The presence of anti-carcinoembryonic antigen (CEA) antibodies in the sera of patients with gastrointestinal malignancies.

abstract：:Intravenous immunoglobulin (IVIg) has been used to treat autoimmune diseases and lymphoid malignancies with some therapeutic effect. In both these pathological conditions, there is an overproduction of BAFF (for "B-cell-activating factor of the TNF family"), and APRIL (for "a proliferation-inducing ligand"). The prese...

journal_title：Journal of clinical immunology

authors： Le Pottier L,Bendaoud B,Dueymes M,Daridon C,Youinou P,Shoenfeld Y,Pers JO

更新日期：2007-05-01 00:00:00

abstract：:A molecular analysis of complement components (C3, C4, and factor B) in human saliva was performed by SDS-PAGE and immunoblotting. Complement C3 was detected as a molecule composed of a 115-kDa alpha-chain linked to a 70-kDa beta chain by disulfide bonds, and C3 levels ranged from 0.52 to 15.0 micrograms/ml (n = 15). ...

journal_title：Journal of clinical immunology

authors： Andoh A,Fujiyama Y,Kimura T,Uchihara H,Sakumoto H,Okabe H,Bamba T

更新日期：1997-09-01 00:00:00

abstract：:The staphylococcal enterotoxins have been termed superantigens based on their ability to stimulate polyclonal proliferative responses of murine and human T lymphocytes expressing particular T-cell receptor V beta gene products. Certain of these toxins have been shown both to activate and to induce anergy in reactive T...

journal_title：Journal of clinical immunology

authors： Gelfand EW,Saloga J,Lack G

更新日期：1995-11-01 00:00:00

abstract：:Human papillomavirus (HPV) infects the transformation zone of the cervix and is the primary cause of cervical cancer. The infection is localized to the cervix and mucosal immunity is likely to be an important determinant for viral clearance. Previous studies of immunity to HPV have measured immune markers in the blood...

journal_title：Journal of clinical immunology

authors： Castle PE,Hildesheim A,Bowman FP,Strickler HD,Walker JL,Pustilnik T,Edwards RP,Crowley-Nowick PA

更新日期：2002-01-01 00:00:00

abstract：:The prevalence of lymphoma in primary immunodeficiency cases and autoimmune diseases, as well as on a background of immunodeficiency following organ transplants, is increasing. The lymphoma treatment success rate is known to be a low prognosis. Our study aimed to emphasize the low survival rates in immunodeficient vs....

journal_title：Journal of clinical immunology

authors： Tanyildiz HG,Dincaslan H,Yavuz G,Unal E,Ikinciogulları A,Dogu F,Tacyildiz N

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:The mechanisms underlying the loss of self-tolerance in systemic lupus erythematosus (SLE) are incompletely deciphered. TGF-β plays a key role in self-tolerance demonstrated by the onset of a fatal autoimmune syndrome associated with lupus autoantibodies in mice lacking a functional TGF-β receptor. The prese...

journal_title：Journal of clinical immunology

authors： Elbeldi-Ferchiou A,Ben Ahmed M,Smiti-Khanfir M,Houman MH,Abdeladhim M,Belhadj Hmida N,Cerf-Bensussan N,Louzir H

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Recently, two functional IL18 promoter variants, -607C>A (rs1946518) and -137G>C (rs187238), were associated with viral clearance in patients with hepatitis C. The present study focused on their relevance for treatment response. METHODS:Seven hundred fifty-seven chronically infected European patients and 79...

journal_title：Journal of clinical immunology

authors： Haas SL,Weiss C,Bugert P,Gundt J,Witt H,Singer MV,Berg T,Böcker U

更新日期：2009-09-01 00:00:00

abstract：:Subjects with primary immune deficiency diseases treated with intravenous immunoglobulin (n=42) received intravenous infusions of Carimune NF Liquid every 3-4 weeks for 6 months without routine premedication. The mean dose/patient/infusion was 278.5-800.7 mg/kg. Also, 80.4% of infusions achieved maximum rates of >or=3...

journal_title：Journal of clinical immunology

authors： Berger M,Cunningham-Rundles C,Bonilla FA,Melamed I,Bichler J,Zenker O,Ballow M

更新日期：2007-09-01 00:00:00

abstract：PURPOSE:To investigate whether there is an increased incidence of chronic autoimmune thyroiditis (CAT) in individuals living in the vicinity of industrial plants that manufacture petroleum byproducts in the state of São Paulo, Brazil. METHODS:Between 1989 and 2004, 6,306 patients of both sexes, from 5 to 78 years old ...

journal_title：Journal of clinical immunology

authors： Zaccarelli-Marino MA

更新日期：2012-10-01 00:00:00

abstract：:A monoclonal antibody produced by hybridomas obtained from a mouse immunized with drug-resistant cells recognizes certain hamster and human drug-resistant cell lines but not their drug-sensitive parental lines. Preliminary characterization of the antigen indicates that it is a molecule of approximately 180,000 daltons...

journal_title：Journal of clinical immunology

authors： O'Hara CJ,Grover J,Price GB

更新日期：1984-09-01 00:00:00

abstract：PURPOSE:To review the clinical and laboratory spectrum of RAG gene defects in humans, and discuss the mechanisms underlying phenotypic heterogeneity, the basis of immune dysregulation, and the current and perspective treatment modalities. METHODS:Literature review and analysis of medical records RESULTS: RAG gene defe...

journal_title：Journal of clinical immunology

authors： Delmonte OM,Schuetz C,Notarangelo LD

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:Hemophagocytic lymphohistiocytosis (HLH) is a rare systematic immune disease manifested with excessive activation of lymphocytes and macrophages. This study was designed to explore the feasible prognostic factors of secondary HLH (sHLH). METHOD:We retrospectively analyzed 179 patients with newly diagnosed sHLH...

journal_title：Journal of clinical immunology

authors： Huang J,Yin G,Duan L,Tian T,Xu J,Wang J,Gao X,Cheng W,Liu L,Qiu H

更新日期：2020-07-01 00:00:00

abstract：:Familial Hemophagocytic Lymphohistiocytosis type 2 (FHL2) results from mutations in PRF1. We described two unrelated individuals who presented with FHL, in whom severely impaired NK cytotoxicity and decrease perforin expression was observed. DNA sequencing of PRF1 demonstrated that both were not only heterozygous for ...

journal_title：Journal of clinical immunology

authors： Romero CA,Sánchez IP,Gutierrez-Hincapié S,Álvarez-Álvarez JA,Pereañez JA,Ochoa R,Muskus-López CE,Eraso RG,Echeverry C,Arango C,Restrepo JL,Trujillo-Vargas CM

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:Adenosine deaminase (ADA) deficiency is a systemic disorder of purine metabolism. Deficiency of the purine salvage enzyme ADA leads to the build-up of the toxic metabolites, deoxyadenosine triphosphate and deoxyadenosine. ADA is ubiquitously expressed in all tissues of the body but most profoundly affects lymph...

journal_title：Journal of clinical immunology

authors： Nikolajeva O,Worth A,Hague R,Martinez-Alier N,Smart J,Adams S,Davies EG,Gaspar HB

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:Complete DiGeorge syndrome (cDGS) describes a subset of patients with DiGeorge syndrome that have thymic aplasia, and thus are at risk for severe opportunistic infections. Patients with cDGS and mycobacterial infection have not previously been described. We present this case to illustrate that patients with cDG...

journal_title：Journal of clinical immunology

authors： Yin SM,Ferdman RM,Wang L,Markert ML,Tam JS

更新日期：2015-07-01 00:00:00

abstract：:The immune response of 42 gastrointestinal and ovarian cancer patients at 1 month after exposure to murine monoclonal antibodies (B72.3 and CC49) reactive with the tumor-associated antigen TAG-72 was studied. The incidence of human anti-mouse antibody response was 89% to B72.3 and 70% to CC49. To evaluate the antiidio...

journal_title：Journal of clinical immunology

authors： Blanco I,Kawatsu R,Harrison K,Leichner P,Augustine S,Baranowska-Kortylewicz J,Tempero M,Colcher D

更新日期：1997-01-01 00:00:00

abstract：:To compare the efficacy of immunoglobulin replacement therapy given intravenously versus subcutaneously to prevent infections in patients with primary antibody deficiency syndromes, an international, multicenter, open label, crossover study was designed. Forty patients were randomized to receive either subcutaneous or...

journal_title：Journal of clinical immunology

authors： Chapel HM,Spickett GP,Ericson D,Engl W,Eibl MM,Bjorkander J

更新日期：2000-03-01 00:00:00

abstract：:Antibodies to certain self-antigens are detected in normal individuals as well as in patients with autoimmune diseases. Natural autoantibodies found in normal human sera are thought to act as an immune regulator, a functional controller of specific proteins, or the first-line defense against pathogenic microorganisms....

journal_title：Journal of clinical immunology

authors： Suk K,Hwang DY,Lee MS

更新日期：1999-05-01 00:00:00

abstract：:The experiments described have shown that, whereas the injection of tetanus toxoid (tet) into 8 of 12 control individuals resulted in the appearance of specific anti-tet-IgG antibodies in their plasma, immunization of 14 anergic patients did not elicit an antibody response. This observation was extended to an in vitro...

journal_title：Journal of clinical immunology

authors： Mazaheri R,Rode HN,Abikar K,Ing A,Nohr C,Gordon J

更新日期：1984-01-01 00:00:00

abstract：:Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency among adults and is characterized by a B cell dysfunction and increased risk of respiratory tract infections with encapsulated bacteria. However, a large proportion of patients also has inflammatory and autoimmune complicat...

journal_title：Journal of clinical immunology

authors： Jørgensen SF,Fevang B,Aukrust P

更新日期：2019-01-01 00:00:00

abstract：:The spectrum of illness attributed to Epstein-Barr virus (EBV) includes patients with symptoms persisting for more than 1 year without any other obvious underlying disease. High titers of antibodies to EBV, either IgG antiviral capsid antigen or anti-early antigen, can be demonstrated. In this study, 13 patients diagn...

journal_title：Journal of clinical immunology

authors： Kibler R,Lucas DO,Hicks MJ,Poulos BT,Jones JF

更新日期：1985-01-01 00:00:00

abstract：:An absolute requirement for monocytes was demonstrated in the T-cell proliferative response to tetanus toxoid (TT) antigen. Antigen-pulsed monocytes were shown to be effective in triggering T-cell proliferation. Using 125I-radiolabeled TT antigen, uptake by monocytes increased progressively over an 18-hr period, at wh...

journal_title：Journal of clinical immunology

authors： Alpert SD,Jonsen ME,Broff MD,Schneeberger E,Geha RS

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:To elucidate the relative role of the immune system and intestinal epithelium in the ethiopatogenesis of Celiac disease (CD). METHODS:A patient with childhood CD who underwent allogeneic bone marrow transplantation (BMT) for chronic myelogenous leukemia was followed for 5 years after resumption of gluten conta...

journal_title：Journal of clinical immunology

authors： Ben-Horin S,Polak-Charcon S,Barshack I,Picard O,Fudim E,Yavzori M,Avivi C,Mardoukh C,Shimoni A,Chowers Y,Maor Y

更新日期：2013-11-01 00:00:00

abstract：:Emotional stress is often followed by increased susceptibility to infections. One major role in the immediate immune response to infection is played by natural killer (NK) cells. This study was designed to establish whether acute psychological stress influences cellular immune functions and to elucidate the role of en...

journal_title：Journal of clinical immunology

authors： Schedlowski M,Jacobs R,Stratmann G,Richter S,Hädicke A,Tewes U,Wagner TO,Schmidt RE

更新日期：1993-03-01 00:00:00

abstract：:Matrix metalloproteinases (also named matrixin or MMPs) are a major group of enzymes that regulate cell-matrix composition by using zinc for their proteolytic activities. They are essential for various normal biological processes such as embryonic development, morphogenesis, reproduction tissue resorption, and remodel...

journal_title：Journal of clinical immunology

authors： Ram M,Sherer Y,Shoenfeld Y

更新日期：2006-07-01 00:00:00

abstract：PURPOSE:Survival of the Leishmania parasite within monocytes hinges on its ability to effectively nullify their microbicidal effector mechanisms. Accordingly, this study aimed to delineate this biological niche in patients with visceral leishmaniasis (VL). METHODS:In monocytes, the redox status, antigen presenting cap...

journal_title：Journal of clinical immunology

authors： Roy S,Mukhopadhyay D,Mukherjee S,Ghosh S,Kumar S,Sarkar K,Pal D,Bhowmik P,Mandal K,Modak D,Guha SK,Pramanik N,Goswami RP,Saha B,Chatterjee M

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Experimental allergic encephalomyelitis (EAE) is a T cell-mediated autoimmune disease model for multiple sclerosis (MS). We have shown earlier that 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) and curcumin ameliorate EAE by modulating inflammatory signaling pathways in T lymphocytes. Toll-like rec...

journal_title：Journal of clinical immunology

authors： Chearwae W,Bright JJ

更新日期：2008-09-01 00:00:00

abstract：:We report the long-term follow-up of 12 pediatric-aged patients with chronic granulomatous disease (CGD). The mean age at the onset of infections was 5 months with a median delay in diagnosis of 2.5 years. Bacille Calmette-Guérin lymphadenitis was the most common presenting infection (6) followed by suppurative lympha...

journal_title：Journal of clinical immunology

authors： Pasic S,Minic A,Minic P,Veljkovic D,Lilic D,Slavkovic B,Pejnovic N,Abinun M

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:To evaluate mortality risk factors in pediatric-onset common variable immunodeficiency disorders (CVID), we evaluated the largest single-institution cohort of pediatric-onset CVID patients. Previous publications on CVID have provided valuable descriptive data, but lack risk stratification to guide physicians in...

journal_title：Journal of clinical immunology

authors： Baloh C,Reddy A,Henson M,Prince K,Buckley R,Lugar P

更新日期：2019-10-01 00:00:00

abstract：:Unusual susceptibility to mycobacterial infections can be caused by deleterious mutations in genes that encode the interferon-gamma receptor 1 chain. Such mutations hamper the activation of macrophages by a type 1 immune response and result in enhanced survival of intracellular pathogens. We here report two patients w...

journal_title：Journal of clinical immunology

authors： Noordzij JG,Hartwig NG,Verreck FA,De Bruin-Versteeg S,De Boer T,Van Dissel JT,De Groot R,Ottenhoff TH,Van Dongen JJ

更新日期：2007-09-01 00:00:00