Abstract:
:Experimental data suggest a role for the microflora in Systemic Lupus Erythematosus (SLE). Anti-ds-DNA antibodies may be pathogenic in SLE by forming immune complexes with DNA. Foreign bacteria in the intestines could constitute the stimulus for anti-ds-DNA antibody production in SLE. Colonization Resistance (CR) is the defence capacity of the indigenous microflora against colonization of the intestines by foreign bacteria. A low CR implies increase of translocation of bacteria and a higher chance of subsequent, possibly DNA-cross-reacting antibacterial antibody production. We measured CR by a comprehensive biotyping technique in healthy individuals and patients with inactive and active SLE. CR tended to be lower in active SLE patients than in healthy individuals (P = 0.09, Wilcoxon one sided, with correction for ties). This could indicate that in SLE more and different bacteria translocate across the gut wall due to a lower CR. Some of these may serve as polyclonal B cell activators or as antigens cross-reacting with DNA.
journal_name
Epidemiol Infectjournal_title
Epidemiology and infectionauthors
Apperloo-Renkema HZ,Bootsma H,Mulder BI,Kallenberg CG,van der Waaij Ddoi
10.1017/s0950268800057770subject
Has Abstractpub_date
1994-04-01 00:00:00pages
367-73issue
2eissn
0950-2688issn
1469-4409journal_volume
112pub_type
杂志文章abstract::The number of patients with severe invasive group-G streptococcal (Streptococcus dysgalactiae subsp. equisimilis) infections has been increasing in Japan. The emm genotypes and SmaI-digested pulsed-field gel electrophoresis DNA profiles were variable among the strains isolated, suggesting there has not been clonal exp...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/s0950268803001262
更新日期:2004-01-01 00:00:00
abstract::Two global (re-)emerging zoonoses, leptospirosis and hantavirus infections, are clinically indistinguishable. Thirty-one patients, hospitalized in Sri Lanka for acute severe leptospirosis, were after exclusion of other potentially involved pathogens, prospectively screened with IgM ELISA for both pathogens. Of these, ...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268814003707
更新日期:2015-07-01 00:00:00
abstract::Sera from an outbreak of acute respiratory illness in a boys boarding school originally thought to have been due to psittacosis (1) have been re-examined and evidence is presented that suggests that the outbreak was caused by Chlamydia pneumoniae, strain TWAR (2). ...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/s0950268800030752
更新日期:1989-10-01 00:00:00
abstract::Information about the changing epidemiology of drug-resistant tuberculosis (TB) in hospitals in China over the past decade remains largely unknown. This study examined the susceptibility patterns and trends of drug-resistant TB cases in the 309 Hospital in Beijing, China. Mycobacterium tuberculosis isolates were retro...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268810003158
更新日期:2011-12-01 00:00:00
abstract::A synthetic oligodeoxynucleotide of 40 nucleotides corresponding to nucleotides 33-72 of the gene coding for the viral protein VP7 of rotavirus, was used as a nucleic acid probe to develop a non-radioactive hybridization method for rotavirus detection. The probe was labelled at the 3' end with biotin-7-dATP. The sensi...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/s0950268800049621
更新日期:1992-02-01 00:00:00
abstract::In May 1992, a small, circumscribed community outbreak of infection due to verotoxin-producing Escherichia coli O157 phage type 49 occurred in a semi-rural area of south-east Scotland. On the basis of stool cultures, six cases were identified, one of whom was asymptomatic. One child developed the haemolytic uraemic sy...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/s0950268800051141
更新日期:1994-06-01 00:00:00
abstract::This paper is the first to describe characterization of monoclonal antibodies (MAbs) against a South African Territories 2 (SAT 2) foot-and-mouth disease virus (isolate Rho 1/48). Twelve MAbs which neutralized homologous virus were characterized in indirect and sandwich ELISA using purified Rho 1/48 virus particles, s...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/s0950268800057083
更新日期:1993-10-01 00:00:00
abstract::In recent years, the effect of Toxoplasma gondii infection on the cerebrum and neuropsychiatric patients has been increasingly highlighted. However, there is limited information about the epidemiology of T. gondii infection in psychiatric patients in Shandong province, eastern China. Therefore, through a case-control ...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268814003835
更新日期:2015-10-01 00:00:00
abstract::A case-control study was undertaken in an acute district general hospital to identify risk factors for hospital-acquired bacteraemia caused by methicillin-resistant Staphylococcus aureus (MRSA). Cases of hospital-acquired MRSA bacteraemia were defined as consecutive patients from whom MRSA was isolated from a blood sa...
journal_title:Epidemiology and infection
pub_type: 杂志文章,随机对照试验
doi:10.1017/S0950268806006327
更新日期:2006-12-01 00:00:00
abstract::Despite many years of state-sponsored efforts to eradicate the disease from cattle through testing and slaughter, bovine tuberculosis (bTB) is still regarded as the most important and complex of animal health challenges facing the British livestock agricultural industry. This paper provides a historical analysis of th...
journal_title:Epidemiology and infection
pub_type: 历史文章,杂志文章
doi:10.1017/S0950268815000291
更新日期:2015-11-01 00:00:00
abstract::This longitudinal field study investigated the hypothesis that persistently high antibody levels indicate a high risk of Salmonella Dublin shedding in animals in 14 endemically infected dairy herds. A hierarchical multivariable logistic regression was used to analyse 6614 paired faecal cultures and four types of tempo...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268812002579
更新日期:2013-09-01 00:00:00
abstract::We systematically investigated risk factors for typhoid fever in Kamalapur, a poor urban area of Bangladesh, to inform targeted public health measures for its control. We interviewed patients with typhoid fever and two age-matched controls per case about exposures during the 14 days before the onset of illness. The mu...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268806007114
更新日期:2007-04-01 00:00:00
abstract::To determine the extent age, sex and co-infection affect morbidity in people infected with hepatitis C virus (HCV), we performed a population-based study linking HCV notifications in New South Wales, Australia with their hospital (July 2000 to June 2006), hepatitis B virus (HBV) and HIV notification, and death records...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S095026881000258X
更新日期:2011-08-01 00:00:00
abstract::Q fever patients are often reported to experience a long-term impaired health status, including fatigue, which can persist for many years. During the large Q fever epidemic in The Netherlands, many patients with a laboratory-confirmed Coxiella burnetii infection were not notified as acute Q fever because they did not ...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268814003689
更新日期:2015-09-01 00:00:00
abstract::Foodborne non-typhoidal salmonellosis causes approximately 1 million illnesses annually in the USA. In April 2015, we investigated a multistate outbreak of 65 Salmonella Paratyphi B variant L(+) tartrate(+) infections associated with frozen raw tuna imported from Indonesia, which was consumed raw in sushi. Forty-six (...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268818001462
更新日期:2018-08-01 00:00:00
abstract::Laboratory-based surveillance of invasive pneumococcal infections in adults in Finland from 1983 to 1992 identified 862 episodes of pneumococcal bacteraemia and 97 episodes of meningitis. The overall incidence of invasive pneumococcal infections was 9.1 per 100,000 for all adults per year, but 27.1, 35.8, and 44.5 per...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/s0950268896007169
更新日期:1997-02-01 00:00:00
abstract::Ribotype, biotype and resistance phenotype were used to characterize 37 Acinetobacter baumannii-A. calcoaceticus complex isolates responsible for nosocomial infections in Buenos Aires. Nineteen isolates were recovered from endemic infections at 2 hospitals and 18 represent an intensive care unit outbreak that occurred...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/s0950268800051979
更新日期:1995-02-01 00:00:00
abstract::We conducted a seroepidemiological study to evaluate the potential impact of mass varicella vaccination on the transmission of varicella-zoster virus (VZV) in Italy, where vaccination is not mandatory. We tested 3179 serum samples, collected from September 1996 to October 1997, for specific anti-VZV antibodies using a...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/s0950268801005398
更新日期:2001-06-01 00:00:00
abstract::From 1985 to 1988, a total of 2496 swine sera from 60 farms in the Tohoku District of the Honshu Island of Japan were examined for antibodies to swine haemagglutinating encephalomyelitis virus (HEV), human coronavirus (HCV) and bovine coronavirus (BCV) by haemagglutination-inhibition (HI) test. Antibodies to HEV 67N s...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/s0950268899002332
更新日期:1999-06-01 00:00:00
abstract::Since the late 1990s, hand, foot and mouth disease (HFMD) has become a common health problem that mostly affects children and infants in Southeast and East Asia. Global climate change is considered to be one of the major risk factors for HFMD. This study aimed to assess the correlation between meteorological factors a...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268818003035
更新日期:2018-11-19 00:00:00
abstract::Diabetes mellitus (DM) is currently known to be one of the risk factors for pulmonary tuberculosis (PTB) and the proportion of DM in PTB is rising along with the increased prevalence of DM in countries with high PTB burden. This study was designed to explore the impact of DM on clinical presentation and treatment outc...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S095026881400079X
更新日期:2015-01-01 00:00:00
abstract::During the period 2000-2003, wild grey foxes (Urocyon cinereoargenteus) in northern Colombia became infected with rabies. In order to derive phylogenetic relationships between rabies viruses isolated in foxes, dogs and humans in this region, 902 nt cDNA fragments containing the G-L intergenic region and encoding the c...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/s0950268805003699
更新日期:2005-06-01 00:00:00
abstract::In late 2002, health professionals from the ministries of health and academia of Jordan, the Palestinian Authority and Israel formed the Middle East Consortium on Infectious Disease Surveillance (MECIDS) to facilitate trans-border cooperation in response to infectious disease outbreaks. The first mission of MECIDS was...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268810000270
更新日期:2010-10-01 00:00:00
abstract::We examined multistate outbreaks attributed to raw tomatoes in the United States from 1990 to 2010. We summarized the demographic and epidemiological characteristics of 15 outbreaks resulting in 1959 illnesses, 384 hospitalizations, and three deaths. Most (80%) outbreaks were reported during 2000-2010; 73% occurred Ma...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268814002167
更新日期:2015-05-01 00:00:00
abstract::Foot-and-mouth disease virus (FMDV) can be spread by a variety of mechanisms, including wind. Simulation models, developed to predict the risk of airborne spread, have played an important part in decision making in some outbreaks. The amount of airborne virus excreted as well as the minimal infectious dose (MID) of FM...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/s0950268801006501
更新日期:2002-04-01 00:00:00
abstract::An outbreak of legionellosis associated with a hotel in Sydney, Australia, and the subsequent epidemiological and environmental investigations are described. Four cases of Legionnaires' disease were notified to the Public Health Unit. A cross-sectional study of 184 people who attended a seminar at the hotel was carrie...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/s0950268800052420
更新日期:1996-04-01 00:00:00
abstract::The use of the methylene blue test for the examination of cows milk was investigated in an inter-laboratory survey. A poor relationship was found between results of these tests and total viable counts. Coliforms were detected in a large number of pasteurized milks, indicating frequent post-pasteurization contamination...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/s0950268800067121
更新日期:1988-06-01 00:00:00
abstract::Plague is a re-emerging disease endemic in at least 24 countries. Non-endemic countries should be able to confirm plague to prevent outbreaks due to imported cases. We established a combination of a IgG/IgM screening ELISA and a confirmation immunoblot employing F1 capsular antigen (CA) for the serodiagnosis of plague...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/s0950268800004647
更新日期:2000-12-01 00:00:00
abstract::Despite national guidance recommending testing and vaccination of household contacts of hepatitis B-infected pregnant women, provision and uptake of this is sub-optimal. The aim of this study was to evaluate the use of in-home dried blood spot (DBS) testing to increase testing and vaccination of household contacts of ...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268815003325
更新日期:2016-07-01 00:00:00
abstract::In this study we collected and analysed data of the severe burn patients at our institution over an 11-year period in order to shed light on the controversial role of bloodstream infection (BSI) as a predictive factor for mortality in this burn population. The factors examined were age, total body surface area, smoke ...
journal_title:Epidemiology and infection
pub_type: 杂志文章
doi:10.1017/S0950268813002501
更新日期:2014-10-01 00:00:00