Influence of smoking and CYP2C19 genotypes on H. pylori eradication success.


:CYP2C19 polymorphisms and smoking influence the efficacy of H. pylori eradication therapy, but interaction between the two have hitherto not been examined. A total of 142 H. pylori-positive patients who received triple drug therapy with lansoprazole, amoxicillin and clarithromycin were categorized into three groups with regard to diplotypes of CYP2C19: homozygous extensive metabolizer (homEM), heterozygous EM (hetEM), and poor metabolizer (PM). The overall success rate was 61.3%. Smoking was an independent risk factor of eradication failure (OR 2.81, 95% CI 1.14-6.91), whereas CYP2C19 polymorphisms were less influential. Among non-smokers, the homEM and hetEM groups showed worse eradication rates (58.5 and 67.3%) relative to PM (76.2%) as expected; however, an opposite trend was observed among smokers (homEM 50.0%, hetEM 46.7%, PM 20.0%), indicating possible interactions with CYP2C19 polymorphisms. Smoking has a greater influence on H. pylori eradication than the CYP2C19 genotype. Interaction between smoking and CYP2C19 should be examined in the future.


Epidemiol Infect


Suzuki T,Matsuo K,Sawaki A,Wakai K,Hirose K,Ito H,Saito T,Nakamura T,Yamao K,Hamajima N,Tajima K




Has Abstract


2007-01-01 00:00:00














  • Intestinal colonization of broiler chickens by Campylobacter spp. in an experimental infection study.

    abstract::Consumption of poultry meat is considered as one of the main sources of human campylobacteriosis, and there is clearly a need for new surveillance and control measures based on quantitative data on Campylobacter spp. colonization dynamics in broiler chickens. We conducted four experimental infection trials, using four...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Bahrndorff S,Garcia AB,Vigre H,Nauta M,Heegaard PM,Madsen M,Hoorfar J,Hald B

    更新日期:2015-08-01 00:00:00

  • Incidence of cardiovascular diseases in a nationwide HIV/AIDS patient cohort in Taiwan from 2000 to 2014.

    abstract::The purpose of the study was to determine the incidence of cardiovascular disease (CVD) among people living with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (PLWHA) in Taiwan. PLWHA were identified from the Taiwan Centers for Disease Control HIV Surveillance System between 2000 and 2014. To e...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Lai YJ,Chen YY,Huang HH,Ko MC,Chen CC,Yen YF

    更新日期:2018-12-01 00:00:00

  • An outbreak of hepatitis A in Gloucester, UK.

    abstract::During an outbreak of hepatitis A that occurred in Gloucester, UK between September 1989 and January 1991, 162 clinical cases were identified through notifications and laboratory reports, a monthly attack rate of 1.05 per 10,000 residents. The highest attack rate was seen in 5-14-year-olds. There were significant corr...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Majeed FA,Stuart JM,Cartwright KA,Room R,Gilkes JR,Smith MC,Watson BE

    更新日期:1992-08-01 00:00:00

  • DNA fingerprinting of Streptococcus uberis: a useful tool for epidemiology of bovine mastitis.

    abstract::A simple and reproducible typing system based on restriction fragment size of chromosomal DNA was developed to compare isolates of Streptococcus uberis obtained from the bovine mammary gland. The endonuclease giving the most useful restriction patterns was Hind III. Although seven other endonucleases (Bgl 1, Eco R1, N...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Hill AW,Leigh JA

    更新日期:1989-08-01 00:00:00

  • Contribution of acute-phase reaction proteins to the diagnosis and treatment of 2019 novel coronavirus disease (COVID-19).

    abstract::The emergence of 2019 novel coronavirus disease (COVID-19) is currently a global concern. In this study, our goal was to explore the changing expression levels of acute-phase reaction proteins (APRPs) in the serum of COVID-19 patients and to elucidate the immunological characteristics of COVID-19. In the study design,...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Li L,Chen C

    更新日期:2020-07-27 00:00:00

  • Strain differentiation of Candida albicans by morphotyping.

    abstract::Strains of Candida albicans can be differentiated by the morphological features of streak colonies developed on malt agar. A morphotyping system is proposed, where numerical codes are assigned primarily on the basis of the nature and extent of marginal fringing and the surface topography of the streak colony. The syst...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Phongpaichit S,Mackenzie DW,Fraser C

    更新日期:1987-10-01 00:00:00

  • Daily shedding dynamics of E. coli O157 in an Australian grass-fed beef herd.

    abstract::This study aimed to describe the diurnal shedding dynamics of Escherichia coli O157 in cattle managed on pasture. The purpose was to identify the value of a single measurement for predicting the shedding status on subsequent days. Over a 14-day period, 24 beef cows with known E. coli O157 shedding status were sampled ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Lammers GA,Jordan D,McCONNEL CS,Heller J

    更新日期:2016-10-01 00:00:00

  • Risk factors for recent toxoplasma infection in pregnant women in Naples.

    abstract::Effective primary prevention of congenital toxoplasmosis requires up to date information on locally relevant risk factors for infection in pregnant women. In Naples, risk factors for toxoplasma infection were compared in recently infected women (as assessed by detection of specific IgM in serum) and susceptible, IgG n...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Buffolano W,Gilbert RE,Holland FJ,Fratta D,Palumbo F,Ades AE

    更新日期:1996-06-01 00:00:00

  • Methicillin-resistant Staphylococcus aureus (MRSA) in food production animals.

    abstract::Until recently, reports on methicillin-resistant Staphylococcus aureus (MRSA) in food production animals were mainly limited to occasional detections in dairy cattle mastitis. However, since 2005 a MRSA clone, CC398, has been reported colonizing pigs, veal calves and broiler chickens and infecting dairy cows. Many asp...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章,评审


    authors: Vanderhaeghen W,Hermans K,Haesebrouck F,Butaye P

    更新日期:2010-05-01 00:00:00

  • Comparison of pulsed-field gel electrophoresis and ribotyping for subtyping of Vibrio cholerae O139 isolated in Thailand.

    abstract::Pulsed-field gel electrophoresis (PFGE) of Cpo I-digested genomic DNA and ribotyping (Bgl I) were applied to 60 Vibrio cholerae strains including 48 V. cholerae O139 from Thailand to compare their value in differentiating strains of the present V. cholerae O139 epidemic. PFGE patterns were divided into groups A and B ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Dalsgaard A,Skov MN,Serichantalergs O,Echeverria P

    更新日期:1996-08-01 00:00:00

  • Modelling the transmission of airborne infections in enclosed spaces.

    abstract::The Wells-Riley equation for modelling airborne infection in indoor environments is incorporated into an SEIR epidemic model with a short incubation period to simulate the transmission dynamics of airborne infectious diseases in ventilated rooms. The model enables the effect of environmental factors such as the ventil...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Noakes CJ,Beggs CB,Sleigh PA,Kerr KG

    更新日期:2006-10-01 00:00:00

  • Serodiagnosis of leptospirosis in China by the one-point MCA method.

    abstract::The one-point MCA method is very simple to perform and useful as a screening test in diagnosing leptospirosis in routine clinical laboratories. The kit, sensitized with six serovars occurring in Japan, was also useful in detecting serum antibodies of patients with leptospirosis in China. ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Arimitsu Y,Matuhasi T,Kobayashi S,Sato T,Cui JJ

    更新日期:1987-10-01 00:00:00

  • Evidence of leptospirosis in the kidneys and serum of feral swine (Sus scrofa) in the United States.

    abstract::Leptospirosis is the most widespread zoonosis in humans worldwide. In the United States, widespread detection of antibodies to leptospirosis have been identified in feral swine (Sus scrofa) with the highest detection of serovars, Bratislava, Icterohaemorrhagiae, and Pomona. Over the past few years, feral swine populat...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Pedersen K,Anderson TD,Bevins SN,Pabilonia KL,Whitley PN,Virchow DR,Gidlewski T

    更新日期:2017-01-01 00:00:00

  • Deviating from IDSA treatment guidelines for non-purulent skin infections increases the risk of treatment failure in emergency department patients.

    abstract::The Infectious Disease Society of America (IDSA) publishes guidelines regularly for the management of skin and soft tissue infections; however, the extent to which practice patterns follow these guidelines and if this can affect treatment failure rates is unknown. We observed the treatment failure rates from a multice...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Haran JP,Wilsterman E,Zeoli T,Goulding M,McLendon E,Clark MA

    更新日期:2018-12-05 00:00:00

  • Dengue, chikungunya and zika virus coinfection: results of the national surveillance during the zika epidemic in Colombia.

    abstract::Our objective was to determine the frequency of zika (ZIKV), chikungunya (CHIKV) and dengue (DENV) virus coinfection and describe the mortality cases that occurred during the epidemiologic surveillance of the ZIKV epidemic in Colombia. We analysed all cases of suspected ZIKV infection that were reported to the Nationa...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Mercado-Reyes M,Acosta-Reyes J,Navarro-Lechuga E,Corchuelo S,Rico A,Parra E,Tolosa N,Pardo L,González M,Martìn-Rodriguez-Hernández J,Karime-Osorio L,Ospina-Martinez M,Rodriguez-Perea H,Del Rio-Pertuz G,Viasus D

    更新日期:2019-01-01 00:00:00

  • Detection of antibodies to Japanese encephalitis virus in the wild boars in Hiroshima prefecture, Japan.

    abstract::Serum specimens were collected from 25 wild boars in Hiroshima prefecture located in the western region of Japan from November 2004 to February 2005. The sera were tested for antibodies to Japanese encephalitis virus (JEV) by IgM capture and IgG enzyme-linked immunosorbent assays (ELISA), and plaque reduction neutrali...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Hamano M,Lim CK,Takagi H,Sawabe K,Kuwayama M,Kishi N,Kurane I,Takasaki T

    更新日期:2007-08-01 00:00:00

  • Multi-country outbreak of Salmonella enteritidis infection linked to the international ice hockey tournament.

    abstract::In April 2015, Finnish public health authorities alerted European Union member states of a possible multi-country Salmonella enteritidis outbreak linked to an international youth ice-hockey tournament in Latvia. The European Centre for Disease Prevention and Control (ECDC), Finnish and Latvian authorities initiated an...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Pärn T,Dahl V,Lienemann T,Perevosčikovs J,De Jong B

    更新日期:2017-08-01 00:00:00

  • Assessment of neonatal tetanus elimination in an African setting by lot quality assurance cluster sampling (LQA-CS).

    abstract::Neonatal tetanus (NT) elimination, < 1 case per 1,000 live births (LB), was assessed at district level in Zimbabwe using a combined lot quality assurance-cluster sampling survey (LQA-CS). Three of the highest risk districts were selected. NT was considered eliminated if fewer than a specified number of NT deaths (prox...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Cotter B,Bremer V,Stroh G,Msambichaka K,Mabuzane E,Munyoro M,Shirehwa F,Biellik R,Birmingham M

    更新日期:2003-04-01 00:00:00

  • Community studies on hepatitis B in Rajahmundry town of Andhra Pradesh, India, 1997-8: unnecessary therapeutic injections are a major risk factor.

    abstract::In Rajahmundry town in India, 234 community cases of jaundice were interviewed for risk factors of viral hepatitis B and tested for markers of hepatitis A-E. About 41% and 1.7% of them were positive for anti-HBc and anti-HCV respectively. Of 83 cases who were tested within 3 months of onset of jaundice, 5 (6%), 11 (13...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Singh J,Bhatia R,Patnaik SK,Khare S,Bora D,Jain DC,Sokhey J

    更新日期:2000-10-01 00:00:00

  • Hepatitis B virus infection in general population in Madagascar: evidence for different epidemiological patterns in urban and in rural areas.

    abstract::To describe the features of hepatitis B virus (HBV) infection in Madagascar, a randomized sero-epidemiological survey was undertaken in the general population > or = 1 year old of two provinces which represents 45% of the total population. In the 921 sera tested, the prevalence of HBV markers was 20.5% for HBsAg, 38.2...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Boisier P,Rabarijaona L,Piollet M,Roux JF,Zeller HG

    更新日期:1996-08-01 00:00:00

  • Epidemiology of classic and AIDS-related Kaposi's sarcoma in the USA: incidence, survival, and geographical distribution from 1975 to 2005.

    abstract::This study aimed to examine trends in incidence, geographical distribution, and survival of classic and AIDS-related Kaposi's sarcoma (KS) in the general US population using Surveillance, Epidemiology, and End Results (SEER) tumour registries with 12 066 patients diagnosed with KS between 1975 and 2005. Although the a...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Armstrong AW,Lam KH,Chase EP

    更新日期:2013-01-01 00:00:00

  • A modified case-control study of cryptosporidiosis (using non-Cryptosporidium-infected enteric cases as controls) in a community setting.

    abstract::Data from the first sentinel site (Waterloo Region, Ontario) of the Canadian Integrated Enteric Disease Surveillance System (C-EnterNet) were used in a secondary-based case-control study of laboratory-confirmed Cryptosporidium infections to study the role of various exposure factors. The incidence of cryptosporidiosis...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Pintar KD,Pollari F,Waltner-Toews D,Charron DF,McEwen SA,Fazil A,Nesbitt A

    更新日期:2009-12-01 00:00:00

  • West Nile virus lineage 2 in Sardinian wild birds in 2012: a further threat to public health.

    abstract::West Nile virus (WNV) strains belonging to lineage 2 were detected and isolated from the tissues of a goshawk and two carrion crows in Sardinia in August 2012. According to NS3 sequence analysis, the Sardinian isolates shared a high level of similarity with those of Italian lineage 2 strains which circulated in 2011 a...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Savini G,Puggioni G,DI Gennaro A,DI Francesco G,Rocchigiani AM,Polci A,Marini V,Pinoni C,Rolesu S,Marruchella G,Lorusso A,Monaco F

    更新日期:2013-11-01 00:00:00

  • Maternal antibody to hepatitis B core antigen detected in dried neonatal blood spot samples.

    abstract::Despite Department of Health recommendations, universal antenatal testing for hepatitis B virus (HBV) is not performed throughout Scotland. We describe the evaluation of an assay to document past or present infection with HBV, by identifying maternal antibody in routine Guthrie dried neonatal blood spot samples taken ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Tappin DM,Greer K,Cameron S,Kennedy R,Brown AJ,Girdwood RW

    更新日期:1998-10-01 00:00:00

  • Kinetics of the IgG antibody response to pertussis toxin after infection with B. pertussis.

    abstract::We aimed to provide a quantitative description of decay in pertussis antibody levels to aid in finding a serological estimate of the incidence of pertussis. The serum IgG response against pertussis toxin was studied in a group of clinically diagnosed patients. Individual records consisted of repeated serum IgG measure...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Teunis PF,van der Heijden OG,de Melker HE,Schellekens JF,Versteegh FG,Kretzschmar ME

    更新日期:2002-12-01 00:00:00

  • Quantitative risk assessment of the introduction of rabies into Japan through the importation of dogs and cats worldwide.

    abstract::Japan has been free from rabies since 1958. A strict import regimen has been adopted since 2004 consisting of identification of an animal with microchip, two-time rabies vaccination, neutralizing antibody titration test and a waiting period of 180 days. The present study aims to quantitatively assess the risk of rabie...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Kwan NC,Sugiura K,Hosoi Y,Yamada A,Snary EL

    更新日期:2017-04-01 00:00:00

  • Influenza vaccine failure in the tropics: a retrospective cohort study of waning effectiveness.

    abstract::Influenza vaccine effectiveness (VE) wanes over the course of a temperate climate winter season but little data are available from tropical countries with year-round influenza virus activity. In Singapore, a retrospective cohort study of adults vaccinated from 2013 to 2017 was conducted. Influenza vaccine failure was ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Young BE,Mak TM,Ang LW,Sadarangani S,Ho HJ,Wilder-Smith A,Barkham T,Chen M

    更新日期:2020-12-02 00:00:00

  • Mapping of control measures to prevent secondary transmission of STEC infections in Europe during 2016 and revision of the national guidelines in Norway.

    abstract::In 2016, we reviewed preventive control measures for secondary transmission of Shiga-toxin producing Escherichia coli (STEC) in humans in European Union (EU)/European Free Trade Association (EEA) countries to inform the revision of the respective Norwegian guidelines which at that time did not accommodate for the vary...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Veneti L,Lange H,Brandal L,Danis K,Vold L

    更新日期:2019-09-09 00:00:00

  • Effect of climatological factors on respiratory syncytial virus epidemics.

    abstract::Respiratory syncytial virus (RSV) presents as yearly epidemics in temperate climates. We analysed the association of atmospheric conditions to RSV epidemics in San Luis Potosí, S.L.P., Mexico. The weekly number of RSV detections from October 2002 and May 2006 were correlated to ambient temperature, barometric pressure...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Noyola DE,Mandeville PB

    更新日期:2008-10-01 00:00:00

  • The incidence of pneumonia using data from a computerized general practice database.

    abstract::Despite being widely recognized as a significant public health problem there are surprisingly few contemporary data available on the incidence of pneumonia in the UK. We conducted a general population-based cohort study to determine the incidence of pneumonia in general practice in the United Kingdom. Data were obtain...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Myles PR,McKeever TM,Pogson Z,Smith CJ,Hubbard RB

    更新日期:2009-05-01 00:00:00