当前位置： SCI文献检索 > JOURNAL OF CLINICAL IMMUNOLOGY期刊下所有文献 > I kappa B alpha promoter polymorphisms in patients with systemic lupus erythematosus.

I kappa B alpha promoter polymorphisms in patients with systemic lupus erythematosus.

Abstract：

:To investigate the associations of IkappaBalpha gene polymorphisms with the development and clinical manifestations of systemic lupus erythematosus (SLE), 110 patients with SLE and 120 unrelated healthy controls were enrolled in this study. The IkappaBalpha -881 A/G, -826 C/T, -550 A/T, -519 C/T, and -297 C/T polymorphisms were determined by the polymerase chain reaction/reaction fragment length polymorphism method. The genotype frequency of IkappaBalpha -826 C/T in the patients with SLE was significantly higher than that of the controls (p = 0.003, OR = 2.2, 95% CI = 1.3-3.9). The SLE patients also have significantly higher carriage rate of IkappaBalpha -826 T than the controls (p = 0.01, OR = 2.0, 95% CI = 1.2-3.4). We also found that the estimated haplotype frequency of IkappaBalpha -881A -826T -550A -519C -297C was significantly increased in the patients with SLE in comparison with that of the controls. This study also demonstrated that the association of IkappaBalpha -826 T with SLE was independent of HLA-DR15, which is associated with susceptibility to SLE in Taiwan. Moreover, a synergistic effect could also be found between IkappaBalpha -826 T and HLA-DR15. IkappaBalpha -826 T is associated with the development of SLE in Taiwan. The IkappaBalpha -881A -826T -550A -519C -297C haplotype is also associated with susceptibility to SLE. This study also demonstrated that IkappaBalpha -881G was associated with the occurrence of vasculitis in SLE patients. IkappaBalpha -550T might be a protective factor for the development of malar rash.

journal_name

J Clin Immunol

journal_title

Journal of clinical immunology

authors

Lin CH,Wang SC,Ou TT,Li RN,Tsai WC,Liu HW,Yen JH

doi

10.1007/s10875-007-9156-1

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

207-13

issue

3

eissn

0271-9142

issn

1573-2592

journal_volume

28

pub_type

杂志文章

相关文献

JOURNAL OF CLINICAL IMMUNOLOGY文献大全
  • Human fetal liver cells induce colonies in spleen of lethally irradiated mice.

    abstract：:Murine hematopoietic tissues contain cells which, upon injection into lethally irradiated mice, produce nodules on the surface of their spleen (colony-forming unit--spleen; CFU-S). The exact hierarchical level of the hematopoietic progenitors which give rise to CFU-S is not fully established; however, cell populations...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1023/a:1027302310505

    authors： Rezzoug F,Tocci A,Safsafi K,Vivier G,Touraine JL

    更新日期：1997-05-01 00:00:00

  • Matrix metalloproteinase-9 and autoimmune diseases.

    abstract：:Matrix metalloproteinases (also named matrixin or MMPs) are a major group of enzymes that regulate cell-matrix composition by using zinc for their proteolytic activities. They are essential for various normal biological processes such as embryonic development, morphogenesis, reproduction tissue resorption, and remodel...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章,评审

    doi：10.1007/s10875-006-9022-6

    authors： Ram M,Sherer Y,Shoenfeld Y

    更新日期：2006-07-01 00:00:00

  • gammadelta T lymphocytes-selectable cells within the innate system?

    abstract：:Lymphocytes expressing gammadelta T cell receptors (TCR) constitute an entire system of functionally specialized subsets that have been implicated in the regulation of immune responses, including responses to pathogens and allergens, and in tissue repair. The gammadelta TCRs share structural features with adaptive rec...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章,评审

    doi：10.1007/s10875-007-9077-z

    authors： Born WK,Jin N,Aydintug MK,Wands JM,French JD,Roark CL,O'Brien RL

    更新日期：2007-03-01 00:00:00

  • Defective monocyte function in acquired immune deficiency syndrome (AIDS): evidence from a monocyte-dependent T-cell proliferative system.

    abstract：:T-cell proliferative responses to the mitogenic monoclonal antibody anti-Leu 4 were assessed in healthy controls, lymphadenopathy syndrome (LAS) patients, and acquired immune deficiency syndrome (AIDS) patients. While 19% of the control group showed low anti-Leu 4 responses (less than 12,000 cpm), 60% of the LAS patie...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00915164

    authors： Prince HE,Moody DJ,Shubin BI,Fahey JL

    更新日期：1985-01-01 00:00:00

  • Probing the human B-cell repertoire: isolation of Epstein-Barr virus (EBV)-transformed human B lymphocytes making antibodies with a common idiotope that have different antigen-binding specificities.

    abstract：:Human peripheral B lymphocytes were transformed with Epstein-Barr virus and probed with an antiidiotypic antibody made against a human monoclonal autoantibody. Six cell lines were isolated that produced antibodies bearing a common idiotope. Despite the presence of this common idiotope, the antibodies showed antigen-bi...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00916951

    authors： Uchigata Y,Prabhakar BS,Notkins AL

    更新日期：1988-11-01 00:00:00

  • Lymphotoxin production by regional lymph node lymphocytes in patients with uterine cervical cancer.

    abstract：:The cytotoxin production by regional lymph node cells was examined in 25 patients with uterine cervical cancer and 10 patients with uterine myoma. The patients in stage I had significantly increased spontaneous release of cytotoxins compared with that in stages II, III, and IV. The spontaneous release in stages III an...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00916702

    authors： Matsunaga K,Mashiba H,Kurano A,Jimi S

    更新日期：1990-09-01 00:00:00

  • Anti-SM and anti-U1-RNP lupus antibody fine specificities.

    abstract：:Evidence for the presence of multiple shared epitopes on the target cellular antigens was found when 290 anti-Sm and anti-U1-RNP lupus sera were analyzed by immunoblotting. Forty-eight different immunoblot patterns were observed with the sera. Studies with selected antigen-affinity-purified antibodies confirmed the pr...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00916822

    authors： Francoeur AM

    更新日期：1989-05-01 00:00:00

  • Pineal germinoma in a child with interferon-γ receptor 1 deficiency. case report and literature review.

    abstract：:Interferon-γ receptor 1 (IFN-γR1) deficiency is one of the primary immunodeficiencies conferring Mendelian Susceptibility to Mycobacterial Disease (MSMD). Some cases of neoplasms have been recently reported in patients with MSMD, underlying the already known link between immunodeficiency and carcinogenesis. We report ...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章,评审

    doi：10.1007/s10875-014-0098-0

    authors： Taramasso L,Boisson-Dupuis S,Garrè ML,Bondi E,Cama A,Nozza P,Morana G,Casanova JL,Marazzi MG

    更新日期：2014-11-01 00:00:00

  • Serodiagnostic assays for celiac disease based on the open or closed conformation of the autoantigen, transglutaminase 2.

    abstract：:The autoantigen of celiac disease, transglutaminase 2 (TG2), adopts an open conformation during enzymatic activation. We studied diagnostic accuracy of serodiagnostic assays using TG2 in its open and closed conformation as antigens in patients with diagnostic difficulties. The open TG2 antibody (TG2ab) test identified...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-011-9514-x

    authors： Lindfors K,Koskinen O,Kurppa K,Laurila K,Collin P,Haimila K,Partanen J,Saavalainen P,Mäki M,Kaukinen K

    更新日期：2011-06-01 00:00:00

  • A novel pathogenic variant in PRF1 associated with hemophagocytic lymphohistiocytosis.

    abstract：:Familial Hemophagocytic Lymphohistiocytosis type 2 (FHL2) results from mutations in PRF1. We described two unrelated individuals who presented with FHL, in whom severely impaired NK cytotoxicity and decrease perforin expression was observed. DNA sequencing of PRF1 demonstrated that both were not only heterozygous for ...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-015-0169-x

    authors： Romero CA,Sánchez IP,Gutierrez-Hincapié S,Álvarez-Álvarez JA,Pereañez JA,Ochoa R,Muskus-López CE,Eraso RG,Echeverry C,Arango C,Restrepo JL,Trujillo-Vargas CM

    更新日期：2015-07-01 00:00:00

  • Allotype-associated differences in concentrations of human IgG subclasses.

    abstract：:The concentrations of seven immunoglobulin isotypes (IgA, IgE, IgM, IgG1, IgG2, IgG3, and IgG4) were measured in the sera of 207 Finnish blood donors, and they were allotyped with anti-Gm antibodies: anti-f, anti-a, anti-x, and anti-n. The above population could be divided into 12 phenotypes, and significant differenc...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00918793

    authors： Sarvas H,Rautonen N,Mäkelä O

    更新日期：1991-01-01 00:00:00

  • A novel approach for cancer immunotherapy: tumor cells with anchored superantigen SEA generate effective antitumor immunity.

    abstract：:Murine B16 melanoma cell line is poorly immunogenic and highly aggressive. We recently reported that the transmembrane staphylococcal enterotoxin A (TM-SEA) anchors onto B16 cells and stimulates lymphocyte proliferation. The purpose of the study was to investigate whether vaccination with B16 cells bearing membrane-an...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1023/B:JOCI.0000025451.41948.94

    authors： Ma W,Yu H,Wang Q,Jin H,Solheim J,Labhasetwar V

    更新日期：2004-05-01 00:00:00

  • Anti-ribosomal ribonucleoprotein autoantibodies in systemic lupus erythematosus.

    abstract：:Sera from systemic lupus erythematosus (SLE) patients giving a fluorescent ribosomal pattern on tissue and cell preparations also showed precipitating autoantibodies against purified rat liver ribosomes. Ribosomal antigen is also present in rabbit thymus cellular extract (RTE), since the same sera gave precipitin line...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00915287

    authors： Meroni PL,de Bartolo G,Barcellini W,Riboldi PS,Basile R,Betterle C,Zanussi C

    更新日期：1984-01-01 00:00:00

  • Evidence for a correlation between antibody-dependent cellular cytotoxicity-mediating anti-HIV-1 antibodies and prognostic predictors of HIV infection.

    abstract：:Using our gp120/41-expressing, NK cell activity-resistant CEM.NKR cell clones as targets in HIV-1-specific antibody-dependent cellular cytotoxicity (ADCC) assays, we demonstrate here that the serum titers of anti-HIV-1 ADCC antibodies bear a significant (P < 0.05) positive correlation with the peripheral blood CD4+ T ...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1023/a:1011087132180

    authors： Ahmad R,Sindhu ST,Toma E,Morisset R,Vincelette J,Menezes J,Ahmad A

    更新日期：2001-05-01 00:00:00

  • Immunoglobulin isotype expression of normal pre-B cells as determined by immunofluorescence.

    abstract：:We have undertaken an immunofluorescent analysis of the immunoglobulin heavy and light chains expressed by pre-B cells from normal human fetal and adult bone marrow using purified mouse monoclonal and goat antibodies to human immunoglobulin isotypes. Our results indicate that (i) the great majority of normal pre-B cel...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00915065

    authors： Kubagawa H,Gathings WE,Levitt D,Kearney JF,Cooper MD

    更新日期：1982-10-01 00:00:00

  • TLR-mediated B cell defects and IFN-α in common variable immunodeficiency.

    abstract：:Common variable immune deficiency (CVID) B cells have impaired responses to TLR7 and TLR9 agonists including poor cell proliferation, loss of cytokine production, and failure to produce IgG or IgA. We show that TLR7- or 9-activated B cells from CVID subjects with >0.5% peripheral isotype-switched CD27(+) B cells (grou...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-011-9602-y

    authors： Yu JE,Zhang L,Radigan L,Sanchez-Ramon S,Cunningham-Rundles C

    更新日期：2012-02-01 00:00:00

  • The role of HLA DQ2 and DQ8 in dissecting celiac-like disease in common variable immunodeficiency.

    abstract：OBJECTIVES:Gastrointestinal manifestations are frequent in patients with common variable immunodeficiency (CVID), and some of the patients present with celiac-like features. Diagnosing celiac disease (CD) in CVID however is challenging, as autoantibody detection and histopathology of the small intestine cannot reliably...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-013-9892-3

    authors： Venhoff N,Emmerich F,Neagu M,Salzer U,Koehn C,Driever S,Kreisel W,Rizzi M,Effelsberg NM,Kollert F,Goldacker S,Voll RE,Warnatz K,Thiel J

    更新日期：2013-07-01 00:00:00

  • Acidomonas methanolica-associated necrotizing lymphadenitis in a patient with chronic granulomatous disease.

    abstract：PURPOSE:Adenitis for which no causative organism can be isolated is a common occurrence in patients with chronic granulomatous disease (CGD). Here we identify Acidomonas methanolica as a pathogen associated with adenitis in a patient with CGD. METHODS:The causative pathogen was obtained after prolonged incubation of a...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-012-9728-6

    authors： Chase JM,Holland SM,Greenberg DE,Marshall-Batty K,Zelazny AM,Church JA

    更新日期：2012-12-01 00:00:00

  • Inhibitor IkappaBalpha promoter functional polymorphisms in patients with rheumatoid arthritis.

    abstract：INTRODUCTION:Rheumatoid arthritis (RA) is a chronic inflammation disease that may involve extra-articular organs in addition to joints. Many proinflammatory cytokines are involved in the inflammatory process of RA. IkappaBalpha conjugates with NF-kappaB and is a key player in regulation of the inflammatory process. We ...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-010-9439-9

    authors： Li RN,Hung YH,Lin CH,Chen YH,Yen JH

    更新日期：2010-09-01 00:00:00

  • Proteolytically inactive per a 10 allergen of Periplaneta americana modulates Th2 response and enhances IL-10 in mouse model.

    abstract：BACKGROUND:Purified allergens with reduced IgE reactivity are required to improve the safety and efficacy of allergen-specific immunotherapy (IT). OBJECTIVE:The present study investigates the efficacy of purified cockroach allergen immunotherapy with proteolytically active and inactive Per a 10 in allergic mouse model...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-009-9362-0

    authors： Srivastava D,Mehta AK,Arora N,Gaur SN,Singh BP

    更新日期：2010-05-01 00:00:00

  • Post-transplantation B cell function in different molecular types of SCID.

    abstract：PURPOSE:Severe combined immunodeficiency (SCID) is a syndrome of diverse genetic cause characterized by profound deficiencies of T, B and sometimes NK cell function. Non-ablative HLA-identical or rigorously T cell-depleted haploidentical parental bone marrow transplantation (BMT) results in thymus-dependent genetically...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-012-9797-6

    authors： Buckley RH,Win CM,Moser BK,Parrott RE,Sajaroff E,Sarzotti-Kelsoe M

    更新日期：2013-01-01 00:00:00

  • The presence of anti-carcinoembryonic antigen (CEA) antibodies in the sera of patients with gastrointestinal malignancies.

    abstract：:Using an enzyme-linked immunoassay we tested the sera of 71 patients with digestive system cancer, 35 patients with various nonmalignant disorders, and 28 normal individuals for anti-CEA activity. Antibodies were found in the sera of 51% of the patients. Most of the patients positive for the antibodies (70%) had no ev...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF01540984

    authors： Konstadoulakis MM,Syrigos KN,Albanopoulos C,Mayers G,Golematis B

    更新日期：1994-09-01 00:00:00

  • Effect of lidocaine on neutrophil chemotaxis in newborn infants.

    abstract：:Anesthetic drugs can influence the immune system, particularly granulocyte function. The goal of the present study was to evaluate if lidocaine used for epidural anesthesia during cesarean section can influence neonatal neutrophil chemotaxis. We measured chemotaxis and plasma cord lidocaine and cortisol levels in (A) ...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1023/a:1020583022614

    authors： Gasparoni A,De Amici D,Ciardelli L,Autelli M,Regazzi-Bonora M,Bartoli A,Chirico G,Rondini G

    更新日期：1998-05-01 00:00:00

  • A paraprotein IgA1 occurring in serum, urine, and cerebrospinal fluid (CSF): immunochemical and idiotypic evidence of synthesis in situ by the central nervous system (CNS).

    abstract：:A patient affected with multiple myeloma displayed in the serum, urine, and cerebrospinal fluid a paraprotein with identical electrophoretic mobility. The paraprotein, which was polymeric, appeared in the serum and cerebrospinal fluid mainly as the dimer and tetramer, whereas in the urine the tetramer was predominant....

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/BF00917333

    authors： Bollengier F,Mahler A,Gillard A,Wijffels E

    更新日期：1986-07-01 00:00:00

  • DOCK8 deficiency: clinical and immunological phenotype and treatment options - a review of 136 patients.

    abstract：:Mutations in DOCK8 result in autosomal recessive Hyper-IgE syndrome with combined immunodeficiency (CID). However, the natural course of disease, long-term prognosis, and optimal therapeutic management have not yet been clearly defined. In an international retrospective survey of patients with DOCK8 mutations, focused...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-014-0126-0

    authors： Aydin SE,Kilic SS,Aytekin C,Kumar A,Porras O,Kainulainen L,Kostyuchenko L,Genel F,Kütükcüler N,Karaca N,Gonzalez-Granado L,Abbott J,Al-Zahrani D,Rezaei N,Baz Z,Thiel J,Ehl S,Marodi L,Orange JS,Sawalle-Belohradsky J

    更新日期：2015-02-01 00:00:00

  • Glucocorticoid regulates interleukin-37 in systemic lupus erythematosus.

    abstract：:The aim of this study was to research the expression of IL-37 in systemic lupus erythematosus (SLE) patients and the effect of glucocorticoid on IL-37. Thirty newly diagnosed severe SLE patients receiving prednisone 1 mg/kg/day for 14 consecutive days and 30 healthy subjects were enrolled into this study. The plasma l...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-012-9791-z

    authors： Song L,Qiu F,Fan Y,Ding F,Liu H,Shu Q,Liu W,Li X

    更新日期：2013-01-01 00:00:00

  • Regulation and privilege in transplantation tolerance.

    abstract：BACKGROUND:There are now many ways of achieving transplantation tolerance in rodents that do not require stem cell chimerism. The best studied of these utilize short courses of antibody treatment aimed at blocking the co-receptors CD4 and CD8, and/or co-stimulatory molecules such as CD40L. Unlike tolerance through mixe...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-008-9249-5

    authors： Waldmann H,Adams E,Fairchild P,Cobbold S

    更新日期：2008-11-01 00:00:00

  • Significance of unconventional peripheral CD4+CD8dim T cell subsets.

    abstract：:Routine T cells phenotyping occasionally reveals a CD4+CD8dim T cell subset with an apparently homogeneous dot plot. The aim of this study was to elucidate their immunological significance from analysis of 31 healthy donors, 21 elderly and 220 immune deficient patients. CD4+CD8dim T cells expressed reduced levels of C...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-005-5257-x

    authors： Lambert C,Ibrahim M,Iobagiu C,Genin C

    更新日期：2005-09-01 00:00:00

  • Resistance to exogenous TGF-β effects in patients with systemic lupus erythematosus.

    abstract：BACKGROUND:The mechanisms underlying the loss of self-tolerance in systemic lupus erythematosus (SLE) are incompletely deciphered. TGF-β plays a key role in self-tolerance demonstrated by the onset of a fatal autoimmune syndrome associated with lupus autoantibodies in mice lacking a functional TGF-β receptor. The prese...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1007/s10875-011-9531-9

    authors： Elbeldi-Ferchiou A,Ben Ahmed M,Smiti-Khanfir M,Houman MH,Abdeladhim M,Belhadj Hmida N,Cerf-Bensussan N,Louzir H

    更新日期：2011-08-01 00:00:00

  • Persistent hypogammaglobulinemia following mononucleosis in boys is highly suggestive of X-linked lymphoproliferative disease--report of three cases.

    abstract：:Hypogammaglobulinemia is a common symptom in different immunodeficiencies. It is, however, not usually associated with Epstein-Barr virus (EBV) infections. The X-linked lymphoproliferative disease (XLP) on the other hand shows immunological changes in response to the EBV. Here we report three previously healthy boys, ...

    journal_title：Journal of clinical immunology

    pub_type： 杂志文章

    doi：10.1023/B:JOCI.0000040922.26286.36

    authors： Hügle B,Suchowerskyj P,Hellebrand H,Adler B,Borte M,Sack U,Overberg-Schmidt US,Strnad N,Otto J,Meindl A,Schuster V

    更新日期：2004-09-01 00:00:00