Abstract:
:Bias in cytokine responses has been proposed as a contributing mechanism to pathogenesis in persistent HIV or hepatitis C virus (HCV) infections. We investigated whether coinfection with HCV modifies the profile of antigen-specific cytokine secretion in women persistently infected with HIV compared to women with single HIV or HCV infection. The T helper response to HIV, HCV and cytomegalovirus (CMV) as a positive viral control was dominated by type 1 cytokines (interleukin- [IL] 2, interferon- [IFN] gamma and tumor necrosis factor- [TNF] alpha), with IFN-gamma as the most abundantly secreted. IL-4, IL-5 and IL-10 were low in healthy controls and patients. Robust CMV-specific responses contrasted with curtailed HCV-specific responses in HCV-infected women. The overall anti-viral profile was dominated by Th1 cytokines even in coinfected women but both type 1 and type 2 responses were reduced in HIV-infected women and more extensively in women with HCV/HIV coinfection.
journal_name
J Clin Immunoljournal_title
Journal of clinical immunologyauthors
Villacres MC,Literat O,Degiacomo M,Du W,La Rosa C,Diamond DJ,Kovacs Adoi
10.1007/s10875-005-2819-xsubject
Has Abstractpub_date
2005-03-01 00:00:00pages
134-41issue
2eissn
0271-9142issn
1573-2592journal_volume
25pub_type
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