Abstract:
:Two common forms of invasive disease due to Haemophilus influenzae type b (Hib) are epiglottitis and meningitis. It is not known why some children develop epiglottitis and others meningitis. To examine the hypothesis that epiglottitis occurs in children who may have been previously exposed to Hib, and who would therefore exhibit a more vigorous antibody response in convalescence, we measured levels of antibody to Hib capsule in 92 children. Geometric mean convalescent-phase IgG, IgA, IgM and total antibody levels were significantly higher in 45 children with epiglottitis than in 47 with meningitis, even after adjustment for age differences (mean total antibody, 95% confidence intervals: meningitis 0.38, 0.34-0.43; epiglottitis: 2.25, 2.0-2.54 micrograms/ml). However, contrary to previous reports, a poor antibody response was only observed in a minority of children with meningitis; the antibody response of the majority was indistinguishable from that observed in children with epiglottitis.
journal_name
Epidemiol Infectjournal_title
Epidemiology and infectionauthors
Johnson PD,Hanlon M,Isaacs D,Gilbert GLdoi
10.1017/s095026880005891xsubject
Has Abstractpub_date
1996-02-01 00:00:00pages
21-6issue
1eissn
0950-2688issn
1469-4409journal_volume
116pub_type
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