Emerging Paradigm of Primary Immunodeficiency Disease: Individualizing Immunoglobulin Dose and Delivery to Enhance Outcomes.

abstract：PURPOSE:Adenosine deaminase (ADA) deficiency is a systemic disorder of purine metabolism. Deficiency of the purine salvage enzyme ADA leads to the build-up of the toxic metabolites, deoxyadenosine triphosphate and deoxyadenosine. ADA is ubiquitously expressed in all tissues of the body but most profoundly affects lymph...

journal_title：Journal of clinical immunology

authors： Nikolajeva O,Worth A,Hague R,Martinez-Alier N,Smart J,Adams S,Davies EG,Gaspar HB

更新日期：2015-05-01 00:00:00

abstract：:This is the second report on the continuing efforts of LAGID to increase the recognition and registration of patients with primary immunodeficiency diseases in 12 Latin American countries: Argentina, Brazil, Chile, Colombia, Costa Rica, Honduras, Mexico, Panama, Paraguay, Peru, Uruguay, and Venezuela. This report reve...

journal_title：Journal of clinical immunology

authors： Leiva LE,Zelazco M,Oleastro M,Carneiro-Sampaio M,Condino-Neto A,Costa-Carvalho BT,Grumach AS,Quezada A,Patiño P,Franco JL,Porras O,Rodríguez FJ,Espinosa-Rosales FJ,Espinosa-Padilla SE,Almillategui D,Martínez C,Tafur JR,

更新日期：2007-01-01 00:00:00

abstract：:Liver infiltrating lymphocytes (LIL) were isolated from HCV-positive (+) and HCV-negative (-) end-stage livers. Phenotypic analysis and functional studies using proliferative and lymphocytotoxic assays were performed with the isolated LIL. Two CD3+ lymphocyte populations were found in LIL using FITC anti-CD3 monoclona...

journal_title：Journal of clinical immunology

authors： Jin Y,Fuller L,Carreno M,Zucker K,Roth D,Esquenazi V,Karatzas T,Swanson SJ 3rd,Tzakis AG,Miller J

更新日期：1997-03-01 00:00:00

abstract：PURPOSE:Chronic granulomatous disease (CGD) is a primary immunodeficiency for which allogeneic hematopoietic stem cell transplant (HSCT) offers potential cure. Direct comparison of HSCT to non-HSCT management in the North American population was performed to identify clinical factors associated with overall survival (O...

journal_title：Journal of clinical immunology

authors： Yonkof JR,Gupta A,Fu P,Garabedian E,Dalal J,the United States Immunodeficiency Network Consortium.

更新日期：2019-05-01 00:00:00

abstract：:Using fresh whole blood or isolated lymphocytes, the activity of in vivo generated cytotoxic T-lymphocytes (CTL) was measured as the OKT3-specific lysis of HL-60 targets, in a cross-sectional study of 53 HIV (+) patients. CTL activity in the entire HIV(+) group was two to three times higher than in HIV(-) controls, wi...

journal_title：Journal of clinical immunology

authors： Vanham G,Kestens L,Penne G,Goilav C,Gigase P,Colebunders R,Vandenbruaene M,Goeman J,van der Groen G,Ceuppens JL

更新日期：1991-11-01 00:00:00

abstract：PURPOSE:Survival of the Leishmania parasite within monocytes hinges on its ability to effectively nullify their microbicidal effector mechanisms. Accordingly, this study aimed to delineate this biological niche in patients with visceral leishmaniasis (VL). METHODS:In monocytes, the redox status, antigen presenting cap...

journal_title：Journal of clinical immunology

authors： Roy S,Mukhopadhyay D,Mukherjee S,Ghosh S,Kumar S,Sarkar K,Pal D,Bhowmik P,Mandal K,Modak D,Guha SK,Pramanik N,Goswami RP,Saha B,Chatterjee M

更新日期：2015-01-01 00:00:00

abstract：:Recombinant human erythropoietin (rhEPO) treatment of hemodialyzed (HD) patients normalizes the altered phenotype of CD4(+) lymphocytes and restores the balance of Th1/Th2 cytokines. We decided to test how the presence of rhEPO in cell culture modulates cytokine production of CD4(+) lymphocytes in HD patients with sta...

journal_title：Journal of clinical immunology

authors： Lisowska KA,Dębska-Ślizień A,Jasiulewicz A,Daca A,Bryl E,Witkowski JM

更新日期：2013-04-01 00:00:00

abstract：:The human monoclonal autoantibody 16/6 is a common anti-DNA idiotype found to have clinical relevance in patients with systemic lupus erythematosus (SLE). Therefore the ability of peripheral blood T cells of SLE patients and healthy controls to proliferate and to produce helper T-cell factors following stimulation wit...

journal_title：Journal of clinical immunology

authors： Mendlovic S,Shoenfeld Y,Bakimer R,Segal R,Dayan M,Mozes E

更新日期：1988-05-01 00:00:00

abstract：:The cytotoxin production by regional lymph node cells was examined in 25 patients with uterine cervical cancer and 10 patients with uterine myoma. The patients in stage I had significantly increased spontaneous release of cytotoxins compared with that in stages II, III, and IV. The spontaneous release in stages III an...

journal_title：Journal of clinical immunology

authors： Matsunaga K,Mashiba H,Kurano A,Jimi S

更新日期：1990-09-01 00:00:00

abstract：:An absolute requirement for monocytes was demonstrated in the T-cell proliferative response to tetanus toxoid (TT) antigen. Antigen-pulsed monocytes were shown to be effective in triggering T-cell proliferation. Using 125I-radiolabeled TT antigen, uptake by monocytes increased progressively over an 18-hr period, at wh...

journal_title：Journal of clinical immunology

authors： Alpert SD,Jonsen ME,Broff MD,Schneeberger E,Geha RS

更新日期：1981-01-01 00:00:00

abstract：:The inflammasome is an intracellular multimolecular complex that controls caspase-1 activity in the innate immune system. NLRP3, a member of the NLR family of cytosolic pattern recognition receptors, along with the adaptor protein ASC, mediates caspase-1 activation via assembly of the inflammasome in response to vario...

journal_title：Journal of clinical immunology

authors： Jin C,Flavell RA

更新日期：2010-09-01 00:00:00

abstract：:Intravenous immunoglobin (i.v.IG) is generated from the plasma of more than 10,000 healthy subjects. Originally i.v.IG was employed to supplement the missing Igs in subjects with immune-deficiencies. Later on it was given successfully to patients with autoimmune conditions, in some of which the benefits were confirmed...

journal_title：Journal of clinical immunology

authors： Shoenfeld Y,Krause I

更新日期：2004-03-01 00:00:00

abstract：:Immunoglobulin isolated from sera of homosexual men infected with human immunodeficiency virus (HIV) inhibited the reverse transcriptase (RT) activity of HIV. The inhibitory activity was specifically directed against HIV RT, and not against other mammalian retrovirus RT, including human T-lymphotropic virus type I. Th...

journal_title：Journal of clinical immunology

authors： Chatterjee R,Rinaldo CR Jr,Gupta P

更新日期：1987-05-01 00:00:00

abstract：:Utilizing a rat model of semiallogeneic intestinal transplantation, recipients were evaluated for accumulation of donor-specific cytotoxic T cells in spleen, mesenteric lymph nodes, Peyer's patches, lamina propria, and intraepithelial lymphocytes using limiting dilution analysis. Naive animals exhibited a low frequenc...

journal_title：Journal of clinical immunology

authors： Sirinek LP,O'Dorisio MS,Dunaway DJ

更新日期：1995-09-01 00:00:00

abstract：PURPOSE:The interaction of Shiga toxin (Stx) and/or lipopolysaccharide (LPS) with monocytes (Mo) may be central to the pathogenesis of hemolytic uremic syndrome (HUS), providing the cytokines necessary to sensitize endothelial cells to Stx action. We have previously demonstrated phenotypical alterations in Mo from HUS ...

journal_title：Journal of clinical immunology

authors： Fernández GC,Ramos MV,Landoni VI,Bentancor LV,Fernández-Brando RJ,Exeni R,Laso Mdel C,Exeni A,Grimoldi I,Isturiz MA,Palermo MS

更新日期：2012-06-01 00:00:00

abstract：:Anesthetic drugs can influence the immune system, particularly granulocyte function. The goal of the present study was to evaluate if lidocaine used for epidural anesthesia during cesarean section can influence neonatal neutrophil chemotaxis. We measured chemotaxis and plasma cord lidocaine and cortisol levels in (A) ...

journal_title：Journal of clinical immunology

authors： Gasparoni A,De Amici D,Ciardelli L,Autelli M,Regazzi-Bonora M,Bartoli A,Chirico G,Rondini G

更新日期：1998-05-01 00:00:00

abstract：:Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency among adults and is characterized by a B cell dysfunction and increased risk of respiratory tract infections with encapsulated bacteria. However, a large proportion of patients also has inflammatory and autoimmune complicat...

journal_title：Journal of clinical immunology

authors： Jørgensen SF,Fevang B,Aukrust P

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:Multiple sclerosis (MS) is an autoimmune disease of the central nervous system mediated by T cells. B7-H3 plays a diverse role in regulating T cell responses. However, its expression and clinical significance in MS are not well known. This study analyzed the expression of membrane B7-H3 (mB7-H3) and levels of s...

journal_title：Journal of clinical immunology

authors： Jiang J,Jiang J,Liu C,Zhang G,Gao L,Chen Y,Zhu R,Wang T,Wang F,Zhang X,Xue Q

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:Gastrointestinal manifestations are frequent in patients with common variable immunodeficiency (CVID), and some of the patients present with celiac-like features. Diagnosing celiac disease (CD) in CVID however is challenging, as autoantibody detection and histopathology of the small intestine cannot reliably...

journal_title：Journal of clinical immunology

authors： Venhoff N,Emmerich F,Neagu M,Salzer U,Koehn C,Driever S,Kreisel W,Rizzi M,Effelsberg NM,Kollert F,Goldacker S,Voll RE,Warnatz K,Thiel J

更新日期：2013-07-01 00:00:00

abstract：:Human papillomavirus (HPV) infects the transformation zone of the cervix and is the primary cause of cervical cancer. The infection is localized to the cervix and mucosal immunity is likely to be an important determinant for viral clearance. Previous studies of immunity to HPV have measured immune markers in the blood...

journal_title：Journal of clinical immunology

authors： Castle PE,Hildesheim A,Bowman FP,Strickler HD,Walker JL,Pustilnik T,Edwards RP,Crowley-Nowick PA

更新日期：2002-01-01 00:00:00

abstract：:A 35-year-old man with common variable hypogammaglobulinemia had repeated anaphylactic reactions to intramuscular human immune serum globulin (HISG), preventing him from receiving the injections. He was able to tolerate slow subcutaneous HISG infusions without local or systemic side effects at a dose of 12 ml/week giv...

journal_title：Journal of clinical immunology

authors： Welch MJ,Stiehm ER

更新日期：1983-07-01 00:00:00

abstract：:The induction of cell death in immune cells by naturally occurring antibodies specific for death receptors may present an important antiinflammatory mechanism of intravenous immunoglobulin (IVIG). Conversely, the protection of tissue cells from death receptor-mediated apoptosis by blocking antibodies is thought to con...

journal_title：Journal of clinical immunology

authors： von Gunten S,Simon HU

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:Spondyloenchondrodysplasia is a rare immuno-osseous dysplasia caused by biallelic mutations in ACP5. We aimed to provide a survey of the skeletal, neurological and immune manifestations of this disease in a cohort of molecularly confirmed cases. METHODS:We compiled clinical, genetic and serological data from a...

journal_title：Journal of clinical immunology

authors： Briggs TA,Rice GI,Adib N,Ades L,Barete S,Baskar K,Baudouin V,Cebeci AN,Clapuyt P,Coman D,De Somer L,Finezilber Y,Frydman M,Guven A,Heritier S,Karall D,Kulkarni ML,Lebon P,Levitt D,Le Merrer M,Linglart A,Livingst

更新日期：2016-04-01 00:00:00

abstract：:The experiments described have shown that, whereas the injection of tetanus toxoid (tet) into 8 of 12 control individuals resulted in the appearance of specific anti-tet-IgG antibodies in their plasma, immunization of 14 anergic patients did not elicit an antibody response. This observation was extended to an in vitro...

journal_title：Journal of clinical immunology

authors： Mazaheri R,Rode HN,Abikar K,Ing A,Nohr C,Gordon J

更新日期：1984-01-01 00:00:00

abstract：:The noncanonical NF-κB pathway is implicated in diverse biological and immunological processes. Monoallelic C-terminus loss-of-function and gain-of-function mutations of NFKB2 have been recently identified as a cause of immunodeficiency manifesting with common variable immunodeficiency (CVID) or combined immunodeficie...

journal_title：Journal of clinical immunology

authors： Kuehn HS,Bernasconi A,Niemela JE,Almejun MB,Gallego WAF,Goel S,Stoddard JL,Sánchez RGP,Franco CAA,Oleastro M,Grunebaum E,Ballas Z,Cunningham-Rundles C,Fleisher TA,Franco JL,Danielian S,Rosenzweig SD

更新日期：2020-11-01 00:00:00

abstract：:Activated PI3K δ syndrome (APDS) is a primary immunodeficiency caused by heterogeneous germline gain-of-function mutations which ultimately lead to the hyperactivation of the phosphoinositide-3-kinase δ (PI3K δ). PI3K δ exists as a heterodimer composed of a catalytic and a regulatory subunit. APDS type 2 is caused by ...

journal_title：Journal of clinical immunology

authors： Ramirez L,Tamayo W,Ale H

更新日期：2020-10-01 00:00:00

abstract：:Skin window techniques to investigate neutrophil inflammatory reactions in human skin have been limited by cellular distortion and difficulties in quantitation. We have developed a quantitative approach based on the assessment of the myeloperoxidase (MPO) released from sonicated membrane filters to which exuding infla...

journal_title：Journal of clinical immunology

authors： Bedard PM,Zweiman B,Atkins PC

更新日期：1983-01-01 00:00:00

abstract：:The Latin American Group for Primary Immunodeficiencies, formed in 1993, presently includes 12 countries. One goal was to study the frequency of primary immunodeficiencies in various regions of the American continent and to enhance knowledge about these diseases among primary-care physicians, as well as allergist-immu...

journal_title：Journal of clinical immunology

authors： Zelazko M,Carneiro-Sampaio M,Cornejo de Luigi M,Garcia de Olarte D,Porras Madrigal O,Berrón Perez R,Cabello A,Rostan MV,Sorensen RU

更新日期：1998-03-01 00:00:00

abstract：:Immunosuppression-associated lymphoproliferative disorders can be related to primary as well as acquired immune disorders. Interferon gamma receptor (IFN-γR) deficiency is a rare primary immune disorder, characterized by increased susceptibility to mycobacterial infections. Here we report the first case of an Epstein ...

journal_title：Journal of clinical immunology

authors： Bax HI,Freeman AF,Anderson VL,Vesterhus P,Laerum D,Pittaluga S,Wilson WH,Holland SM

更新日期：2013-08-01 00:00:00

abstract：PURPOSE:Mycobacterium leprae exploits complement activation and opsonophagocytosis to infect phagocytes. M-ficolin is encoded by the FCN1 gene and initiates the lectin pathway on monocyte surfaces. We investigated FCN1 promoter polymorphisms that could be responsible for the high interindividual variability of M-ficoli...

journal_title：Journal of clinical immunology

authors： Boldt AB,Sanchez MI,Stahlke ER,Steffensen R,Thiel S,Jensenius JC,Prevedello FC,Mira MT,Kun JF,Messias-Reason IJ

更新日期：2013-01-01 00:00:00