Differing antibody responses to Haemophilus influenzae type b after meningitis or epiglottitis.

Abstract:

:Two common forms of invasive disease due to Haemophilus influenzae type b (Hib) are epiglottitis and meningitis. It is not known why some children develop epiglottitis and others meningitis. To examine the hypothesis that epiglottitis occurs in children who may have been previously exposed to Hib, and who would therefore exhibit a more vigorous antibody response in convalescence, we measured levels of antibody to Hib capsule in 92 children. Geometric mean convalescent-phase IgG, IgA, IgM and total antibody levels were significantly higher in 45 children with epiglottitis than in 47 with meningitis, even after adjustment for age differences (mean total antibody, 95% confidence intervals: meningitis 0.38, 0.34-0.43; epiglottitis: 2.25, 2.0-2.54 micrograms/ml). However, contrary to previous reports, a poor antibody response was only observed in a minority of children with meningitis; the antibody response of the majority was indistinguishable from that observed in children with epiglottitis.

journal_name

Epidemiol Infect

authors

Johnson PD,Hanlon M,Isaacs D,Gilbert GL

doi

10.1017/s095026880005891x

subject

Has Abstract

pub_date

1996-02-01 00:00:00

pages

21-6

issue

1

eissn

0950-2688

issn

1469-4409

journal_volume

116

pub_type

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