Antigen-specific expansion of TCR Vbeta3+ CD4+ T cells in the early stage of collagen-induced arthritis and its arthritogenic role in DBA/1J mice.

abstract：:Palifermin (recombinant human keratinocyte growth factor) prevents the development of acute, lethal graft-versus-host disease (GVHD). It does so, at least in part, by protecting cells from injury. Another property of Palifermin is immune regulation. How the latter influences the evolution of GVHD remains uncertain. We...

journal_title：Journal of clinical immunology

authors： Ellison CA,Gibson IW,Hayglass KT,Gartner JG

更新日期：2006-09-01 00:00:00

abstract：:Among a population of uniformly differentiated TH(2) cells, only a portion express IL-4 upon stimulation and those that do often express the product of only a single allele. We review the evidence for the basis of IL-4 monoallelism and argue that it depends upon probabilistic expression of the Il4 gene. Further, we ar...

journal_title：Journal of clinical immunology

authors： Guo L,Hu-Li J,Paul WE

更新日期：2005-11-01 00:00:00

abstract：:To better understand the role of Ia antigen expression, accessory cell function, and antigen ingestion in antigen presentation and the initiation of T cell proliferation, we studied these events in two acute monoblastic leukemia (AMoL) lines. The cell lines were positive for surface Ia antigen; one stimulated prolifer...

journal_title：Journal of clinical immunology

authors： Giller RH,Mori M,Hayward AR

更新日期：1984-11-01 00:00:00

abstract：BACKGROUND:The peroxisome proliferator-activated receptors (PPARs) have been implicated in immune regulation. We determined the transcriptional expression of the three isoforms, PPARalpha, PPARgamma1, and PPARgamma2 in the peritoneal macrophages, CD4- and CD8-positive lymphocytes in non-obese diabetic (NOD) mice at 5 a...

journal_title：Journal of clinical immunology

authors： Yaacob NS,Kaderi MA,Norazmi MN

更新日期：2009-09-01 00:00:00

abstract：:Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by hypogammaglobulinemia and increased susceptibility to recurrent pyogenic infections, autoimmunity, and malignancies. Twenty-five cases with CVID (18 male and 7 female) and 25 healthy volunteers were investigate in this stud...

journal_title：Journal of clinical immunology

authors： Rezaei N,Haji-Molla-Hoseini M,Aghamohammadi A,Pourfathollah AA,Moghtadaie M,Pourpak Z

更新日期：2008-01-01 00:00:00

abstract：:The immune system is affected by the aging process and undergoes significant age-related changes, termed immunosenescence. Different T cell subsets are affected by this process. Alterations within the bone marrow and thymus lead to a shift in the composition of the T cell repertoire from naïve to antigen-experienced T...

journal_title：Journal of clinical immunology

authors： Arnold CR,Wolf J,Brunner S,Herndler-Brandstetter D,Grubeck-Loebenstein B

更新日期：2011-04-01 00:00:00

abstract：PURPOSE:T-helper (Th) cells abnormalities are considered to be associated with the pathogenesis of Systemic lupus erythematosus (SLE). Recently, The Th22 cells have been identified and implicated in the pathogenesis of autoimmune diseases such as Rheumatoid arthritis (RA), although therir role in Systemic lupus erythem...

journal_title：Journal of clinical immunology

authors： Yang XY,Wang HY,Zhao XY,Wang LJ,Lv QH,Wang QQ

更新日期：2013-05-01 00:00:00

abstract：:Prior to the advent of cardiac bypass, most children with congenital cardiac anomalies and chromosome 22q11.2 deletion syndrome died. With improved technology, there is now a wave of young adults with chromosome 22q11.2 deletion syndrome requiring clinical care. Fifteen young children and 20 adults with chromosome 22q...

journal_title：Journal of clinical immunology

authors： Jawad AF,Prak EL,Boyer J,McDonald-McGinn DM,Zackai E,McDonald K,Sullivan KE

更新日期：2011-12-01 00:00:00

abstract：:Cytokines are powerful mediator and communication molecules capable of regulating a wide spectrum of biologic functions, including immune responses. Although the role of cytokines in the pathogenesis of human disease is not yet understood, assays for cytokines have become a common feature in research and clinical labo...

journal_title：Journal of clinical immunology

authors： Whiteside TL

更新日期：1994-11-01 00:00:00

abstract：PURPOSE:Nocardiosis is a life-threatening infectious disease. We aimed at describing nocardiosis in patients with primary immunodeficiency diseases (PID). METHODS:This international retrospective cohort included patients with PID and nocardiosis diagnosed and/or published from Jan 1, 2000, to Dec 31, 2016. To identify...

journal_title：Journal of clinical immunology

authors： Lafont E,Marciano BE,Mahlaoui N,Neven B,Bustamante J,Rodriguez-Nava V,Rawat A,Unzaga MJ,Fischer A,Blanche S,Lortholary O,Holland SM,Lebeaux D

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Several autoimmune disorders have been linked to adverse pregnancy outcome. IgA deficiency shares many autoimmune traits, but its association with pregnancy outcome is unknown. METHODS:Prospective population-based cohort study in Sweden of 613 mothers with IgA deficiency (IgA levels < .07 g/L) diagnosed in ...

journal_title：Journal of clinical immunology

authors： Ludvigsson JF,Neovius M,Stephansson O,Hammarström L

更新日期：2014-10-01 00:00:00

abstract：:MECP2 (methyl CpG binding protein 2) duplication causes syndromic intellectual disability. Patients often suffer from life-threatening infections, suggesting an additional immunodeficiency. We describe for the first time the detailed infectious and immunological phenotype of MECP2 duplication syndrome. 17/27 analyzed ...

journal_title：Journal of clinical immunology

authors： Bauer M,Kölsch U,Krüger R,Unterwalder N,Hameister K,Kaiser FM,Vignoli A,Rossi R,Botella MP,Budisteanu M,Rosello M,Orellana C,Tejada MI,Papuc SM,Patat O,Julia S,Touraine R,Gomes T,Wenner K,Xu X,Afenjar A,Toutain

更新日期：2015-02-01 00:00:00

abstract：:Cross-sectional and limited sequential studies of neutrophil and monocyte chemotaxis were done using cells isolated from cord blood and peripheral blood of 2- to 6-day-old neonates and infants at 4 and 6 months of age. These studies show that cord blood phagocyte chemotaxis is comparable to adult values, whereas phago...

journal_title：Journal of clinical immunology

authors： Raghunathan R,Miller ME,Everett S,Leake RD

更新日期：1982-07-01 00:00:00

abstract：:Familial Hemophagocytic Lymphohistiocytosis type 2 (FHL2) results from mutations in PRF1. We described two unrelated individuals who presented with FHL, in whom severely impaired NK cytotoxicity and decrease perforin expression was observed. DNA sequencing of PRF1 demonstrated that both were not only heterozygous for ...

journal_title：Journal of clinical immunology

authors： Romero CA,Sánchez IP,Gutierrez-Hincapié S,Álvarez-Álvarez JA,Pereañez JA,Ochoa R,Muskus-López CE,Eraso RG,Echeverry C,Arango C,Restrepo JL,Trujillo-Vargas CM

更新日期：2015-07-01 00:00:00

abstract：:Intravenous immunoglobulin (IVIg) has been used to treat autoimmune diseases and lymphoid malignancies with some therapeutic effect. In both these pathological conditions, there is an overproduction of BAFF (for "B-cell-activating factor of the TNF family"), and APRIL (for "a proliferation-inducing ligand"). The prese...

journal_title：Journal of clinical immunology

authors： Le Pottier L,Bendaoud B,Dueymes M,Daridon C,Youinou P,Shoenfeld Y,Pers JO

更新日期：2007-05-01 00:00:00

abstract：PURPOSE:To evaluate mortality risk factors in pediatric-onset common variable immunodeficiency disorders (CVID), we evaluated the largest single-institution cohort of pediatric-onset CVID patients. Previous publications on CVID have provided valuable descriptive data, but lack risk stratification to guide physicians in...

journal_title：Journal of clinical immunology

authors： Baloh C,Reddy A,Henson M,Prince K,Buckley R,Lugar P

更新日期：2019-10-01 00:00:00

abstract：:Administration of a tumor necrosis factor (TNF) inhibitor-encoding adenoviral vector decreases the severity of colonic inflammation in a DBA/2-->B6D2F1 murine model of colonic graft-versus-host disease (GVHD). The present studies evaluated the effect of TNF blockade on the splenic and colonic T-cell responses. cDNA en...

journal_title：Journal of clinical immunology

authors： Brown GR,Thiele DL

更新日期：2000-09-01 00:00:00

abstract：:Allogeneic bone marrow-engrafted adults immunized with meningococcal types A and C and pneumococcal type 14 polysaccharide antigens showed only low antibody titers of the IgM class, no antibody titers of the IgG or IgA classes, and no bactericidal activity in vitro. The analytical isoelectrofocusing showed the appeara...

journal_title：Journal of clinical immunology

authors： Quinti I,Velardi A,Le Moli S,Guerra E,D'Amelio R,Mastrantonio P,Martelli MF,Aiuti F

更新日期：1990-05-01 00:00:00

abstract：INTRODUCTION:This study was done to further reveal the role of the innate immune system in celiac disease. METHODS:Dendritic cells were matured from venous blood of patients with active or treated celiac disease and DQ2-DQ8-positive or negative controls. Dendritic cells were treated with a peptic-tryptic digest of gli...

journal_title：Journal of clinical immunology

authors： Rakhimova M,Esslinger B,Schulze-Krebs A,Hahn EG,Schuppan D,Dieterich W

更新日期：2009-01-01 00:00:00

abstract：:Total levels of IgM and secretory IgM as well as specific antibodies to poliovirus type I antigen, Escherichia coli O antigens, and beta-lactoglobulin were measured in unstimulated and stimulated saliva as well as nasal secretion using an enzyme-linked immunosorbent assay (ELISA). The levels of these antibodies in IgA...

journal_title：Journal of clinical immunology

authors： Mellander L,Björkander J,Carlsson B,Hanson LA

更新日期：1986-07-01 00:00:00

abstract：:Fas-associated death domain (FADD) is an adapter protein that is recruited to the death-inducing signaling complex (DISC) during signaling via death receptors. FADD is a common conduit in both CD95-mediated and TNF-R-mediated apoptosis. In aging, T cells show increased susceptibility to death receptor-induced apoptosi...

journal_title：Journal of clinical immunology

authors： Gupta S,Kim C,Yel L,Gollapudi S

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Primary immunodeficiency disorders (PID) are a group of heterogeneous disorders mainly characterized by severe and recurrent infections and increased susceptibility to malignancies, lymphoproliferative and autoimmune conditions. National registries of PID disorders provide epidemiological data and increase t...

journal_title：Journal of clinical immunology

authors： Aghamohammadi A,Mohammadinejad P,Abolhassani H,Mirminachi B,Movahedi M,Gharagozlou M,Parvaneh N,Zeiaee V,Mirsaeed-Ghazi B,Chavoushzadeh Z,Mahdaviani A,Mansouri M,Yousefzadegan S,Sharifi B,Zandieh F,Hedayat E,Nadjafi A,S

更新日期：2014-05-01 00:00:00

abstract：:The concentrations of the neuropeptides substance P, somatostatin, and calcitonin gene-related peptide in human nasal secretions were quantified by radioimmunoassays, concurrently with that of histamine, in the course of nasal challenge of allergic and control subjects with ryegrass antigen to examine contributions of...

journal_title：Journal of clinical immunology

authors： Walker KB,Serwonska MH,Valone FH,Harkonen WS,Frick OL,Scriven KH,Ratnoff WD,Browning JG,Payan DG,Goetzl EJ

更新日期：1988-03-01 00:00:00

abstract：PURPOSE:Nijmegen Breakage Syndrome (NBS) is a rare inherited condition, characterized by microcephaly, chromosomal instability, immunodeficiency, and predisposition to malignancy. This retrospective study, characterizing the clinical and immunological status of patients with NBS at time of diagnosis, was designed to as...

journal_title：Journal of clinical immunology

authors： Wolska-Kuśnierz B,Gregorek H,Chrzanowska K,Piątosa B,Pietrucha B,Heropolitańska-Pliszka E,Pac M,Klaudel-Dreszler M,Kostyuchenko L,Pasic S,Marodi L,Belohradsky BH,Čižnár P,Shcherbina A,Kilic SS,Baumann U,Seidel MG,Genner

更新日期：2015-08-01 00:00:00

abstract：:Stimulator of interferon genes (STING)-associated vasculopathy with onset in infancy (SAVI) is a rare disorder that is associated with extensive inflammation throughout the body due to a high interferon state. Common clinical manifestations of this disorder include chronic lung disease, digital necrosis, recurrent low...

journal_title：Journal of clinical immunology

authors： Ma M,Mazumder S,Kwak H,Adams M,Gregory M

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to assess the diagnostic delay in pediatric patients with primary immunodeficiencies (PID) at a tertiary care hospital in Peru. METHODS:A descriptive study was carried out in which patients from a third-level referral center in Peru were included. Those without a specific diagnosis o...

journal_title：Journal of clinical immunology

authors： Veramendi-Espinoza LE,Zafra-Tanaka JH,Pérez-Casquino GA,Córdova-Calderón WO

更新日期：2017-05-01 00:00:00

abstract：:Using an enzyme-linked immunoassay we tested the sera of 71 patients with digestive system cancer, 35 patients with various nonmalignant disorders, and 28 normal individuals for anti-CEA activity. Antibodies were found in the sera of 51% of the patients. Most of the patients positive for the antibodies (70%) had no ev...

journal_title：Journal of clinical immunology

authors： Konstadoulakis MM,Syrigos KN,Albanopoulos C,Mayers G,Golematis B

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:The mechanisms underlying the loss of self-tolerance in systemic lupus erythematosus (SLE) are incompletely deciphered. TGF-β plays a key role in self-tolerance demonstrated by the onset of a fatal autoimmune syndrome associated with lupus autoantibodies in mice lacking a functional TGF-β receptor. The prese...

journal_title：Journal of clinical immunology

authors： Elbeldi-Ferchiou A,Ben Ahmed M,Smiti-Khanfir M,Houman MH,Abdeladhim M,Belhadj Hmida N,Cerf-Bensussan N,Louzir H

更新日期：2011-08-01 00:00:00

abstract：:Mutations in DOCK8 result in autosomal recessive Hyper-IgE syndrome with combined immunodeficiency (CID). However, the natural course of disease, long-term prognosis, and optimal therapeutic management have not yet been clearly defined. In an international retrospective survey of patients with DOCK8 mutations, focused...

journal_title：Journal of clinical immunology

authors： Aydin SE,Kilic SS,Aytekin C,Kumar A,Porras O,Kainulainen L,Kostyuchenko L,Genel F,Kütükcüler N,Karaca N,Gonzalez-Granado L,Abbott J,Al-Zahrani D,Rezaei N,Baz Z,Thiel J,Ehl S,Marodi L,Orange JS,Sawalle-Belohradsky J

更新日期：2015-02-01 00:00:00

abstract：:Antibodies to certain self-antigens are detected in normal individuals as well as in patients with autoimmune diseases. Natural autoantibodies found in normal human sera are thought to act as an immune regulator, a functional controller of specific proteins, or the first-line defense against pathogenic microorganisms....

journal_title：Journal of clinical immunology

authors： Suk K,Hwang DY,Lee MS

更新日期：1999-05-01 00:00:00