Intravenous immunoglobulin: an update on the clinical use and mechanisms of action.

abstract：:The role of tumor necrosis factor-alpha in the shedding of soluble tumor necrosis factor receptors in endotoxemia was investigated. The appearance of the soluble tumor necrosis factor receptors was assessed in four healthy volunteers following an intravenous injection of tumor necrosis factor-alpha and in eight chimpa...

journal_title：Journal of clinical immunology

authors： Jansen J,van der Poll T,Levi M,ten Cate H,Gallati H,ten Cate JW,van Deventer SJ

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:Chronic granulomatous disease (CGD) is a primary immunodeficiency for which allogeneic hematopoietic stem cell transplant (HSCT) offers potential cure. Direct comparison of HSCT to non-HSCT management in the North American population was performed to identify clinical factors associated with overall survival (O...

journal_title：Journal of clinical immunology

authors： Yonkof JR,Gupta A,Fu P,Garabedian E,Dalal J,the United States Immunodeficiency Network Consortium.

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:Nijmegen Breakage Syndrome (NBS) is a rare inherited condition, characterized by microcephaly, chromosomal instability, immunodeficiency, and predisposition to malignancy. This retrospective study, characterizing the clinical and immunological status of patients with NBS at time of diagnosis, was designed to as...

journal_title：Journal of clinical immunology

authors： Wolska-Kuśnierz B,Gregorek H,Chrzanowska K,Piątosa B,Pietrucha B,Heropolitańska-Pliszka E,Pac M,Klaudel-Dreszler M,Kostyuchenko L,Pasic S,Marodi L,Belohradsky BH,Čižnár P,Shcherbina A,Kilic SS,Baumann U,Seidel MG,Genner

更新日期：2015-08-01 00:00:00

abstract：:Cytokines are powerful mediator and communication molecules capable of regulating a wide spectrum of biologic functions, including immune responses. Although the role of cytokines in the pathogenesis of human disease is not yet understood, assays for cytokines have become a common feature in research and clinical labo...

journal_title：Journal of clinical immunology

authors： Whiteside TL

更新日期：1994-11-01 00:00:00

abstract：:A number of primary immunodeficiency diseases represent a paradox of immunodeficiency and autoimmunity. In this minireview, we present basic concepts of apoptosis and disorder of apoptosis as one of the mechanisms to explain such a paradox between immunodeficiency and autoimmunity, which is exemplified by autoimmune l...

journal_title：Journal of clinical immunology

authors： Oliveira JB,Gupta S

更新日期：2008-05-01 00:00:00

abstract：:Thirty two HIV-infected children, on highly active antiretroviral therapy (HAART) and > 500 CD4+ T cells/mm3, were rated according to the time-course of viral load (VL) during the whole follow-up period (> 18 months) in a longitudinal retrospective study. (a) uVL group: 15 children with VL below 400 copies/mL; (b) dVL...

journal_title：Journal of clinical immunology

authors： Resino S,Galán I,Bellón JM,Navarro ML,León JA,Muñoz-Fernandez MA

更新日期：2003-07-01 00:00:00

abstract：:Palifermin (recombinant human keratinocyte growth factor) prevents the development of acute, lethal graft-versus-host disease (GVHD). It does so, at least in part, by protecting cells from injury. Another property of Palifermin is immune regulation. How the latter influences the evolution of GVHD remains uncertain. We...

journal_title：Journal of clinical immunology

authors： Ellison CA,Gibson IW,Hayglass KT,Gartner JG

更新日期：2006-09-01 00:00:00

abstract：PURPOSE:Autosomal Dominant Hyper IgE Recurrent Infection Syndrome (AD-HIES) is caused by mutations in STAT3 and characterized by eczema, recurrent bacterial infections, and skeletal and connective tissue abnormalities. To further understand the minimal trauma fractures of AD-HIES, we examined bone mineral density (BMD)...

journal_title：Journal of clinical immunology

authors： Sowerwine KJ,Shaw PA,Gu W,Ling JC,Collins MT,Darnell DN,Anderson VL,Davis J,Hsu A,Welch P,Puck JM,Holland SM,Freeman AF

更新日期：2014-02-01 00:00:00

abstract：:The aim of this study was to research the expression of IL-37 in systemic lupus erythematosus (SLE) patients and the effect of glucocorticoid on IL-37. Thirty newly diagnosed severe SLE patients receiving prednisone 1 mg/kg/day for 14 consecutive days and 30 healthy subjects were enrolled into this study. The plasma l...

journal_title：Journal of clinical immunology

authors： Song L,Qiu F,Fan Y,Ding F,Liu H,Shu Q,Liu W,Li X

更新日期：2013-01-01 00:00:00

abstract：:This study was undertaken to investigate whether maternal periodontal disease and variant genotypes of IL-6 gene are associated with adverse pregnancy outcomes. A total of 145 pregnant women were recruited from St Mary's Hospital, Manchester, UK. Bleeding on probing (BOP) and pocket depth indices were recorded on all ...

journal_title：Journal of clinical immunology

authors： Dashash M,Nugent J,Baker P,Tansinda D,Blinkhorn F

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Primary immunodeficiency disorders (PID) are a group of heterogeneous disorders mainly characterized by severe and recurrent infections and increased susceptibility to malignancies, lymphoproliferative and autoimmune conditions. National registries of PID disorders provide epidemiological data and increase t...

journal_title：Journal of clinical immunology

authors： Aghamohammadi A,Mohammadinejad P,Abolhassani H,Mirminachi B,Movahedi M,Gharagozlou M,Parvaneh N,Zeiaee V,Mirsaeed-Ghazi B,Chavoushzadeh Z,Mahdaviani A,Mansouri M,Yousefzadegan S,Sharifi B,Zandieh F,Hedayat E,Nadjafi A,S

更新日期：2014-05-01 00:00:00

abstract：:Natural killer (NK) cell deficiency (NKD) is a subset of primary immunodeficiency disorders (PID) in which an abnormality of NK cells represents a major immunological defect resulting in the patient's clinical immunodeficiency. This is distinct from a much larger group of PIDs that include an NK cell abnormality as a ...

journal_title：Journal of clinical immunology

authors： Orange JS

更新日期：2020-01-01 00:00:00

abstract：:Fas-associated death domain (FADD) is an adapter protein that is recruited to the death-inducing signaling complex (DISC) during signaling via death receptors. FADD is a common conduit in both CD95-mediated and TNF-R-mediated apoptosis. In aging, T cells show increased susceptibility to death receptor-induced apoptosi...

journal_title：Journal of clinical immunology

authors： Gupta S,Kim C,Yel L,Gollapudi S

更新日期：2004-01-01 00:00:00

abstract：:Prior to the advent of cardiac bypass, most children with congenital cardiac anomalies and chromosome 22q11.2 deletion syndrome died. With improved technology, there is now a wave of young adults with chromosome 22q11.2 deletion syndrome requiring clinical care. Fifteen young children and 20 adults with chromosome 22q...

journal_title：Journal of clinical immunology

authors： Jawad AF,Prak EL,Boyer J,McDonald-McGinn DM,Zackai E,McDonald K,Sullivan KE

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Nonalcoholic steatohepatitis (NASH) is a chronic inflammatory liver disease influenced by risk factors for the metabolic syndrome. In adult patients, NASH is associated with an altered phenotype and functionality of peripheral immune cells, the recruitment of leukocytes and intrahepatic activation, and an ex...

journal_title：Journal of clinical immunology

authors： Ferreyra Solari NE,Inzaugarat ME,Baz P,De Matteo E,Lezama C,Galoppo M,Galoppo C,Cherñavsky AC

更新日期：2012-06-01 00:00:00

abstract：:The addition of indomethacin to concanavalin A (Con A)-induced cultures of human peripheral blood leukocytes (PBL) caused an increase in interferon response, regardless of whether the PBLs were derived from multiple sclerosis (MS) patients or from control donors. Specifically the response rates increased from 71 to 10...

journal_title：Journal of clinical immunology

authors： Vervliet G,Deckmyn H,Carton H,Billiau A

更新日期：1985-03-01 00:00:00

abstract：:Lymphocytes expressing gammadelta T cell receptors (TCR) constitute an entire system of functionally specialized subsets that have been implicated in the regulation of immune responses, including responses to pathogens and allergens, and in tissue repair. The gammadelta TCRs share structural features with adaptive rec...

journal_title：Journal of clinical immunology

authors： Born WK,Jin N,Aydintug MK,Wands JM,French JD,Roark CL,O'Brien RL

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:Health-related quality of life (HRQOL) has not been examined in patients with predominant antibody deficiency both pre- and post-immunoglobulin G (IgG) treatment initiation. HRQOL and health resource utilization (HRU) were assessed in newly diagnosed patients with primary immunodeficiency disease (PIDD) pre- an...

journal_title：Journal of clinical immunology

authors： Routes J,Costa-Carvalho BT,Grimbacher B,Paris K,Ochs HD,Filipovich A,Hintermeyer M,de Melo KM,Workman S,Ito D,Ye X,Bonnet P,Li-McLeod J

更新日期：2016-07-01 00:00:00

abstract：:An absolute requirement for monocytes was demonstrated in the T-cell proliferative response to tetanus toxoid (TT) antigen. Antigen-pulsed monocytes were shown to be effective in triggering T-cell proliferation. Using 125I-radiolabeled TT antigen, uptake by monocytes increased progressively over an 18-hr period, at wh...

journal_title：Journal of clinical immunology

authors： Alpert SD,Jonsen ME,Broff MD,Schneeberger E,Geha RS

更新日期：1981-01-01 00:00:00

abstract：:Administration of a tumor necrosis factor (TNF) inhibitor-encoding adenoviral vector decreases the severity of colonic inflammation in a DBA/2-->B6D2F1 murine model of colonic graft-versus-host disease (GVHD). The present studies evaluated the effect of TNF blockade on the splenic and colonic T-cell responses. cDNA en...

journal_title：Journal of clinical immunology

authors： Brown GR,Thiele DL

更新日期：2000-09-01 00:00:00

abstract：INTRODUCTION:Several differences have been described between neonatal and adult immune responses. The predisposition in early life to Th2-type response or tolerance makes it a susceptible period for infections and allergic sensitization. OBJECTIVE:The aim of this work was to evaluate the effects of CpG-containing olig...

journal_title：Journal of clinical immunology

authors： de Brito CA,Fusaro AE,Victor JR,Rigato PO,Goldoni AL,Muniz BP,Duarte AJ,Sato MN

更新日期：2010-03-01 00:00:00

abstract：:We studied immunological functions of peripheral blood lymphocytes (PBL) from human T-cell leukemia virus type I (HTLV-I)-seropositive healthy carriers in vitro. Proliferative responses of PBL to T-cell and B-cell mitogens such as concanavalin A (Con A), pokeweed mitogen (PWM), and Staphylococcus aureus Cowan I (SAC) ...

journal_title：Journal of clinical immunology

authors： Tanaka Y,Oda S,Nagata K,Mori N,Sakamoto H,Eto S,Yamashita U

更新日期：1989-11-01 00:00:00

abstract：PURPOSE:Colitis is a common and serious complication of chronic granulomatous disorder (CGD) and requires assessment. Colonoscopy is invasive and carries risks of serious complication. We therefore assessed non-invasive monitoring via magnetic resonance imaging (MRI). We also evaluated fecal calprotectin (FCP), the Har...

journal_title：Journal of clinical immunology

authors： Lowe DM,Smith PJ,Moreira F,Workman S,Braggins H,Koukias N,Buckland MS,Wylie P,Taylor SA,Murray CD

更新日期：2019-07-01 00:00:00

abstract：:The complement system plays a central role in defense to encapsulated bacteria through opsonization and membrane attack complex (MAC) dependent lysis. The three activation pathways (classical, lectin, and alternative) converge in the cleavage of C5, which initiates MAC formation and target lysis. C5 deficiency is asso...

journal_title：Journal of clinical immunology

authors： Colobran R,Franco-Jarava C,Martín-Nalda A,Baena N,Gabau E,Padilla N,de la Cruz X,Pujol-Borrell R,Comas D,Soler-Palacín P,Hernández-González M

更新日期：2016-05-01 00:00:00

abstract：:Leishmaniasis is caused by parasitic protozoa transmitted by the bite of a female sand fly and is currently endemic in 88 countries. BALB/c mice are highly susceptible to the infection with the parasite Leishmania major, and this susceptibility has been attributed, in part, to the expansion of Th2 cells, production of...

journal_title：Journal of clinical immunology

authors： Hosseini N,Abolhassani M

更新日期：2011-06-01 00:00:00

abstract：INTRODUCTION:Autoantibodies to granulocyte-macrophage colony-stimulating factor (GM-CSF) can cause acquired pulmonary alveolar proteinosis (PAP). Cases of acquired PAP susceptible to typical respiratory pathogens and opportunistic infections have been reported. Anti-GM-CSF autoantibodies have been reported in a few pat...

journal_title：Journal of clinical immunology

authors： Kuo CY,Wang SY,Shih HP,Tu KH,Huang WC,Ding JY,Lin CH,Yeh CF,Ho MW,Chang SC,He CY,Chen HK,Ho CH,Lee CH,Chi CY,Ku CL

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:The interaction of Shiga toxin (Stx) and/or lipopolysaccharide (LPS) with monocytes (Mo) may be central to the pathogenesis of hemolytic uremic syndrome (HUS), providing the cytokines necessary to sensitize endothelial cells to Stx action. We have previously demonstrated phenotypical alterations in Mo from HUS ...

journal_title：Journal of clinical immunology

authors： Fernández GC,Ramos MV,Landoni VI,Bentancor LV,Fernández-Brando RJ,Exeni R,Laso Mdel C,Exeni A,Grimoldi I,Isturiz MA,Palermo MS

更新日期：2012-06-01 00:00:00

abstract：:Immunosuppression-associated lymphoproliferative disorders can be related to primary as well as acquired immune disorders. Interferon gamma receptor (IFN-γR) deficiency is a rare primary immune disorder, characterized by increased susceptibility to mycobacterial infections. Here we report the first case of an Epstein ...

journal_title：Journal of clinical immunology

authors： Bax HI,Freeman AF,Anderson VL,Vesterhus P,Laerum D,Pittaluga S,Wilson WH,Holland SM

更新日期：2013-08-01 00:00:00

abstract：PURPOSE:To investigate whether there is an increased incidence of chronic autoimmune thyroiditis (CAT) in individuals living in the vicinity of industrial plants that manufacture petroleum byproducts in the state of São Paulo, Brazil. METHODS:Between 1989 and 2004, 6,306 patients of both sexes, from 5 to 78 years old ...

journal_title：Journal of clinical immunology

authors： Zaccarelli-Marino MA

更新日期：2012-10-01 00:00:00

abstract：:Unusual susceptibility to mycobacterial infections can be caused by deleterious mutations in genes that encode the interferon-gamma receptor 1 chain. Such mutations hamper the activation of macrophages by a type 1 immune response and result in enhanced survival of intracellular pathogens. We here report two patients w...

journal_title：Journal of clinical immunology

authors： Noordzij JG,Hartwig NG,Verreck FA,De Bruin-Versteeg S,De Boer T,Van Dissel JT,De Groot R,Ottenhoff TH,Van Dongen JJ

更新日期：2007-09-01 00:00:00