Abstract：
:Chemotherapeutic agent is characterized by its concentration in tumor cells with minimum side effects. Oleandrin, a polyphenolic cardiac glycoside is known to induce apoptosis in tumor cells. However, no report is available on its efficacy in primary cells. In this report we are providing the evidence that oleandrin induces apoptosis, not necrosis in tumor cells but not in primary cells like peripheral blood mononuclear cells (PBMC) and neutrophils. Oleandrin inhibited NF-kappaB activation in tumor cells but not in primary cells. It induced cell death in NF-kappaB-overexpressed tumor cells. Oleandrin induced Fas expression thereby inducing apoptosis in tumor cells but not in primary cells. Dominant negative FADD inhibited oleandrin-induced cell death in tumor cells. Overall, these results suggest that oleandrin mediates apoptosis in tumor cells by inducing Fas but not in primary cells indicating its potential anti-cancer property with no or slight side effect.
journal_name
J Clin Immunoljournal_title
Journal of clinical immunologyauthors
Sreenivasan Y,Raghavendra PB,Manna SKdoi
10.1007/s10875-006-9028-0subject
Has Abstractpub_date
2006-07-01 00:00:00pages
308-22issue
4eissn
0271-9142issn
1573-2592journal_volume
26pub_type
杂志文章,收录出版abstract：:The cellular and molecular basis of immune senescence is unclear. A number of mechanisms have been proposed. In this issue of the Journal of Clinical Immunology, some of the mechanisms for various immunologic abnormalities in aging are presented. In this article, various molecular steps of both death receptor and mito...
journal_title：Journal of clinical immunology
pub_type： 杂志文章,评审
doi：10.1023/a:1006653917314
更新日期：2000-07-01 00:00:00
abstract：:An emerging paradigm for the treatment of primary immunodeficiency disease (PIDD) with immunoglobulin (IgG) replacement therapy emphasizes the tailoring of treatments to each patient with the goal of preventing infections and minimizing side effects. Increasing evidence shows that the IgG dose needed to prevent infect...
journal_title：Journal of clinical immunology
pub_type： 杂志文章,评审
doi：10.1007/s10875-014-9990-x
更新日期：2017-02-01 00:00:00
abstract：PURPOSE:To review the clinical and laboratory spectrum of RAG gene defects in humans, and discuss the mechanisms underlying phenotypic heterogeneity, the basis of immune dysregulation, and the current and perspective treatment modalities. METHODS:Literature review and analysis of medical records RESULTS: RAG gene defe...
journal_title：Journal of clinical immunology
pub_type： 杂志文章,评审
doi：10.1007/s10875-018-0537-4
更新日期：2018-08-01 00:00:00
abstract：:A 35-year-old man with common variable hypogammaglobulinemia had repeated anaphylactic reactions to intramuscular human immune serum globulin (HISG), preventing him from receiving the injections. He was able to tolerate slow subcutaneous HISG infusions without local or systemic side effects at a dose of 12 ml/week giv...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/BF00915353
更新日期：1983-07-01 00:00:00
abstract：INTRODUCTION:Treating recipient mice with palifermin (recombinant human keratinocyte growth factor) prevents the development of acute, lethal, graft-versus-host disease (GVHD). This is due, at least in part, to the ability of palifermin to protect epithelial cells from injury. Using the C57BL/6-->(C57BL/6 x DBA/2)F(1)-...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-008-9216-1
更新日期：2008-09-01 00:00:00
abstract：:Sera from systemic lupus erythematosus (SLE) patients giving a fluorescent ribosomal pattern on tissue and cell preparations also showed precipitating autoantibodies against purified rat liver ribosomes. Ribosomal antigen is also present in rabbit thymus cellular extract (RTE), since the same sera gave precipitin line...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/BF00915287
更新日期：1984-01-01 00:00:00
abstract：:T lymphocytes expressing NK1.1 marker (NK1.1+) have been suggested as being important in peripheral immune modulation. Alteration of the balance between Th1 proinflammatory and Th2 anti-inflammatory cytokine-producing cells can ameliorate immune-mediated disorders. The aim of the study was to determine the role of NK1...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1023/a:1019974005134
更新日期：2002-09-01 00:00:00
abstract：:Using our gp120/41-expressing, NK cell activity-resistant CEM.NKR cell clones as targets in HIV-1-specific antibody-dependent cellular cytotoxicity (ADCC) assays, we demonstrate here that the serum titers of anti-HIV-1 ADCC antibodies bear a significant (P < 0.05) positive correlation with the peripheral blood CD4+ T ...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1023/a:1011087132180
更新日期：2001-05-01 00:00:00
abstract：:Fever is frequently observed in cancer patients treated with high-dose recombinant human interleukin-2 (rIL-2). The preincubation of rIL-2 with polymyxin B, an antibiotic that inhibits the biologic effects of endotoxins, did not diminish the pyrogenicity of IL-2 in New Zealand rabbits, indicating that IL-2-induced fev...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/BF00916947
更新日期：1988-11-01 00:00:00
abstract：:The original version of this article unfortunately contained mistake in the following sentence in the Abstract. ...
journal_title：Journal of clinical immunology
pub_type： 已发布勘误
doi：10.1007/s10875-019-00653-0
更新日期：2019-07-01 00:00:00
abstract：PURPOSE:The interaction of Shiga toxin (Stx) and/or lipopolysaccharide (LPS) with monocytes (Mo) may be central to the pathogenesis of hemolytic uremic syndrome (HUS), providing the cytokines necessary to sensitize endothelial cells to Stx action. We have previously demonstrated phenotypical alterations in Mo from HUS ...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-011-9646-z
更新日期：2012-06-01 00:00:00
abstract：:Intravenous immunoglobin (i.v.IG) is generated from the plasma of more than 10,000 healthy subjects. Originally i.v.IG was employed to supplement the missing Igs in subjects with immune-deficiencies. Later on it was given successfully to patients with autoimmune conditions, in some of which the benefits were confirmed...
journal_title：Journal of clinical immunology
pub_type： 杂志文章,评审
doi：10.1023/b:joci.0000019809.55787.ec
更新日期：2004-03-01 00:00:00
abstract：:Treatment of primary immunodeficiency (PI) is typically initiated with intravenous immunoglobulin (IVIG) loading and then continued with IVIG or subcutaneous IgG (SCIG). This prospective, open-label, multicenter, 6-month study evaluated a new regimen of initiating IgG therapy with SCIG in 18 previously untreated patie...
journal_title：Journal of clinical immunology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s10875-011-9588-5
更新日期：2011-12-01 00:00:00
abstract：:Human papillomavirus (HPV) infects the transformation zone of the cervix and is the primary cause of cervical cancer. The infection is localized to the cervix and mucosal immunity is likely to be an important determinant for viral clearance. Previous studies of immunity to HPV have measured immune markers in the blood...
journal_title：Journal of clinical immunology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1023/a:1014252402630
更新日期：2002-01-01 00:00:00
abstract：:Thirty two HIV-infected children, on highly active antiretroviral therapy (HAART) and > 500 CD4+ T cells/mm3, were rated according to the time-course of viral load (VL) during the whole follow-up period (> 18 months) in a longitudinal retrospective study. (a) uVL group: 15 children with VL below 400 copies/mL; (b) dVL...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1023/a:1024536816684
更新日期：2003-07-01 00:00:00
abstract：PURPOSE:Home-based subcutaneous immunoglobulin (SCIg) therapy is an alternative to hospital-based intravenous infusions (IVIg). However, SCIg requires patient training and long-term support to ensure proper adherence, optimal efficacy and safety. We evaluated if switching patients to home-based SCIg including an interp...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-016-0288-z
更新日期：2016-07-01 00:00:00
abstract：:The concentrations of serum IgG and IgM antibodies to polyclonal IgA (IgAp), IgA1, and IgA2 were determined by enzyme immunoassay in 31 patients with IgA nephropathy and 30 healthy controls. Patients with IgA nephropathy had significantly raised concentrations of serum IgA compared to controls (Mann-Whitney U test, P ...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/BF00918662
更新日期：1989-07-01 00:00:00
abstract：PURPOSE:To elucidate the relative role of the immune system and intestinal epithelium in the ethiopatogenesis of Celiac disease (CD). METHODS:A patient with childhood CD who underwent allogeneic bone marrow transplantation (BMT) for chronic myelogenous leukemia was followed for 5 years after resumption of gluten conta...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-013-9943-9
更新日期：2013-11-01 00:00:00
abstract：:Live-attenuated vaccines (LAVs) can protect humans against 12 viral and three bacterial diseases. By definition, any clinical infection caused by a LAV that is sufficiently severe to require medical intervention attests to an inherited or acquired immunodeficiency that must be diagnosed or identified. Self-healing inf...
journal_title：Journal of clinical immunology
pub_type： 杂志文章,评审
doi：10.1007/s10875-019-00642-3
更新日期：2019-05-01 00:00:00
abstract：:Palifermin (recombinant human keratinocyte growth factor) prevents the development of acute, lethal graft-versus-host disease (GVHD). It does so, at least in part, by protecting cells from injury. Another property of Palifermin is immune regulation. How the latter influences the evolution of GVHD remains uncertain. We...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-006-9039-x
更新日期：2006-09-01 00:00:00
abstract：PURPOSE:This study aimed to characterize the clinical phenotype, genetic basis, and consequent immunological phenotype of a boy with severe infantile-onset colitis and eosinophilic gastrointestinal disease, and no evidence of recurrent or severe infections. METHODS:Trio whole-exome sequencing (WES) was utilized for pa...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-019-00631-6
更新日期：2019-05-01 00:00:00
abstract：:The role of lymphocytes in the pathogenesis of bullous pemphigoid was examined by assaying the blister fluid obtained from bullous pemphigoid patients for the presence of the lymphokine, lymphotoxin. Blister fluids from six bullous pemphigoid were assayed on L-929 target cells for the presence of cytolytic molecules i...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/BF00915284
更新日期：1984-01-01 00:00:00
abstract：:To compare the efficacy of immunoglobulin replacement therapy given intravenously versus subcutaneously to prevent infections in patients with primary antibody deficiency syndromes, an international, multicenter, open label, crossover study was designed. Forty patients were randomized to receive either subcutaneous or...
journal_title：Journal of clinical immunology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1023/a:1006678312925
更新日期：2000-03-01 00:00:00
abstract：:Emotional stress is often followed by increased susceptibility to infections. One major role in the immediate immune response to infection is played by natural killer (NK) cells. This study was designed to establish whether acute psychological stress influences cellular immune functions and to elucidate the role of en...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/BF00919268
更新日期：1993-03-01 00:00:00
abstract：:Intravenous immunoglobulin (IVIg) has been used to treat autoimmune diseases and lymphoid malignancies with some therapeutic effect. In both these pathological conditions, there is an overproduction of BAFF (for "B-cell-activating factor of the TNF family"), and APRIL (for "a proliferation-inducing ligand"). The prese...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-007-9082-2
更新日期：2007-05-01 00:00:00
abstract：:CFSE dye dilution analysis and [3H] thymidine incorporation were used side by side to assess proliferative responses of peripheral blood mononuclear cells (PBMCs) after vaccination of renal cell carcinoma patients (n=6) with antigen-loaded dendritic cells. Immune responses against the control antigen keyhole limpet he...
journal_title：Journal of clinical immunology
pub_type： 临床试验,杂志文章
doi：10.1007/s10875-004-6237-2
更新日期：2004-11-01 00:00:00
abstract：:We previously reported that several DNA fragments from human prostate-specific membrane antigen (hPSM), mouse prostatic acid phosphatase (mPAP), and human prostate-specific antigen (hPSA) genes were selected and fused to create a novel hPSM-mPAP-hPSA fusion gene (named 3P gene), and human secondary lymphoid tissue che...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-006-9053-z
更新日期：2007-01-01 00:00:00
abstract：:Stimulator of interferon genes (STING)-associated vasculopathy with onset in infancy (SAVI) is a rare disorder that is associated with extensive inflammation throughout the body due to a high interferon state. Common clinical manifestations of this disorder include chronic lung disease, digital necrosis, recurrent low...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-020-00850-2
更新日期：2020-11-01 00:00:00
abstract：:The role of tumor necrosis factor-alpha in the shedding of soluble tumor necrosis factor receptors in endotoxemia was investigated. The appearance of the soluble tumor necrosis factor receptors was assessed in four healthy volunteers following an intravenous injection of tumor necrosis factor-alpha and in eight chimpa...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/BF01489489
更新日期：1995-01-01 00:00:00
abstract：:Immune complexes and 1-O-alkyl-2-acetyl-SN-glycero-3-phosphorylcholine (AGEPC) are potent platelet-activating factors which interact with distinct receptors on human platelets. The mechanisms of platelet activation by these two stimuli were investigated by examining the effects of AGEPC on human platelets which had be...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/BF00915365
更新日期：1986-01-01 00:00:00
