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CD4+ Th2 cell response cytokine production in bacterial meningitis.

Abstract：

:There has been a growing body of evidence suggesting that CD4+ Th1/Th2 cell responses participate in pathologic and immunologic processes in infectious disease. Bacterial meningitis is a fatal disease of children and is associated with a spectrum of clinical syndromes. This study provides evidence of CD4+ enhanced interleukin (IL)-4 and IL-6 but decreased IL-2 and interferon-gamma (IFN-gamma) production, the induction of characteristic Th2 cell response cytokines in bacterial meningitis, which may play an important role in disease mechanism. Additionally, monocyte-induced enhanced IL-6, IL-8, and tumor necrosis factor-alpha production may be associated with distinct clinical features such as fever, seizures, and neurological sequelae. A striking finding was also the highly deficient monocyte-induced granulocyte-macrophage colony-stimulating factor production. Of particular interest, the CD(8+)-enhanced IFN-gamma production may be required for the cytolytic activity or protective response to be maintained in this disease. Taken together, these data reveal that monocytes and CD4+ (Th2) and CD8+ subsets produce distinct cytokines in bacterial meningitis, which may exert an immunoregulatory and immunopathologic effect and thus mediate some of the clinical manifestations of the disease.

journal_name

J Clin Immunol

journal_title

Journal of clinical immunology

authors

Raziuddin S,el-Awad ME,Telmesani AW,Bilal NE,al-Janadi M

doi

10.1007/BF01541324

subject

Has Abstract

pub_date

1995-11-01 00:00:00

pages

338-48

issue

6

eissn

0271-9142

issn

1573-2592

journal_volume

15

pub_type

杂志文章

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