当前位置： SCI文献检索 > JOURNAL OF CLINICAL IMMUNOLOGY期刊下所有文献 > Prognostic Value of Blood-Based Inflammatory Biomarkers in Secondary Hemophagocytic Lymphohistiocytosis.

Prognostic Value of Blood-Based Inflammatory Biomarkers in Secondary Hemophagocytic Lymphohistiocytosis.

Abstract：

PURPOSE:Hemophagocytic lymphohistiocytosis (HLH) is a rare systematic immune disease manifested with excessive activation of lymphocytes and macrophages. This study was designed to explore the feasible prognostic factors of secondary HLH (sHLH). METHOD:We retrospectively analyzed 179 patients with newly diagnosed sHLH from January 2016 to May 2019 according to the HLH-2004 protocol. Baseline characteristics and laboratory results were reviewed. RESULTS:The median age of all patients was 53 years, with a male/female ratio of 1.45. The commonest cause of HLH was malignancy. Of the 179 patients, 48.6% presented with Epstein-Barr virus (EBV) infection, 92.8% with hemocytopenia (at least 2 lineages), 60.3% with hypofibrinogenemia, 43.0% with hypertriglyceridemia (≥ 3 mmol/L), 99.4% with high ferritin, 97.8% with fever, 72.1% with splenomegaly, and 72.6% with hemophagocytosis. As to their prognosis, 122 patients died; the median survival was 88 days, with a 2-year survival rate of 26.72%. Univariate analysis confirmed neutrophil-to-lymphocyte ratio ˃ 2.53, lymphocyte-to-monocyte ratio (LMR) ≤ 4.43, platelet-to-lymphocyte ratio ˃ 227.27, red blood cell distribution width ˃ 14.6, red blood cell distribution width-to-platelet ratio (RPR) > 0.33, EBV infection, platelet ≤ 34 × 109 /L, fibrinogen ≤ 1.34 g/L, alkaline phosphatase ˃ 182.4 U/L, adenosine deaminase ˃ 69.2 U/L, and ferritin ˃ 2318 ng/mL were associated with an inferior survival. In a multivariate model, LMR, RPR, and ferritin were considered as three independent factors. CONCLUSION:Some blood-based inflammatory markers, which can be easily and cheaply detected, are significantly associated with the OS of HLH patients. LMR and RPR, superior to NLR, PLR, RDW, can be taken to predict the OS of patients with HLH.

journal_name

J Clin Immunol

journal_title

Journal of clinical immunology

authors

Huang J,Yin G,Duan L,Tian T,Xu J,Wang J,Gao X,Cheng W,Liu L,Qiu H

doi

10.1007/s10875-020-00801-x

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

718-728

issue

5

eissn

0271-9142

issn

1573-2592

pii

10.1007/s10875-020-00801-x

journal_volume

40

pub_type

杂志文章

相关文献

JOURNAL OF CLINICAL IMMUNOLOGY文献大全
  • Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee.

    abstract：:We report the updated classification of Inborn Errors of Immunity/Primary Immunodeficiencies, compiled by the International Union of Immunological Societies Expert Committee. This report documents the key clinical and laboratory features of 430 inborn errors of immunity, including 64 gene defects that have either been...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-019-00737-x

    authors： Tangye SG,Al-Herz W,Bousfiha A,Chatila T,Cunningham-Rundles C,Etzioni A,Franco JL,Holland SM,Klein C,Morio T,Ochs HD,Oksenhendler E,Picard C,Puck J,Torgerson TR,Casanova JL,Sullivan KE

    更新日期：2020-01-01 00:00:00

  • Glucocorticoid regulates interleukin-37 in systemic lupus erythematosus.

    abstract：:The aim of this study was to research the expression of IL-37 in systemic lupus erythematosus (SLE) patients and the effect of glucocorticoid on IL-37. Thirty newly diagnosed severe SLE patients receiving prednisone 1 mg/kg/day for 14 consecutive days and 30 healthy subjects were enrolled into this study. The plasma l...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-012-9791-z

    authors： Song L,Qiu F,Fan Y,Ding F,Liu H,Shu Q,Liu W,Li X

    更新日期：2013-01-01 00:00:00

  • N-acetylcysteine administration is associated with reduced activation of NF-kB and preserves lung dendritic cells function in a zymosan-induced generalized inflammation model.

    abstract：PURPOSE:In severe sepsis, functional impairment and decreased numbers of dendritic cells (DCs) are essential reasons for immune function paralysis, secondary organ infection, and organ failure. We investigated the effects of N-acetylcysteine (NAC) administration on protecting lung DCs function in a zymosan-induced gene...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-012-9852-3

    authors： Wang HW,Yang W,Lu JY,Li F,Sun JZ,Zhang W,Guo NN,Gao L,Kang JR

    更新日期：2013-04-01 00:00:00

  • Frequent anti-V-region immune response to mouse B72.3 monoclonal antibody.

    abstract：:The immune response of 56 colorectal cancer patients to a single infusion of 1 mg of radiolabeled (111In) mouse B72.3-GYK-DTPA immunoconjugate was examined using a double-antigen radiometric assay system. The incidence of antibody response was 48% to polyclonal mouse IgG, 71% to mouse B72.3, and 62% to chimeric B72.3....

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00918141

    authors： Khazaeli MB,Saleh MN,Liu T,Kaladas PM,Gilman SC,LoBuglio AF

    更新日期：1992-03-01 00:00:00

  • Disorders of apoptosis: mechanisms for autoimmunity in primary immunodeficiency diseases.

    abstract：:A number of primary immunodeficiency diseases represent a paradox of immunodeficiency and autoimmunity. In this minireview, we present basic concepts of apoptosis and disorder of apoptosis as one of the mechanisms to explain such a paradox between immunodeficiency and autoimmunity, which is exemplified by autoimmune l...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章,评审

    doi：10.1007/s10875-007-9161-4

    authors： Oliveira JB,Gupta S

    更新日期：2008-05-01 00:00:00

  • Th22, but not Th17 might be a good index to predict the tissue involvement of systemic lupus erythematosus.

    abstract：PURPOSE:T-helper (Th) cells abnormalities are considered to be associated with the pathogenesis of Systemic lupus erythematosus (SLE). Recently, The Th22 cells have been identified and implicated in the pathogenesis of autoimmune diseases such as Rheumatoid arthritis (RA), although therir role in Systemic lupus erythem...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-013-9878-1

    authors： Yang XY,Wang HY,Zhao XY,Wang LJ,Lv QH,Wang QQ

    更新日期：2013-05-01 00:00:00

  • Subset markers of CD8(+) cells and their relation to enhanced cytotoxic T-cell activity during human immunodeficiency virus infection.

    abstract：:Using fresh whole blood or isolated lymphocytes, the activity of in vivo generated cytotoxic T-lymphocytes (CTL) was measured as the OKT3-specific lysis of HL-60 targets, in a cross-sectional study of 53 HIV (+) patients. CTL activity in the entire HIV(+) group was two to three times higher than in HIV(-) controls, wi...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00918800

    authors： Vanham G,Kestens L,Penne G,Goilav C,Gigase P,Colebunders R,Vandenbruaene M,Goeman J,van der Groen G,Ceuppens JL

    更新日期：1991-11-01 00:00:00

  • Expression of immunoglobulin genes in common variable immunodeficiency.

    abstract：:Five common variable immunodeficiency (CVI) patients were analyzed for expression of immunoglobulin (Ig) genes. In the pokeweed mitogen (PWM)-induced Ig-production assay, the combination of T and B cells showed that all patients' T cells had normal helper functions and all patients' B cells had profound defects. The d...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00918184

    authors： Kaneko H,Kondo N,Motoyoshi F,Mori S,Kobayashi Y,Inoue Y,Orii T

    更新日期：1991-09-01 00:00:00

  • Purified native and recombinant human alpha lymphotoxin [tumor necrosis factor (TNF)-beta] induces inflammatory reactions in normal skin.

    abstract：:These studies report findings that demonstrate that human alpha lymphotoxin (LT) induces local, visible, and microscopic inflammatory reactions in normal skin. Skin sites in rabbits, when inoculated with a single injection of native or recombinant human alpha lymphotoxin, demonstrated erythema, swelling, and warmth wi...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00915556

    authors： Averbook BJ,Yamamoto RS,Ulich TR,Jeffes EW,Masunaka I,Granger GA

    更新日期：1987-07-01 00:00:00

  • Ethnic differences in DNA methyltransferases expression in patients with systemic lupus erythematosus.

    abstract：PURPOSE:Systemic lupus erythematous (SLE) is a systemic autoimmune inflammatory disease with both genetic and epigenetic etiologies. Evidence suggests that deregulation of specific genes through epigenetic mechanisms may be a contributing factor to SLE pathology. There is increasing evidence that DNA methyltransferase ...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-012-9803-z

    authors： Wiley KL,Treadwell E,Manigaba K,Word B,Lyn-Cook BD

    更新日期：2013-02-01 00:00:00

  • Lymphotoxin detected in the blister fluid of bullous pemphigoid patients.

    abstract：:The role of lymphocytes in the pathogenesis of bullous pemphigoid was examined by assaying the blister fluid obtained from bullous pemphigoid patients for the presence of the lymphokine, lymphotoxin. Blister fluids from six bullous pemphigoid were assayed on L-929 target cells for the presence of cytolytic molecules i...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00915284

    authors： Jeffes EW,Yamamoto RS,Ahmed AR,Granger GA

    更新日期：1984-01-01 00:00:00

  • Infectious and immunologic phenotype of MECP2 duplication syndrome.

    abstract：:MECP2 (methyl CpG binding protein 2) duplication causes syndromic intellectual disability. Patients often suffer from life-threatening infections, suggesting an additional immunodeficiency. We describe for the first time the detailed infectious and immunological phenotype of MECP2 duplication syndrome. 17/27 analyzed ...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-015-0129-5

    authors： Bauer M,Kölsch U,Krüger R,Unterwalder N,Hameister K,Kaiser FM,Vignoli A,Rossi R,Botella MP,Budisteanu M,Rosello M,Orellana C,Tejada MI,Papuc SM,Patat O,Julia S,Touraine R,Gomes T,Wenner K,Xu X,Afenjar A,Toutain

    更新日期：2015-02-01 00:00:00

  • Dual analysis for mycobacteria and propionibacteria in sarcoidosis BAL.

    abstract：PURPOSE:Sarcoidosis is a non-caseating granulomatous disease for which a role for infectious antigens continues to strengthen. Recent studies have reported molecular evidence of mycobacteria or propionibacteria. We assessed for immune responses against mycobacterial and propionibacterial antigens in sarcoidosis broncho...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-012-9700-5

    authors： Oswald-Richter KA,Beachboard DC,Seeley EH,Abraham S,Shepherd BE,Jenkins CA,Culver DA,Caprioli RM,Drake WP

    更新日期：2012-10-01 00:00:00

  • Primary immunodeficiency diseases in Latin America: first report from eight countries participating in the LAGID. Latin American Group for Primary Immunodeficiency Diseases.

    abstract：:The Latin American Group for Primary Immunodeficiencies, formed in 1993, presently includes 12 countries. One goal was to study the frequency of primary immunodeficiencies in various regions of the American continent and to enhance knowledge about these diseases among primary-care physicians, as well as allergist-immu...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1023/a:1023255102170

    authors： Zelazko M,Carneiro-Sampaio M,Cornejo de Luigi M,Garcia de Olarte D,Porras Madrigal O,Berrón Perez R,Cabello A,Rostan MV,Sorensen RU

    更新日期：1998-03-01 00:00:00

  • Disseminated Cryptococcosis Due to Anti-Granulocyte-Macrophage Colony-Stimulating Factor Autoantibodies in the Absence of Pulmonary Alveolar Proteinosis.

    abstract：INTRODUCTION:Autoantibodies to granulocyte-macrophage colony-stimulating factor (GM-CSF) can cause acquired pulmonary alveolar proteinosis (PAP). Cases of acquired PAP susceptible to typical respiratory pathogens and opportunistic infections have been reported. Anti-GM-CSF autoantibodies have been reported in a few pat...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-016-0364-4

    authors： Kuo CY,Wang SY,Shih HP,Tu KH,Huang WC,Ding JY,Lin CH,Yeh CF,Ho MW,Chang SC,He CY,Chen HK,Ho CH,Lee CH,Chi CY,Ku CL

    更新日期：2017-02-01 00:00:00

  • Inhibition of the release of soluble tumor necrosis factor receptors in experimental endotoxemia by an anti-tumor necrosis factor-alpha antibody.

    abstract：:The role of tumor necrosis factor-alpha in the shedding of soluble tumor necrosis factor receptors in endotoxemia was investigated. The appearance of the soluble tumor necrosis factor receptors was assessed in four healthy volunteers following an intravenous injection of tumor necrosis factor-alpha and in eight chimpa...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF01489489

    authors： Jansen J,van der Poll T,Levi M,ten Cate H,Gallati H,ten Cate JW,van Deventer SJ

    更新日期：1995-01-01 00:00:00

  • Decreased serum levels of TGF-beta in patients with acute Plasmodium falciparum malaria.

    abstract：:Apart from cellular immunity and immunopathology, various cytokines have been implicated in malaria-associated immunosuppression. In this study, serum levels of transforming growth factor-beta (TGF-beta) were determined with an enzyme-linked immunosorbent assay in 37 patients with acute Plasmodium falciparum malaria p...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF01541734

    authors： Wenisch C,Parschalk B,Burgmann H,Looareesuwan S,Graninger W

    更新日期：1995-03-01 00:00:00

  • 15-deoxy-Delta(12,14)-prostaglandin J(2) and curcumin modulate the expression of toll-like receptors 4 and 9 in autoimmune T lymphocyte.

    abstract：INTRODUCTION:Experimental allergic encephalomyelitis (EAE) is a T cell-mediated autoimmune disease model for multiple sclerosis (MS). We have shown earlier that 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) and curcumin ameliorate EAE by modulating inflammatory signaling pathways in T lymphocytes. Toll-like rec...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-008-9202-7

    authors： Chearwae W,Bright JJ

    更新日期：2008-09-01 00:00:00

  • Immunological functions and phenotypes of peripheral blood lymphocytes from human T-cell leukemia virus-I carriers.

    abstract：:We studied immunological functions of peripheral blood lymphocytes (PBL) from human T-cell leukemia virus type I (HTLV-I)-seropositive healthy carriers in vitro. Proliferative responses of PBL to T-cell and B-cell mitogens such as concanavalin A (Con A), pokeweed mitogen (PWM), and Staphylococcus aureus Cowan I (SAC) ...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00918017

    authors： Tanaka Y,Oda S,Nagata K,Mori N,Sakamoto H,Eto S,Yamashita U

    更新日期：1989-11-01 00:00:00

  • NK 1.1+ T cell: a two-faced lymphocyte in immune modulation of the IL-4/IFN-gamma paradigm.

    abstract：:T lymphocytes expressing NK1.1 marker (NK1.1+) have been suggested as being important in peripheral immune modulation. Alteration of the balance between Th1 proinflammatory and Th2 anti-inflammatory cytokine-producing cells can ameliorate immune-mediated disorders. The aim of the study was to determine the role of NK1...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1023/a:1019974005134

    authors： Trop S,Ilan Y

    更新日期：2002-09-01 00:00:00

  • TLR-mediated B cell defects and IFN-α in common variable immunodeficiency.

    abstract：:Common variable immune deficiency (CVID) B cells have impaired responses to TLR7 and TLR9 agonists including poor cell proliferation, loss of cytokine production, and failure to produce IgG or IgA. We show that TLR7- or 9-activated B cells from CVID subjects with >0.5% peripheral isotype-switched CD27(+) B cells (grou...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-011-9602-y

    authors： Yu JE,Zhang L,Radigan L,Sanchez-Ramon S,Cunningham-Rundles C

    更新日期：2012-02-01 00:00:00

  • Macrophage T-cell interaction in man: handling of tetanus toxoid antigen by human monocytes.

    abstract：:An absolute requirement for monocytes was demonstrated in the T-cell proliferative response to tetanus toxoid (TT) antigen. Antigen-pulsed monocytes were shown to be effective in triggering T-cell proliferation. Using 125I-radiolabeled TT antigen, uptake by monocytes increased progressively over an 18-hr period, at wh...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00915473

    authors： Alpert SD,Jonsen ME,Broff MD,Schneeberger E,Geha RS

    更新日期：1981-01-01 00:00:00

  • Anti-SM and anti-U1-RNP lupus antibody fine specificities.

    abstract：:Evidence for the presence of multiple shared epitopes on the target cellular antigens was found when 290 anti-Sm and anti-U1-RNP lupus sera were analyzed by immunoblotting. Forty-eight different immunoblot patterns were observed with the sera. Studies with selected antigen-affinity-purified antibodies confirmed the pr...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00916822

    authors： Francoeur AM

    更新日期：1989-05-01 00:00:00

  • Effect of IL-2 therapy on CD8+ cell noncytotoxic anti-HIV response during primary HIV-1 infection.

    abstract：:Early treatment intervention during human immunodeficiency virus (HIV) infection is a strategy aimed to preserve and/or enhance the developing anti-HIV immune responses. We report the effect of highly active antiretroviral therapy (HAART) combined with intermittent subcutaneous doses of Interleukin 2 (IL-2) on CD8(+) ...

    journal_title：Journal of clinical immunology

    pub_type： 临床试验,杂志文章

    doi：10.1023/B:JOCI.0000019778.96564.26

    authors： Martinez-Mariño B,Ashlock BM,Shiboski S,Hecht FM,Levy JA

    更新日期：2004-03-01 00:00:00

  • Cells resistant to cytotoxic drugs are recognized by monoclonal antibody.

    abstract：:A monoclonal antibody produced by hybridomas obtained from a mouse immunized with drug-resistant cells recognizes certain hamster and human drug-resistant cell lines but not their drug-sensitive parental lines. Preliminary characterization of the antigen indicates that it is a molecule of approximately 180,000 daltons...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00917144

    authors： O'Hara CJ,Grover J,Price GB

    更新日期：1984-09-01 00:00:00

  • Clinical and immunological studies in patients with an increased serum IgD level.

    abstract：:Increased levels of serum IgD can be found in single patients with a variety of clinical syndromes and in the disease entity designated hyper-IgD syndrome which is associated with periodic fever and lymphadenopathy. We investigated 17 patients, both children and adults, with high serum IgD levels ranging from 220 to 5...

    journal_title：Journal of clinical immunology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1007/BF00917104

    authors： Hiemstra I,Vossen JM,van der Meer JW,Weemaes CM,Out TA,Zegers BJ

    更新日期：1989-09-01 00:00:00

  • DNA methylation and the expression of IL-4 and IFN-gamma promoter genes in patients with bronchial asthma.

    abstract：:Although CpG methylation is thought to be a negative regulator of gene transcription, its relationship with cytokine expression remains unclear. Interleukin (IL)-4 and interferon (IFN)-gamma are major cytokines that affect the differentiation of naïve CD4+ T lymphocytes into the Th1 and Th2 lineage. We used bisulfite ...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-007-9148-1

    authors： Kwon NH,Kim JS,Lee JY,Oh MJ,Choi DC

    更新日期：2008-03-01 00:00:00

  • Chronic enteroviral meningoencephalitis in agammaglobulinemia: case report and literature review.

    abstract：:Chronic enteroviral meningoencephalitis is a well-recognized complication in patients with X-linked agammaglobulinemia (XLA). The majority of published cases refers to its occurrence in patients on no replacement therapy or on only intramuscular immunoglobulin. The advent of intravenous immunoglobulin (IVIg) in the ea...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章,评审

    doi：10.1007/BF00918150

    authors： Misbah SA,Spickett GP,Ryba PC,Hockaday JM,Kroll JS,Sherwood C,Kurtz JB,Moxon ER,Chapel HM

    更新日期：1992-07-01 00:00:00

  • The presence of anti-carcinoembryonic antigen (CEA) antibodies in the sera of patients with gastrointestinal malignancies.

    abstract：:Using an enzyme-linked immunoassay we tested the sera of 71 patients with digestive system cancer, 35 patients with various nonmalignant disorders, and 28 normal individuals for anti-CEA activity. Antibodies were found in the sera of 51% of the patients. Most of the patients positive for the antibodies (70%) had no ev...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF01540984

    authors： Konstadoulakis MM,Syrigos KN,Albanopoulos C,Mayers G,Golematis B

    更新日期：1994-09-01 00:00:00

  • Palifermin mediates immunoregulatory effects in addition to its cytoprotective effects in mice with acute graft-versus-host disease.

    abstract：INTRODUCTION:Treating recipient mice with palifermin (recombinant human keratinocyte growth factor) prevents the development of acute, lethal, graft-versus-host disease (GVHD). This is due, at least in part, to the ability of palifermin to protect epithelial cells from injury. Using the C57BL/6-->(C57BL/6 x DBA/2)F(1)-...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-008-9216-1

    authors： Ellison CA,Makar BM,Wiseman JM,Gheorghiu I,Taniguchi M,Gartner JG

    更新日期：2008-09-01 00:00:00