Characterizing the immune system after long-term undetectable viral load in HIV-1-infected children.

abstract：:Interferon-γ receptor 1 (IFN-γR1) deficiency is one of the primary immunodeficiencies conferring Mendelian Susceptibility to Mycobacterial Disease (MSMD). Some cases of neoplasms have been recently reported in patients with MSMD, underlying the already known link between immunodeficiency and carcinogenesis. We report ...

journal_title：Journal of clinical immunology

authors： Taramasso L,Boisson-Dupuis S,Garrè ML,Bondi E,Cama A,Nozza P,Morana G,Casanova JL,Marazzi MG

更新日期：2014-11-01 00:00:00

abstract：:The Wiskott-Aldrich syndrome (WAS) is a rare X-linked disorder originally described by Dr. Alfred Wiskott in 1937 and Dr. Robert Aldrich in 1954 as a familial disease characterized by infections, bleeding tendency, and eczema. Today, it is well recognized that the syndrome has a wide clinical spectrum ranging from mil...

journal_title：Journal of clinical immunology

authors： Candotti F

更新日期：2018-01-01 00:00:00

abstract：:Using fresh whole blood or isolated lymphocytes, the activity of in vivo generated cytotoxic T-lymphocytes (CTL) was measured as the OKT3-specific lysis of HL-60 targets, in a cross-sectional study of 53 HIV (+) patients. CTL activity in the entire HIV(+) group was two to three times higher than in HIV(-) controls, wi...

journal_title：Journal of clinical immunology

authors： Vanham G,Kestens L,Penne G,Goilav C,Gigase P,Colebunders R,Vandenbruaene M,Goeman J,van der Groen G,Ceuppens JL

更新日期：1991-11-01 00:00:00

abstract：PURPOSE:Colitis is a common and serious complication of chronic granulomatous disorder (CGD) and requires assessment. Colonoscopy is invasive and carries risks of serious complication. We therefore assessed non-invasive monitoring via magnetic resonance imaging (MRI). We also evaluated fecal calprotectin (FCP), the Har...

journal_title：Journal of clinical immunology

authors： Lowe DM,Smith PJ,Moreira F,Workman S,Braggins H,Koukias N,Buckland MS,Wylie P,Taylor SA,Murray CD

更新日期：2019-07-01 00:00:00

abstract：INTRODUCTION:Systemic lupus erythematosus (SLE) is a systemic autoimmune disease associated with aberrant activation of T and B lymphocytes. Abnormal activation of intracellular signaling molecules in lymphocytes by inflammatory cytokines can instigate the inflammation in SLE. MATERIALS AND METHODS:The activation of e...

journal_title：Journal of clinical immunology

authors： Wong CK,Wong PT,Tam LS,Li EK,Chen DP,Lam CW

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:The increased risk of morbidity and mortality from certain microbial infections and the demonstrated improvements in the clinical course of some autoimmune diseases support the existence of pregnancy-related alterations in immune status. Elucidating the changes in innate and adaptive immunity during gestation m...

journal_title：Journal of clinical immunology

authors： Kraus TA,Engel SM,Sperling RS,Kellerman L,Lo Y,Wallenstein S,Escribese MM,Garrido JL,Singh T,Loubeau M,Moran TM

更新日期：2012-04-01 00:00:00

abstract：:The addition of indomethacin to concanavalin A (Con A)-induced cultures of human peripheral blood leukocytes (PBL) caused an increase in interferon response, regardless of whether the PBLs were derived from multiple sclerosis (MS) patients or from control donors. Specifically the response rates increased from 71 to 10...

journal_title：Journal of clinical immunology

authors： Vervliet G,Deckmyn H,Carton H,Billiau A

更新日期：1985-03-01 00:00:00

abstract：:Cytotoxic lymphocytes are critical in the control of HIV replication, it has been shown that perforin is the key effector of killing machinery for CTLs and NK cells, so we investigated the circulating levels of perforin in CD8+ T cells and NK cells by flow cytometry intracellular stain in Chinese HIV infected individu...

journal_title：Journal of clinical immunology

authors： Qi W,Yongjun J,Yanan W,Zining Z,Xiaoxu H,Jing L,Hong S

更新日期：2006-07-01 00:00:00

abstract：:We report the long-term follow-up of 12 pediatric-aged patients with chronic granulomatous disease (CGD). The mean age at the onset of infections was 5 months with a median delay in diagnosis of 2.5 years. Bacille Calmette-Guérin lymphadenitis was the most common presenting infection (6) followed by suppurative lympha...

journal_title：Journal of clinical immunology

authors： Pasic S,Minic A,Minic P,Veljkovic D,Lilic D,Slavkovic B,Pejnovic N,Abinun M

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVES:Mutations affecting the TMEM173 gene cause STING-associated vasculopathy with onset in infancy (SAVI). No standard immunosuppressive treatment approach is able to control disease progression in patients with SAVI. We studied the efficacy and safety of targeting type I IFN signaling with the Janus kinase inhi...

journal_title：Journal of clinical immunology

authors： Volpi S,Insalaco A,Caorsi R,Santori E,Messia V,Sacco O,Terheggen-Lagro S,Cardinale F,Scarselli A,Pastorino C,Moneta G,Cangemi G,Passarelli C,Ricci M,Girosi D,Derchi M,Bocca P,Diociaiuti A,El Hachem M,Cancrini C,To

更新日期：2019-07-01 00:00:00

abstract：:Chronic Granulomatous Disease (CGD) is a rare primary immunodeficiency due to a defect in one of the NADPH oxidase complex subunits; 70 % of cases are X-linked, due to a CYBB mutation, resulting in defective production of gp91PHOX. Female carriers of X-linked CGD have previously been considered to be unaffected. It is...

journal_title：Journal of clinical immunology

authors： Battersby AC,Cale AM,Goldblatt D,Gennery AR

更新日期：2013-11-01 00:00:00

abstract：:The use of exogenous serum to provide protection against infections began more than a century ago. Over time, this concept matured and led to the preparation of concentrated immunoglobulin (IgG) products that were safe and effective when delivered subcutaneously (SC) or intramuscularly (IM) but were not ideal for intr...

journal_title：Journal of clinical immunology

authors： Torgerson TR

更新日期：2013-01-01 00:00:00

abstract：:Lymphocytes expressing gammadelta T cell receptors (TCR) constitute an entire system of functionally specialized subsets that have been implicated in the regulation of immune responses, including responses to pathogens and allergens, and in tissue repair. The gammadelta TCRs share structural features with adaptive rec...

journal_title：Journal of clinical immunology

authors： Born WK,Jin N,Aydintug MK,Wands JM,French JD,Roark CL,O'Brien RL

更新日期：2007-03-01 00:00:00

abstract：:Early treatment intervention during human immunodeficiency virus (HIV) infection is a strategy aimed to preserve and/or enhance the developing anti-HIV immune responses. We report the effect of highly active antiretroviral therapy (HAART) combined with intermittent subcutaneous doses of Interleukin 2 (IL-2) on CD8(+) ...

journal_title：Journal of clinical immunology

authors： Martinez-Mariño B,Ashlock BM,Shiboski S,Hecht FM,Levy JA

更新日期：2004-03-01 00:00:00

abstract：:The immune response of 56 colorectal cancer patients to a single infusion of 1 mg of radiolabeled (111In) mouse B72.3-GYK-DTPA immunoconjugate was examined using a double-antigen radiometric assay system. The incidence of antibody response was 48% to polyclonal mouse IgG, 71% to mouse B72.3, and 62% to chimeric B72.3....

journal_title：Journal of clinical immunology

authors： Khazaeli MB,Saleh MN,Liu T,Kaladas PM,Gilman SC,LoBuglio AF

更新日期：1992-03-01 00:00:00

abstract：:To compare the efficacy of immunoglobulin replacement therapy given intravenously versus subcutaneously to prevent infections in patients with primary antibody deficiency syndromes, an international, multicenter, open label, crossover study was designed. Forty patients were randomized to receive either subcutaneous or...

journal_title：Journal of clinical immunology

authors： Chapel HM,Spickett GP,Ericson D,Engl W,Eibl MM,Bjorkander J

更新日期：2000-03-01 00:00:00

abstract：:Live-attenuated vaccines (LAVs) can protect humans against 12 viral and three bacterial diseases. By definition, any clinical infection caused by a LAV that is sufficiently severe to require medical intervention attests to an inherited or acquired immunodeficiency that must be diagnosed or identified. Self-healing inf...

journal_title：Journal of clinical immunology

authors： Pöyhönen L,Bustamante J,Casanova JL,Jouanguy E,Zhang Q

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:Different sets of warning signs can be used if primary immunodeficiency (PID) is suspected: those of the Jeffrey Modell Foundation (JMF), the German Patients' Organisation for Primary Immunodeficiencies (DSAI) and the Association of the Scientific Medical Societies in Germany (AWMF). A few studies have tested...

journal_title：Journal of clinical immunology

authors： Lankisch P,Schiffner J,Ghosh S,Babor F,Borkhardt A,Laws HJ

更新日期：2015-04-01 00:00:00

abstract：:Adiponectin is an adipocyte-derived cytokine with anti-inflammatory properties. Paradoxically, circulating adiponectin levels are increased in a number of inflammatory diseases. Thus, we sought to define the role of adiponectin deficiency in mouse models of autoimmunity. Adiponectin-deficient mice on a C57BL/6 backgro...

journal_title：Journal of clinical immunology

authors： Parker J,Menn-Josephy H,Laskow B,Takemura Y,Aprahamian T

更新日期：2011-04-01 00:00:00

abstract：:To better understand the role of Ia antigen expression, accessory cell function, and antigen ingestion in antigen presentation and the initiation of T cell proliferation, we studied these events in two acute monoblastic leukemia (AMoL) lines. The cell lines were positive for surface Ia antigen; one stimulated prolifer...

journal_title：Journal of clinical immunology

authors： Giller RH,Mori M,Hayward AR

更新日期：1984-11-01 00:00:00

abstract：:Immune complexes and 1-O-alkyl-2-acetyl-SN-glycero-3-phosphorylcholine (AGEPC) are potent platelet-activating factors which interact with distinct receptors on human platelets. The mechanisms of platelet activation by these two stimuli were investigated by examining the effects of AGEPC on human platelets which had be...

journal_title：Journal of clinical immunology

authors： Valone FH

更新日期：1986-01-01 00:00:00

abstract：INTRODUCTION:Autoantibodies to granulocyte-macrophage colony-stimulating factor (GM-CSF) can cause acquired pulmonary alveolar proteinosis (PAP). Cases of acquired PAP susceptible to typical respiratory pathogens and opportunistic infections have been reported. Anti-GM-CSF autoantibodies have been reported in a few pat...

journal_title：Journal of clinical immunology

authors： Kuo CY,Wang SY,Shih HP,Tu KH,Huang WC,Ding JY,Lin CH,Yeh CF,Ho MW,Chang SC,He CY,Chen HK,Ho CH,Lee CH,Chi CY,Ku CL

更新日期：2017-02-01 00:00:00

abstract：:Adoptive immunotherapy with in vitro expanded cytotoxic T lymphocytes specific for Epstein-Barr virus (EBV) can successfully treat post-transplant lymphoproliferative disease (PTLD). However, extension of a similar strategy to Hodgkin's disease (HD) and nasopharyngeal carcinoma (NPC) is limited by the poor immunogenic...

journal_title：Journal of clinical immunology

authors： Jurgens LA,Khanna R,Weber J,Orentas RJ

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:There are now many ways of achieving transplantation tolerance in rodents that do not require stem cell chimerism. The best studied of these utilize short courses of antibody treatment aimed at blocking the co-receptors CD4 and CD8, and/or co-stimulatory molecules such as CD40L. Unlike tolerance through mixe...

journal_title：Journal of clinical immunology

authors： Waldmann H,Adams E,Fairchild P,Cobbold S

更新日期：2008-11-01 00:00:00

abstract：:The cellular and molecular basis of immune senescence is unclear. A number of mechanisms have been proposed. In this issue of the Journal of Clinical Immunology, some of the mechanisms for various immunologic abnormalities in aging are presented. In this article, various molecular steps of both death receptor and mito...

journal_title：Journal of clinical immunology

authors： Gupta S

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVES:Gastrointestinal manifestations are frequent in patients with common variable immunodeficiency (CVID), and some of the patients present with celiac-like features. Diagnosing celiac disease (CD) in CVID however is challenging, as autoantibody detection and histopathology of the small intestine cannot reliably...

journal_title：Journal of clinical immunology

authors： Venhoff N,Emmerich F,Neagu M,Salzer U,Koehn C,Driever S,Kreisel W,Rizzi M,Effelsberg NM,Kollert F,Goldacker S,Voll RE,Warnatz K,Thiel J

更新日期：2013-07-01 00:00:00

abstract：:Chemotherapeutic agent is characterized by its concentration in tumor cells with minimum side effects. Oleandrin, a polyphenolic cardiac glycoside is known to induce apoptosis in tumor cells. However, no report is available on its efficacy in primary cells. In this report we are providing the evidence that oleandrin i...

journal_title：Journal of clinical immunology

authors： Sreenivasan Y,Raghavendra PB,Manna SK

更新日期：2006-07-01 00:00:00

abstract：PURPOSE:The present study was designed to evaluate the efficacy and safety of a novel, 10% liquid formulation of intravenous immunoglobulin, stabilized with 250 mmol/L L-proline (Privigen), in patients with primary immunodeficiency disease. MATERIALS AND METHODS:Eighty adults and children diagnosed with common variabl...

journal_title：Journal of clinical immunology

authors： Stein MR,Nelson RP,Church JA,Wasserman RL,Borte M,Vermylen C,Bichler J,IgPro10 in PID study group.

更新日期：2009-01-01 00:00:00

abstract：:We have examined the primary immune responses, the numbers of total T (T11+) cells, T-helper (T4+) cells, T-suppressor (T8+) cells, and natural killer (NK) (Leu7+) cells, in 118 healthy control subjects and compared the data to those obtained from 20 patients with clinically diagnosed malignant mesothelioma and 375 lo...

journal_title：Journal of clinical immunology

authors： Lew F,Tsang P,Holland JF,Warner N,Selikoff IJ,Bekesi JG

更新日期：1986-05-01 00:00:00

abstract：:The spectrum of illness attributed to Epstein-Barr virus (EBV) includes patients with symptoms persisting for more than 1 year without any other obvious underlying disease. High titers of antibodies to EBV, either IgG antiviral capsid antigen or anti-early antigen, can be demonstrated. In this study, 13 patients diagn...

journal_title：Journal of clinical immunology

authors： Kibler R,Lucas DO,Hicks MJ,Poulos BT,Jones JF

更新日期：1985-01-01 00:00:00