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Good's syndrome and pure white cell aplasia complicated by cryptococcus infection: A case report and review of the literature.

Abstract：

:Thymomas can present with a variety of paraneoplastic manifestations, mostly of autoimmune origin, including Good's syndrome when there is associated hypogammaglobulinemia. Although pure red cell aplasia is a recognised complication of thymoma, selective white cell aplasia is very rare, particularly in Good's syndrome. Lethal opportunistic infections are a feature of Good's syndrome, usually occurring in those patients with associated severe T lymphocyte defects. Although the cryptococcus is a recognised fungal pathogen in patients with other causes of CD4+ T cell lymphopenia, surprisingly this complication has not been reported in patients with Good's syndrome. We now describe a 70 year old man with Good's syndrome and pure white cell aplasia who presented with disseminated cryptococcosis, and provide an up-to-date review of the relevant literature. Despite meningeal involvement our patient recovered after combined treatment with intravenous globulin, granulocyte stimulating growth, corticosteroids and antifungal therapy.

journal_name

J Clin Immunol

journal_title

Journal of clinical immunology

authors

Akinosoglou K,Melachrinou M,Siagris D,Koletsis E,Marangos M,Gogos CA,Solomou EE

doi

10.1007/s10875-014-0014-7

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

283-8

issue

3

eissn

0271-9142

issn

1573-2592

journal_volume

34

pub_type

杂志文章,评审

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