Primary immunodeficiency diseases in Latin America: first report from eight countries participating in the LAGID. Latin American Group for Primary Immunodeficiency Diseases.

Abstract:

:The Latin American Group for Primary Immunodeficiencies, formed in 1993, presently includes 12 countries. One goal was to study the frequency of primary immunodeficiencies in various regions of the American continent and to enhance knowledge about these diseases among primary-care physicians, as well as allergist-immunologists. Important for this purpose was the development of a registry of primary immunodeficiencies using a uniform questionnaire and computerized database. To date, eight countries have collected information on a total of 1428 patients. Predominantly antibody deficiencies were reported in 58% of patients, followed by cellular and antibody immunodeficiencies associated with other abnormalities in 18%, immunodeficiency syndromes associated with granulocyte dysfunction in 8%, phagocytic disorders in 9%, combined cellular and antibody immunodeficiencies in 5%, and complement deficiencies in 2% of patients. The information gathered from this initial analysis of data will serve to expand the patient database to more areas within participating countries and to new countries and to increase collaboration toward better diagnosis and treatment of these diseases.

journal_name

J Clin Immunol

authors

Zelazko M,Carneiro-Sampaio M,Cornejo de Luigi M,Garcia de Olarte D,Porras Madrigal O,Berrón Perez R,Cabello A,Rostan MV,Sorensen RU

doi

10.1023/a:1023255102170

subject

Has Abstract

pub_date

1998-03-01 00:00:00

pages

161-6

issue

2

eissn

0271-9142

issn

1573-2592

journal_volume

18

pub_type

杂志文章
  • Molecular steps of cell suicide: an insight into immune senescence.

    abstract::The cellular and molecular basis of immune senescence is unclear. A number of mechanisms have been proposed. In this issue of the Journal of Clinical Immunology, some of the mechanisms for various immunologic abnormalities in aging are presented. In this article, various molecular steps of both death receptor and mito...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1023/a:1006653917314

    authors: Gupta S

    更新日期:2000-07-01 00:00:00

  • I kappa B alpha promoter polymorphisms in patients with systemic lupus erythematosus.

    abstract::To investigate the associations of IkappaBalpha gene polymorphisms with the development and clinical manifestations of systemic lupus erythematosus (SLE), 110 patients with SLE and 120 unrelated healthy controls were enrolled in this study. The IkappaBalpha -881 A/G, -826 C/T, -550 A/T, -519 C/T, and -297 C/T polymorp...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-007-9156-1

    authors: Lin CH,Wang SC,Ou TT,Li RN,Tsai WC,Liu HW,Yen JH

    更新日期:2008-05-01 00:00:00

  • Autologous human cytomegalovirus-specific cytotoxic T cells as rescue therapy for ulcerative enteritis in primary immunodeficiency.

    abstract:PURPOSE:Patients affected by primary immunodeficiency usually undergo a wide range of infections, including reactivation of latent ones. Here we report two cases suffering from late-onset combined immunodeficiency in which ulcerative enteritis due to human Cytomegalovirus caused a life-threatening malabsorption syndrom...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-014-0060-1

    authors: Ciccocioppo R,Comoli P,Gallia A,Basso S,Baldanti F,Corazza GR

    更新日期:2014-08-01 00:00:00

  • Distinctive patterns of release of neuroendocrine peptides after nasal challenge of allergic subjects with ryegrass antigen.

    abstract::The concentrations of the neuropeptides substance P, somatostatin, and calcitonin gene-related peptide in human nasal secretions were quantified by radioimmunoassays, concurrently with that of histamine, in the course of nasal challenge of allergic and control subjects with ryegrass antigen to examine contributions of...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/BF00917898

    authors: Walker KB,Serwonska MH,Valone FH,Harkonen WS,Frick OL,Scriven KH,Ratnoff WD,Browning JG,Payan DG,Goetzl EJ

    更新日期:1988-03-01 00:00:00

  • Characterizing the immune system after long-term undetectable viral load in HIV-1-infected children.

    abstract::Thirty two HIV-infected children, on highly active antiretroviral therapy (HAART) and > 500 CD4+ T cells/mm3, were rated according to the time-course of viral load (VL) during the whole follow-up period (> 18 months) in a longitudinal retrospective study. (a) uVL group: 15 children with VL below 400 copies/mL; (b) dVL...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1023/a:1024536816684

    authors: Resino S,Galán I,Bellón JM,Navarro ML,León JA,Muñoz-Fernandez MA

    更新日期:2003-07-01 00:00:00

  • Glucocorticoid regulates interleukin-37 in systemic lupus erythematosus.

    abstract::The aim of this study was to research the expression of IL-37 in systemic lupus erythematosus (SLE) patients and the effect of glucocorticoid on IL-37. Thirty newly diagnosed severe SLE patients receiving prednisone 1 mg/kg/day for 14 consecutive days and 30 healthy subjects were enrolled into this study. The plasma l...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-012-9791-z

    authors: Song L,Qiu F,Fan Y,Ding F,Liu H,Shu Q,Liu W,Li X

    更新日期:2013-01-01 00:00:00

  • The transfer of antigen-specific humoral immunity from marrow donors to marrow recipients.

    abstract::This study shows that specific humoral immunity could be transferred from marrow donors to marrow recipients. Peripheral blood lymphocytes from long-term human marrow recipients produced IgG anti-tetanus toxoid antibody after in vitro tetanus toxoid stimulation. Antitetanus toxoid antibody biosynthesis was induced usi...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/BF00915378

    authors: Lum LG,Seigneuret MC,Storb R

    更新日期:1986-09-01 00:00:00

  • Activation profile of intracellular mitogen-activated protein kinases in peripheral lymphocytes of patients with systemic lupus erythematosus.

    abstract:INTRODUCTION:Systemic lupus erythematosus (SLE) is a systemic autoimmune disease associated with aberrant activation of T and B lymphocytes. Abnormal activation of intracellular signaling molecules in lymphocytes by inflammatory cytokines can instigate the inflammation in SLE. MATERIALS AND METHODS:The activation of e...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-009-9318-4

    authors: Wong CK,Wong PT,Tam LS,Li EK,Chen DP,Lam CW

    更新日期:2009-11-01 00:00:00

  • Lysophosphatidylethanolamine is the antigen to which apparent antibody to phosphatidylethanolamine binds.

    abstract::Because binding of antiphospholipid antibody (aPL) to phosphatidylethanolamine (PE) is central to the definition of the antigenic epitope targeted by aPLs, we examined the binding of aPL-positive SLE sera to PE under various conditions. No serum bound to PE uncontaminated with lysophosphatidylethanolamine (1PE), but m...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/BF00918652

    authors: Qamar T,Gharavi AE,Levy RA,Lockshin MD

    更新日期:1990-07-01 00:00:00

  • A novel pathogenic variant in PRF1 associated with hemophagocytic lymphohistiocytosis.

    abstract::Familial Hemophagocytic Lymphohistiocytosis type 2 (FHL2) results from mutations in PRF1. We described two unrelated individuals who presented with FHL, in whom severely impaired NK cytotoxicity and decrease perforin expression was observed. DNA sequencing of PRF1 demonstrated that both were not only heterozygous for ...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-015-0169-x

    authors: Romero CA,Sánchez IP,Gutierrez-Hincapié S,Álvarez-Álvarez JA,Pereañez JA,Ochoa R,Muskus-López CE,Eraso RG,Echeverry C,Arango C,Restrepo JL,Trujillo-Vargas CM

    更新日期:2015-07-01 00:00:00

  • Molecular characterization of complement components (C3, C4, and factor B) in human saliva.

    abstract::A molecular analysis of complement components (C3, C4, and factor B) in human saliva was performed by SDS-PAGE and immunoblotting. Complement C3 was detected as a molecule composed of a 115-kDa alpha-chain linked to a 70-kDa beta chain by disulfide bonds, and C3 levels ranged from 0.52 to 15.0 micrograms/ml (n = 15). ...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1023/a:1027320425291

    authors: Andoh A,Fujiyama Y,Kimura T,Uchihara H,Sakumoto H,Okabe H,Bamba T

    更新日期:1997-09-01 00:00:00

  • Effect of lidocaine on neutrophil chemotaxis in newborn infants.

    abstract::Anesthetic drugs can influence the immune system, particularly granulocyte function. The goal of the present study was to evaluate if lidocaine used for epidural anesthesia during cesarean section can influence neonatal neutrophil chemotaxis. We measured chemotaxis and plasma cord lidocaine and cortisol levels in (A) ...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1023/a:1020583022614

    authors: Gasparoni A,De Amici D,Ciardelli L,Autelli M,Regazzi-Bonora M,Bartoli A,Chirico G,Rondini G

    更新日期:1998-05-01 00:00:00

  • The Elements Steering Pathogenesis in IgG-Mediated Alloimmune Diseases.

    abstract::Alloimmune diseases can occur in pregnancy and after blood transfusions, where antibodies are formed, targeting foreign cells and tissues for destruction by myeloid cells through IgG Fc-receptors (FcγR). In pregnancy, antibodies against human blood group or platelet antigens (e.g. HPA1-a) cause life-threatening anemia...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1007/s10875-016-0253-x

    authors: Sonneveld ME,van der Schoot CE,Vidarsson G

    更新日期:2016-05-01 00:00:00

  • Purified native and recombinant human alpha lymphotoxin [tumor necrosis factor (TNF)-beta] induces inflammatory reactions in normal skin.

    abstract::These studies report findings that demonstrate that human alpha lymphotoxin (LT) induces local, visible, and microscopic inflammatory reactions in normal skin. Skin sites in rabbits, when inoculated with a single injection of native or recombinant human alpha lymphotoxin, demonstrated erythema, swelling, and warmth wi...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/BF00915556

    authors: Averbook BJ,Yamamoto RS,Ulich TR,Jeffes EW,Masunaka I,Granger GA

    更新日期:1987-07-01 00:00:00

  • Clinical manifestations of disease in X-linked carriers of chronic granulomatous disease.

    abstract::Chronic Granulomatous Disease (CGD) is a rare primary immunodeficiency due to a defect in one of the NADPH oxidase complex subunits; 70 % of cases are X-linked, due to a CYBB mutation, resulting in defective production of gp91PHOX. Female carriers of X-linked CGD have previously been considered to be unaffected. It is...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1007/s10875-013-9939-5

    authors: Battersby AC,Cale AM,Goldblatt D,Gennery AR

    更新日期:2013-11-01 00:00:00

  • Switching Patients to Home-Based Subcutaneous Immunoglobulin: an Economic Evaluation of an Interprofessional Drug Therapy Management Program.

    abstract:PURPOSE:Home-based subcutaneous immunoglobulin (SCIg) therapy is an alternative to hospital-based intravenous infusions (IVIg). However, SCIg requires patient training and long-term support to ensure proper adherence, optimal efficacy and safety. We evaluated if switching patients to home-based SCIg including an interp...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-016-0288-z

    authors: Perraudin C,Bourdin A,Spertini F,Berger J,Bugnon O

    更新日期:2016-07-01 00:00:00

  • Glucocorticoid sensitivity and proinflammatory cytokines pattern in pemphigus.

    abstract::Glucocorticoids (GC) represent the main treatment for pemphigus; however, some patients show GC resistance. GC sensitivity was evaluated in 19 pemphigus patients and 41 controls by the number of binding sites [B(max) (fmol/mg protein)] and the affinity of GC receptor [Kd (nM)] to dexamethasone (DEX) as well as by the ...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-012-9679-y

    authors: Chriguer RS,Roselino AM,de Castro M

    更新日期:2012-08-01 00:00:00

  • Antigen-specific expansion of TCR Vbeta3+ CD4+ T cells in the early stage of collagen-induced arthritis and its arthritogenic role in DBA/1J mice.

    abstract::To investigate type II collagen (CII)-specific CD4+ T cell receptors involving in Collagen-induced arthritis (CIA) in DBA/1J mice as a model of rheumatoid arthritis in humans, TCR Vbeta usage in draining lymph nodes (dLNs) was assessed by flow cytometric analysis at 3, 5, and 8 weeks after bovine CII immunizations. In...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-006-9012-8

    authors: Lee JS,Cho ML,Jhun JY,Min SY,Ju JH,Yoon CH,Min JK,Park SH,Kim HY,Cho YG

    更新日期:2006-05-01 00:00:00

  • Anti-SM and anti-U1-RNP lupus antibody fine specificities.

    abstract::Evidence for the presence of multiple shared epitopes on the target cellular antigens was found when 290 anti-Sm and anti-U1-RNP lupus sera were analyzed by immunoblotting. Forty-eight different immunoblot patterns were observed with the sera. Studies with selected antigen-affinity-purified antibodies confirmed the pr...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/BF00916822

    authors: Francoeur AM

    更新日期:1989-05-01 00:00:00

  • Effect of hyperoxia on pulmonary SIgA and its components, IgA and SC.

    abstract:PURPOSE:Oxygen therapy (hyperoxia) is essential for the treatment of some neonatal critical care conditions. The lung is the primary target for the changes induced by hyperoxia. Secretory immunoglobulin A (SIgA), IgA and secretory component (SC) reflect the local immunity in the respiratory tract induced by hyperoxia. ...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-013-9891-4

    authors: Liu DY,Jiang T,Wang S,Cao X

    更新日期:2013-07-01 00:00:00

  • Overview of routes of IgG administration.

    abstract::The use of exogenous serum to provide protection against infections began more than a century ago. Over time, this concept matured and led to the preparation of concentrated immunoglobulin (IgG) products that were safe and effective when delivered subcutaneously (SC) or intramuscularly (IM) but were not ideal for intr...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1007/s10875-012-9845-2

    authors: Torgerson TR

    更新日期:2013-01-01 00:00:00

  • Inhibition of the release of soluble tumor necrosis factor receptors in experimental endotoxemia by an anti-tumor necrosis factor-alpha antibody.

    abstract::The role of tumor necrosis factor-alpha in the shedding of soluble tumor necrosis factor receptors in endotoxemia was investigated. The appearance of the soluble tumor necrosis factor receptors was assessed in four healthy volunteers following an intravenous injection of tumor necrosis factor-alpha and in eight chimpa...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/BF01489489

    authors: Jansen J,van der Poll T,Levi M,ten Cate H,Gallati H,ten Cate JW,van Deventer SJ

    更新日期:1995-01-01 00:00:00

  • C5 complement deficiency in a Saudi family, molecular characterization of mutation and literature review.

    abstract:INTRODUCTION:Complement deficiencies are rare primary immunodeficiency disorders, the diagnosis of which is often underestimated. Only a small number of molecular studies have been carried out for the characterization of the underlying genetic defects in these cases. PURPOSE:Reporting the first family from the Arabian...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1007/s10875-013-9872-7

    authors: Arnaout R,Al Shorbaghi S,Al Dhekri H,Al-Mousa H,Al Ghonaium A,Al Saud B,Al Muhsen S,Al Baik L,Hawwari A

    更新日期:2013-05-01 00:00:00

  • A novel missense mutation in the nuclear factor-κB essential modulator (NEMO) gene resulting in impaired activation of the NF-κB pathway and a unique clinical phenotype presenting as MRSA subdural empyema.

    abstract:INTRODUCTION:We describe a previously unreported 437 T→G missense mutation producing a V146G substitution in the first coiled-coil (CC1) domain of nuclear factor-κB essential modulator (NEMO) in a 9-month-old boy with ectodermal dysplasia with immunodeficiency who presented with methicillin-resistant Staphylococcus aur...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-010-9445-y

    authors: Devora GA,Sun L,Chen Z,van Oers NS,Hanson EP,Orange JS,de la Morena MT

    更新日期:2010-11-01 00:00:00

  • Recurrent Respiratory Infections Revealing CD8α Deficiency.

    abstract::CD8A encodes the CD8α chain of the dimeric CD8 protein, a critical coreceptor of cytotoxic T cells. We report here the comprehensive immunological evaluation of a child with a CD8A missense mutation, providing evidence that CD8 deficiency increases susceptibility to recurrent respiratory infections without interfering...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-015-0213-x

    authors: Dumontet E,Osman J,Guillemont-Lambert N,Cros G,Moshous D,Picard C

    更新日期:2015-11-01 00:00:00

  • Catecholamines induce alterations of distribution and activity of human natural killer (NK) cells.

    abstract::Catecholamines have been suggested to be responsible for altered cellular immunity after stress. This study was performed to determine the effects of adrenaline and noradrenaline on lymphocyte subpopulations and NK cell functions. Subjects were given a subcutaneous injection of either NaCl, adrenaline (5 micrograms/kg...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/BF00920243

    authors: Schedlowski M,Falk A,Rohne A,Wagner TO,Jacobs R,Tewes U,Schmidt RE

    更新日期:1993-09-01 00:00:00

  • Newborn screening for severe combined immunodeficiency; the Wisconsin experience (2008-2011).

    abstract::Severe combined immunodeficiency is a life-threatening primary immune deficiency characterized by low numbers of naïve T cells. Early diagnosis and treatment of this disease decreases mortality. In 2008, Wisconsin began newborn screening of infants for severe combined immunodeficiency and other forms of T-cell lymphop...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-011-9609-4

    authors: Verbsky JW,Baker MW,Grossman WJ,Hintermeyer M,Dasu T,Bonacci B,Reddy S,Margolis D,Casper J,Gries M,Desantes K,Hoffman GL,Brokopp CD,Seroogy CM,Routes JM

    更新日期:2012-02-01 00:00:00

  • A 1-Year Prospective French Nationwide Study of Emergency Hospital Admissions in Children and Adults with Primary Immunodeficiency.

    abstract:PURPOSE:Patients with primary immunodeficiency (PID) are at risk of serious complications. However, data on the incidence and causes of emergency hospital admissions are scarce. The primary objective of the present study was to describe emergency hospital admissions among patients with PID, with a view to identifying "...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-019-00658-9

    authors: Coignard-Biehler H,Mahlaoui N,Pilmis B,Barlogis V,Brosselin P,De Vergnes N,Debré M,Malphettes M,Frange P,Catherinot E,Pellier I,Durieu I,Perlat A,Royer B,Le Quellec A,Jeziorski E,Fischer A,Lortholary O,CEREDIH French

    更新日期:2019-10-01 00:00:00

  • Modulation of lupus phenotype by adiponectin deficiency in autoimmune mouse models.

    abstract::Adiponectin is an adipocyte-derived cytokine with anti-inflammatory properties. Paradoxically, circulating adiponectin levels are increased in a number of inflammatory diseases. Thus, we sought to define the role of adiponectin deficiency in mouse models of autoimmunity. Adiponectin-deficient mice on a C57BL/6 backgro...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-010-9486-2

    authors: Parker J,Menn-Josephy H,Laskow B,Takemura Y,Aprahamian T

    更新日期:2011-04-01 00:00:00

  • Potent systemic antitumor immunity induced by vaccination with chemotactic-prostate tumor associated antigen gene-modified tumor cell and blockade of B7-H1.

    abstract::We previously reported that several DNA fragments from human prostate-specific membrane antigen (hPSM), mouse prostatic acid phosphatase (mPAP), and human prostate-specific antigen (hPSA) genes were selected and fused to create a novel hPSM-mPAP-hPSA fusion gene (named 3P gene), and human secondary lymphoid tissue che...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-006-9053-z

    authors: Li N,Qin H,Li X,Zhou C,Wang D,Ma W,Lin C,Zhang Y,Wang S,Zhang S

    更新日期:2007-01-01 00:00:00