Abstract：
:Matrix metalloproteinases (also named matrixin or MMPs) are a major group of enzymes that regulate cell-matrix composition by using zinc for their proteolytic activities. They are essential for various normal biological processes such as embryonic development, morphogenesis, reproduction tissue resorption, and remodeling. Metalloproteinases also play a role in pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases and cancer. Herein we review the involvement of MMP-9 in a variety of autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, systemic sclerosis, rheumatoid arthritis, multiple sclerosis, polymyositis and atherosclerosis. MMP-9 plays either a primary or secondary role in each one of those autoimmune diseases by its up or down-regulation. It is not expressed constantly but rather is induced or suppressed by many regulating molecules. This feature of MMP-9 along with its involvement in disease pathogenesis turns it into a target for therapy of autoimmune diseases.
journal_name
J Clin Immunoljournal_title
Journal of clinical immunologyauthors
Ram M,Sherer Y,Shoenfeld Ydoi
10.1007/s10875-006-9022-6subject
Has Abstractpub_date
2006-07-01 00:00:00pages
299-307issue
4eissn
0271-9142issn
1573-2592journal_volume
26pub_type
杂志文章,评审abstract：:Light chain amyloidosis (AL) is a protein folding disorder with an underlying B cell neoplasia where the monoclonal immunoglobulin light chains (LCs) produced from insoluble amyloid fibrils. The deposition of these fibrillar aggregates in vital organs causes severe organ dysfunction over time and is associated with hi...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1023/B:JOCI.0000029113.68758.9f
更新日期：2004-07-01 00:00:00
abstract：PURPOSE:Health-related quality of life (HRQOL) has not been examined in patients with predominant antibody deficiency both pre- and post-immunoglobulin G (IgG) treatment initiation. HRQOL and health resource utilization (HRU) were assessed in newly diagnosed patients with primary immunodeficiency disease (PIDD) pre- an...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-016-0279-0
更新日期：2016-07-01 00:00:00
abstract：PURPOSE:The increased risk of morbidity and mortality from certain microbial infections and the demonstrated improvements in the clinical course of some autoimmune diseases support the existence of pregnancy-related alterations in immune status. Elucidating the changes in innate and adaptive immunity during gestation m...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-011-9627-2
更新日期：2012-04-01 00:00:00
abstract：PURPOSE:T-helper (Th) cells abnormalities are considered to be associated with the pathogenesis of Systemic lupus erythematosus (SLE). Recently, The Th22 cells have been identified and implicated in the pathogenesis of autoimmune diseases such as Rheumatoid arthritis (RA), although therir role in Systemic lupus erythem...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-013-9878-1
更新日期：2013-05-01 00:00:00
abstract：:Thirty two HIV-infected children, on highly active antiretroviral therapy (HAART) and > 500 CD4+ T cells/mm3, were rated according to the time-course of viral load (VL) during the whole follow-up period (> 18 months) in a longitudinal retrospective study. (a) uVL group: 15 children with VL below 400 copies/mL; (b) dVL...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1023/a:1024536816684
更新日期：2003-07-01 00:00:00
abstract：INTRODUCTION:Treating recipient mice with palifermin (recombinant human keratinocyte growth factor) prevents the development of acute, lethal, graft-versus-host disease (GVHD). This is due, at least in part, to the ability of palifermin to protect epithelial cells from injury. Using the C57BL/6-->(C57BL/6 x DBA/2)F(1)-...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-008-9216-1
更新日期：2008-09-01 00:00:00
abstract：:Chemotherapeutic agent is characterized by its concentration in tumor cells with minimum side effects. Oleandrin, a polyphenolic cardiac glycoside is known to induce apoptosis in tumor cells. However, no report is available on its efficacy in primary cells. In this report we are providing the evidence that oleandrin i...
journal_title：Journal of clinical immunology
pub_type： 杂志文章,收录出版
doi：10.1007/s10875-006-9028-0
更新日期：2006-07-01 00:00:00
abstract：:Oligoclonal free light chains (FLC) banding has been described in multiple sclerosis (MS) and should be correlated with disease activity. However, discrepancies between studies have been reported because of differences in methods. A new quantitative, rapid, and automated method using nephelometry is now available. Our...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-005-5371-9
更新日期：2005-07-01 00:00:00
abstract：:Murine B16 melanoma cell line is poorly immunogenic and highly aggressive. We recently reported that the transmembrane staphylococcal enterotoxin A (TM-SEA) anchors onto B16 cells and stimulates lymphocyte proliferation. The purpose of the study was to investigate whether vaccination with B16 cells bearing membrane-an...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1023/B:JOCI.0000025451.41948.94
更新日期：2004-05-01 00:00:00
abstract：:These studies report findings that demonstrate that human alpha lymphotoxin (LT) induces local, visible, and microscopic inflammatory reactions in normal skin. Skin sites in rabbits, when inoculated with a single injection of native or recombinant human alpha lymphotoxin, demonstrated erythema, swelling, and warmth wi...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/BF00915556
更新日期：1987-07-01 00:00:00
abstract：INTRODUCTION:The molecular and cellular interactions between the immune system and bone tissue have been established. Sex hormone deficiency after menopause has multifunctional role by influencing growth, differentiation, and metabolism of the skeletal and the immune system. DISCUSSION:We have used nonparametric and m...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-009-9321-9
更新日期：2009-11-01 00:00:00
abstract：OBJECTIVE:The aim of the study was to assess the diagnostic delay in pediatric patients with primary immunodeficiencies (PID) at a tertiary care hospital in Peru. METHODS:A descriptive study was carried out in which patients from a third-level referral center in Peru were included. Those without a specific diagnosis o...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-017-0398-2
更新日期：2017-05-01 00:00:00
abstract：:Bias in cytokine responses has been proposed as a contributing mechanism to pathogenesis in persistent HIV or hepatitis C virus (HCV) infections. We investigated whether coinfection with HCV modifies the profile of antigen-specific cytokine secretion in women persistently infected with HIV compared to women with singl...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-005-2819-x
更新日期：2005-03-01 00:00:00
abstract：PURPOSE:In severe sepsis, functional impairment and decreased numbers of dendritic cells (DCs) are essential reasons for immune function paralysis, secondary organ infection, and organ failure. We investigated the effects of N-acetylcysteine (NAC) administration on protecting lung DCs function in a zymosan-induced gene...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-012-9852-3
更新日期：2013-04-01 00:00:00
abstract：:Subjects with primary immune deficiency diseases treated with intravenous immunoglobulin (n=42) received intravenous infusions of Carimune NF Liquid every 3-4 weeks for 6 months without routine premedication. The mean dose/patient/infusion was 278.5-800.7 mg/kg. Also, 80.4% of infusions achieved maximum rates of >or=3...
journal_title：Journal of clinical immunology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s10875-007-9096-9
更新日期：2007-09-01 00:00:00
abstract：OBJECTIVE:Different sets of warning signs can be used if primary immunodeficiency (PID) is suspected: those of the Jeffrey Modell Foundation (JMF), the German Patients' Organisation for Primary Immunodeficiencies (DSAI) and the Association of the Scientific Medical Societies in Germany (AWMF). A few studies have tested...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-015-0149-1
更新日期：2015-04-01 00:00:00
abstract：OBJECTIVES:Gastrointestinal manifestations are frequent in patients with common variable immunodeficiency (CVID), and some of the patients present with celiac-like features. Diagnosing celiac disease (CD) in CVID however is challenging, as autoantibody detection and histopathology of the small intestine cannot reliably...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-013-9892-3
更新日期：2013-07-01 00:00:00
abstract：:Testing of cytotoxic function using a panel of natural killer (NK)-sensitive target cells, including a unique herpes simplex virus-infected Raji-cell target, was performed in conjunction with phenotypic cell analysis by dual-color flow cytometry to characterize the NK system. Subjects included in the study were at ris...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/BF00915420
更新日期：1987-01-01 00:00:00
abstract：PURPOSE:The aim of the present study was to evaluate whether the anti-Rheumatoid arthritis (RA) effect of curcumin is associated with the regulation of B cell-activating factor belonging to the TNF family (BAFF) production. METHODS:Collagen-induced arthritis (CIA) was induced in DBA/1 J mice by immunization with bovin...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-012-9839-0
更新日期：2013-04-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is associated with T- and B-cell dysfunction. Immunoglobulin (Ig) production is under the control of T cells and their derived cytokines such as interleukin 2 (IL-2) and IL-4. Herein we studied the regulation of the production of immunoglobulins and cytokines by peripheral blood mononuclear c...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/BF00918271
更新日期：1992-01-01 00:00:00
abstract：:Anti-CD3 monoclonal antibody (MoAb) induces proliferation of freshly isolated peripheral blood T cells only in the presence of monocytes/macrophages and requires binding of the Fc portion of antibody to monocytes/macrophages. In this investigation, we examined whether monocytes process anti-CD3 similar to any soluble ...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/BF00916700
更新日期：1990-09-01 00:00:00
abstract：:The origin of natural antibodies has long been a subject of controversy. Polyreactive natural antibodies recognize multiple ligands and are thought to arise from B1 B cells. Natural antibodies against carbohydrate antigens such as Gal alpha 1-3Gal or against blood groups A and B are thought to be "elicited" by gut bac...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1023/a:1027378716015
更新日期：1997-07-01 00:00:00
abstract：:A monoclonal antibody produced by hybridomas obtained from a mouse immunized with drug-resistant cells recognizes certain hamster and human drug-resistant cell lines but not their drug-sensitive parental lines. Preliminary characterization of the antigen indicates that it is a molecule of approximately 180,000 daltons...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/BF00917144
更新日期：1984-09-01 00:00:00
abstract：INTRODUCTION:Several differences have been described between neonatal and adult immune responses. The predisposition in early life to Th2-type response or tolerance makes it a susceptible period for infections and allergic sensitization. OBJECTIVE:The aim of this work was to evaluate the effects of CpG-containing olig...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-009-9358-9
更新日期：2010-03-01 00:00:00
abstract：:Fever is frequently observed in cancer patients treated with high-dose recombinant human interleukin-2 (rIL-2). The preincubation of rIL-2 with polymyxin B, an antibiotic that inhibits the biologic effects of endotoxins, did not diminish the pyrogenicity of IL-2 in New Zealand rabbits, indicating that IL-2-induced fev...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/BF00916947
更新日期：1988-11-01 00:00:00
abstract：PURPOSE:Systemic lupus erythematous (SLE) is a systemic autoimmune inflammatory disease with both genetic and epigenetic etiologies. Evidence suggests that deregulation of specific genes through epigenetic mechanisms may be a contributing factor to SLE pathology. There is increasing evidence that DNA methyltransferase ...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-012-9803-z
更新日期：2013-02-01 00:00:00
abstract：:Glucocorticoids (GC) represent the main treatment for pemphigus; however, some patients show GC resistance. GC sensitivity was evaluated in 19 pemphigus patients and 41 controls by the number of binding sites [B(max) (fmol/mg protein)] and the affinity of GC receptor [Kd (nM)] to dexamethasone (DEX) as well as by the ...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/s10875-012-9679-y
更新日期：2012-08-01 00:00:00
abstract：:CFSE dye dilution analysis and [3H] thymidine incorporation were used side by side to assess proliferative responses of peripheral blood mononuclear cells (PBMCs) after vaccination of renal cell carcinoma patients (n=6) with antigen-loaded dendritic cells. Immune responses against the control antigen keyhole limpet he...
journal_title：Journal of clinical immunology
pub_type： 临床试验,杂志文章
doi：10.1007/s10875-004-6237-2
更新日期：2004-11-01 00:00:00
abstract：:T lymphocytes expressing NK1.1 marker (NK1.1+) have been suggested as being important in peripheral immune modulation. Alteration of the balance between Th1 proinflammatory and Th2 anti-inflammatory cytokine-producing cells can ameliorate immune-mediated disorders. The aim of the study was to determine the role of NK1...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1023/a:1019974005134
更新日期：2002-09-01 00:00:00
abstract：:Augmentation of the cytolytic activity of human natural killer cells and of antibody-dependent cell-mediated cytotoxicity has been attributed to human interferons. With the purification to homogeneity of human leukocyte interferon, it became possible to test directly whether pure interferon could increase the activity...
journal_title：Journal of clinical immunology
pub_type： 杂志文章
doi：10.1007/BF00922756
更新日期：1981-07-01 00:00:00
