunodeficiency (PI) is typically initiated with intravenous immunoglobulin (IVIG) loading and then continued with IVIG or subcutaneous IgG (SCIG). This prospective, open-label, multicenter, 6-month study evaluated a new regimen of initiating IgG therapy with SCIG in 18 previously untreated patie...

journal_title：Journal of clinical immunology

authors： Borte M,Quinti I,Soresina A,Fernández-Cruz E,Ritchie B,Schmidt DS,McCusker C

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Although some previous studies have reported that genetic and immunological factors play important roles in the pathogenesis of Kawasaki disease (KD), the etiological factors of this enigmatical pediatric disease are still poorly understood. PURPOSE:This study aims to investigate whether polymorphisms of th...

journal_title：Journal of clinical immunology

authors： Huang FY,Chang TY,Chen MR,Chiu NC,Chi H,Lee HC,Lin SP,Chen CK,Chan HW,Chen WF,Liu HF,Chu CC,Lin M,Lee YJ

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:To review the clinical and laboratory spectrum of RAG gene defects in humans, and discuss the mechanisms underlying phenotypic heterogeneity, the basis of immune dysregulation, and the current and perspective treatment modalities. METHODS:Literature review and analysis of medical records RESULTS: RAG gene defe...

journal_title：Journal of clinical immunology

authors： Delmonte OM,Schuetz C,Notarangelo LD

更新日期：2018-08-01 00:00:00

abstract：:Leishmaniasis is caused by parasitic protozoa transmitted by the bite of a female sand fly and is currently endemic in 88 countries. BALB/c mice are highly susceptible to the infection with the parasite Leishmania major, and this susceptibility has been attributed, in part, to the expansion of Th2 cells, production of...

journal_title：Journal of clinical immunology

authors： Hosseini N,Abolhassani M

更新日期：2011-06-01 00:00:00

abstract：:An emerging paradigm for the treatment of primary immunodeficiency disease (PIDD) with immunoglobulin (IgG) replacement therapy emphasizes the tailoring of treatments to each patient with the goal of preventing infections and minimizing side effects. Increasing evidence shows that the IgG dose needed to prevent infect...

journal_title：Journal of clinical immunology

authors： Shapiro RS,Wasserman RL,Bonagura V,Gupta S

更新日期：2017-02-01 00:00:00