The effects of indomethacin and interleukin-2 on the proliferation of lymphocytes from patients with lung cancer.

Abstract:

:The effects of the addition of indomethacin and interleukin-2 (IL-2) to phytohemagglutinin (PHA)-stimulated lymphocytes from patients with untreated squamous-cell carcinoma of the lung and with chronic obstructive pulmonary disease and from normal individuals were studied. In 13 of 21 patients with lung carcinoma, the response of lymphocytes to PHA stimulation was significantly augmented by indomethacin. In these 13 patients, the nonaugmented PHA response was also significantly depressed, with only 1 patient falling in the normal range. In the other 8 patients, the average PHA reactivity was normal, as was the degree of augmentation by indomethacin. In additional studies, IL-2 was added to PHA-stimulated lymphocytes with and without the addition of indomethacin. In the normal group, IL-2 further increased PHA reactivity by an average of 46.0%. The addition of indomethacin to these cultures increased the PHA reactivity by only 8.8%, which is similar to the indomethacin effect for the PHA-stimulated cells without the addition of IL-2. In the cancer group, the PHA reactivity of 13 of 19 patients was significantly increased by the addition of IL-2. When indomethacin was added simultaneously with IL-2, the proliferative response for 12 of 19 patients was increased significantly more than for the normal controls. Thus, this study indicates that the PHA reactivity of lymphocytes from many lung carcinoma patients is augmented to a greater extent than for normal individuals by inhibiting prostaglandin synthesis. Also, the addition of IL-2 to these PHA-stimulated cultures did not mimic the addition of indomethacin, but instead the effects were usually additive.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

J Clin Immunol

authors

Maca RD,Burford JG,Taylor RT

doi

10.1007/BF00915506

subject

Has Abstract

pub_date

1985-05-01 00:00:00

pages

158-65

issue

3

eissn

0271-9142

issn

1573-2592

journal_volume

5

pub_type

杂志文章
  • Long-Term Health Outcome and Quality of Life Post-HSCT for IL7Rα-, Artemis-, RAG1- and RAG2-Deficient Severe Combined Immunodeficiency: a Single Center Report.

    abstract::Hematopoietic stem cell transplantation (HSCT) is curative for severe combined immunodeficiency (SCID), but data on long-term impact of pre-HSCT chemotherapy, immune reconstitution and quality of life (QoL) of specific SCID genotypes are limited. We evaluated the long-term immune-reconstitution, health outcome and QoL...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-018-0540-9

    authors: Abd Hamid IJ,Slatter MA,McKendrick F,Pearce MS,Gennery AR

    更新日期:2018-08-01 00:00:00

  • Augmentation of natural and antibody-dependent cell-mediated cytotoxicity by pure human leukocyte interferon.

    abstract::Augmentation of the cytolytic activity of human natural killer cells and of antibody-dependent cell-mediated cytotoxicity has been attributed to human interferons. With the purification to homogeneity of human leukocyte interferon, it became possible to test directly whether pure interferon could increase the activity...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/BF00922756

    authors: Herberman RB,Ortaldo JR,Rubinstein M,Pestka S

    更新日期:1981-07-01 00:00:00

  • Inhibitor IkappaBalpha promoter functional polymorphisms in patients with rheumatoid arthritis.

    abstract:INTRODUCTION:Rheumatoid arthritis (RA) is a chronic inflammation disease that may involve extra-articular organs in addition to joints. Many proinflammatory cytokines are involved in the inflammatory process of RA. IkappaBalpha conjugates with NF-kappaB and is a key player in regulation of the inflammatory process. We ...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-010-9439-9

    authors: Li RN,Hung YH,Lin CH,Chen YH,Yen JH

    更新日期:2010-09-01 00:00:00

  • Immunomodulatory properties of borage (Echium amoenum) on BALB/c mice infected with Leishmania major.

    abstract::Leishmaniasis is caused by parasitic protozoa transmitted by the bite of a female sand fly and is currently endemic in 88 countries. BALB/c mice are highly susceptible to the infection with the parasite Leishmania major, and this susceptibility has been attributed, in part, to the expansion of Th2 cells, production of...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-010-9502-6

    authors: Hosseini N,Abolhassani M

    更新日期:2011-06-01 00:00:00

  • Differential transcriptional expression of PPARalpha, PPARgamma1, and PPARgamma2 in the peritoneal macrophages and T-cell subsets of non-obese diabetic mice.

    abstract:BACKGROUND:The peroxisome proliferator-activated receptors (PPARs) have been implicated in immune regulation. We determined the transcriptional expression of the three isoforms, PPARalpha, PPARgamma1, and PPARgamma2 in the peritoneal macrophages, CD4- and CD8-positive lymphocytes in non-obese diabetic (NOD) mice at 5 a...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-009-9300-1

    authors: Yaacob NS,Kaderi MA,Norazmi MN

    更新日期:2009-09-01 00:00:00

  • The comparison of the efficacy and safety of intravenous versus subcutaneous immunoglobulin replacement therapy.

    abstract::To compare the efficacy of immunoglobulin replacement therapy given intravenously versus subcutaneously to prevent infections in patients with primary antibody deficiency syndromes, an international, multicenter, open label, crossover study was designed. Forty patients were randomized to receive either subcutaneous or...

    journal_title:Journal of clinical immunology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1023/a:1006678312925

    authors: Chapel HM,Spickett GP,Ericson D,Engl W,Eibl MM,Bjorkander J

    更新日期:2000-03-01 00:00:00

  • Disparity in FcεRI-induced degranulation of primary human lung and skin mast cells exposed to adenosine.

    abstract::Inhaled and intravenously administered adenosine induces mast cell-mediated (histamine-dependent) bronchospasm in asthmatics without causing urticaria. A differential response to adenosine by human lung and skin mast cells is shown: low concentrations potentiate FcεRI-induced degranulation of human lung mast cells but...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-011-9517-7

    authors: Gomez G,Zhao W,Schwartz LB

    更新日期:2011-06-01 00:00:00

  • DOCK8 deficiency: clinical and immunological phenotype and treatment options - a review of 136 patients.

    abstract::Mutations in DOCK8 result in autosomal recessive Hyper-IgE syndrome with combined immunodeficiency (CID). However, the natural course of disease, long-term prognosis, and optimal therapeutic management have not yet been clearly defined. In an international retrospective survey of patients with DOCK8 mutations, focused...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-014-0126-0

    authors: Aydin SE,Kilic SS,Aytekin C,Kumar A,Porras O,Kainulainen L,Kostyuchenko L,Genel F,Kütükcüler N,Karaca N,Gonzalez-Granado L,Abbott J,Al-Zahrani D,Rezaei N,Baz Z,Thiel J,Ehl S,Marodi L,Orange JS,Sawalle-Belohradsky J

    更新日期:2015-02-01 00:00:00

  • Persistent hypogammaglobulinemia following mononucleosis in boys is highly suggestive of X-linked lymphoproliferative disease--report of three cases.

    abstract::Hypogammaglobulinemia is a common symptom in different immunodeficiencies. It is, however, not usually associated with Epstein-Barr virus (EBV) infections. The X-linked lymphoproliferative disease (XLP) on the other hand shows immunological changes in response to the EBV. Here we report three previously healthy boys, ...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1023/B:JOCI.0000040922.26286.36

    authors: Hügle B,Suchowerskyj P,Hellebrand H,Adler B,Borte M,Sack U,Overberg-Schmidt US,Strnad N,Otto J,Meindl A,Schuster V

    更新日期:2004-09-01 00:00:00

  • Monitoring of CD4+ and CD8+ T-cell responses after dendritic cell-based immunotherapy using CFSE dye dilution analysis.

    abstract::CFSE dye dilution analysis and [3H] thymidine incorporation were used side by side to assess proliferative responses of peripheral blood mononuclear cells (PBMCs) after vaccination of renal cell carcinoma patients (n=6) with antigen-loaded dendritic cells. Immune responses against the control antigen keyhole limpet he...

    journal_title:Journal of clinical immunology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10875-004-6237-2

    authors: Putz T,Ramoner R,Gander H,Rahm A,Bartsch G,Höltl L,Thurnher M

    更新日期:2004-11-01 00:00:00

  • Pineal germinoma in a child with interferon-γ receptor 1 deficiency. case report and literature review.

    abstract::Interferon-γ receptor 1 (IFN-γR1) deficiency is one of the primary immunodeficiencies conferring Mendelian Susceptibility to Mycobacterial Disease (MSMD). Some cases of neoplasms have been recently reported in patients with MSMD, underlying the already known link between immunodeficiency and carcinogenesis. We report ...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1007/s10875-014-0098-0

    authors: Taramasso L,Boisson-Dupuis S,Garrè ML,Bondi E,Cama A,Nozza P,Morana G,Casanova JL,Marazzi MG

    更新日期:2014-11-01 00:00:00

  • Complexes of serum amyloid P component and DNA in serum from healthy individuals and systemic lupus erythematosus patients.

    abstract::Serum amyloid P component (SAP) binds in vitro to DNA; based on findings in SAP-deficient mice it was proposed that SAP's role is to handle chromatin and DNA, thereby preventing formation of anti-DNA antibodies. For the first time we have shown the presence of Ca2+-dependent SAP-DNA complexes, measured by ELISA, in se...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1023/a:1026478914129

    authors: Sørensen IJ,Holm Nielsen E,Schrøder L,Voss A,Horváth L,Svehag SE

    更新日期:2000-11-01 00:00:00

  • Effect of palifermin in a murine model of graft-versus-host disease (GVHD) associated with Th2 cytokine production, autoantibody production, and glomerulonephritis.

    abstract::Palifermin (recombinant human keratinocyte growth factor) prevents the development of acute, lethal graft-versus-host disease (GVHD). It does so, at least in part, by protecting cells from injury. Another property of Palifermin is immune regulation. How the latter influences the evolution of GVHD remains uncertain. We...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-006-9039-x

    authors: Ellison CA,Gibson IW,Hayglass KT,Gartner JG

    更新日期:2006-09-01 00:00:00

  • Correction to: Life-Threatening Infections Due to Live-Attenuated Vaccines: Early Manifestations of Inborn Errors of Immunity.

    abstract::The original version of this article unfortunately contained mistake in the following sentence in the Abstract. ...

    journal_title:Journal of clinical immunology

    pub_type: 已发布勘误

    doi:10.1007/s10875-019-00653-0

    authors: Pöyhönen L,Bustamante J,Casanova JL,Jouanguy E,Zhang Q

    更新日期:2019-07-01 00:00:00

  • T cell subsets in autoimmune and HBV-induced chronic liver disease, HBs antigen carriers with normal histology and primary biliary cirrhosis: a review of the abnormalities and the effects of treatment.

    abstract::Review of the limited data currently available on the ratios of helper (OKT4+) to suppressor (OKT8+) T cells in autoimmune liver disease (primary biliary cirrhosis and chronic active lupoid hepatitis) and virally induced liver disease indicates that this OKT4+:OKT8+ ratio is elevated in autoimmune liver disease manife...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章,评审

    doi:

    authors: Thomas HC,Brown D,Labrooy J,Epstein O

    更新日期:1982-07-01 00:00:00

  • Effect of hyperoxia on pulmonary SIgA and its components, IgA and SC.

    abstract:PURPOSE:Oxygen therapy (hyperoxia) is essential for the treatment of some neonatal critical care conditions. The lung is the primary target for the changes induced by hyperoxia. Secretory immunoglobulin A (SIgA), IgA and secretory component (SC) reflect the local immunity in the respiratory tract induced by hyperoxia. ...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-013-9891-4

    authors: Liu DY,Jiang T,Wang S,Cao X

    更新日期:2013-07-01 00:00:00

  • Analyses of CD27++ plasma cells in peripheral blood from patients with bacterial infections and patients with serum antinuclear antibodies.

    abstract::The number of CD27++ plasma cells (PCs) in peripheral blood may be a valuable biomarker for systemic lupus erythematosus (SLE) disease management. More insights into the behavior of the PC population are, however, required to validate CD27 as a reliable biomarker. In the current study, we have monitored the PC compart...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-007-9099-6

    authors: Ten Boekel E,Siegert CE,Vrielink GJ,Van Dam VC,Ceelen A,De Kieviet W

    更新日期:2007-09-01 00:00:00

  • Long-term follow-up of health in blood donors with primary selective IgA deficiency.

    abstract::A 20-year health follow-up study of 159 initially healthy blood donors with a severe deficiency of serum IgA ( < 0.05 x 10(-3) g/L) and of 45 donors with decreased serum IgA (0.05 x 10(-3)-0.8 g/L) was carried out. The findings indicate that persons with a severe deficiency of and decreased serum IgA who are healthy a...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/BF01540915

    authors: Koskinen S

    更新日期:1996-05-01 00:00:00

  • Evidence of a plasma-mediated "window" of immunodeficiency in rats following trauma.

    abstract::The etiology of immunodeficiency following trauma was investigated. Plasma collected from Fischer rats 1-8 hr following a 40% surface area thermal injury (TI) displays immunosuppressive activity (ISA). Peak ISA (4 hr) exceeded 90% inhibition of Con A3-induced proliferation of normal spleen cells. Splenic macrophage IL...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/BF00916942

    authors: Mills CD,Caldwell MD,Gann DS

    更新日期:1989-03-01 00:00:00

  • Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification.

    abstract::Since 2013, the International Union of Immunological Societies (IUIS) expert committee (EC) on Inborn Errors of Immunity (IEI) has published an updated phenotypic classification of IEI, which accompanies and complements their genotypic classification into ten tables. This phenotypic classification is user-friendly and...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-020-00758-x

    authors: Bousfiha A,Jeddane L,Picard C,Al-Herz W,Ailal F,Chatila T,Cunningham-Rundles C,Etzioni A,Franco JL,Holland SM,Klein C,Morio T,Ochs HD,Oksenhendler E,Puck J,Torgerson TR,Casanova JL,Sullivan KE,Tangye SG

    更新日期:2020-01-01 00:00:00

  • DNA methylation and the expression of IL-4 and IFN-gamma promoter genes in patients with bronchial asthma.

    abstract::Although CpG methylation is thought to be a negative regulator of gene transcription, its relationship with cytokine expression remains unclear. Interleukin (IL)-4 and interferon (IFN)-gamma are major cytokines that affect the differentiation of naïve CD4+ T lymphocytes into the Th1 and Th2 lineage. We used bisulfite ...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-007-9148-1

    authors: Kwon NH,Kim JS,Lee JY,Oh MJ,Choi DC

    更新日期:2008-03-01 00:00:00

  • Spondyloenchondrodysplasia Due to Mutations in ACP5: A Comprehensive Survey.

    abstract:PURPOSE:Spondyloenchondrodysplasia is a rare immuno-osseous dysplasia caused by biallelic mutations in ACP5. We aimed to provide a survey of the skeletal, neurological and immune manifestations of this disease in a cohort of molecularly confirmed cases. METHODS:We compiled clinical, genetic and serological data from a...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10875-016-0252-y

    authors: Briggs TA,Rice GI,Adib N,Ades L,Barete S,Baskar K,Baudouin V,Cebeci AN,Clapuyt P,Coman D,De Somer L,Finezilber Y,Frydman M,Guven A,Heritier S,Karall D,Kulkarni ML,Lebon P,Levitt D,Le Merrer M,Linglart A,Livingst

    更新日期:2016-04-01 00:00:00

  • Current Status of the Management of Mendelian Susceptibility to Mycobacterial Disease in Mainland China.

    abstract:PURPOSE:Although many studies have investigated Mendelian susceptibility to mycobacterial disease (MSMD) worldwide, there is no report of the long-term clinical management and prognosis for MSMD in China. METHODS:This is a cohort study from January 2000 to June 2018. Three hundred and twenty-four patients with bacillu...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-019-00672-x

    authors: Ying W,Liu D,Dong X,Wang W,Hui X,Hou J,Yao H,Zhou Q,Sun B,Sun J,Wang X

    更新日期:2019-08-01 00:00:00

  • Life-Threatening Infections Due to Live-Attenuated Vaccines: Early Manifestations of Inborn Errors of Immunity.

    abstract::Live-attenuated vaccines (LAVs) can protect humans against 12 viral and three bacterial diseases. By definition, any clinical infection caused by a LAV that is sufficiently severe to require medical intervention attests to an inherited or acquired immunodeficiency that must be diagnosed or identified. Self-healing inf...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章,评审

    doi:10.1007/s10875-019-00642-3

    authors: Pöyhönen L,Bustamante J,Casanova JL,Jouanguy E,Zhang Q

    更新日期:2019-05-01 00:00:00

  • Significance of unconventional peripheral CD4+CD8dim T cell subsets.

    abstract::Routine T cells phenotyping occasionally reveals a CD4+CD8dim T cell subset with an apparently homogeneous dot plot. The aim of this study was to elucidate their immunological significance from analysis of 31 healthy donors, 21 elderly and 220 immune deficient patients. CD4+CD8dim T cells expressed reduced levels of C...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-005-5257-x

    authors: Lambert C,Ibrahim M,Iobagiu C,Genin C

    更新日期:2005-09-01 00:00:00

  • Developmental, malignancy-related, and cross-species analysis of eosinophil, mast cell, and basophil siglec-8 expression.

    abstract:OBJECTIVE:The aim of this study is to determine when during hematopoiesis Siglec-8 gets expressed, whether it is expressed on hematologic malignancies, and if there are other non-human species that express Siglec-8. METHODS:Siglec-8 mRNA and cell surface expression was monitored during in vitro maturation of human eos...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-011-9589-4

    authors: Hudson SA,Herrmann H,Du J,Cox P,Haddad el-B,Butler B,Crocker PR,Ackerman SJ,Valent P,Bochner BS

    更新日期:2011-12-01 00:00:00

  • Toll-like receptor expression pattern: clinical application.

    abstract::We read with interest the recent paper in the JoCI, entitled 'Study of the expression of Toll-Like Receptors in Different Histological Types of Colorectal Polyps and Their Relationship with Colorectal Cancer' by Eiró et al. TLR7 and 9 expression is altered in CRC vs. normal control; which is proposed to be correlated ...

    journal_title:Journal of clinical immunology

    pub_type: 评论,信件

    doi:10.1007/s10875-012-9719-7

    authors: Moossavi S,Rezaei N

    更新日期:2012-12-01 00:00:00

  • Antibodies to polyclonal IgA, IgA1, and IgA2 and isotype-specific immune complexes in IgA nephropathy.

    abstract::The concentrations of serum IgG and IgM antibodies to polyclonal IgA (IgAp), IgA1, and IgA2 were determined by enzyme immunoassay in 31 patients with IgA nephropathy and 30 healthy controls. Patients with IgA nephropathy had significantly raised concentrations of serum IgA compared to controls (Mann-Whitney U test, P ...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/BF00918662

    authors: Jones CL,Hosking CS,Kincaid-Smith P,Powell HR,Richardson SC,Sennhauser FH,Roberton DM

    更新日期:1989-07-01 00:00:00

  • Impaired IgG antibody production to pneumococcal polysaccharides in patients with ataxia-telangiectasia.

    abstract::Various factors seem to be etiologic in the susceptibility to sinopulmonary infections in ataxia-telangiectasia (A-T) patients, i.e., low serum and salivary IgA, low serum IgG2, and even aspiration of saliva. S. pneumoniae is a common pathogen responsible from pulmonary infections and impaired antibody response to pol...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1023/a:1020599810261

    authors: Sanal O,Ersoy F,Yel L,Tezcan I,Metin A,Ozyürek H,Gariboglu S,Fikrig S,Berkel AI,Rijkers GT,Zegers BJ

    更新日期:1999-09-01 00:00:00

  • Identification of Critical Transcriptomic Signaling Pathways in Patients with H Syndrome and Rosai-Dorfman Disease.

    abstract::Biallelic mutations in SLC29A3 cause histiocytosis-lymphadenopathy plus syndrome, also known as H syndrome (HS). HS is a complex disorder, with ~ 25% of patients developing autoinflammatory complications consisting of unexplained fevers, persistently elevated inflammatory markers, and unusual lymphadenopathies, with i...

    journal_title:Journal of clinical immunology

    pub_type: 杂志文章

    doi:10.1007/s10875-020-00932-1

    authors: Lara-Reyna S,Poulter JA,Vasconcelos EJR,Kacar M,McDermott MF,Tooze R,Doffinger R,Savic S

    更新日期:2020-12-07 00:00:00