Anti-SM and anti-U1-RNP lupus antibody fine specificities.

abstract：:This is the second report on the continuing efforts of LAGID to increase the recognition and registration of patients with primary immunodeficiency diseases in 12 Latin American countries: Argentina, Brazil, Chile, Colombia, Costa Rica, Honduras, Mexico, Panama, Paraguay, Peru, Uruguay, and Venezuela. This report reve...

journal_title：Journal of clinical immunology

authors： Leiva LE,Zelazco M,Oleastro M,Carneiro-Sampaio M,Condino-Neto A,Costa-Carvalho BT,Grumach AS,Quezada A,Patiño P,Franco JL,Porras O,Rodríguez FJ,Espinosa-Rosales FJ,Espinosa-Padilla SE,Almillategui D,Martínez C,Tafur JR,

更新日期：2007-01-01 00:00:00

abstract：:Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by hypogammaglobulinemia and increased susceptibility to recurrent pyogenic infections, autoimmunity, and malignancies. Twenty-five cases with CVID (18 male and 7 female) and 25 healthy volunteers were investigate in this stud...

journal_title：Journal of clinical immunology

authors： Rezaei N,Haji-Molla-Hoseini M,Aghamohammadi A,Pourfathollah AA,Moghtadaie M,Pourpak Z

更新日期：2008-01-01 00:00:00

abstract：:Despite multiple sexual exposures to HIV-1 virus, some individuals remain HIV-1 seronegative. Although several genetic factors have been related to HIV-1 resistance, the homozygosity for a mutation in CCR5 gene (the 32-bp deletion, i.e., CCR5-Delta32 allele) is presently considered the most relevant one. The C-type le...

journal_title：Journal of clinical immunology

authors： Rathore A,Chatterjee A,Sivarama P,Yamamoto N,Dhole TN

更新日期：2008-01-01 00:00:00

abstract：:Skin window techniques to investigate neutrophil inflammatory reactions in human skin have been limited by cellular distortion and difficulties in quantitation. We have developed a quantitative approach based on the assessment of the myeloperoxidase (MPO) released from sonicated membrane filters to which exuding infla...

journal_title：Journal of clinical immunology

authors： Bedard PM,Zweiman B,Atkins PC

更新日期：1983-01-01 00:00:00

abstract：:Live-attenuated vaccines (LAVs) can protect humans against 12 viral and three bacterial diseases. By definition, any clinical infection caused by a LAV that is sufficiently severe to require medical intervention attests to an inherited or acquired immunodeficiency that must be diagnosed or identified. Self-healing inf...

journal_title：Journal of clinical immunology

authors： Pöyhönen L,Bustamante J,Casanova JL,Jouanguy E,Zhang Q

更新日期：2019-05-01 00:00:00

abstract：:The present study analyzes the role of CD28-B7-mediated costimulation during in vitro human peripheral blood memory T cell activation by influenza A virus. Inhibition studies using the B7-binding fusion protein CTLA4Ig and antibodies against CD80 and CD86 demonstrate that CTLA4Ig and anti-CD86 inhibited influenza-spec...

journal_title：Journal of clinical immunology

authors： Blazevic V,Trubey CM,Shearer GM

更新日期：2001-07-01 00:00:00

abstract：PURPOSE:Systemic lupus erythematous (SLE) is a systemic autoimmune inflammatory disease with both genetic and epigenetic etiologies. Evidence suggests that deregulation of specific genes through epigenetic mechanisms may be a contributing factor to SLE pathology. There is increasing evidence that DNA methyltransferase ...

journal_title：Journal of clinical immunology

authors： Wiley KL,Treadwell E,Manigaba K,Word B,Lyn-Cook BD

更新日期：2013-02-01 00:00:00

abstract：PURPOSE:DNA Ligase 4 (LIG4) is a key factor in the non-homologous end-joining (NHEJ) DNA double-strand break repair pathway needed for V(D)J recombination and the generation of the T cell receptor and immunoglobulin molecules. Defects in LIG4 result in a variable syndrome of growth retardation, pancytopenia, combined i...

journal_title：Journal of clinical immunology

authors： Felgentreff K,Baxi SN,Lee YN,Dobbs K,Henderson LA,Csomos K,Tsitsikov EN,Armanios M,Walter JE,Notarangelo LD

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVES:Gastrointestinal manifestations are frequent in patients with common variable immunodeficiency (CVID), and some of the patients present with celiac-like features. Diagnosing celiac disease (CD) in CVID however is challenging, as autoantibody detection and histopathology of the small intestine cannot reliably...

journal_title：Journal of clinical immunology

authors： Venhoff N,Emmerich F,Neagu M,Salzer U,Koehn C,Driever S,Kreisel W,Rizzi M,Effelsberg NM,Kollert F,Goldacker S,Voll RE,Warnatz K,Thiel J

更新日期：2013-07-01 00:00:00

abstract：:Recombinant human erythropoietin (rhEPO) treatment of hemodialyzed (HD) patients normalizes the altered phenotype of CD4(+) lymphocytes and restores the balance of Th1/Th2 cytokines. We decided to test how the presence of rhEPO in cell culture modulates cytokine production of CD4(+) lymphocytes in HD patients with sta...

journal_title：Journal of clinical immunology

authors： Lisowska KA,Dębska-Ślizień A,Jasiulewicz A,Daca A,Bryl E,Witkowski JM

更新日期：2013-04-01 00:00:00

abstract：PURPOSE:Autosomal recessive hyper-IgE syndrome is a rare combined immunodeficiency characterized by susceptibility to viral infections, atopic eczema, high serum IgE and defective T cell activation. The genetic etiologies are diverse. Null mutations in DOCK8 and TYK2 are responsible for many cases. This study aims to p...

journal_title：Journal of clinical immunology

authors： Alsum Z,Hawwari A,Alsmadi O,Al-Hissi S,Borrero E,Abu-Staiteh A,Khalak HG,Wakil S,Eldali AM,Arnaout R,Al-Ghonaium A,Al-Muhsen S,Al-Dhekri H,Al-Saud B,Al-Mousa H

更新日期：2013-01-01 00:00:00

abstract：:Autism is a complex polygenic neurodevelopmental disorder characterized by deficits in communication and social interactions as well as specific stereotypical behaviors. Both genetic and environmental factors appear to contribute to the pathogenesis of autism. Accumulating data including changes in immune responses, l...

journal_title：Journal of clinical immunology

authors： Gupta S,Samra D,Agrawal S

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:To assess the serum profile of factors involved in endothelial, T-cell, and fibroblast interplay in patients with Raynaud's phenomenon (RP) associated with nailfold vodeocapillaroscopy (NVC) scleroderma findings and/or systemic sclerosis (SSc) marker autoantibodies, recently labeled as early SSc patients. METH...

journal_title：Journal of clinical immunology

authors： Vettori S,Cuomo G,Iudici M,D'Abrosca V,Giacco V,Barra G,De Palma R,Valentini G

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:An outbreak of multisystem inflammatory syndrome in children, including Kawasaki disease (KD), emerged during COVID-19 pandemic. We explored whether Kawasaki-like disease (KD), when associated with confirmed SARS-CoV-2 infection, has specific characteristics. METHODS:We included children and adolescents wit...

journal_title：Journal of clinical immunology

authors： Toubiana J,Cohen JF,Brice J,Poirault C,Bajolle F,Curtis W,Moulin F,Matczak S,Leruez M,Casanova JL,Chalumeau M,Taylor M,Allali S

更新日期：2021-01-04 00:00:00

abstract：:Chronic Granulomatous Disease (CGD), caused by genetic defects in components of the phagocyte NADPH oxidase pathway, leads to recurrent life-threatening bacterial and invasive fungal infections. While a number of unique pathogens have been associated with this disease, the causative organisms may be difficult to ident...

journal_title：Journal of clinical immunology

authors： Ramesh M,Resnick E,Hui Y,Maglione PJ,Mehta H,Kattan J,Bouvier NM,LaBombardi V,Victor TR,Chaturvedi S,Cunningham-Rundles C

更新日期：2014-02-01 00:00:00

abstract：INTRODUCTION:Complement deficiencies are rare primary immunodeficiency disorders, the diagnosis of which is often underestimated. Only a small number of molecular studies have been carried out for the characterization of the underlying genetic defects in these cases. PURPOSE:Reporting the first family from the Arabian...

journal_title：Journal of clinical immunology

authors： Arnaout R,Al Shorbaghi S,Al Dhekri H,Al-Mousa H,Al Ghonaium A,Al Saud B,Al Muhsen S,Al Baik L,Hawwari A

更新日期：2013-05-01 00:00:00

abstract：PURPOSE:Sarcoidosis is a non-caseating granulomatous disease for which a role for infectious antigens continues to strengthen. Recent studies have reported molecular evidence of mycobacteria or propionibacteria. We assessed for immune responses against mycobacterial and propionibacterial antigens in sarcoidosis broncho...

journal_title：Journal of clinical immunology

authors： Oswald-Richter KA,Beachboard DC,Seeley EH,Abraham S,Shepherd BE,Jenkins CA,Culver DA,Caprioli RM,Drake WP

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Recently, two functional IL18 promoter variants, -607C>A (rs1946518) and -137G>C (rs187238), were associated with viral clearance in patients with hepatitis C. The present study focused on their relevance for treatment response. METHODS:Seven hundred fifty-seven chronically infected European patients and 79...

journal_title：Journal of clinical immunology

authors： Haas SL,Weiss C,Bugert P,Gundt J,Witt H,Singer MV,Berg T,Böcker U

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:Oxygen therapy (hyperoxia) is essential for the treatment of some neonatal critical care conditions. The lung is the primary target for the changes induced by hyperoxia. Secretory immunoglobulin A (SIgA), IgA and secretory component (SC) reflect the local immunity in the respiratory tract induced by hyperoxia. ...

journal_title：Journal of clinical immunology

authors： Liu DY,Jiang T,Wang S,Cao X

更新日期：2013-07-01 00:00:00

abstract：:An emerging paradigm for the treatment of primary immunodeficiency disease (PIDD) with immunoglobulin (IgG) replacement therapy emphasizes the tailoring of treatments to each patient with the goal of preventing infections and minimizing side effects. Increasing evidence shows that the IgG dose needed to prevent infect...

journal_title：Journal of clinical immunology

authors： Shapiro RS,Wasserman RL,Bonagura V,Gupta S

更新日期：2017-02-01 00:00:00

abstract：:Inhaled and intravenously administered adenosine induces mast cell-mediated (histamine-dependent) bronchospasm in asthmatics without causing urticaria. A differential response to adenosine by human lung and skin mast cells is shown: low concentrations potentiate FcεRI-induced degranulation of human lung mast cells but...

journal_title：Journal of clinical immunology

authors： Gomez G,Zhao W,Schwartz LB

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:The peroxisome proliferator-activated receptors (PPARs) have been implicated in immune regulation. We determined the transcriptional expression of the three isoforms, PPARalpha, PPARgamma1, and PPARgamma2 in the peritoneal macrophages, CD4- and CD8-positive lymphocytes in non-obese diabetic (NOD) mice at 5 a...

journal_title：Journal of clinical immunology

authors： Yaacob NS,Kaderi MA,Norazmi MN

更新日期：2009-09-01 00:00:00

abstract：:Unusual susceptibility to mycobacterial infections can be caused by deleterious mutations in genes that encode the interferon-gamma receptor 1 chain. Such mutations hamper the activation of macrophages by a type 1 immune response and result in enhanced survival of intracellular pathogens. We here report two patients w...

journal_title：Journal of clinical immunology

authors： Noordzij JG,Hartwig NG,Verreck FA,De Bruin-Versteeg S,De Boer T,Van Dissel JT,De Groot R,Ottenhoff TH,Van Dongen JJ

更新日期：2007-09-01 00:00:00

abstract：PURPOSE:The present study was designed to evaluate the efficacy and safety of a novel, 10% liquid formulation of intravenous immunoglobulin, stabilized with 250 mmol/L L-proline (Privigen), in patients with primary immunodeficiency disease. MATERIALS AND METHODS:Eighty adults and children diagnosed with common variabl...

journal_title：Journal of clinical immunology

authors： Stein MR,Nelson RP,Church JA,Wasserman RL,Borte M,Vermylen C,Bichler J,IgPro10 in PID study group.

更新日期：2009-01-01 00:00:00

abstract：:Review of the limited data currently available on the ratios of helper (OKT4+) to suppressor (OKT8+) T cells in autoimmune liver disease (primary biliary cirrhosis and chronic active lupoid hepatitis) and virally induced liver disease indicates that this OKT4+:OKT8+ ratio is elevated in autoimmune liver disease manife...

journal_title：Journal of clinical immunology

authors： Thomas HC,Brown D,Labrooy J,Epstein O

更新日期：1982-07-01 00:00:00

abstract：PURPOSE:Spondyloenchondrodysplasia is a rare immuno-osseous dysplasia caused by biallelic mutations in ACP5. We aimed to provide a survey of the skeletal, neurological and immune manifestations of this disease in a cohort of molecularly confirmed cases. METHODS:We compiled clinical, genetic and serological data from a...

journal_title：Journal of clinical immunology

authors： Briggs TA,Rice GI,Adib N,Ades L,Barete S,Baskar K,Baudouin V,Cebeci AN,Clapuyt P,Coman D,De Somer L,Finezilber Y,Frydman M,Guven A,Heritier S,Karall D,Kulkarni ML,Lebon P,Levitt D,Le Merrer M,Linglart A,Livingst

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:The purpose of the study was to determine associations between pre-antiretroviral therapy (ART) senescent CD8+ T lymphocytes and naïve versus non-naive CD8+ and CD4+ T lymphocyte subpopulations and CD4+ responses after initiation of ART in younger versus older individuals. METHODS:Retrospective analysis of 1...

journal_title：Journal of clinical immunology

authors： Hoffman RM,Jamieson BD,Bosch RJ,Currier J,Kitchen CM,Schmid I,Zhu Y,Bennett K,Mitsuyasu R

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Wiskott-Aldrich syndrome (WAS) is a rare primary immunodeficiency disease, with an incidence of 4/1,000,000 live male births. In China, an estimated number of 35 babies with WAS are born each year, but likely many remain undiagnosed. OBJECTIVES:The objectives of study were to review the clinical and molecul...

journal_title：Journal of clinical immunology

authors： Lee PP,Chen TX,Jiang LP,Chen J,Chan KW,Lee TL,Ho MH,Nong SH,Yang Y,Fang YJ,Li Q,Wang XC,Yang XQ,Lau YL

更新日期：2009-07-01 00:00:00

abstract：:A monoclonal antibody produced by hybridomas obtained from a mouse immunized with drug-resistant cells recognizes certain hamster and human drug-resistant cell lines but not their drug-sensitive parental lines. Preliminary characterization of the antigen indicates that it is a molecule of approximately 180,000 daltons...

journal_title：Journal of clinical immunology

authors： O'Hara CJ,Grover J,Price GB

更新日期：1984-09-01 00:00:00

abstract：PURPOSE:Adenitis for which no causative organism can be isolated is a common occurrence in patients with chronic granulomatous disease (CGD). Here we identify Acidomonas methanolica as a pathogen associated with adenitis in a patient with CGD. METHODS:The causative pathogen was obtained after prolonged incubation of a...

journal_title：Journal of clinical immunology

authors： Chase JM,Holland SM,Greenberg DE,Marshall-Batty K,Zelazny AM,Church JA

更新日期：2012-12-01 00:00:00