当前位置： SCI文献检索 > JOURNAL OF CLINICAL IMMUNOLOGY期刊下所有文献 > T-cell activation and differentiation are regulated by TNF during murine DBA/2-->B6D2F1 intestinal graft-versus-host disease.

T-cell activation and differentiation are regulated by TNF during murine DBA/2-->B6D2F1 intestinal graft-versus-host disease.

Abstract：

:Administration of a tumor necrosis factor (TNF) inhibitor-encoding adenoviral vector decreases the severity of colonic inflammation in a DBA/2-->B6D2F1 murine model of colonic graft-versus-host disease (GVHD). The present studies evaluated the effect of TNF blockade on the splenic and colonic T-cell responses. cDNA encoding an artificial fusion protein consisting of the extracellular domain of the human 55-kDa receptor for TNF fused to a mouse IgG heavy chain was subcloned into an E1a-deficient adenoviral vector. Following transfer of DBA/2 T cells and bone marrow cells into irradiated B6D2F1 mice, the mice then received either the control adenovirus or the TNF inhibitor-encoding adenovirus. Splenic and colonic lymphocytes were isolated, stained with anti-H-2b, anti-H-2d, anti-CD3, anti-CD4, anti-CD8, and anti-CD45RB antibodies, and analyzed by flow cytometry. Splenic and colonic lymphocyte cytokine profiles also were assessed. More colonic T cells of donor origin were isolated from the control adenovirus recipients than from recipients of the TNF inhibitor encoding adenovirus (P = .027). Fewer CD4+ and CD8+ T cells were observed in colon but not in the spleen in the TNF inhibitor recipients. Fewer CD45RBlow (memory) T cells were observed in the CD4+ colonic lymphocytes isolated from the TNF inhibitor recipients than from controls. Importantly, lower levels of interleukin-2(IL-2) and interferon-gamma (INF-gamma) but not of IL-4 were observed in the lamina propria lymphocyte RNA isolated from the TNF inhibitor recipients. Infiltration and expansion of donor T cells and T-cell activation in the colon appear to be regulated by TNF during murine DBA/2 --> B6D2F1 gut GVHD.

journal_name

J Clin Immunol

journal_title

Journal of clinical immunology

authors

Brown GR,Thiele DL

doi

10.1023/a:1006676315093

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

379-88

issue

5

eissn

0271-9142

issn

1573-2592

journal_volume

20

pub_type

杂志文章

相关文献

JOURNAL OF CLINICAL IMMUNOLOGY文献大全
  • Membrane IgD-positive B cells of "low-IgD serum phenotype" individuals fail to secrete IgD and fail to shift to preferential lambda light-chain expression in vitro.

    abstract：:IgD production by short-term human peripheral blood mononuclear cell (PBM) cultures was studied to establish the in vitro correlates of low serum IgD expression. Cells of persons with less than 3 micrograms/ml IgD in the serum, referred to as the low-serum IgD phenotype (LISP), were analyzed. Advantage was taken of re...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00916005

    authors： Litwin SD,Zehr BD

    更新日期：1987-03-01 00:00:00

  • Novel Mutations Causing C5 Deficiency in Three North-African Families.

    abstract：:The complement system plays a central role in defense to encapsulated bacteria through opsonization and membrane attack complex (MAC) dependent lysis. The three activation pathways (classical, lectin, and alternative) converge in the cleavage of C5, which initiates MAC formation and target lysis. C5 deficiency is asso...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-016-0275-4

    authors： Colobran R,Franco-Jarava C,Martín-Nalda A,Baena N,Gabau E,Padilla N,de la Cruz X,Pujol-Borrell R,Comas D,Soler-Palacín P,Hernández-González M

    更新日期：2016-05-01 00:00:00

  • Postmenopausal expression changes of immune system-related genes in human bone tissue.

    abstract：INTRODUCTION:The molecular and cellular interactions between the immune system and bone tissue have been established. Sex hormone deficiency after menopause has multifunctional role by influencing growth, differentiation, and metabolism of the skeletal and the immune system. DISCUSSION:We have used nonparametric and m...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-009-9321-9

    authors： Kósa JP,Balla B,Kiss J,Podani J,Takács I,Lazáry A,Nagy Z,Bácsi K,Karsai A,Speer G,Lakatos P

    更新日期：2009-11-01 00:00:00

  • Interleukin 18 promoter variants (-137G>C and -607C>A) in patients with chronic hepatitis C: association with treatment response.

    abstract：BACKGROUND:Recently, two functional IL18 promoter variants, -607C>A (rs1946518) and -137G>C (rs187238), were associated with viral clearance in patients with hepatitis C. The present study focused on their relevance for treatment response. METHODS:Seven hundred fifty-seven chronically infected European patients and 79...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-009-9302-z

    authors： Haas SL,Weiss C,Bugert P,Gundt J,Witt H,Singer MV,Berg T,Böcker U

    更新日期：2009-09-01 00:00:00

  • Immunoregulatory T cells in men with a new acquired immunodeficiency syndrome.

    abstract：:We have evaluated the functional properties of the OK-T8+/OKT4+ T-cell subpopulations in nine patients with a new syndrome of acquired immune deficiency (AIDS). Despite polyclonal hypergammaglobulinemia in the sera of these patients, their peripheral blood lymphocytes (PBL) produced negligible quantities of immunoglob...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00915797

    authors： Benveniste E,Schroff R,Stevens RH,Gottlieb MS

    更新日期：1983-10-01 00:00:00

  • Probabilistic regulation of IL-4 production.

    abstract：:Among a population of uniformly differentiated TH(2) cells, only a portion express IL-4 upon stimulation and those that do often express the product of only a single allele. We review the evidence for the basis of IL-4 monoallelism and argue that it depends upon probabilistic expression of the Il4 gene. Further, we ar...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章,评审

    doi：10.1007/s10875-005-8218-5

    authors： Guo L,Hu-Li J,Paul WE

    更新日期：2005-11-01 00:00:00

  • Oral tolerance.

    abstract：:Oral tolerance is the immunologic mechanism by which the mucosal immune system maintains unresponsiveness to the myriad of antigens in the mucosal environment which might otherwise induce untoward immune responses. Recent studies have shown that it is mediated by several distinct, yet interacting mechanisms including ...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章,评审

    doi：10.1023/a:1023222003039

    authors： Strober W,Kelsall B,Marth T

    更新日期：1998-01-01 00:00:00

  • Immunogenicity of human immunodeficiency virus (HIV) reverse transcriptase: detection of high levels of antibodies to HIV reverse transcriptase in sera of homosexual men.

    abstract：:Immunoglobulin isolated from sera of homosexual men infected with human immunodeficiency virus (HIV) inhibited the reverse transcriptase (RT) activity of HIV. The inhibitory activity was specifically directed against HIV RT, and not against other mammalian retrovirus RT, including human T-lymphotropic virus type I. Th...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00915727

    authors： Chatterjee R,Rinaldo CR Jr,Gupta P

    更新日期：1987-05-01 00:00:00

  • Characterizing the pregnancy immune phenotype: results of the viral immunity and pregnancy (VIP) study.

    abstract：PURPOSE:The increased risk of morbidity and mortality from certain microbial infections and the demonstrated improvements in the clinical course of some autoimmune diseases support the existence of pregnancy-related alterations in immune status. Elucidating the changes in innate and adaptive immunity during gestation m...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-011-9627-2

    authors： Kraus TA,Engel SM,Sperling RS,Kellerman L,Lo Y,Wallenstein S,Escribese MM,Garrido JL,Singh T,Loubeau M,Moran TM

    更新日期：2012-04-01 00:00:00

  • Insights into Mutation Effect in Three Poikiloderma with Neutropenia Patients by Transcript Analysis and Disease Evolution of Reported Patients with the Same Pathogenic Variants.

    abstract：PURPOSE:Poikiloderma with neutropenia (PN) is a genodermatosis currently described in 77 patients, all presenting with early-onset poikiloderma, neutropenia, and several additional signs. Biallelic loss-of-function mutations in USB1 gene are detected in all molecularly tested patients but genotype-phenotype correlation...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-018-0508-9

    authors： Colombo EA,Elcioglu NH,Graziano C,Farinelli P,Di Fede E,Neri I,Facchini E,Greco M,Gervasini C,Larizza L

    更新日期：2018-05-01 00:00:00

  • Effect of palifermin in a murine model of graft-versus-host disease (GVHD) associated with Th2 cytokine production, autoantibody production, and glomerulonephritis.

    abstract：:Palifermin (recombinant human keratinocyte growth factor) prevents the development of acute, lethal graft-versus-host disease (GVHD). It does so, at least in part, by protecting cells from injury. Another property of Palifermin is immune regulation. How the latter influences the evolution of GVHD remains uncertain. We...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-006-9039-x

    authors： Ellison CA,Gibson IW,Hayglass KT,Gartner JG

    更新日期：2006-09-01 00:00:00

  • Persistent hypogammaglobulinemia following mononucleosis in boys is highly suggestive of X-linked lymphoproliferative disease--report of three cases.

    abstract：:Hypogammaglobulinemia is a common symptom in different immunodeficiencies. It is, however, not usually associated with Epstein-Barr virus (EBV) infections. The X-linked lymphoproliferative disease (XLP) on the other hand shows immunological changes in response to the EBV. Here we report three previously healthy boys, ...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1023/B:JOCI.0000040922.26286.36

    authors： Hügle B,Suchowerskyj P,Hellebrand H,Adler B,Borte M,Sack U,Overberg-Schmidt US,Strnad N,Otto J,Meindl A,Schuster V

    更新日期：2004-09-01 00:00:00

  • Approach to Molecular Diagnosis of Chronic Granulomatous Disease (CGD): an Experience from a Large Cohort of 90 Indian Patients.

    abstract：BACKGROUND:Chronic granulomatous disease (CGD) is characterized by mutation in any one of the five genes coding NADPH oxidase components that leads to functional abnormality preventing the killing of phagocytosed microbes by affecting the progression of a respiratory burst. CGD patients have an increased susceptibility...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-018-0567-y

    authors： Kulkarni M,Hule G,de Boer M,van Leeuwen K,Kambli P,Aluri J,Gupta M,Dalvi A,Mhatre S,Taur P,Desai M,Madkaikar M

    更新日期：2018-11-01 00:00:00

  • Complex patterns of regulation of chemokine secretion by Th2-cytokines, dexamethasone, and PGE2 in tuberculous osteomyelitis.

    abstract：:Tuberculous osteomyelitis is characterized by uncontrolled inflammation leading to bone destruction. Chemokines recruit inflammatory cells but there are no data on the mechanisms limiting cell influx. We investigated the potential down-regulators of chemokine secretion IL-4, IL-10, IL-13, dexamethasone, and PGE2, IL-1...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1023/a:1023357812041

    authors： Wright KM,Friedland JS

    更新日期：2003-05-01 00:00:00

  • Differential transcriptional expression of PPARalpha, PPARgamma1, and PPARgamma2 in the peritoneal macrophages and T-cell subsets of non-obese diabetic mice.

    abstract：BACKGROUND:The peroxisome proliferator-activated receptors (PPARs) have been implicated in immune regulation. We determined the transcriptional expression of the three isoforms, PPARalpha, PPARgamma1, and PPARgamma2 in the peritoneal macrophages, CD4- and CD8-positive lymphocytes in non-obese diabetic (NOD) mice at 5 a...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-009-9300-1

    authors： Yaacob NS,Kaderi MA,Norazmi MN

    更新日期：2009-09-01 00:00:00

  • Loss of NHEJ1 Protein Due to a Novel Splice Site Mutation in a Family Presenting with Combined Immunodeficiency, Microcephaly, and Growth Retardation and Literature Review.

    abstract：INTRODUCTION:Non-homologous end joining gene 1 (NHEJ1) defect is a rare form of primary immune deficiency. Very few cases have been described from around the world. PURPOSE:We are reporting the first family from the Arabian Gulf with three siblings presenting with combined immunodeficiency (CID), microcephaly, and gro...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章,评审

    doi：10.1007/s10875-017-0423-5

    authors： Sheikh F,Hawwari A,Alhissi S,Al Gazlan S,Al Dhekri H,Rehan Khaliq AM,Borrero E,El-Baik L,Arnaout R,Al-Mousa H,Alazami AM

    更新日期：2017-08-01 00:00:00

  • Defective monocyte function in acquired immune deficiency syndrome (AIDS): evidence from a monocyte-dependent T-cell proliferative system.

    abstract：:T-cell proliferative responses to the mitogenic monoclonal antibody anti-Leu 4 were assessed in healthy controls, lymphadenopathy syndrome (LAS) patients, and acquired immune deficiency syndrome (AIDS) patients. While 19% of the control group showed low anti-Leu 4 responses (less than 12,000 cpm), 60% of the LAS patie...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00915164

    authors： Prince HE,Moody DJ,Shubin BI,Fahey JL

    更新日期：1985-01-01 00:00:00

  • Lysophosphatidylethanolamine is the antigen to which apparent antibody to phosphatidylethanolamine binds.

    abstract：:Because binding of antiphospholipid antibody (aPL) to phosphatidylethanolamine (PE) is central to the definition of the antigenic epitope targeted by aPLs, we examined the binding of aPL-positive SLE sera to PE under various conditions. No serum bound to PE uncontaminated with lysophosphatidylethanolamine (1PE), but m...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00918652

    authors： Qamar T,Gharavi AE,Levy RA,Lockshin MD

    更新日期：1990-07-01 00:00:00

  • Analysis of the costimulatory requirements for generating human virus-specific in vitro T helper and effector responses.

    abstract：:The present study analyzes the role of CD28-B7-mediated costimulation during in vitro human peripheral blood memory T cell activation by influenza A virus. Inhibition studies using the B7-binding fusion protein CTLA4Ig and antibodies against CD80 and CD86 demonstrate that CTLA4Ig and anti-CD86 inhibited influenza-spec...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1023/a:1010987426835

    authors： Blazevic V,Trubey CM,Shearer GM

    更新日期：2001-07-01 00:00:00

  • The Duesseldorf warning signs for primary immunodeficiency: is it time to change the rules?

    abstract：OBJECTIVE:Different sets of warning signs can be used if primary immunodeficiency (PID) is suspected: those of the Jeffrey Modell Foundation (JMF), the German Patients' Organisation for Primary Immunodeficiencies (DSAI) and the Association of the Scientific Medical Societies in Germany (AWMF). A few studies have tested...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-015-0149-1

    authors： Lankisch P,Schiffner J,Ghosh S,Babor F,Borkhardt A,Laws HJ

    更新日期：2015-04-01 00:00:00

  • Vaccination with rabies to study the humoral and cellular immune response to a T-cell dependent neoantigen in man.

    abstract：:We investigated the humoral (antigen-specific immunoglobulin isotypes, IgG subclasses, and avidity maturation) and cellular (antigen-specific in vitro proliferation) immune response in 18 healthy adult volunteers, following a primary and a single booster vaccination with the T-cell dependent neoantigen rabies administ...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1023/b:joci.0000010429.36461.6b

    authors： Brinkman DM,Jol-van der Zijde CM,ten Dam MM,Vossen JM,Osterhaus AD,Kroon FP,van Tol MJ

    更新日期：2003-11-01 00:00:00

  • In vitro T-cell functions specific to an anti-DNA idiotype and serological markers in patients with systemic lupus erythematosus (SLE).

    abstract：:The human monoclonal autoantibody 16/6 is a common anti-DNA idiotype found to have clinical relevance in patients with systemic lupus erythematosus (SLE). Therefore the ability of peripheral blood T cells of SLE patients and healthy controls to proliferate and to produce helper T-cell factors following stimulation wit...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00917564

    authors： Mendlovic S,Shoenfeld Y,Bakimer R,Segal R,Dayan M,Mozes E

    更新日期：1988-05-01 00:00:00

  • Novel Heterogeneous Mutation of TNFAIP3 in a Chinese Patient with Behçet-Like Phenotype and Persistent EBV Viremia.

    abstract：PURPOSE:Tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) is a negative regulator of the nuclear factor-κB (NF-κB) pathway. It has recently been recognized that TNFAIP3 deficiency leads to early onset of autoinflammatory and autoimmune syndrome resembling Behçet's disease. Here, we report a novel mutation in...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-019-00604-9

    authors： Dong X,Liu L,Wang Y,Yang X,Wang W,Lin L,Sun B,Hou J,Ying W,Hui X,Zhou Q,Liu D,Yao H,Sun J,Wang X

    更新日期：2019-02-01 00:00:00

  • How I Manage Natural Killer Cell Deficiency.

    abstract：:Natural killer (NK) cell deficiency (NKD) is a subset of primary immunodeficiency disorders (PID) in which an abnormality of NK cells represents a major immunological defect resulting in the patient's clinical immunodeficiency. This is distinct from a much larger group of PIDs that include an NK cell abnormality as a ...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-019-00711-7

    authors： Orange JS

    更新日期：2020-01-01 00:00:00

  • Platelet-associated IgG in hepatitis and cirrhosis.

    abstract：:Increasing evidence is accumulating which indicates that immunological abnormalities contribute to the development of liver disease and its signs and symptoms. Platelet-associated IgG (PAIgG) levels were quantified in 42 patients with biopsy-proven liver disease of various etiologies to determine the relationship of t...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00915043

    authors： Graber D,Giuliani D,Leevy CM,Morse BS

    更新日期：1984-03-01 00:00:00

  • The influence of recombinant human erythropoietin on apoptosis and cytokine production of CD4+ lymphocytes from hemodialyzed patients.

    abstract：:Recombinant human erythropoietin (rhEPO) treatment of hemodialyzed (HD) patients normalizes the altered phenotype of CD4(+) lymphocytes and restores the balance of Th1/Th2 cytokines. We decided to test how the presence of rhEPO in cell culture modulates cytokine production of CD4(+) lymphocytes in HD patients with sta...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-012-9835-4

    authors： Lisowska KA,Dębska-Ślizień A,Jasiulewicz A,Daca A,Bryl E,Witkowski JM

    更新日期：2013-04-01 00:00:00

  • Disorders of apoptosis: mechanisms for autoimmunity in primary immunodeficiency diseases.

    abstract：:A number of primary immunodeficiency diseases represent a paradox of immunodeficiency and autoimmunity. In this minireview, we present basic concepts of apoptosis and disorder of apoptosis as one of the mechanisms to explain such a paradox between immunodeficiency and autoimmunity, which is exemplified by autoimmune l...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章,评审

    doi：10.1007/s10875-007-9161-4

    authors： Oliveira JB,Gupta S

    更新日期：2008-05-01 00:00:00

  • Myasthenia gravis induces the activation and maturation of lymphocytes in thymoma.

    abstract：:The biological differences between lymphocytes separated from thymoma patients with myasthenia gravis (MG) and those separated from thymoma patients without MG was examined. We investigated whether lymphocytes in thymoma (Th-L) of patients with and without MG could react to interleukin-2 (IL-2) to develop cytolytic ac...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF01541224

    authors： Takahashi K,Monden Y,Saito S,Kamamura Y,Uyama T

    更新日期：1996-07-01 00:00:00

  • Significance of unconventional peripheral CD4+CD8dim T cell subsets.

    abstract：:Routine T cells phenotyping occasionally reveals a CD4+CD8dim T cell subset with an apparently homogeneous dot plot. The aim of this study was to elucidate their immunological significance from analysis of 31 healthy donors, 21 elderly and 220 immune deficient patients. CD4+CD8dim T cells expressed reduced levels of C...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-005-5257-x

    authors： Lambert C,Ibrahim M,Iobagiu C,Genin C

    更新日期：2005-09-01 00:00:00

  • Inhibitor IkappaBalpha promoter functional polymorphisms in patients with rheumatoid arthritis.

    abstract：INTRODUCTION:Rheumatoid arthritis (RA) is a chronic inflammation disease that may involve extra-articular organs in addition to joints. Many proinflammatory cytokines are involved in the inflammatory process of RA. IkappaBalpha conjugates with NF-kappaB and is a key player in regulation of the inflammatory process. We ...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-010-9439-9

    authors： Li RN,Hung YH,Lin CH,Chen YH,Yen JH

    更新日期：2010-09-01 00:00:00