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Platelet-associated IgG in hepatitis and cirrhosis.

Abstract：

:Increasing evidence is accumulating which indicates that immunological abnormalities contribute to the development of liver disease and its signs and symptoms. Platelet-associated IgG (PAIgG) levels were quantified in 42 patients with biopsy-proven liver disease of various etiologies to determine the relationship of thrombocytopenia to immunologic abnormalities in these disorders. Five of six nonthrombocytopenic patients with acute viral hepatitis B had elevated PAIgG. Six of ten patients with chronic active hepatitis had elevated PAIgG and thrombocytopenia. In contrast, only one of six patients with chronic persistent hepatitis had elevated PAIgG. Nine of ten patients with alcoholic hepatitis had elevated PAIgG; seven of the nine were thrombocytopenic. Seven of ten alcoholic patients with cirrhosis had elevated PAIgG; six of seven were thrombocytopenic. Thus the increase in PAIgG may be present without thrombocytopenia in acute liver injury, while patients with chronic persistent hepatitis do not usually exhibit this abnormality. Severe chronic active liver disease is accompanied by thrombocytopenia and an increase in PAIgG levels.

journal_name

J Clin Immunol

journal_title

Journal of clinical immunology

authors

Graber D,Giuliani D,Leevy CM,Morse BS

doi

10.1007/BF00915043

subject

Has Abstract

pub_date

1984-03-01 00:00:00

pages

108-11

issue

2

eissn

0271-9142

issn

1573-2592

journal_volume

4

pub_type

杂志文章

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