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Anti-ribosomal ribonucleoprotein autoantibodies in systemic lupus erythematosus.

Abstract：

:Sera from systemic lupus erythematosus (SLE) patients giving a fluorescent ribosomal pattern on tissue and cell preparations also showed precipitating autoantibodies against purified rat liver ribosomes. Ribosomal antigen is also present in rabbit thymus cellular extract (RTE), since the same sera gave precipitin lines against RTE in identity with ribosomes. Immunofluorescent staining was completely inhibited by serum absorption with ribosomes or with RTE. However ribosomal RNA and RNase or trypsin-treated ribosomes failed to react with these autoantibodies as demonstrated in immunoabsorption and immunodiffusion studies. These data suggest that these sera contain autoantibodies directed against some antigenic site composed of a portion of both RNA and ribosomal protein. Ribosomal autoantibodies were detectable at a low frequency in SLE patients characterized by an active disease and renal involvement.

journal_name

J Clin Immunol

journal_title

Journal of clinical immunology

authors

Meroni PL,de Bartolo G,Barcellini W,Riboldi PS,Basile R,Betterle C,Zanussi C

doi

10.1007/BF00915287

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

45-54

issue

1

eissn

0271-9142

issn

1573-2592

journal_volume

4

pub_type

杂志文章

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