Influence of smoking and CYP2C19 genotypes on H. pylori eradication success.

Abstract:

:CYP2C19 polymorphisms and smoking influence the efficacy of H. pylori eradication therapy, but interaction between the two have hitherto not been examined. A total of 142 H. pylori-positive patients who received triple drug therapy with lansoprazole, amoxicillin and clarithromycin were categorized into three groups with regard to diplotypes of CYP2C19: homozygous extensive metabolizer (homEM), heterozygous EM (hetEM), and poor metabolizer (PM). The overall success rate was 61.3%. Smoking was an independent risk factor of eradication failure (OR 2.81, 95% CI 1.14-6.91), whereas CYP2C19 polymorphisms were less influential. Among non-smokers, the homEM and hetEM groups showed worse eradication rates (58.5 and 67.3%) relative to PM (76.2%) as expected; however, an opposite trend was observed among smokers (homEM 50.0%, hetEM 46.7%, PM 20.0%), indicating possible interactions with CYP2C19 polymorphisms. Smoking has a greater influence on H. pylori eradication than the CYP2C19 genotype. Interaction between smoking and CYP2C19 should be examined in the future.

journal_name

Epidemiol Infect

authors

Suzuki T,Matsuo K,Sawaki A,Wakai K,Hirose K,Ito H,Saito T,Nakamura T,Yamao K,Hamajima N,Tajima K

doi

10.1017/S0950268806006613

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

171-6

issue

1

eissn

0950-2688

issn

1469-4409

pii

S0950268806006613

journal_volume

135

pub_type

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