Melanotic macule of nail unit and its clinicopathologic spectrum.

abstract：:There is no topical antiacne medication that acts against all four of the major pathophysiologic features of acne: hyperkeratinization, sebum production, bacterial proliferation, and inflammation. Topical azelaic acid cream helps both to normalize keratinization and to reduce the proliferation of Propionibacterium acn...

journal_title：Journal of the American Academy of Dermatology

authors： Webster G

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND:The genetic heterogeneity of melanomas and melanocytic nevi of the female genital tract is poorly understood. OBJECTIVE:We aim to characterize the frequency of mutations of the following genes: BRAF, NRAS, KIT, GNA11, and GNAQ in female genital tract melanomas. We also characterize the frequency of BRAF mut...

journal_title：Journal of the American Academy of Dermatology

authors： Tseng D,Kim J,Warrick A,Nelson D,Pukay M,Beadling C,Heinrich M,Selim MA,Corless CL,Nelson K

更新日期：2014-08-01 00:00:00

abstract：:A newborn infant with subcutaneous fat necrosis and hypercalcemia is presented. Literature on the association between subcutaneous fat necrosis of the newborn and hypercalcemia is reviewed. Affected infants generally experience severe perinatal difficulties. Both vaginal deliveries and cesarean sections can be associa...

journal_title：Journal of the American Academy of Dermatology

authors： Norwood-Galloway A,Lebwohl M,Phelps RG,Raucher H

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND:Patients with rosacea have increased amounts of cathelicidin and protease activity but their usefulness as disease biomarkers is unclear. OBJECTIVE:We sought to evaluate the effect of doxycycline treatment on cathelicidin expression, protease activity, and clinical response in rosacea. METHODS:In all, 170 ...

journal_title：Journal of the American Academy of Dermatology

authors： Di Nardo A,Holmes AD,Muto Y,Huang EY,Preston N,Winkelman WJ,Gallo RL

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Griseofulvin has been used in the treatment of toenail onychomycosis with limited success. Evidence suggests that terbinafine may be more effective. OBJECTIVE:In a double-blind, parallel-group study we compared 250 mg/day terbinafine for 16 weeks with 500 mg/day griseofulvin for 52 weeks (or for shorter per...

journal_title：Journal of the American Academy of Dermatology

authors： Faergemann J,Anderson C,Hersle K,Hradil E,Nordin P,Kaaman T,Molin L,Pettersson A

更新日期：1995-05-01 00:00:00

abstract：:A patient is described who developed sore throat, palpable purpura, and a distinctive panniculitis. The pathologic alterations in the subcutis were similar to what Wells described in the dermis as eosinophilic cellulitis. In our experience the presence of such a picture primarily in the subcutis is unique. Streptococc...

journal_title：Journal of the American Academy of Dermatology

authors： Burket JM,Burket BJ

更新日期：1985-01-01 00:00:00

abstract：:As the most common human cancer worldwide and continuing to increase in incidence, basal cell carcinoma is associated with significant morbidity and cost. Continued advances in research have refined both our insight and approach to this seemingly ubiquitous disease. This 2-part continuing medical education article wil...

journal_title：Journal of the American Academy of Dermatology

authors： Cameron MC,Lee E,Hibler BP,Barker CA,Mori S,Cordova M,Nehal KS,Rossi AM

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:The American Academy of Dermatology (AAD) practice profile surveys have been conducted for more than a decade to gauge trends in our workforce supply and demand. OBJECTIVE:To update the trends and current workforce issues for the field of dermatology. METHODS:The AAD Practice Profile Survey is sent by both...

journal_title：Journal of the American Academy of Dermatology

authors： Ehrlich A,Kostecki J,Olkaba H

更新日期：2017-10-01 00:00:00

abstract：:When treating psoriasis, various topical emollients exist that can affect the penetration of ultraviolet radiation in phototherapy. Compared with normal-appearing skin with a reflectance of 4% to 5%, psoriatic skin has higher reflectance as a result of its increased air-to-corneocyte interfaces. Studies have tested th...

journal_title：Journal of the American Academy of Dermatology

authors： Asztalos ML,Heller MM,Lee ES,Koo J

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Psoralen plus ultraviolet A (PUVA) for the treatment of psoriasis has never been evaluated using the Psoriasis Area Severity Index (PASI) in a randomized, double-blind, placebo-controlled trial. The lack of such data limits our capacity to estimate PUVA's efficacy relative to other treatment options that are...

journal_title：Journal of the American Academy of Dermatology

authors： Sivanesan SP,Gattu S,Hong J,Chavez-Frazier A,Bandow GD,Malick F,Kricorian G,Koo J

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Few studies have reported the accuracy of measures used to assess sun-protection practices. Valid measures are critical to the internal validity and use of skin cancer control research. OBJECTIVES:We sought to validate self-reported covering-up practices of pool-goers. METHODS:A total of 162 lifeguards and...

journal_title：Journal of the American Academy of Dermatology

authors： O'Riordan DL,Nehl E,Gies P,Bundy L,Burgess K,Davis E,Glanz K

更新日期：2009-05-01 00:00:00

abstract：:Multiple basal cell epitheliomas developed in two psoriatic patients during treatment with orally administered 8-methoxypsoralen and long-wave ultraviolet radiation (PUVA). Twenty-two basal cell epitheliomas (BCEs) were seen in the two patients, 80% occurring in non-sun-exposed areas. Since neither patient had any his...

journal_title：Journal of the American Academy of Dermatology

authors： Brown FS,Burnett JW,Robinson HM Jr

更新日期：1980-05-01 00:00:00

abstract：:Infections with mycobacteria are of importance in the differential diagnosis of skin lesions in immunocompromised patients. We report the case of a human immunodeficency virus (HIV)-infected patient who presented with an annular plaque as cutaneous manifestation of Mycobacterium haemophilum. Improvement of the immunol...

journal_title：Journal of the American Academy of Dermatology

authors： Friedli A,Krischer J,Hirschel B,Saurat JH,Pechère M

更新日期：2000-11-01 00:00:00

abstract：:We report the excellent therapeutic response obtained with amikacin alone and in combination with trimethoprim-sulfamethoxazole in the treatment of 15 patients with actinomycotic mycetoma who had a poor response to the traditional pharmacologic agents and/or in whom important organs such as lungs, spinal cord, and bon...

journal_title：Journal of the American Academy of Dermatology

authors： Welsh O,Sauceda E,Gonzalez J,Ocampo J

更新日期：1987-09-01 00:00:00

abstract：:The yeasts of the genus Malassezia have been associated with a number of diseases affecting the human skin, such as pityriasis versicolor, Malassezia (Pityrosporum) folliculitis, seborrheic dermatitis and dandruff, atopic dermatitis, psoriasis, and--less commonly--with other dermatologic disorders such as confluent an...

journal_title：Journal of the American Academy of Dermatology

authors： Gupta AK,Batra R,Bluhm R,Boekhout T,Dawson TL Jr

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVE:Classical dermatomyositis (CDM) patients display the hallmark cutaneous manifestations of dermatomyositis (DM), proximal muscle weakness, and laboratory evidence of myositis. The epidemiology and management of both adult-onset and juvenile-onset CDM has been well characterized. However, the clinical significa...

journal_title：Journal of the American Academy of Dermatology

authors： Gerami P,Schope JM,McDonald L,Walling HW,Sontheimer RD

更新日期：2006-04-01 00:00:00

abstract：:Three patients with advanced atherosclerotic vascular disease developed multiple cholesterol emboli. The clinical presentation typically includes livedo reticularis of the lower part of the body and purple toes. Small areas of necrosis and ulceration may be present distally, despite palpable pulses. Muscular and abdom...

journal_title：Journal of the American Academy of Dermatology

authors： Kalter DC,Rudolph A,McGavran M

更新日期：1985-08-01 00:00:00

abstract：:Angioedema is characterized by localized swelling of sudden onset affecting the skin and/or mucous membranes. It can be classified into hereditary and acquired forms. Hereditary angioedema is a rare disease inherited as an autosomal dominant trait and caused by a deficiency of C1-esterase inhibitor. Acute attacks are ...

journal_title：Journal of the American Academy of Dermatology

authors： Greaves M,Lawlor F

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:To prevent DNA damage caused by the ultraviolet (UV) radiation of sunlight, sunscreens are commonly used to protect human skin. Current analysis of sunscreens' effectiveness is done through complicated procedures, including human exposure. OBJECTIVE:We sought to design a simple system using thymidine-thymid...

journal_title：Journal of the American Academy of Dermatology

authors： Maw KL,Caton-Williams J,Salon J,Huang Z

更新日期：2011-08-01 00:00:00

abstract：:We report an unusual case of congenital melanocytic nevus presenting in a 19-year-old African woman as widespread papules and variably sized nodules and tumors affecting the entire body, including the palms, soles, and oral mucous membrane. Histopathologic examination of 3 representative skin lesions showed mainly der...

journal_title：Journal of the American Academy of Dermatology

authors： Rose C,Kaddu S,El-Sherif TF,Kerl H

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Psoriasis's effect on diabetes onset is well documented, but its effect on course of diabetes is poorly understood. OBJECTIVE:We sought to compare risks of developing microvascular and macrovascular complications between diabetic patients with and without psoriasis. METHODS:Adults with 2 or more diabetes d...

journal_title：Journal of the American Academy of Dermatology

authors： Armstrong AW,Guérin A,Sundaram M,Wu EQ,Faust ES,Ionescu-Ittu R,Mulani P

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Molluscum contagiosum (MC) is a common and at times severely disfiguring cutaneous viral infection in patients with human immunodeficiency virus (HIV) infection. OBJECTIVE:The purpose of this study was to describe the clinical course of MC in patients with HIV infection and to examine the relation between p...

journal_title：Journal of the American Academy of Dermatology

authors： Schwartz JJ,Myskowski PL

更新日期：1992-10-01 00:00:00

abstract：:Based upon case reports and small case series, it has been known for many years that some types and subtypes of inherited epidermolysis bullosa (EB) may be at risk for developing one or more extracutaneous complications. Many of these are associated with considerable morbidity; some may result in death. Only over the ...

journal_title：Journal of the American Academy of Dermatology

authors： Fine JD,Mellerio JE

更新日期：2009-09-01 00:00:00

abstract：:Blood eosinophilia is a common feature of eosinophilic fasciitis and is variably reported in systemic sclerosis and localized scleroderma. Since these diseases share cutaneous fibrosis as the final outcome and have other clinical and pathologic features that are difficult to differentiate, the presence of blood eosino...

journal_title：Journal of the American Academy of Dermatology

authors： Falanga V,Medsger TA Jr

更新日期：1987-10-01 00:00:00

abstract：BACKGROUND:Australia has one of the highest rates of skin cancer globally. Lifetime risk is associated with childhood sun exposure. OBJECTIVE:We sought to investigate whether skin cancer prevention programs have resulted in improvements in sun-exposure and sun-protection behavior among young children in tropical Austr...

journal_title：Journal of the American Academy of Dermatology

authors： Smith A,Harrison S,Nowak M,Buettner P,Maclennan R

更新日期：2013-05-01 00:00:00

abstract：:Patients with HIV and AIDS are living longer because of advancements in antiretroviral therapy. These patients are often susceptible to debilitating inflammatory disorders that are refractory to standard treatment. We discuss the relationship of tumor necrosis factor-alpha and HIV and then review 27 published cases of...

journal_title：Journal of the American Academy of Dermatology

authors： Gallitano SM,McDermott L,Brar K,Lowenstein E

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Patients with cutaneous melanoma metastases have experienced excellent responses to intralesional interleukin (IL)-2. This has led to its recent inclusion into the US National Comprehensive Cancer Network guidelines for management of cutaneous melanoma metastases. Despite this, intralesional IL-2 has not bee...

journal_title：Journal of the American Academy of Dermatology

authors： Shi VY,Tran K,Patel F,Leventhal J,Konia T,Fung MA,Wilken R,Garcia MS,Fitzmaurice SD,Joo J,Monjazeb AM,Burrall BA,King B,Martinez S,Christensen SD,Maverakis E

更新日期：2015-10-01 00:00:00

abstract：:Vellus hair cysts were present from birth in two of four siblings and their mother. There has been no tendency for remission. This is the first report of vellus hair cysts appearing at birth, and the second report of a kindred in which there was apparent autosomal dominant inheritance. This disorder appears to represe...

journal_title：Journal of the American Academy of Dermatology

authors： Piepkorn MW,Clark L,Lombardi DL

更新日期：1981-12-01 00:00:00

abstract：BACKGROUND:Despite a high incidence of xeroderma pigmentosum, there is no previous publication from Libya. OBJECTIVE:The purpose was to study the clinical profile of Libyan cases of xeroderma pigmentosum. METHODS:With the help of a special protocol, 24 cases of xeroderma pigmentosum treated between 1981 and 1990 were...

journal_title：Journal of the American Academy of Dermatology

authors： Khatri ML,Shafi M,Mashina A

更新日期：1992-01-01 00:00:00

abstract：:Sixty-eight cutaneous squamous cell neoplasms (in situ and invasive) and 26 basal cell carcinomas from 89 patients were analyzed for DNA sequences homologous to the human papillomavirus (HPV) types found predominantly in the genital tract. Thirty-six (53%) of the squamous cell neoplasms contained HPV DNA as detected b...

journal_title：Journal of the American Academy of Dermatology

authors： Eliezri YD,Silverstein SJ,Nuovo GJ

更新日期：1990-11-01 00:00:00