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Effect of lidocaine on neutrophil chemotaxis in newborn infants.

Abstract：

:Anesthetic drugs can influence the immune system, particularly granulocyte function. The goal of the present study was to evaluate if lidocaine used for epidural anesthesia during cesarean section can influence neonatal neutrophil chemotaxis. We measured chemotaxis and plasma cord lidocaine and cortisol levels in (A) 15 infants born by cesarean section with epidural anesthesia, (B) 15 infants born by vaginal delivery, and (C) 20 infants born by cesarean section with general anesthesia. Chemotaxis levels were significantly lower in group A infants (35.5 +/- 16.1 microns) compared to groups B (54.6 +/- 10.5 microns) and C (71.4 +/- 23 microns). The highest cortisol levels were observed in vaginally delivered infants. A significant inverse relationship was observed between chemotaxis and lidocaine levels (r = -0.6, P = 0.016) in infants born by cesarean section after epidural anesthesia, while no significant correlation was observed between chemotaxis and cortisol level. In conclusion, lidocaine, transferred through the placenta to the fetus during epidural anesthesia, may have an inhibitory effect on chemotaxis.

journal_name

J Clin Immunol

journal_title

Journal of clinical immunology

authors

Gasparoni A,De Amici D,Ciardelli L,Autelli M,Regazzi-Bonora M,Bartoli A,Chirico G,Rondini G

doi

10.1023/a:1020583022614

subject

Has Abstract

pub_date

1998-05-01 00:00:00

pages

210-3

issue

3

eissn

0271-9142

issn

1573-2592

journal_volume

18

pub_type

杂志文章

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