Abstract:
:Unusual susceptibility to mycobacterial infections can be caused by deleterious mutations in genes that encode the interferon-gamma receptor 1 chain. Such mutations hamper the activation of macrophages by a type 1 immune response and result in enhanced survival of intracellular pathogens. We here report two patients with unusual mycobacterial infections, both diagnosed with homozygous deleterious interferon-gamma receptor 1 gene mutations. Patient 1 became ill after Bacillus Calmette-Guérin vaccination at the age of 9 months and died at the age of 18 months. She carried a homozygous C71Y mutation in the extracellular part of the mature interferon-gamma receptor 1 protein, resulting in the lack of detectable protein expression and absence of interferon-gamma dependent signaling. Patient 2 became ill at the age of 3 years, is still alive at 19 years of age, and has suffered from five successive infection episodes with atypical mycobacteria. A homozygous splice-site mutation in intron 3 was identified, resulting in the deletion of exon 3 at the mRNA level and consequently a truncated interferon-gamma receptor 1 protein with absence of the transmembrane domain. Protein expression and interferon-gamma dependent signaling were not detectable.
journal_name
J Clin Immunoljournal_title
Journal of clinical immunologyauthors
Noordzij JG,Hartwig NG,Verreck FA,De Bruin-Versteeg S,De Boer T,Van Dissel JT,De Groot R,Ottenhoff TH,Van Dongen JJdoi
10.1007/s10875-007-9097-8subject
Has Abstractpub_date
2007-09-01 00:00:00pages
490-6issue
5eissn
0271-9142issn
1573-2592journal_volume
27pub_type
杂志文章abstract::Adiponectin is an adipocyte-derived cytokine with anti-inflammatory properties. Paradoxically, circulating adiponectin levels are increased in a number of inflammatory diseases. Thus, we sought to define the role of adiponectin deficiency in mouse models of autoimmunity. Adiponectin-deficient mice on a C57BL/6 backgro...
journal_title:Journal of clinical immunology
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更新日期:2011-04-01 00:00:00
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journal_title:Journal of clinical immunology
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journal_title:Journal of clinical immunology
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更新日期:2018-11-01 00:00:00
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journal_title:Journal of clinical immunology
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journal_title:Journal of clinical immunology
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doi:10.1007/s10875-007-9148-1
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更新日期:2013-05-01 00:00:00
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journal_title:Journal of clinical immunology
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更新日期:2014-08-01 00:00:00
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journal_title:Journal of clinical immunology
pub_type: 杂志文章
doi:10.1007/s10875-009-9285-9
更新日期:2009-07-01 00:00:00
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journal_title:Journal of clinical immunology
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更新日期:2004-09-01 00:00:00
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journal_title:Journal of clinical immunology
pub_type: 杂志文章
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更新日期:1985-09-01 00:00:00
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journal_title:Journal of clinical immunology
pub_type: 杂志文章
doi:10.1023/a:1010987426835
更新日期:2001-07-01 00:00:00
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journal_title:Journal of clinical immunology
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更新日期:2007-09-01 00:00:00
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journal_title:Journal of clinical immunology
pub_type: 杂志文章
doi:10.1007/BF00917898
更新日期:1988-03-01 00:00:00
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journal_title:Journal of clinical immunology
pub_type: 杂志文章
doi:10.1023/a:1027320425291
更新日期:1997-09-01 00:00:00
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journal_title:Journal of clinical immunology
pub_type: 杂志文章
doi:10.1007/BF00915057
更新日期:1987-11-01 00:00:00
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journal_title:Journal of clinical immunology
pub_type: 杂志文章,评审
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更新日期:2013-05-01 00:00:00
abstract:PURPOSE:Sarcoidosis is a non-caseating granulomatous disease for which a role for infectious antigens continues to strengthen. Recent studies have reported molecular evidence of mycobacteria or propionibacteria. We assessed for immune responses against mycobacterial and propionibacterial antigens in sarcoidosis broncho...
journal_title:Journal of clinical immunology
pub_type: 杂志文章
doi:10.1007/s10875-012-9700-5
更新日期:2012-10-01 00:00:00
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journal_title:Journal of clinical immunology
pub_type: 杂志文章
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更新日期:2010-03-01 00:00:00
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journal_title:Journal of clinical immunology
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pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Journal of clinical immunology
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journal_title:Journal of clinical immunology
pub_type: 杂志文章
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更新日期:1988-05-01 00:00:00
abstract::Human peripheral B lymphocytes were transformed with Epstein-Barr virus and probed with an antiidiotypic antibody made against a human monoclonal autoantibody. Six cell lines were isolated that produced antibodies bearing a common idiotope. Despite the presence of this common idiotope, the antibodies showed antigen-bi...
journal_title:Journal of clinical immunology
pub_type: 杂志文章
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更新日期:1988-11-01 00:00:00
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journal_title:Journal of clinical immunology
pub_type: 杂志文章
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更新日期:1990-05-01 00:00:00
abstract::The role of tumor necrosis factor-alpha in the shedding of soluble tumor necrosis factor receptors in endotoxemia was investigated. The appearance of the soluble tumor necrosis factor receptors was assessed in four healthy volunteers following an intravenous injection of tumor necrosis factor-alpha and in eight chimpa...
journal_title:Journal of clinical immunology
pub_type: 杂志文章
doi:10.1007/BF01489489
更新日期:1995-01-01 00:00:00
abstract::The complement system plays a central role in defense to encapsulated bacteria through opsonization and membrane attack complex (MAC) dependent lysis. The three activation pathways (classical, lectin, and alternative) converge in the cleavage of C5, which initiates MAC formation and target lysis. C5 deficiency is asso...
journal_title:Journal of clinical immunology
pub_type: 杂志文章
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更新日期:2016-05-01 00:00:00
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journal_title:Journal of clinical immunology
pub_type: 杂志文章
doi:10.1007/s10875-012-9791-z
更新日期:2013-01-01 00:00:00
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journal_title:Journal of clinical immunology
pub_type: 杂志文章,评审
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更新日期:2019-10-01 00:00:00
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journal_title:Journal of clinical immunology
pub_type: 杂志文章
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更新日期:2017-08-01 00:00:00