Switching Patients to Home-Based Subcutaneous Immunoglobulin: an Economic Evaluation of an Interprofessional Drug Therapy Management Program.

abstract：:Atopic dermatitis in humans and dogs is a chronic relapsing allergic skin disease. Dogs show a spontaneous disease similar to the human counterpart and represent a model to improve our understanding of the immunological mechanisms, the pathogenesis of the disease, and new therapy development. The aim of the study was ...

journal_title：Journal of clinical immunology

authors： Ricklin ME,Roosje P,Summerfield A

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:DNA Ligase 4 (LIG4) is a key factor in the non-homologous end-joining (NHEJ) DNA double-strand break repair pathway needed for V(D)J recombination and the generation of the T cell receptor and immunoglobulin molecules. Defects in LIG4 result in a variable syndrome of growth retardation, pancytopenia, combined i...

journal_title：Journal of clinical immunology

authors： Felgentreff K,Baxi SN,Lee YN,Dobbs K,Henderson LA,Csomos K,Tsitsikov EN,Armanios M,Walter JE,Notarangelo LD

更新日期：2016-05-01 00:00:00

abstract：:The etiology of immunodeficiency following trauma was investigated. Plasma collected from Fischer rats 1-8 hr following a 40% surface area thermal injury (TI) displays immunosuppressive activity (ISA). Peak ISA (4 hr) exceeded 90% inhibition of Con A3-induced proliferation of normal spleen cells. Splenic macrophage IL...

journal_title：Journal of clinical immunology

authors： Mills CD,Caldwell MD,Gann DS

更新日期：1989-03-01 00:00:00

abstract：PURPOSE:Spondyloenchondrodysplasia is a rare immuno-osseous dysplasia caused by biallelic mutations in ACP5. We aimed to provide a survey of the skeletal, neurological and immune manifestations of this disease in a cohort of molecularly confirmed cases. METHODS:We compiled clinical, genetic and serological data from a...

journal_title：Journal of clinical immunology

authors： Briggs TA,Rice GI,Adib N,Ades L,Barete S,Baskar K,Baudouin V,Cebeci AN,Clapuyt P,Coman D,De Somer L,Finezilber Y,Frydman M,Guven A,Heritier S,Karall D,Kulkarni ML,Lebon P,Levitt D,Le Merrer M,Linglart A,Livingst

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:Hemophagocytic lymphohistiocytosis (HLH) is a rare systematic immune disease manifested with excessive activation of lymphocytes and macrophages. This study was designed to explore the feasible prognostic factors of secondary HLH (sHLH). METHOD:We retrospectively analyzed 179 patients with newly diagnosed sHLH...

journal_title：Journal of clinical immunology

authors： Huang J,Yin G,Duan L,Tian T,Xu J,Wang J,Gao X,Cheng W,Liu L,Qiu H

更新日期：2020-07-01 00:00:00

abstract：:The first description of the hybridoma technology in 1975 seemed to hold enormous promise for the treatment of a variety of human disease. The ability to produce monoclonal antibodies led to the availability of large amounts of homogeneous and predictable preparations of antibody. The potential to renew indefinitely a...

journal_title：Journal of clinical immunology

authors： Pirofski L,Casadevall A,Rodriguez L,Zuckier LS,Scharff MD

更新日期：1990-11-01 00:00:00

abstract：:Lymphocytes of 18 patients meeting the Centers for Disease Control (CDC) case definition for the chronic fatigue syndrome (CFS), 10 similar, chronically fatigued patients not fully conforming to the CDC case definition, and 17 matched, healthy individuals were studied to determine the presence of abnormalities of peri...

journal_title：Journal of clinical immunology

authors： Straus SE,Fritz S,Dale JK,Gould B,Strober W

更新日期：1993-01-01 00:00:00

abstract：:The role of tumor necrosis factor-alpha in the shedding of soluble tumor necrosis factor receptors in endotoxemia was investigated. The appearance of the soluble tumor necrosis factor receptors was assessed in four healthy volunteers following an intravenous injection of tumor necrosis factor-alpha and in eight chimpa...

journal_title：Journal of clinical immunology

authors： Jansen J,van der Poll T,Levi M,ten Cate H,Gallati H,ten Cate JW,van Deventer SJ

更新日期：1995-01-01 00:00:00

abstract：:The aim of this study was to research the expression of IL-37 in systemic lupus erythematosus (SLE) patients and the effect of glucocorticoid on IL-37. Thirty newly diagnosed severe SLE patients receiving prednisone 1 mg/kg/day for 14 consecutive days and 30 healthy subjects were enrolled into this study. The plasma l...

journal_title：Journal of clinical immunology

authors： Song L,Qiu F,Fan Y,Ding F,Liu H,Shu Q,Liu W,Li X

更新日期：2013-01-01 00:00:00

abstract：:Cross-sectional and limited sequential studies of neutrophil and monocyte chemotaxis were done using cells isolated from cord blood and peripheral blood of 2- to 6-day-old neonates and infants at 4 and 6 months of age. These studies show that cord blood phagocyte chemotaxis is comparable to adult values, whereas phago...

journal_title：Journal of clinical immunology

authors： Raghunathan R,Miller ME,Everett S,Leake RD

更新日期：1982-07-01 00:00:00

abstract：:Serum amyloid P component (SAP) binds in vitro to DNA; based on findings in SAP-deficient mice it was proposed that SAP's role is to handle chromatin and DNA, thereby preventing formation of anti-DNA antibodies. For the first time we have shown the presence of Ca2+-dependent SAP-DNA complexes, measured by ELISA, in se...

journal_title：Journal of clinical immunology

authors： Sørensen IJ,Holm Nielsen E,Schrøder L,Voss A,Horváth L,Svehag SE

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Although interleukin-17 (IL-17) has been reported to participate in the pathogenesis of infectious, autoimmune and allergic disorders, the precise role in allograft rejection remains uncertain. This study illustrates that IL-17 contributes to the pathogenesis of chronic allograft rejection. RESULT:Utilizing...

journal_title：Journal of clinical immunology

authors： Itoh S,Nakae S,Axtell RC,Velotta JB,Kimura N,Kajiwara N,Iwakura Y,Saito H,Adachi H,Steinman L,Robbins RC,Fischbein MP

更新日期：2010-03-01 00:00:00

abstract：:The complement system plays a central role in defense to encapsulated bacteria through opsonization and membrane attack complex (MAC) dependent lysis. The three activation pathways (classical, lectin, and alternative) converge in the cleavage of C5, which initiates MAC formation and target lysis. C5 deficiency is asso...

journal_title：Journal of clinical immunology

authors： Colobran R,Franco-Jarava C,Martín-Nalda A,Baena N,Gabau E,Padilla N,de la Cruz X,Pujol-Borrell R,Comas D,Soler-Palacín P,Hernández-González M

更新日期：2016-05-01 00:00:00

abstract：:Leishmaniasis is caused by parasitic protozoa transmitted by the bite of a female sand fly and is currently endemic in 88 countries. BALB/c mice are highly susceptible to the infection with the parasite Leishmania major, and this susceptibility has been attributed, in part, to the expansion of Th2 cells, production of...

journal_title：Journal of clinical immunology

authors： Hosseini N,Abolhassani M

更新日期：2011-06-01 00:00:00

abstract：:Palifermin (recombinant human keratinocyte growth factor) prevents the development of acute, lethal graft-versus-host disease (GVHD). It does so, at least in part, by protecting cells from injury. Another property of Palifermin is immune regulation. How the latter influences the evolution of GVHD remains uncertain. We...

journal_title：Journal of clinical immunology

authors： Ellison CA,Gibson IW,Hayglass KT,Gartner JG

更新日期：2006-09-01 00:00:00

abstract：:COX2 (prostaglandin G/H synthase, PTGS2) is a well-validated target in the fields of both oncology and inflammation. Despite their significant toxicity profile, non-steroidal anti-inflammatory drugs (NSAIDs) have become standard of care in the treatment of many COX2-mediated inflammatory conditions. In this report, we...

journal_title：Journal of clinical immunology

authors： Ferguson GD,Jensen-Pergakes K,Wilkey C,Jhaveri U,Richard N,Verhelle D,De Parseval LM,Corral LG,Xie W,Morris CL,Brady H,Chan K

更新日期：2007-03-01 00:00:00

abstract：:Sixty patients (16 children, 44 adults) participated in the study aiming at evaluating: (i) IgG levels when switching patients from intravenous IgG (IVIG) infusions in hospital to subcutaneous (SCIG) self-infusions at home using the same cumulative monthly dose, (ii) protections against infections, and (iii) safety of...

journal_title：Journal of clinical immunology

authors： Gardulf A,Nicolay U,Asensio O,Bernatowska E,Böck A,Carvalho BC,Granert C,Haag S,Hernández D,Kiessling P,Kus J,Pons J,Niehues T,Schmidt S,Schulze I,Borte M

更新日期：2006-03-01 00:00:00

abstract：:Adiponectin is an adipocyte-derived cytokine with anti-inflammatory properties. Paradoxically, circulating adiponectin levels are increased in a number of inflammatory diseases. Thus, we sought to define the role of adiponectin deficiency in mouse models of autoimmunity. Adiponectin-deficient mice on a C57BL/6 backgro...

journal_title：Journal of clinical immunology

authors： Parker J,Menn-Josephy H,Laskow B,Takemura Y,Aprahamian T

更新日期：2011-04-01 00:00:00

abstract：PURPOSE:Adenosine deaminase (ADA) deficiency is a systemic disorder of purine metabolism. Deficiency of the purine salvage enzyme ADA leads to the build-up of the toxic metabolites, deoxyadenosine triphosphate and deoxyadenosine. ADA is ubiquitously expressed in all tissues of the body but most profoundly affects lymph...

journal_title：Journal of clinical immunology

authors： Nikolajeva O,Worth A,Hague R,Martinez-Alier N,Smart J,Adams S,Davies EG,Gaspar HB

更新日期：2015-05-01 00:00:00

abstract：INTRODUCTION:Rheumatic fever (RF) is an autoimmune disease caused by the gram-positive bacteria Streptococcus pyogenes that follows a nontreated throat infection in susceptible children. The disease manifests as polyarthritis, carditis, chorea, erythema marginatum, and/or subcutaneous nodules. Carditis, the most seriou...

journal_title：Journal of clinical immunology

authors： Guilherme L,Kalil J

更新日期：2010-01-01 00:00:00

abstract：:During the last five decades, elegant mouse models of hematopoiesis have yielded most of the seminal insights into this complex biological system of self-renewal and lineage commitment. More recent advances in assays to measure human stem and progenitor cells as well as high resolution RNA profiling have revealed that...

journal_title：Journal of clinical immunology

authors： Parekh C,Crooks GM

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:Different sets of warning signs can be used if primary immunodeficiency (PID) is suspected: those of the Jeffrey Modell Foundation (JMF), the German Patients' Organisation for Primary Immunodeficiencies (DSAI) and the Association of the Scientific Medical Societies in Germany (AWMF). A few studies have tested...

journal_title：Journal of clinical immunology

authors： Lankisch P,Schiffner J,Ghosh S,Babor F,Borkhardt A,Laws HJ

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:Nocardiosis is a life-threatening infectious disease. We aimed at describing nocardiosis in patients with primary immunodeficiency diseases (PID). METHODS:This international retrospective cohort included patients with PID and nocardiosis diagnosed and/or published from Jan 1, 2000, to Dec 31, 2016. To identify...

journal_title：Journal of clinical immunology

authors： Lafont E,Marciano BE,Mahlaoui N,Neven B,Bustamante J,Rodriguez-Nava V,Rawat A,Unzaga MJ,Fischer A,Blanche S,Lortholary O,Holland SM,Lebeaux D

更新日期：2020-11-01 00:00:00

abstract：:To better understand the role of Ia antigen expression, accessory cell function, and antigen ingestion in antigen presentation and the initiation of T cell proliferation, we studied these events in two acute monoblastic leukemia (AMoL) lines. The cell lines were positive for surface Ia antigen; one stimulated prolifer...

journal_title：Journal of clinical immunology

authors： Giller RH,Mori M,Hayward AR

更新日期：1984-11-01 00:00:00

abstract：:Sera from systemic lupus erythematosus (SLE) patients giving a fluorescent ribosomal pattern on tissue and cell preparations also showed precipitating autoantibodies against purified rat liver ribosomes. Ribosomal antigen is also present in rabbit thymus cellular extract (RTE), since the same sera gave precipitin line...

journal_title：Journal of clinical immunology

authors： Meroni PL,de Bartolo G,Barcellini W,Riboldi PS,Basile R,Betterle C,Zanussi C

更新日期：1984-01-01 00:00:00

abstract：INTRODUCTION:Major histocompatibility complex class II (MHC-II) expression deficiency is a combined primary immunodeficiency leading to the impairment of the cellular and humoral immune responses. A majority of affected patients belong to consanguineous families particularly from the Maghreb, where a founder effect for...

journal_title：Journal of clinical immunology

authors： Ben-Mustapha I,Ben-Farhat K,Guirat-Dhouib N,Dhemaied E,Larguèche B,Ben-Ali M,Chemli J,Bouguila J,Ben-Mansour L,Mellouli F,Khemiri M,Béjaoui M,Barbouche MR

更新日期：2013-05-01 00:00:00

abstract：:The biological differences between lymphocytes separated from thymoma patients with myasthenia gravis (MG) and those separated from thymoma patients without MG was examined. We investigated whether lymphocytes in thymoma (Th-L) of patients with and without MG could react to interleukin-2 (IL-2) to develop cytolytic ac...

journal_title：Journal of clinical immunology

authors： Takahashi K,Monden Y,Saito S,Kamamura Y,Uyama T

更新日期：1996-07-01 00:00:00

abstract：INTRODUCTION:Rheumatoid arthritis (RA) is a chronic inflammation disease that may involve extra-articular organs in addition to joints. Many proinflammatory cytokines are involved in the inflammatory process of RA. IkappaBalpha conjugates with NF-kappaB and is a key player in regulation of the inflammatory process. We ...

journal_title：Journal of clinical immunology

authors： Li RN,Hung YH,Lin CH,Chen YH,Yen JH

更新日期：2010-09-01 00:00:00

abstract：:Various factors seem to be etiologic in the susceptibility to sinopulmonary infections in ataxia-telangiectasia (A-T) patients, i.e., low serum and salivary IgA, low serum IgG2, and even aspiration of saliva. S. pneumoniae is a common pathogen responsible from pulmonary infections and impaired antibody response to pol...

journal_title：Journal of clinical immunology

authors： Sanal O,Ersoy F,Yel L,Tezcan I,Metin A,Ozyürek H,Gariboglu S,Fikrig S,Berkel AI,Rijkers GT,Zegers BJ

更新日期：1999-09-01 00:00:00

abstract：:A patient affected with multiple myeloma displayed in the serum, urine, and cerebrospinal fluid a paraprotein with identical electrophoretic mobility. The paraprotein, which was polymeric, appeared in the serum and cerebrospinal fluid mainly as the dimer and tetramer, whereas in the urine the tetramer was predominant....

journal_title：Journal of clinical immunology

authors： Bollengier F,Mahler A,Gillard A,Wijffels E

更新日期：1986-07-01 00:00:00