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Elevated serum interleukin-6 levels in patients with acute hepatitis.

Abstract：

:To study the mechanisms of hepatocyte injury, we examined serum interleukin-6 (IL-6) level in acute hepatitis patients. Based on their clinical features, these patients were divided into three groups, acute hepatitis (AH), severe acute hepatitis, and fulminant hepatic failure (FHF). The present study demonstrated that, in association with their clinical status, their serum IL-6 levels were gradually increased (16.5 +/- 14.5 pg/ml in AH, 26.3 +/- 19.0 pg/ml in severe AH, and 470.2 +/- 261.4 pg/ml in FHF; control level, 5.2 +/- 0.6 pg/ml). Furthermore, we found that a significant correlation between serum IL-6 level and prothrombin time existed in these patients and that the elevated serum IL-6 returned to a normal range after recovery from their hepatocyte injury. Thus, our study demonstrates that the serum IL-6 level is a possible marker for identifying the clinical status in acute hepatitis and that this cytokine may have some roles in hepatocyte injury.

journal_name

J Clin Immunol

journal_title

Journal of clinical immunology

authors

Sun Y,Tokushige K,Isono E,Yamauchi K,Obata H

doi

10.1007/BF00918089

subject

Has Abstract

pub_date

1992-05-01 00:00:00

pages

197-200

issue

3

eissn

0271-9142

issn

1573-2592

journal_volume

12

pub_type

杂志文章

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