当前位置： SCI文献检索 > JOURNAL OF CLINICAL IMMUNOLOGY期刊下所有文献 > The immune reactivity role of HCV-induced liver infiltrating lymphocytes in hepatocellular damage.

The immune reactivity role of HCV-induced liver infiltrating lymphocytes in hepatocellular damage.

Abstract：

:Liver infiltrating lymphocytes (LIL) were isolated from HCV-positive (+) and HCV-negative (-) end-stage livers. Phenotypic analysis and functional studies using proliferative and lymphocytotoxic assays were performed with the isolated LIL. Two CD3+ lymphocyte populations were found in LIL using FITC anti-CD3 monoclonal antibodies (mAb). One was a bright fluorescence intensity population (as in PBL), and the other dim. We calculated the number of FITC-anti-CD3 mAbs bound per lymphocyte on PBL and LIL and found 80,040 +/- 4628 and 39,615 +/- 3932, respectively. Therefore, HCV+ and HCV- patient PBL contained approximately twice the number of CD3 molecules per cell than patient CD3+ LIL. LIL also contained approximately a threefold higher concentration of TCR alpha beta +, CD4-CD8-, and CD56,16 (NK) cells than the patient PBL. Thus, a major subset of LIL is phenotypically similar to mouse NK1.1+ "intermediate" T cells. LIL freshly isolated from HCV+ livers exhibited weak CTL activity against EBV- or Con A-transformed lymphoblast targets infected with vaccinia-HCV recombinant virus (rHCV) or primary hepatocyte cultured cells. However, after in vitro coculture of LIL with rHCV, these cells developed a strong cytotoxicity for the above targets. In contrast, LIL from HCV- livers were not cytotoxic against the same targets. Histochemical studies (in situ) demonstrated that these hepatocytes express CD95, and stains demonstrated apoptosis. The HCV+ hepatocytes also express class I MHC molecules and ICAM-1. The addition of mAb specific for these adhesion molecules inhibited CML activity. Short-term cultured hepatocytes (targets) from HCV+ and HCV- patients produced low levels of cytokines IL-1 beta, IL-2, IL-6, TNF alpha, and IFN-gamma but a high level of IL-8. It is speculated that LIL expressing reduced numbers of CD3 molecules may even function as immune regulators as proposed for intermediate T cells in mice.

journal_name

J Clin Immunol

journal_title

Journal of clinical immunology

authors

Jin Y,Fuller L,Carreno M,Zucker K,Roth D,Esquenazi V,Karatzas T,Swanson SJ 3rd,Tzakis AG,Miller J

doi

10.1023/a:1027326415164

subject

Has Abstract

pub_date

1997-03-01 00:00:00

pages

140-53

issue

2

eissn

0271-9142

issn

1573-2592

journal_volume

17

pub_type

杂志文章

相关文献

JOURNAL OF CLINICAL IMMUNOLOGY文献大全
  • The effects of indomethacin and interleukin-2 on the proliferation of lymphocytes from patients with lung cancer.

    abstract：:The effects of the addition of indomethacin and interleukin-2 (IL-2) to phytohemagglutinin (PHA)-stimulated lymphocytes from patients with untreated squamous-cell carcinoma of the lung and with chronic obstructive pulmonary disease and from normal individuals were studied. In 13 of 21 patients with lung carcinoma, the...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00915506

    authors： Maca RD,Burford JG,Taylor RT

    更新日期：1985-05-01 00:00:00

  • Circulating CD3+ CD4+ CD8+ T lymphocytes in multiple sclerosis.

    abstract：:Triple-antibody flow cytometry was used to search for distinctive populations of peripheral blood lymphocyte immunophenotypes in multiple sclerosis (MS). Using monoclonal antibodies to the cell surface markers CD3, CD4, and CD8, T cell subsets were quantified on a cohort of 31 MS patients (not treated with corticoster...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00919267

    authors： Munschauer FE,Stewart C,Jacobs L,Kaba S,Ghorishi Z,Greenberg SJ,Cookfair D

    更新日期：1993-03-01 00:00:00

  • Celiac disease resolution after allogeneic bone marrow transplantation is associated with absence of gliadin-specific memory response by donor-derived intestinal T-cells.

    abstract：PURPOSE:To elucidate the relative role of the immune system and intestinal epithelium in the ethiopatogenesis of Celiac disease (CD). METHODS:A patient with childhood CD who underwent allogeneic bone marrow transplantation (BMT) for chronic myelogenous leukemia was followed for 5 years after resumption of gluten conta...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-013-9943-9

    authors： Ben-Horin S,Polak-Charcon S,Barshack I,Picard O,Fudim E,Yavzori M,Avivi C,Mardoukh C,Shimoni A,Chowers Y,Maor Y

    更新日期：2013-11-01 00:00:00

  • Clinical and molecular characteristics of 35 Chinese children with Wiskott-Aldrich syndrome.

    abstract：BACKGROUND:Wiskott-Aldrich syndrome (WAS) is a rare primary immunodeficiency disease, with an incidence of 4/1,000,000 live male births. In China, an estimated number of 35 babies with WAS are born each year, but likely many remain undiagnosed. OBJECTIVES:The objectives of study were to review the clinical and molecul...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-009-9285-9

    authors： Lee PP,Chen TX,Jiang LP,Chen J,Chan KW,Lee TL,Ho MH,Nong SH,Yang Y,Fang YJ,Li Q,Wang XC,Yang XQ,Lau YL

    更新日期：2009-07-01 00:00:00

  • Regulation and privilege in transplantation tolerance.

    abstract：BACKGROUND:There are now many ways of achieving transplantation tolerance in rodents that do not require stem cell chimerism. The best studied of these utilize short courses of antibody treatment aimed at blocking the co-receptors CD4 and CD8, and/or co-stimulatory molecules such as CD40L. Unlike tolerance through mixe...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-008-9249-5

    authors： Waldmann H,Adams E,Fairchild P,Cobbold S

    更新日期：2008-11-01 00:00:00

  • Serodiagnostic assays for celiac disease based on the open or closed conformation of the autoantigen, transglutaminase 2.

    abstract：:The autoantigen of celiac disease, transglutaminase 2 (TG2), adopts an open conformation during enzymatic activation. We studied diagnostic accuracy of serodiagnostic assays using TG2 in its open and closed conformation as antigens in patients with diagnostic difficulties. The open TG2 antibody (TG2ab) test identified...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-011-9514-x

    authors： Lindfors K,Koskinen O,Kurppa K,Laurila K,Collin P,Haimila K,Partanen J,Saavalainen P,Mäki M,Kaukinen K

    更新日期：2011-06-01 00:00:00

  • Oleandrin-mediated expression of Fas potentiates apoptosis in tumor cells.

    abstract：:Chemotherapeutic agent is characterized by its concentration in tumor cells with minimum side effects. Oleandrin, a polyphenolic cardiac glycoside is known to induce apoptosis in tumor cells. However, no report is available on its efficacy in primary cells. In this report we are providing the evidence that oleandrin i...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章,收录出版

    doi：10.1007/s10875-006-9028-0

    authors： Sreenivasan Y,Raghavendra PB,Manna SK

    更新日期：2006-07-01 00:00:00

  • The Elements Steering Pathogenesis in IgG-Mediated Alloimmune Diseases.

    abstract：:Alloimmune diseases can occur in pregnancy and after blood transfusions, where antibodies are formed, targeting foreign cells and tissues for destruction by myeloid cells through IgG Fc-receptors (FcγR). In pregnancy, antibodies against human blood group or platelet antigens (e.g. HPA1-a) cause life-threatening anemia...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章,评审

    doi：10.1007/s10875-016-0253-x

    authors： Sonneveld ME,van der Schoot CE,Vidarsson G

    更新日期：2016-05-01 00:00:00

  • Regulation of ERK2 dephosphorylation in G1-stimulated rat T lymphoblasts.

    abstract：:Rat T lymphoblasts arrested in the G1 phase of the cell cycle by interleukin-2 (IL-2) deprivation can be forced to proceed to the S phase when they are stimulated with IL-2 or the phorbol ester phorbol 12,13-dibutyrate (PDBu). When PDBu is used as a stimulus, extracellular regulated kinase 2 (ERK2) is activated by thr...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1023/a:1027375828134

    authors： Lisbona C,Alemany S,Fernández-Renart M

    更新日期：1997-11-01 00:00:00

  • Characterizing the pregnancy immune phenotype: results of the viral immunity and pregnancy (VIP) study.

    abstract：PURPOSE:The increased risk of morbidity and mortality from certain microbial infections and the demonstrated improvements in the clinical course of some autoimmune diseases support the existence of pregnancy-related alterations in immune status. Elucidating the changes in innate and adaptive immunity during gestation m...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-011-9627-2

    authors： Kraus TA,Engel SM,Sperling RS,Kellerman L,Lo Y,Wallenstein S,Escribese MM,Garrido JL,Singh T,Loubeau M,Moran TM

    更新日期：2012-04-01 00:00:00

  • Glucocorticoid regulates interleukin-37 in systemic lupus erythematosus.

    abstract：:The aim of this study was to research the expression of IL-37 in systemic lupus erythematosus (SLE) patients and the effect of glucocorticoid on IL-37. Thirty newly diagnosed severe SLE patients receiving prednisone 1 mg/kg/day for 14 consecutive days and 30 healthy subjects were enrolled into this study. The plasma l...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-012-9791-z

    authors： Song L,Qiu F,Fan Y,Ding F,Liu H,Shu Q,Liu W,Li X

    更新日期：2013-01-01 00:00:00

  • i.v.IG for autoimmune, fibrosis, and malignant conditions: our experience with 200 patients.

    abstract：:Intravenous immunoglobin (i.v.IG) is generated from the plasma of more than 10,000 healthy subjects. Originally i.v.IG was employed to supplement the missing Igs in subjects with immune-deficiencies. Later on it was given successfully to patients with autoimmune conditions, in some of which the benefits were confirmed...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章,评审

    doi：10.1023/b:joci.0000019809.55787.ec

    authors： Shoenfeld Y,Krause I

    更新日期：2004-03-01 00:00:00

  • Identification of Critical Transcriptomic Signaling Pathways in Patients with H Syndrome and Rosai-Dorfman Disease.

    abstract：:Biallelic mutations in SLC29A3 cause histiocytosis-lymphadenopathy plus syndrome, also known as H syndrome (HS). HS is a complex disorder, with ~ 25% of patients developing autoinflammatory complications consisting of unexplained fevers, persistently elevated inflammatory markers, and unusual lymphadenopathies, with i...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-020-00932-1

    authors： Lara-Reyna S,Poulter JA,Vasconcelos EJR,Kacar M,McDermott MF,Tooze R,Doffinger R,Savic S

    更新日期：2020-12-07 00:00:00

  • Autoimmunity and Inflammation in CVID: a Possible Crosstalk between Immune Activation, Gut Microbiota, and Epigenetic Modifications.

    abstract：:Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency among adults and is characterized by a B cell dysfunction and increased risk of respiratory tract infections with encapsulated bacteria. However, a large proportion of patients also has inflammatory and autoimmune complicat...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章,评审

    doi：10.1007/s10875-018-0574-z

    authors： Jørgensen SF,Fevang B,Aukrust P

    更新日期：2019-01-01 00:00:00

  • Efficacy, safety and pharmacokinetics of a novel subcutaneous immunoglobulin, Evogam®, in primary immunodeficiency.

    abstract：:This phase III, open-label, multi-centre study investigated the efficacy, safety, pharmacokinetics and quality of life impact of Evogam(®), a new chromatographically fractionated 16% subcutaneous immunoglobulin, utilising a 1:1 dose transition ratio from previous immunoglobulin therapy. Thirty-five previously treated ...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s10875-011-9641-4

    authors： Empson MB,Tang ML,Pearce LK,Rozen L,Gold MS,Katelaris CH,Langton D,Smart J,Smith WB,Steele RH,Ziegler JB,Maher D

    更新日期：2012-10-01 00:00:00

  • Neurological Involvement in Childhood Evans Syndrome.

    abstract：PURPOSE:Immune thrombocytopenic purpura (ITP) and autoimmune hemolytic anemia (AIHA) are associated in the definition of Evans syndrome (ES). The occurrence of neurological involvement in this population is poorly described and suggests an underlying primary immunodeficiency (PID). We aimed to describe the clinical man...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-019-0594-3

    authors： Pincez T,Neven B,Le Pointe HD,Varlet P,Fernandes H,Gareton A,Leverger G,Leblanc T,Chambost H,Michel G,Pasquet M,Millot F,Hermine O,Mathian A,Hully M,Zephir H,Hamidou M,Durand JM,Perel Y,Landman-Parker J,Rieux-Lauc

    更新日期：2019-02-01 00:00:00

  • Carimune NF Liquid is a safe and effective immunoglobulin replacement therapy in patients with primary immunodeficiency diseases.

    abstract：:Subjects with primary immune deficiency diseases treated with intravenous immunoglobulin (n=42) received intravenous infusions of Carimune NF Liquid every 3-4 weeks for 6 months without routine premedication. The mean dose/patient/infusion was 278.5-800.7 mg/kg. Also, 80.4% of infusions achieved maximum rates of >or=3...

    journal_title：Journal of clinical immunology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1007/s10875-007-9096-9

    authors： Berger M,Cunningham-Rundles C,Bonilla FA,Melamed I,Bichler J,Zenker O,Ballow M

    更新日期：2007-09-01 00:00:00

  • Efficacy and safety of subcutaneous vivaglobin® replacement therapy in previously untreated patients with primary immunodeficiency: a prospective, multicenter study.

    abstract：:Treatment of primary immunodeficiency (PI) is typically initiated with intravenous immunoglobulin (IVIG) loading and then continued with IVIG or subcutaneous IgG (SCIG). This prospective, open-label, multicenter, 6-month study evaluated a new regimen of initiating IgG therapy with SCIG in 18 previously untreated patie...

    journal_title：Journal of clinical immunology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1007/s10875-011-9588-5

    authors： Borte M,Quinti I,Soresina A,Fernández-Cruz E,Ritchie B,Schmidt DS,McCusker C

    更新日期：2011-12-01 00:00:00

  • Long-Term Outcome of Adenosine Deaminase-Deficient Patients-a Single-Center Experience.

    abstract：PURPOSE:Inherited defects in the adenosine deaminase (ADA) enzyme can cause severe combined immune deficiency (SCID) and systemic abnormalities. Management options for ADA-deficient patients include enzyme replacement therapy (ERT), hematopoietic stem cell transplantation (HSCT), and gene therapy (GT). Here, we describ...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-017-0421-7

    authors： Scott O,Kim VH,Reid B,Pham-Huy A,Atkinson AR,Aiuti A,Grunebaum E

    更新日期：2017-08-01 00:00:00

  • Thymus-dependent lymphocytes in leprosy. II. Effect of chemotherapy on T-lymphocyte subpopulations.

    abstract：:The basis of the immunological unresponsiveness seen in leprosy patients is unknown. Untreated lepromatous leprosy patients display an unspecific cellular anergy which disappears with treatment, leaving an anergy specific for Mycobacterium leprae. These patients suffer from a complication, erythema nodosum leprosum, c...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00916889

    authors： Mshana RN,Haregewoin A,Belehu A

    更新日期：1982-04-01 00:00:00

  • Diagnostic Delay of Primary Immunodeficiencies at a Tertiary Care Hospital in Peru- Brief Report.

    abstract：OBJECTIVE:The aim of the study was to assess the diagnostic delay in pediatric patients with primary immunodeficiencies (PID) at a tertiary care hospital in Peru. METHODS:A descriptive study was carried out in which patients from a third-level referral center in Peru were included. Those without a specific diagnosis o...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-017-0398-2

    authors： Veramendi-Espinoza LE,Zafra-Tanaka JH,Pérez-Casquino GA,Córdova-Calderón WO

    更新日期：2017-05-01 00:00:00

  • Early lymphocyte transformation abnormalities in human immunodeficiency virus infection.

    abstract：:Two hundred twelve patients with enzyme immunoassay and Western blot confirmation of human immunodeficiency virus (HIV) infection were evaluated with anergy panel, lymphocyte cell surface phenotyping, lymphocyte transformation, and serum immunoglobulins. Mitogen responses were used to develop a lymphocyte transformati...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00916939

    authors： Ridley DJ,Houk RW,Reid MJ,Boswell RN

    更新日期：1989-03-01 00:00:00

  • Immunomodulatory drug CC-4047 is a cell-type and stimulus-selective transcriptional inhibitor of cyclooxygenase 2.

    abstract：:COX2 (prostaglandin G/H synthase, PTGS2) is a well-validated target in the fields of both oncology and inflammation. Despite their significant toxicity profile, non-steroidal anti-inflammatory drugs (NSAIDs) have become standard of care in the treatment of many COX2-mediated inflammatory conditions. In this report, we...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-007-9070-6

    authors： Ferguson GD,Jensen-Pergakes K,Wilkey C,Jhaveri U,Richard N,Verhelle D,De Parseval LM,Corral LG,Xie W,Morris CL,Brady H,Chan K

    更新日期：2007-03-01 00:00:00

  • Inhibition of IFN regulatory factor-1 down-regulate Th1 cell function in patients with acute coronary syndrome.

    abstract：BACKGROUND:The crucial role of T helper (Th) cells and chronic inflammation in atherosclerosis and coronary artery disease is no longer controversial. Evidence has revealed that Th cell type 1 (Th1) is closely associated with the pathogenesis of acute coronary syndrome (ACS). But the mechanisms involved in the generati...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-010-9367-8

    authors： Guo M,Mao X,Ji Q,Lang M,Li S,Peng Y,Zhou W,Xiong B,Zeng Q

    更新日期：2010-03-01 00:00:00

  • Immunoregulatory T cells in men with a new acquired immunodeficiency syndrome.

    abstract：:We have evaluated the functional properties of the OK-T8+/OKT4+ T-cell subpopulations in nine patients with a new syndrome of acquired immune deficiency (AIDS). Despite polyclonal hypergammaglobulinemia in the sera of these patients, their peripheral blood lymphocytes (PBL) produced negligible quantities of immunoglob...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00915797

    authors： Benveniste E,Schroff R,Stevens RH,Gottlieb MS

    更新日期：1983-10-01 00:00:00

  • Role of homozygous DC-SIGNR 5/5 tandem repeat polymorphism in HIV-1 exposed seronegative North Indian individuals.

    abstract：:Despite multiple sexual exposures to HIV-1 virus, some individuals remain HIV-1 seronegative. Although several genetic factors have been related to HIV-1 resistance, the homozygosity for a mutation in CCR5 gene (the 32-bp deletion, i.e., CCR5-Delta32 allele) is presently considered the most relevant one. The C-type le...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-007-9131-x

    authors： Rathore A,Chatterjee A,Sivarama P,Yamamoto N,Dhole TN

    更新日期：2008-01-01 00:00:00

  • Quantitation by myeloperoxidase assay of neutrophil accumulation at the site of in vivo allergic reactions.

    abstract：:Skin window techniques to investigate neutrophil inflammatory reactions in human skin have been limited by cellular distortion and difficulties in quantitation. We have developed a quantitative approach based on the assessment of the myeloperoxidase (MPO) released from sonicated membrane filters to which exuding infla...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00919143

    authors： Bedard PM,Zweiman B,Atkins PC

    更新日期：1983-01-01 00:00:00

  • Role of monocytes in anti-CD3-induced T-cell DNA synthesis: effect of chloroquine and monensin on anti-CD3-induced human T-cell activation.

    abstract：:Anti-CD3 monoclonal antibody (MoAb) induces proliferation of freshly isolated peripheral blood T cells only in the presence of monocytes/macrophages and requires binding of the Fc portion of antibody to monocytes/macrophages. In this investigation, we examined whether monocytes process anti-CD3 similar to any soluble ...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00916700

    authors： Vayuvegula B,Ohira K,Gollapudi S,Gupta S

    更新日期：1990-09-01 00:00:00

  • TLR-mediated B cell defects and IFN-α in common variable immunodeficiency.

    abstract：:Common variable immune deficiency (CVID) B cells have impaired responses to TLR7 and TLR9 agonists including poor cell proliferation, loss of cytokine production, and failure to produce IgG or IgA. We show that TLR7- or 9-activated B cells from CVID subjects with >0.5% peripheral isotype-switched CD27(+) B cells (grou...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-011-9602-y

    authors： Yu JE,Zhang L,Radigan L,Sanchez-Ramon S,Cunningham-Rundles C

    更新日期：2012-02-01 00:00:00

  • Immunomodulatory properties of borage (Echium amoenum) on BALB/c mice infected with Leishmania major.

    abstract：:Leishmaniasis is caused by parasitic protozoa transmitted by the bite of a female sand fly and is currently endemic in 88 countries. BALB/c mice are highly susceptible to the infection with the parasite Leishmania major, and this susceptibility has been attributed, in part, to the expansion of Th2 cells, production of...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-010-9502-6

    authors： Hosseini N,Abolhassani M

    更新日期：2011-06-01 00:00:00